The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1

Biochemical Journal

Volumn 409, Issue 1, 2008, Pages 43-52

  Ordureau, Alban ^a   Smith, Hilary ^a   Windheim, Mark ^a   Peggie, Mark ^a   Carrick, Emma ^a   Morrice, Nick ^a   Cohen, Philip ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

E3 ligase; Inflammation; Interleukin 1 receptor associated kinase (IRAK); Interleukin 1; Pellino; Ubiquitin; Ubiquitin conjugating enzyme 13 (Ubc13)

Indexed keywords

INFLAMMATION; INFLAMMATORY MEDIATORS; INTERLEUKIN 1 RECEPTOR-ASSOCIATED KINASE (IRAK); SIGNALLING PATHWAY; UBIQUITIN;

DNA; ENZYME ACTIVITY; ENZYME KINETICS; PHOSPHORYLATION; PROTEINS;

BIOCHEMISTRY;

BINDING PROTEIN; DNA; I KAPPA B KINASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; ISOENZYME; LYSINE DERIVATIVE; MUTANT PROTEIN; PELLINO 1 ENZYME; PELLINO 2 ENZYME; POLYUBIQUITIN; UBIQUITIN CONJUGATING ENZYME 13; UBIQUITIN CONJUGATING ENZYME E2; UBIQUITIN CONJUGATING ENZYME H3; UBIQUITIN CONJUGATING ENZYME H4; UBIQUITIN CONJUGATING ENZYME H5A; UBIQUITIN CONJUGATING ENZYME H5B; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; IKBKG PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; IRAK1 PROTEIN, HUMAN; IRAK4 PROTEIN, HUMAN; ISOPROTEIN; NFKB1 PROTEIN, HUMAN;

ARTICLE; DNA TRANSFECTION; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN INTERACTION; UBIQUITINATION; WILD TYPE; CATALYSIS; CELL LINE; CHEMISTRY; GENETIC TRANSFECTION; INFLAMMATION; METABOLISM; PHOSPHORYLATION;

BACTERIA (MICROORGANISMS);

CATALYSIS; CELL LINE; ENZYME ACTIVATION; HUMANS; I-KAPPA B KINASE; INFLAMMATION; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; NF-KAPPA B P50 SUBUNIT; PHOSPHORYLATION; PROTEIN ISOFORMS; TRANSFECTION; UBIQUITINATION;

EID: 38149085473     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071365     Document Type: Article

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