메뉴 건너뛰기




Volumn 29, Issue 1, 2008, Pages 12-20

When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; DECTIN 1; GLUCOCORTICOID; LECTIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2;

EID: 46749136412     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2008.06.004     Document Type: Review
Times cited : (308)

References (84)
  • 2
    • 33845438110 scopus 로고    scopus 로고
    • SHP-2 phosphatase negatively regulates the Trif adaptor protein-dependent Type I interferon and proinflammatory cytokine production
    • An H., Zhao W., Hou J., Zhang Y., Xie Y., Zheng Y., Xu H., Qian C., Zhou J., Yu Y., et al. SHP-2 phosphatase negatively regulates the Trif adaptor protein-dependent Type I interferon and proinflammatory cytokine production. Immunity 25 (2006) 919-928
    • (2006) Immunity , vol.25 , pp. 919-928
    • An, H.1    Zhao, W.2    Hou, J.3    Zhang, Y.4    Xie, Y.5    Zheng, Y.6    Xu, H.7    Qian, C.8    Zhou, J.9    Yu, Y.10
  • 3
    • 42449121356 scopus 로고    scopus 로고
    • Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
    • An H., Hou J., Zhou J., Zhao W., Xu H., Zheng Y., Yu Y., Liu S., and Cao X. Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. Nat. Immunol. 9 (2008) 542-550
    • (2008) Nat. Immunol. , vol.9 , pp. 542-550
    • An, H.1    Hou, J.2    Zhou, J.3    Zhao, W.4    Xu, H.5    Zheng, Y.6    Yu, Y.7    Liu, S.8    Cao, X.9
  • 4
    • 0035953547 scopus 로고    scopus 로고
    • TREM-1 amplifies inflammation and is a crucial mediator of septic shock
    • Bouchon A., Facchetti F., Weigand M.A., and Colonna M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410 (2001) 1103-1107
    • (2001) Nature , vol.410 , pp. 1103-1107
    • Bouchon, A.1    Facchetti, F.2    Weigand, M.A.3    Colonna, M.4
  • 6
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • Bowie A.G., and O'Neill L.A.J. The family of five: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7 (2007) 353-364
    • (2007) Nat. Rev. Immunol. , vol.7 , pp. 353-364
    • Bowie, A.G.1    O'Neill, L.A.J.2
  • 7
    • 34848844641 scopus 로고    scopus 로고
    • Mass spectrometric analysis of the endogenous IL-1RI signalling complex formed after IL-1 binding, identifies IL-1RAcP, MyD88 and IRAK-4 as the stable components
    • Brikos C., Wait R., Begum S., O'Neill L.A., and Saklatvala J. Mass spectrometric analysis of the endogenous IL-1RI signalling complex formed after IL-1 binding, identifies IL-1RAcP, MyD88 and IRAK-4 as the stable components. Mol. Cell Proteomics 6 (2007) 1551-1559
    • (2007) Mol. Cell Proteomics , vol.6 , pp. 1551-1559
    • Brikos, C.1    Wait, R.2    Begum, S.3    O'Neill, L.A.4    Saklatvala, J.5
  • 9
    • 35649022764 scopus 로고    scopus 로고
    • Kinase active IRAKs promote polyubiquination and degradation of the pellino family: direct evidence for pellino proteins being E3 ubiquitin ligases
    • Butler M.P., Hanly J.A., and Moynagh P.N. Kinase active IRAKs promote polyubiquination and degradation of the pellino family: direct evidence for pellino proteins being E3 ubiquitin ligases. J. Biol. Chem. 282 (2007) 29729-29737
    • (2007) J. Biol. Chem. , vol.282 , pp. 29729-29737
    • Butler, M.P.1    Hanly, J.A.2    Moynagh, P.N.3
  • 10
    • 33748871187 scopus 로고    scopus 로고
    • The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
    • Carty M., Goodbody R., Schröder M., Stack J., Moynagh P.N., and Bowie A.G. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat. Immunol. 7 (2006) 1074-1081
    • (2006) Nat. Immunol. , vol.7 , pp. 1074-1081
    • Carty, M.1    Goodbody, R.2    Schröder, M.3    Stack, J.4    Moynagh, P.N.5    Bowie, A.G.6
  • 11
    • 46749097334 scopus 로고    scopus 로고
    • TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus
    • 10.1016/j.meegid.2008.03.001 in press. Published online March 12, 2008
    • Castiblanco J., Varela D.C., Castaño-Rodríguez N., Rojas-Villarraga A., Hincapié M.E., and Anaya J.M. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect. Genet. Evol. (2008) 10.1016/j.meegid.2008.03.001 in press. Published online March 12, 2008
    • (2008) Infect. Genet. Evol.
