Bmx regulates LPS-induced IL-6 and VEGF production via mRNA stability in rheumatoid synovial fibroblasts

Biochemical and Biophysical Research Communications

Volumn 370, Issue 4, 2008, Pages 599-602

  Palmer, Christine D ^a   Mutch, Brenda E ^a   Page, Theresa H ^a   Horwood, Nicole J ^a   Foxwell, Brian M J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Bmx; Interleukin 6; Kinase; LPS; Rheumatoid; Synovial fibroblast; Tec; TLR; VEGF

Indexed keywords

INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTEIN BMX; PROTEIN TYROSINE KINASE; TOLL LIKE RECEPTOR; VASCULOTROPIN;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; FIBROBLAST; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RHEUMATOID ARTHRITIS; RNA STABILITY; SIGNAL TRANSDUCTION; SYNOVIUM;

ARTHRITIS, RHEUMATOID; CELLS, CULTURED; FIBROBLASTS; HUMANS; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; PROTEIN-TYROSINE KINASES; RNA STABILITY; SYNOVIAL MEMBRANE; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 43049096082     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.03.142     Document Type: Article

References (20)

1. Feldmann M., and Steinman L. Design of effective immunotherapy for human autoimmunity. Nature 435 (2005) 612-619
2. Smolen J.S., and Maini R.N. Interleukin-6: a new therapeutic target. Arthritis Res. Ther. 8 Suppl. 2 (2006) S5
3. Sumariwalla P.F., Cao Y., Wu H.L., Feldmann M., and Paleolog E.M. The angiogenesis inhibitor protease-activated kringles 1-5 reduces the severity of murine collagen-induced arthritis. Arthritis Res. Ther. 5 (2003) R32-R39
4. Murakami M., Iwai S., Hiratsuka S., Yamauchi M., Nakamura K., Iwakura Y., and Shibuya M. Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocytes/macrophages. Blood 108 (2006) 1849-1856
5. Sacre S.M., Andreakos E., Kiriakidis S., Amjadi P., Lundberg A., Giddins G., Feldmann M., Brennan F., and Foxwell B.M. The Toll-like receptor adaptor proteins MyD88 and Mal/TIRAP contribute to the inflammatory and destructive processes in a human model of rheumatoid arthritis. Am. J. Pathol. 170 (2007) 518-525
6. Abdollahi-Roodsaz S., Joosten L.A., Koenders M.I., Devesa I., Roelofs M.F., Radstake T.R., Heuvelmans-Jacobs M., Akira S., Nicklin M.J., Ribeiro-Dias F., and van den Berg W.B. Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis. J. Clin. Invest. 118 (2008) 205-216
7. Lundberg A.M., Drexler S.K., Monaco C., Williams L.M., Sacre S.M., Feldmann M., and Foxwell B.M. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood 110 (2007) 3245-3252
8. Cho M.L., Ju J.H., Kim H.R., Oh H.J., Kang C.M., Jhun J.Y., Lee S.Y., Park M.K., Min J.K., Park S.H., Lee S.H., and Kim H.Y. Toll-like receptor 2 ligand mediates the upregulation of angiogenic factor, vascular endothelial growth factor and interleukin-8/CXCL8 in human rheumatoid synovial fibroblasts. Immunol. Lett. (2006)
9. Horwood N.J., Mahon T., McDaid J.P., Campbell J., Mano H., Brennan F.M., Webster D., and Foxwell B.M. Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor alpha production. J. Exp. Med. 197 (2003) 1603-1611
10. Horwood N.J., Page T.H., McDaid J.P., Palmer C.D., Campbell J., Mahon T., Brennan F.M., Webster D., and Foxwell B.M. Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but Not IL-6, production. J. Immunol. 176 (2006) 3635-3641
11. Doyle S.L., Jefferies C.A., and O'Neill L.A. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFkappaB activation by lipopolysaccharide. J. Biol. Chem. 280 (2005) 23496-23501
12. Jefferies C.A., Doyle S., Brunner C., Dunne A., Brint E., Wietek C., Walch E., Wirth T., and O'Neill L.A. Bruton's tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J. Biol. Chem. 278 (2003) 26258-26264
13. Schmidt U., Boucheron N., Unger B., and Ellmeier W. The role of Tec family kinases in myeloid cells. Int. Arch. Allergy Immunol. 134 (2004) 65-78
14. Ekman N., Lymboussaki A., Vastrik I., Sarvas K., Kaipainen A., and Alitalo K. Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. Circulation 96 (1997) 1729-1732
15. Palmer C.D., Mutch B.E., Workman S., McDaid J.P., Horwood N.J., and Foxwell B.M. Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NF{kappa}B activity. Blood 111 (2008) 1781-1788
16. Semaan N., Alsaleh G., Gottenberg J.E., Wachsmann D., and Sibilia J. Etk/BMX, a Btk family tyrosine kinase, and Mal contribute to the cross-talk between MyD88 and FAK pathways. J. Immunol. 180 (2008) 3485-3491
17. Ferrara N., and Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev. 18 (1997) 4-25
18. Matsushita K., Motani R., Sakuta T., Nagaoka S., Matsuyama T., Abeyama K., Maruyama I., Takada H., and Torii M. Lipopolysaccharide enhances the production of vascular endothelial growth factor by human pulp cells in culture. Infect. Immun. 67 (1999) 1633-1639
19. Chau C.H., Clavijo C.A., Deng H.T., Zhang Q., Kim K.J., Qiu Y., Le A.D., and Ann D.K. Etk/Bmx mediates expression of stress-induced adaptive genes VEGF, PAI-1, and iNOS via multiple signaling cascades in different cell systems. Am. J. Physiol. Cell Physiol. 289 (2005) C444-C454
20. Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr. Rev. 25 (2004) 581-611