Reduction in the developmental potential of intrathymic T cell progenitors with age

Journal of Immunology

Volumn 173, Issue 1, 2004, Pages 245-250

  Min, Hyeyoung ^a   Montecino Rodriguez, Encarnacion ^a   Dorshkind, Kenneth ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGING; ANIMAL CELL; APOPTOSIS; ARTICLE; BONE MARROW CELL; CELL COMPARTMENTALIZATION; CELL PROLIFERATION; CELL VIABILITY; FEMALE; HEMATOPOIETIC SYSTEM; INVOLUTION; MALE; MICROENVIRONMENT; MOUSE; NONHUMAN; PRIORITY JOURNAL; STEM CELL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 2942700206     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.1.245     Document Type: Article

References (31)

1. Haynes, B. F., M. L. Markert, G. D. Sempowski, D. D. Patel, and L. P. Hale. 2000. The role of the thymus in immune reconstitution in aging, bone marrow transplantation, and HIV-1 infection. Annu. Rev. Immunol. 18:529.
2. Aspinall, R., and D. Andrew. 2000. Thymic involution in aging. J. Clin. Immunol. 20:250.
3. Andrew, D., and R. Aspinall. 2001. II-7 and not stem cell factor reverses both the increase in apoptosis and the decline in thymopoiesis seen in aged mice. J. Immunol. 166:1524.
4. Andrew, D., and R. Aspinall. 2002. Age-associated thymic atrophy is linked to a decline in IL-7 production. Exp. Gerontol. 37:455.
5. Montecino-Rodriguez, E., R. Clark, and K. Dorshkind. 1998. Effects of insulin-like growth factor administration and bone marrow transplantation on thymopoiesis in aged mice. Endocrinology 139:4120.
6. Kelley, K. W., S. Grief, H. J. Westly, J. Novakofski, P. J. Bechtel, J. Simon, and E. B. Walker. 1986. GH3 pituitary adenoma cells can reverse thymic aging in rats. Proc. Natl. Acad. Sci. USA 85:5663.
7. Aspinall, R. 1997. Age-associated thymic atrophy in the mouse is due to a deficiency affecting rearrangement of the TCR during intrathymic T cell development. J. Immunol. 158:3037.
8. Thoman, M. L. 1997. Early steps in T cell development are affected by aging. Cell. Immunol. 178:117.
9. Thoman, M. L. 1995. The pattern of T lymphocyte differentiation is altered during thymic involution. Mech. Ageing Dev. 82:155.
10. - thymocyte population. Cell. Immunol. 212:150.
11. Tyan, M. L. 1977. Age-related decrease in mouse T cell progenitors. J. Immunol. 1187:846.
12. Yu, S., L. Abel, and A. Globerson. 1997. Thymocyte progenitors and T cell development in aging. Mech. Ageing Dev. 94:103.
13. Sudo, K., H. Ema, Y. Morita, and H. Nakauchi. 2000. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192:1273.
14. Hirokawa, K., S. Kubo, M. Utsuyama, C. Kurashima, and T. Sado. 1986. Age-related change in the potential of bone marrow cells to repopulate the thymus and splenic T cells in mice. Cell. Immunol. 100:443.
15. - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150:4244.
16. Ceredig, R., and T. Rolink. 2002. A positive look at double-negative thymocytes. Nat. Rev. Immunol. 2:2.
17. Allman, D., A. Sambandam, S. Kim, J. P. Miller, A. Pagan, D. Well, A. Meraz, and A. Bhandoola. 2003. Thymopoiesis independent of common lymphoid progenitors. Nat. Immunol. 4:168.
18. Jenkinson, E. J., L. L. Franchi, R. Kingston, and J. J. T. Owen. 1982. Effect of deoxyguanosine on lymphopoiesis in the developing thymus rudiment in vitro: application in the production of chimeric thymus rudiments. Eur. J. Immunol. 12:583.
19. + lymphoid-restricted bone marrow cells with T precursor potential. Nat. Immunol. 4:866.
20. Schluter, C., M. Duchrow, C. Wohlenberg, M. H. Becker, G. Key, H. D. Flad, and J. Gerdes. 1993, The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements representing a new kind of cell cycle-maintaining protein. J. Cell Biol. 123:513.
21. Sharp, A., T. Kukulandky, and A. Globerson. 1990. In vitro analysis of age-related changes in the developmental potential of bone marrow thymocyte precursors. Eur. J. Immunol. 20:2541.
22. Eren, R., A. Globerson, L. Abel, and D. Zharary. 1990. Quantitative analysis of bone marrow thymic progenitors in young and aged mice. Cell. Immunol. 127:238.
23. Ortman, C. L., K. A. Dittmar, P. L. Witte, and P. T. Le. 2002. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol. 14:813.
24. Li, L., H. C. Hsu, G. E. Grizzle, C. R. Stockard, K. J. Ho, P. Lott, P. A. Yang, H. G. Zhang, and J. D. Mountz. 2003. Cellular mechanisms of thymic involution. Scand. J. Immunol. 57:410.
25. Kondo, M., I. L. Weissman, and K. Akashi. 1997. Identification of common lymphoid progenitors in mouse bone marrow. Cell 91:661.
26. Dorshkind, K., and E. Montecino-Rodriguez. 2003. To T or not to T: reassessing the common lymphoid progenitor. Nat. Immunol. 4:100.
27. Cotta, C. V., Z. Zhang, H. G. Kim, and C. A. Klug. 2003. Pax5 determines B-versus T-cell fate and does not block early myeloid-lineage development. Blood 101:4342.
28. Miller, J. P., and D. Allman. 2003. The decline in B lymphopoiesis in aged mice reflects loss of very early B-lineage precursors. J. Immunol. 171:2326.
29. Blackburn, C. C., N. R. Manley, D. B. Palmer, R. L. Boyd, G. Anderson, and M. A. Ritter. 2002. One for all and all for one: thymic epithelial stem cells and regeneration. Trends Immunol. 23:391.
30. Anderson, G., and E. J. Jenkinson. 2001. Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1:31.
31. Klug, D. B., C. Carter, I. B. Gimenez-Conti, and R. R. Richie. 2002. Thymocyte-independent and thymocyte dependent phases of epithelial patterning in fetal thymus. J. Immunol. 169:2842.