    • Castiblanco, J.1    Varela, D.C.2    Castaño-Rodríguez, N.3    Rojas-Villarraga, A.4    Hincapié, M.E.5    Anaya, J.M.6
  • 13
    • 34547883918 scopus 로고    scopus 로고
    • Anti-inflammatory functions of glucocorticoid genes
    • Clark A.R. Anti-inflammatory functions of glucocorticoid genes. Mol. Cell. Endocrinol. 275 (2007) 79-97
    • (2007) Mol. Cell. Endocrinol. , vol.275 , pp. 79-97
    • Clark, A.R.1
  • 14
    • 43249120917 scopus 로고    scopus 로고
    • Lys (K)63-linked polyubiquitination of IRAK-1 is required for IL-1 receptor- and Toll-like receptor-mediated NF-kappaB activation
    • 10.1128/MCB.02098-07 in press. Published online March 17, 2008
    • Conze D.B., Wu C.J., Thomas J.A., Landstrom A., and Ashwell J.D. Lys (K)63-linked polyubiquitination of IRAK-1 is required for IL-1 receptor- and Toll-like receptor-mediated NF-kappaB activation. Mol. Cell. Biol. (2008) 10.1128/MCB.02098-07 in press. Published online March 17, 2008
    • (2008) Mol. Cell. Biol.
    • Conze, D.B.1    Wu, C.J.2    Thomas, J.A.3    Landstrom, A.4    Ashwell, J.D.5
  • 15
    • 33745847180 scopus 로고    scopus 로고
    • TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
    • Creagh E.M., and O'Neill L.A.J. TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol. 27 (2006) 352-357
    • (2006) Trends Immunol. , vol.27 , pp. 352-357
    • Creagh, E.M.1    O'Neill, L.A.J.2
  • 16
    • 0034644474 scopus 로고    scopus 로고
    • Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain
    • Deng L., Wang C., Spencer E., Yang L., Braun A., You J., Slaughter C., Pickart C., and Chen Z.J. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell 103 (2000) 351-361
    • (2000) Cell , vol.103 , pp. 351-361
    • Deng, L.1    Wang, C.2    Spencer, E.3    Yang, L.4    Braun, A.5    You, J.6    Slaughter, C.7    Pickart, C.8    Chen, Z.J.9
  • 18
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert C., Pétrilli V., Van Bruggen R., Steele C., Mossman B.T., and Tschopp J. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 320 (2008) 674-677
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Pétrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 19
    • 21244503601 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS
    • Doyle S.L., Jefferies C.A., and O'Neill L.A. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NF-kappa B activation by LPS. J. Biol. Chem. 280 (2005) 23496-23501
    • (2005) J. Biol. Chem. , vol.280 , pp. 23496-23501
    • Doyle, S.L.1    Jefferies, C.A.2    O'Neill, L.A.3
  • 20
    • 37549021148 scopus 로고    scopus 로고
    • Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase
    • Doyle S.L., Jefferies C.A., Feighery C., and O'Neill L.A. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J. Biol. Chem. 282 (2007) 36953-36960
    • (2007) J. Biol. Chem. , vol.282 , pp. 36953-36960
    • Doyle, S.L.1    Jefferies, C.A.2    Feighery, C.3    O'Neill, L.A.4
  • 21
    • 36849069342 scopus 로고    scopus 로고
    • Pivotal involvement of Fc-gamma receptor IIA in the neutralisation of lipopolysaccharide signalling via a potent novel anti-TLR4 monoclonal antibody 15C1
    • Dunn-Siegrist I., Leger O., Daubeuf B., Poitevin Y., Depis F., Herren S., Kosco-Vilbois M., Dean Y., Pugin J., and Elson G. Pivotal involvement of Fc-gamma receptor IIA in the neutralisation of lipopolysaccharide signalling via a potent novel anti-TLR4 monoclonal antibody 15C1. J. Biol. Chem. 282 (2007) 34817-34827
