Germline mutations of EX01 gene in patients with hereditary nonpolyposis colorectal cancer (HNPCC) and atypical HNPCC forms

Gastroenterology

Volumn 120, Issue 7, 2001, Pages 1580-1587

  Wu, Ying ^a   Berends, Maran J W ^a   Post, Jan G ^a   Mensink, Rob G J ^a   Verlind, Edwin ^a   Van der Sluis, Tineke ^a   Kempinga, Claudia ^a   Sijmons, Rolf H ^a   Van der Zee, Ate G J ^a   Hollema, Harry ^a   Kleibeuker, Jan H ^a   Buys, Charles H C M ^a   Hofstra, Robert M W ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

EXO1 PROTEIN, HUMAN; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE I; MICROSATELLITE DNA; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

ARTICLE; BASE MISPAIRING; COLORECTAL TUMOR; DNA REPAIR; GENETICS; HETEROZYGOSITY LOSS; HUMAN; MUTATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ALLELE; COLORECTAL CANCER; CONTROLLED STUDY; GENE MUTATION; MAJOR CLINICAL STUDY; MICROSATELLITE INSTABILITY; MISSENSE MUTATION; MOLECULAR CLONING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

BASE PAIR MISMATCH; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; DNA REPAIR; DNA REPAIR ENZYMES; EXODEOXYRIBONUCLEASES; GERM-LINE MUTATION; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 0034743983     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/gast.2001.25117     Document Type: Article

References (20)

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2. New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative Group on HNPCC
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4. Suspected hereditary nonpolyposis colorectal cancer
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6. Identification of a human gene encoding a homologue of Saccharomyces cerevisiae EXO1, an exonuclease implicated in mismatch repair and recombination
7. Hex1: A new human Rad2 nuclease family member with homology to yeast exonuclease 1
8. Identification and characterization of Saccharomyces cerevisiae EXO1, a gene encoding an exonuclease that interacts with MSH2
9. Human exonuclease 1 functionally complements its yeast homologues in DNA recombination, RNA primer removal, and mutation avoidance
10. Human exonuclease I interacts with the mismatch repair protein hMSH2
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12. Improvement of fragment and primer selection for mutation detection by denaturing gradient gel electrophoresis
13. A National Cancer Institute workshop on microsatellite instability for cancer detection and familial predisposition: Development of international criteria for the determination of microsatellite instability in colorectal cancer
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