Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins

Nature Medicine

Volumn 14, Issue 4, 2008, Pages 399-406

  Cirl, Christine ^a   Wieser, Andreas ^b   Yadav, Manisha ^c   Duerr, Susanne ^a   Schubert, Sören ^b   Fischer, Hans ^c   Stappert, Dominik ^c   Wantia, Nina ^a   Rodriguez, Nuria ^a   Wagner, Hermann ^a   Svanborg, Catharina ^c   Miethke, Thomas ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING PROTEIN B; INTERLEUKIN 1 RECEPTOR DOMAIN CONTAINING PROTEIN C; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ACUTE PYELONEPHRITIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIURIA; BRUCELLA MELITENSIS; COMPUTER MODEL; CONTROLLED STUDY; CYSTITIS; EMBRYO; ESCHERICHIA COLI; ESCHERICHIA COLI CFT073; FEMALE; GENETIC CODE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PYELONEPHRITIS; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); BRUCELLA MELITENSIS; ESCHERICHIA COLI;

EID: 41849102701     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1734     Document Type: Article

References (32)

1. Iwasaki, A. & Medzhitov, R. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5, 987-995 (2004).
2. Akira, S., Uematsu, S. & Takeuchi, O. Pathogen recognition and innate immunity. Cell 124, 783-801 (2006).
3. Svanborg, C. et al. Uropathogenic Escherichia coli as a model of host-parasite interaction. Curr. Opin. Microbiol. 9, 33-39 (2006).
4. Takeuchi, O., Hoshino, K. & Akira, S. Cutting edge: TLR2-deficient and MyD88-deficient mice are highly susceptible to staphylococcus aureus infection. J. Immunol. 165, 5392-5396 (2000).
5. Abel, B. et al. Toll-like receptor 4 expression is required to control chronic Mycobacterium tuberculosis infection in mice. J. Immunol. 169, 3155-3162 (2002).
6. Torres, D. et al. Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect. Immun. 72, 2131-2139 (2004).
7. Rodriguez, N. et al. Differential involvement of TLR2 and TLR4 in host survival during pulmonary infection with Chlamydia pneumoniae. Eur. J. Immunol. 36, 1145-1155 (2006).
8. Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282, 2085-2088 (1998).
9. Kawai, T. & Akira, S. TLR signaling. Cell Death Differ. 13, 816-825 (2006).
10. Burns, K. et al. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197, 263-268 (2003).
11. Bowie, A. et al. A46R and A52R from vaccinia virus are antagonists of host IL-1 and Toll-like receptor signaling. Proc. Natl. Acad. Sci. USA 97, 10162-10167 (2000).
12. Harte, M.T. et al. The poxvirus protein A52R targets Toll-like receptor signaling complexes to suppress host defense. J. Exp. Med. 197, 343-351 (2003).
13. Stack, J. et al. Vaccinia virus protein A46R targets multiple Toll-like-interleukin-1 receptor adaptors and contributes to virulence. J. Exp. Med. 201, 1007-1018 (2005).
14. Newman, R.M., Salunkhe, P., Godzik, A. & Reed, J.C. Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect. Immun. 74, 594-601 (2006).
15. Radons, J. et al. The interleukin 1 (IL-1) receptor accessory protein Toll/IL-1 receptor domain: analysis of putative interaction sites in vitro mutagenesis and molecular modeling. J. Biol. Chem. 278, 49145-49153 (2003).
16. Costa, C.P. et al. Role of chlamydial heat shock protein 60 in the stimulation of innate immune cells by Chlamydia pneumoniae. Eur. J. Immunol. 32, 2460-2470 (2002).
17. Lafont, F. & van der Goot, F.G. Bacterial invasion via lipid rafts. Cell. Microbiol. 7, 613-620 (2005).
18. Pannek, S. et al. Multidrug efflux inhibition in Acinetobacter baumannii: comparison between 1-(1-naphthylmethyl)-piperazine and phenyl-arginine-β-naphthylamide. J. Antimicrob. Chemother. 57, 970-974 (2006).
19. Frendeus, B. et al. Escherichia coli P fimbriae utilize the Toll-like receptor 4 pathway for cell activation. Mol. Microbiol. 40, 37-51 (2001).
20. Samuelsson, P., Hang, L., Wullt, B., Irjala, H. & Svanborg, C. Toll-like receptor 4 expression and cytokine responses in the human urinary tract mucosa. Infect. Immun. 72, 3179-3186 (2004).
21. Gorvel, J.P. & Moreno, E. Brucella intracellular life: from invasion to intracellular replication. Vet. Microbiol. 90, 281-297 (2002).
22. Delrue, R.M. et al. Identification of Brucella spp. genes involved in intracellular trafficking. Cell. Microbiol. 3, 487-497 (2001).
23. Comerci, D.J., Martinez-Lorenzo, M.J., Sieira, R., Gorvel, J.P. & Ugalde, R.A. Essential role of the VirB machinery in the maturation of the Brucella abortus-containing vacuole. Cell. Microbiol. 3, 159-168 (2001).
24. Lapaque, N., Moriyon, I., Moreno, E. & Gorvel, J.P. Brucella lipopolysaccharide acts as a virulence factor. Curr. Opin. Microbiol. 8, 60-66 (2005).
25. Sola-Landa, A. et al. A two-component regulatory system playing a critical role in plant pathogens and endosymbionts is present in Brucella abortus and controls cell invasion and virulence. Mol. Microbiol. 29, 125-138 (1998).
26. Detilleux, P.G., Deyoe, B.L. & Cheville, N.F. Penetration and intracellular growth of Brucella abortus in nonphagocytic cells in vitro. Infect. Immun. 58, 2320-2328 (1990).
27. Welch, R.A. et al. Extensive mosaic structure revealed by the complete genome sequence of uropathogenic Escherichia coli. Proc. Natl. Acad. Sci. USA 99, 17020-17024 (2002).
28. Kern, W.V. et al. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli. J. Antimicrob. Chemother. 57, 339-343 (2006).
29. Schumacher, A. et al. Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Enterobacteriaceae other than Escherichia coli. J. Antimicrob. Chemother. 57, 344-348 (2006).
30. Hagberg, L. et al. Contribution of adhesion to bacterial persistence in the mouse urinary tract. Infect. Immun. 40, 265-272 (1983).
31. Bean, M.A., Pees, H., Fogh, J.E., Grabstald, H. & Oettgen, H.F. Cytotoxicity of lymphocytes from patients with cancer of the urinary bladder: detection by a 3-H-proline microcytotoxicity test. Int. J. Cancer 14, 186-197 (1974).
32. Datsenko, K.A. & Wanner, B.L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97, 6640-6645 (2000).