    • (2007) J. Biol. Chem. , vol.282 , pp. 34817-34827
    • Dunn-Siegrist, I.1    Leger, O.2    Daubeuf, B.3    Poitevin, Y.4    Depis, F.5    Herren, S.6    Kosco-Vilbois, M.7    Dean, Y.8    Pugin, J.9    Elson, G.10
  • 22
    • 33744543517 scopus 로고    scopus 로고
    • MyD88 Adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction
    • Gray P., Dunne A., Brikos C., Jefferies C.A., Doyle S.L., and O'Neill L.A. MyD88 Adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J. Biol. Chem. 281 (2006) 10489-10495
    • (2006) J. Biol. Chem. , vol.281 , pp. 10489-10495
    • Gray, P.1    Dunne, A.2    Brikos, C.3    Jefferies, C.A.4    Doyle, S.L.5    O'Neill, L.A.6
  • 23
    • 20644443886 scopus 로고    scopus 로고
    • Enhanced Toll-like receptor responses in the absence of signalling adaptor DAP12
    • Hamerman J.A., Tchao N.K., Lowell C.A., and Lanier L.L. Enhanced Toll-like receptor responses in the absence of signalling adaptor DAP12. Nat. Immunol. 6 (2005) 579-586
    • (2005) Nat. Immunol. , vol.6 , pp. 579-586
    • Hamerman, J.A.1    Tchao, N.K.2    Lowell, C.A.3    Lanier, L.L.4
  • 30
    • 0037492123 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is a TIR domain binding protein that participates in NFkappa B activation by Toll-like receptor 4
    • Jefferies C.A., Doyle S., Brunner C., Dunne A., Brint E., Wietek C., Walch E., Wirth T., and O'Neill L.A. Bruton's tyrosine kinase is a TIR domain binding protein that participates in NFkappa B activation by Toll-like receptor 4. J. Biol. Chem. 278 (2003) 26258-26264
    • (2003) J. Biol. Chem. , vol.278 , pp. 26258-26264
    • Jefferies, C.A.1    Doyle, S.2    Brunner, C.3    Dunne, A.4    Brint, E.5    Wietek, C.6    Walch, E.7    Wirth, T.8    O'Neill, L.A.9
  • 31
    • 33646908228 scopus 로고    scopus 로고
    • Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling
    • Kagan J.C., and Medzhitov R. Phosphoinositide-mediated adaptor recruitment controls Toll-like receptor signaling. Cell 125 (2006) 943-955
    • (2006) Cell , vol.125 , pp. 943-955
    • Kagan, J.C.1    Medzhitov, R.2
  • 32
    • 40949134086 scopus 로고    scopus 로고
    • Tram couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta
    • Kagan J.C., Su T., Horng T., Chow A., Akira S., and Medzhitov R. Tram couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat. Immunol. 9 (2008) 361-368
    • (2008) Nat. Immunol. , vol.9 , pp. 361-368
    • Kagan, J.C.1    Su, T.2    Horng, T.3    Chow, A.4    Akira, S.5    Medzhitov, R.6
  • 33
    • 34247118826 scopus 로고    scopus 로고
    • Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    • Kanneganti T.D., Lamkanfi M., Kim Y.G., Chen G., Park J.H., Franchi L., Vandenabeele P., and Núñez G. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 26 (2007) 433-443
    • (2007) Immunity , vol.26 , pp. 433-443
    • Kanneganti, T.D.1    Lamkanfi, M.2    Kim, Y.G.3    Chen, G.4    Park, J.H.5    Franchi, L.6    Vandenabeele, P.7    Núñez, G.8
  • 34
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti T.D., Lamkanfi M., and Nunez G. Intracellular NOD-like receptors in host defense and disease. Immunity 27 (2007) 549-559
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 37
