Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment

Nature Medicine

Volumn 13, Issue 6, 2007, Pages 742-747

  Ju, Zhenyu ^a   Jiang, Hong ^a   Jaworski, Maike ^b   Rathinam, Chozhavendan ^a   Gompf, Anne ^a   Klein, Christoph ^a   Trumpp, Andreas ^b   Rudolph, K Lenhard ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b SWISS INST FOR EXP CANCER RESEARCH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GRANULOCYTE COLONY STIMULATING FACTOR;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; B LYMPHOCYTE; CONTROLLED STUDY; CORRELATION ANALYSIS; ENVIRONMENTAL FACTOR; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; KNOCKOUT MOUSE; LYMPHOPOIESIS; MESENCHYMAL STEM CELL; MESENCHYMAL STEM CELL TRANSPLANTATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STROMA CELL; TELOMERE; WILD TYPE;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL AGING; CELL PROLIFERATION; CELLS, CULTURED; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HOMEOSTASIS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOID CELLS; RNA; TELOMERASE; TELOMERE; UP-REGULATION;

MUS;

EID: 34250017413     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1578     Document Type: Article

References (30)

1. Min, H., Montecino-Rodriguez, E. & Dorshkind, K. Effects of aging on early B- and T-cell development. Immunol. Rev. 205, 7-17 (2005).
2. Van Zant, G. & Liang, Y. The role of stem cells in aging. Exp. Hematol. 31, 659-672 (2003).
3. Nishimura, E.K., Granter, S.R. & Fisher, D.E. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307, 720-724 (2005).
4. Rando, T.A. Stem cells, aging and the quest for immortality. Nature 441, 1080-1086 (2006).
5. Conboy, I.M. et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433, 760-764 (2005).
6. Lieber, M.R. & Karanjawala, Z.E. Aging, repetitive genomes and DNA damage. Nat. Rev. Mol. Cell Biol. 5, 69-75 (2004).
7. d'Adda di Fagagna, F. et al. A DNA damage checkpoint response in telomere-initiated senescence. Nature 426, 194-198 (2003).
8. Vaziri, H. & Benchimol, S. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging. Exp. Gerontol. 31, 295-301 (1996).
9. Djojosubroto, M.W., Choi, Y.S., Lee, H.W. & Rudolph, K.L. Telomeres and telomerase in aging, regeneration and cancer. Mol. Cells 15, 164-175 (2003).
10. Vulliamy, T. et al. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat. Genet. 36, 447-449 (2004).
11. Rudolph, K.L. et al. Longevity, stress response, and cancer in aging telomerase-deficient mice. Cell 96, 701-712 (1999).
12. Herrera, E. et al. Disease states associated with telomerase deficiency appear earlier in mice with short telomeres. EMBO J. 18, 2950-2960 (1999).
13. Allsopp, R.C., Morin, G.B., DePinho, R.A., Harley, C.B. & Weissman, I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102, 517-520 (2003).
14. Choudhury, A.R. et al. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat. Genet. 39, 99-105 (2007).
15. Hemann, M.T., Strong, M.A., Hao, L.Y. & Greider, C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosomal stability. Cell 107, 67-77 (2001).
16. Hardy, R.R. & Shinton, S.A. Characterization of B lymphopoiesis in mouse bone marrow and spleen. Methods Mol. Biol. 271, 1-24 (2004).
17. Wilson, A. & Trumpp, A. Bone-marrow haematopoietic-stem-cell niches. Nat. Rev. Immunol. 6, 93-106 (2006).
18. Adams, G.B. & Scadden, D.T. The hematopoietic stem cell in its place. Nat. Immunol. 7, 333-337 (2006).
19. Drize, N., Gan, O. & Zander, A. Effect of recombinant human granulocyte colony-stimulating factor treatment of mice on spleen colony-forming unit number and self-renewal capacity. Exp. Hematol. 21, 1289-1293 (1993).
20. Neben, S., Marcus, K. & Mauch, P. Mobilization of hematopoietic stem and progenitor cell subpopulations from the marrow to the blood of mice following cyclophosphamide and/or granulocyte colony-stimulating factor. Blood 81, 1960-1967 (1993).
21. Min, H., Montecino-Rodriguez, E. & Dorshkind, K. Effects of aging on the common lymphoid progenitor to pro-B cell transition. J. Immunol. 176, 1007-1012 (2006).
22. Saba, H.I. Myelodysplastic syndromes in the elderly. Cancer Control 8, 79-102 (2001).
23. Hornsby, P.J. Telomerization of mammalian cells and transplantation of telomerized cells in immunodeficient mice. Methods Mol. Biol. 240, 147-166 (2004).
24. Shay, J.W. & Wright, W.E. The use of telomerized cells for tissue engineering. Nat. Biotechnol. 18, 22-23 (2000).
25. Shelton, D.N., Chang, E., Whittier, P.S., Choi, D. & Funk, W.D. Microarray analysis of replicative senescence. Curr. Biol. 9, 939-945 (1999).
26. Caruso, C., Lio, D., Cavallone, L. & Franceschi, C. Aging, longevity, inflammation, and cancer. Ann. NY Acad. Sci. 1028, 1-13 (2004).
27. Davis, T. & Kipling, D. Werner syndrome as an example of inflamm-aging: possible therapeutic opportunities for a progeroid syndrome? Rejuvenation Res. 9, 402-407 (2006).
28. Zatz, M.M. & Goldstein, A.L. Thymosins, lymphokines, and the immunology of aging. Gerontology 31, 263-277 (1985).
29. Parrinello, S., Coppe, J.P., Krtolica, A. & Campisi, J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci. 118, 485-496 (2005).
30. Rudolph, K.L., Millard, M., Bosenberg, M.W. & DePinho, R.A. Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat. Genet. 28, 155-159 (2001).