    • 36348932904 scopus 로고    scopus 로고
    • IRAK-2 participates in multiple Toll-like receptor signaling pathways to NF-kappaB via activation of Traf6 ubiquitination
    • Keating S.E., Maloney G.M., Morna E.M., and Bowie A.G. IRAK-2 participates in multiple Toll-like receptor signaling pathways to NF-kappaB via activation of Traf6 ubiquitination. J. Biol. Chem. 282 (2007) 33435-33443
    • (2007) J. Biol. Chem. , vol.282 , pp. 33435-33443
    • Keating, S.E.1    Maloney, G.M.2    Morna, E.M.3    Bowie, A.G.4
  • 39
    • 34548424488 scopus 로고    scopus 로고
    • MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival
    • Kim Y., Zhou P., Qian L., Chuang J.Z., Lee J., Li C., Iadecola C., Nathan C., and Ding A. MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J. Exp. Med. 204 (2007) 2063-2074
    • (2007) J. Exp. Med. , vol.204 , pp. 2063-2074
    • Kim, Y.1    Zhou, P.2    Qian, L.3    Chuang, J.Z.4    Lee, J.5    Li, C.6    Iadecola, C.7    Nathan, C.8    Ding, A.9
  • 40
    • 39149094587 scopus 로고    scopus 로고
    • The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands
    • Kim Y.G., Park J.H., Shaw M.H., Franchi L., Inohara N., and Nunez G. The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 28 (2008) 246-257
    • (2008) Immunity , vol.28 , pp. 246-257
    • Kim, Y.G.1    Park, J.H.2    Shaw, M.H.3    Franchi, L.4    Inohara, N.5    Nunez, G.6
  • 42
    • 0036841288 scopus 로고    scopus 로고
    • Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
    • Lasa M., Abraham S.M., Boucheron C., Saklatvala J., and Clark A.R. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Mol. Cell. Biol. 22 (2002) 7802-7811
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7802-7811
    • Lasa, M.1    Abraham, S.M.2    Boucheron, C.3    Saklatvala, J.4    Clark, A.R.5
  • 44
    • 45549085993 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase separately regulates NF-kappaB p65relA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B cells
    • Lee K.G., Xu S., Wong E.T., Tergaonkar V., and Lam K.P. Bruton's tyrosine kinase separately regulates NF-kappaB p65relA activation and cytokine interleukin (IL)-10/IL-12 production in TLR9-stimulated B cells. J. Biol. Chem. 283 (2008) 11189-11198
    • (2008) J. Biol. Chem. , vol.283 , pp. 11189-11198
    • Lee, K.G.1    Xu, S.2    Wong, E.T.3    Tergaonkar, V.4    Lam, K.P.5
  • 45
    • 33846246989 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages
    • Liljeroos M., Vuolteenaho R., Morath S., Hartung T., Hallman M., and Ojaniemi M. Bruton's tyrosine kinase together with PI 3-kinase are part of Toll-like receptor 2 multiprotein complex and mediate LTA induced Toll-like receptor 2 responses in macrophages. Cell. Signal. 19 (2007) 625-633
    • (2007) Cell. Signal. , vol.19 , pp. 625-633
    • Liljeroos, M.1    Vuolteenaho, R.2    Morath, S.3    Hartung, T.4    Hallman, M.5    Ojaniemi, M.6
  • 48
    • 43349086139 scopus 로고    scopus 로고
    • Detection of immune danger signals by NALP3
    • Martinon F. Detection of immune danger signals by NALP3. J. Leukoc. Biol. 83 (2008) 507-511
    • (2008) J. Leukoc. Biol. , vol.83 , pp. 507-511
    • Martinon, F.1
  • 49
    • 32944468985 scopus 로고    scopus 로고
    • Gout-associated uric acid crystals activate the NALP3 inflammasome
    • Martinon F., Pétrilli V., Mayor A., Tardivel A., and Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006) 237-241
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Pétrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 50
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • Martinon F., Agostini L., Meylan E., and Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14 (2004) 1929-1934
    • (2004) Curr. Biol. , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 51
    • 46749133303 scopus 로고    scopus 로고
    • Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation
    • McCoy C.E., Carpenter S., Palsson-McDermott E.M., Gearing L.J., and O'Neill L.A. Glucocorticoids inhibit IRF3 phosphorylation in response to Toll-like receptor-3 and -4 by targeting TBK1 activation. J. Biol. Chem. 283 (2008) 14277-14285
    • (2008) J. Biol. Chem. , vol.283 , pp. 14277-14285
    • McCoy, C.E.1    Carpenter, S.2    Palsson-McDermott, E.M.3    Gearing, L.J.4    O'Neill, L.A.5
  • 53
    • 0030912071 scopus 로고    scopus 로고
    • Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn
    • Meng F., and Lowell C.A. Lipopolysaccharide (LPS)-induced macrophage activation and signal transduction in the absence of Src-family kinases Hck, Fgr, and Lyn. J. Exp. Med. 185 (1997) 1661-1670
    • (1997) J. Exp. Med. , vol.185 , pp. 1661-1670
    • Meng, F.1    Lowell, C.A.2
  • 55
    • 46749150768 scopus 로고    scopus 로고
    • Netea, M.G., Nold, C., Nold, M., Opitz, B., van den Meer, J., Kullberg, B.J., Van den Meer, J., and Dinarello, C.A. (2008) Monocytes are not macrophages: One-hit fresus tow-hit stimulation of LPS-driven activation of the human inflammasome for IL-1beta. Abstract 265, Keystone Symposium: Innate Immunity: Signalling Mechanisms.
    • Netea, M.G., Nold, C., Nold, M., Opitz, B., van den Meer, J., Kullberg, B.J., Van den Meer, J., and Dinarello, C.A. (2008) Monocytes are not macrophages: One-hit fresus tow-hit stimulation of LPS-driven activation of the human inflammasome for IL-1beta. Abstract 265, Keystone Symposium: Innate Immunity: Signalling Mechanisms.
  • 56
    • 29644438009 scopus 로고    scopus 로고
    • Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins
    • Newman R.M., Salunkhe P., Godzik A., and Reed J.C. Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect. Immun. 74 (2006) 594-601
    • (2006) Infect. Immun. , vol.74 , pp. 594-601
    • Newman, R.M.1    Salunkhe, P.2    Godzik, A.3    Reed, J.C.4
  • 57
    • 40749097627 scopus 로고    scopus 로고
    • A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
    • Núñez Miguel R., Wong J., Westoll J.F., Brooks H.J., O'Neill L.A., Gay N.J., Bryant C.E., and Monie T.P. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS ONE. 2 (2007) e788
    • (2007) PLoS ONE. , vol.2
    • Núñez Miguel, R.1    Wong, J.2    Westoll, J.F.3    Brooks, H.J.4    O'Neill, L.A.5    Gay, N.J.6    Bryant, C.E.7    Monie, T.P.8
  • 59
    • 38149085473 scopus 로고    scopus 로고
    • The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1
    • Ordureau A., Smith H., Windheim M., Peggie M., Carrick E., Morrice N., and Cohen P. The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. Biochem. J. 409 (2008) 43-52
    • (2008) Biochem. J. , vol.409 , pp. 43-52
    • Ordureau, A.1    Smith, H.2    Windheim, M.3    Peggie, M.4    Carrick, E.5    Morrice, N.6    Cohen, P.7
  • 60
    • 43049096082 scopus 로고    scopus 로고
    • Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts
    • Palmer C.D., Mutch B.E., Page T.H., Horwood N.J., and Foxwell B.M.J. Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts. Biochem. Biophys. Res. Commun. 370 (2008) 599-602
    • (2008) Biochem. Biophys. Res. Commun. , vol.370 , pp. 599-602
    • Palmer, C.D.1    Mutch, B.E.2    Page, T.H.3    Horwood, N.J.4    Foxwell, B.M.J.5
  • 61
    • 41349109980 scopus 로고    scopus 로고
    • Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NF-kappaB activity
    • Palmer C.D., Mutch B.E., Workman S., McDaid J.P., Horwood N.J., and Foxwell B.M.J. Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NF-kappaB activity. Blood 111 (2008) 1781-1788
    • (2008) Blood , vol.111 , pp. 1781-1788
    • Palmer, C.D.1    Mutch, B.E.2    Workman, S.3    McDaid, J.P.4    Horwood, N.J.5    Foxwell, B.M.J.6
  • 62
    • 41249084567 scopus 로고    scopus 로고
    • Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance
    • Piao W., Song C., Chen H., Wahl L.M., Fitzgerald K.A., O'Neill L.A., and Medvedev A.E. Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J. Biol. Chem. 282 (2008) 3109-3119
    • (2008) J. Biol. Chem. , vol.282 , pp. 3109-3119
    • Piao, W.1    Song, C.2    Chen, H.3    Wahl, L.M.4    Fitzgerald, K.A.5    O'Neill, L.A.6    Medvedev, A.E.7
  • 63
    • 30444456366 scopus 로고    scopus 로고
    • The GRIP:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression
    • Reily M.M., Pantoja C., Hu X., Chinenov Y., and Rogatsky I. The GRIP:IRF3 interaction as a target for glucocorticoid receptor-mediated immunosuppression. EMBO J. 25 (2006) 108-117
    • (2006) EMBO J. , vol.25 , pp. 108-117
    • Reily, M.M.1    Pantoja, C.2    Hu, X.3    Chinenov, Y.4    Rogatsky, I.5
  • 64
    • 36849033963 scopus 로고    scopus 로고
    • TAM receptors are pleiotropic inhibitors of the innate immune response
    • Rothlin C.V., Ghosh S., Zuniga E.I., Oldstone M.B.A., and Lemke G. TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131 (2007) 1124-1136
    • (2007) Cell , vol.131 , pp. 1124-1136
    • Rothlin, C.V.1    Ghosh, S.2    Zuniga, E.I.3    Oldstone, M.B.A.4    Lemke, G.5
  • 66
    • 33750840753 scopus 로고    scopus 로고
    • Bruton's tyrosine kinase is required for TLR-induced IL-10 production
    • Schmidt N.W., Thieu V.T., Mann B.A., Ahyi A.N., and Kaplan M.H. Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J. Immunol. 177 (2006) 7203-7210
    • (2006) J. Immunol. , vol.177 , pp. 7203-7210
    • Schmidt, N.W.1    Thieu, V.T.2    Mann, B.A.3    Ahyi, A.N.4    Kaplan, M.H.5
  • 67
    • 40949163764 scopus 로고    scopus 로고
    • TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation
    • Shi M., Deng W., Bi E., Mao K., Ji Y., Lin G., Wu X., Tao Z., Li Z., Cai X., et al. TRIM30 alpha negatively regulates TLR-mediated NF-kappa B activation by targeting TAB2 and TAB3 for degradation. Nat. Immunol. 9 (2008) 369-377
    • (2008) Nat. Immunol. , vol.9 , pp. 369-377
    • Shi, M.1    Deng, W.2    Bi, E.3    Mao, K.4    Ji, Y.5    Lin, G.6    Wu, X.7    Tao, Z.8    Li, Z.9    Cai, X.10
  • 69
    • 0028913076 scopus 로고
    • The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases
    • Stitt T.N., Conn G., Gore M., Lai C., Bruno J., Radziejewski C., Mattsson K., Fisher J., Gies D.R., Jones P.F., et al. The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases. Cell 80 (1995) 661-670
    • (1995) Cell , vol.80 , pp. 661-670
    • Stitt, T.N.1    Conn, G.2    Gore, M.3    Lai, C.4    Bruno, J.5    Radziejewski, C.6    Mattsson, K.7    Fisher, J.8    Gies, D.R.9    Jones, P.F.10
  • 70
    • 28444471235 scopus 로고    scopus 로고
    • Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells
    • Tada H., Aiba S., Shibata K., Ohteki T., and Takada H. Synergistic effect of Nod1 and Nod2 agonists with toll-like receptor agonists on human dendritic cells to generate interleukin-12 and T helper type 1 cells. Infect. Immun. 73 (2005) 7967-7976
    • (2005) Infect. Immun. , vol.73 , pp. 7967-7976
    • Tada, H.1    Aiba, S.2    Shibata, K.3    Ohteki, T.4    Takada, H.5
  • 75
    • 20244388983 scopus 로고    scopus 로고
    • Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction
    • Uematsu S., Sato S., Yamamoto M., Hirotani T., Kato H., Takeshita F., Matsuda M., Coban C., Ishii K.J., Kawai T., et al. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-{alpha} induction. J. Exp. Med. 201 (2005) 915-923
    • (2005) J. Exp. Med. , vol.201 , pp. 915-923
    • Uematsu, S.1    Sato, S.2    Yamamoto, M.3    Hirotani, T.4    Kato, H.5    Takeshita, F.6    Matsuda, M.7    Coban, C.8    Ishii, K.J.9    Kawai, T.10
  • 78
    • 38849163741 scopus 로고    scopus 로고
    • Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis
    • Watanabe T., Asano N., Murray P.J., Ozato K., Tailor P., Fuss I.J., Kitani A., and Strober W. Muramyl dipeptide activation of nucleotide-binding oligomerization domain 2 protects mice from experimental colitis. J. Clin. Invest. 118 (2008) 545-559
    • (2008) J. Clin. Invest. , vol.118 , pp. 545-559
    • Watanabe, T.1    Asano, N.2    Murray, P.J.3    Ozato, K.4    Tailor, P.5    Fuss, I.J.6    Kitani, A.7    Strober, W.8
  • 79
    • 20744451399 scopus 로고    scopus 로고
    • Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway
    • Weber A.N., Moncrieffe M.C., Gangloff M., Imler J.L., and Gay N.J. Ligand-receptor and receptor-receptor interactions act in concert to activate signaling in the Drosophila toll pathway. J. Biol. Chem. 280 (2005) 22793-22799
    • (2005) J. Biol. Chem. , vol.280 , pp. 22793-22799
    • Weber, A.N.1    Moncrieffe, M.C.2    Gangloff, M.3    Imler, J.L.4    Gay, N.J.5
  • 80
    • 0347065364 scopus 로고    scopus 로고
    • Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa
    • Wietek C., Miggin S.M., Jefferies C.A., and O'Neill L.A. Interferon regulatory factor-3-mediated activation of the interferon-sensitive response element by Toll-like receptor (TLR) 4 but not TLR3 requires the p65 subunit of NF-kappa. J. Biol. Chem. 278 (2003) 50923-50931
    • (2003) J. Biol. Chem. , vol.278 , pp. 50923-50931
    • Wietek, C.1    Miggin, S.M.2    Jefferies, C.A.3    O'Neill, L.A.4
  • 81
    • 37849045813 scopus 로고    scopus 로고
    • C-type lectin receptors in antifungal immunity
    • Willment J.A., and Brown G.D. C-type lectin receptors in antifungal immunity. Trends Microbiol. 16 (2008) 27-32
    • (2008) Trends Microbiol. , vol.16 , pp. 27-32
    • Willment, J.A.1    Brown, G.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.