-
1
-
-
3142724031
-
Toll-like receptor signalling
-
Akira, S. & Takeda, K. Toll-like receptor signalling. Nat. Rev. Immunol. 4, 499-511 (2004).
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
2
-
-
0034503091
-
The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function
-
Lanier, L.L. & Bakker, A.B. The ITAM-bearing transmembrane adaptor DAP12 in lymphoid and myeloid cell function. Immunol. Today 21, 611-614 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 611-614
-
-
Lanier, L.L.1
Bakker, A.B.2
-
3
-
-
0034657890
-
Cutting edge: Inflammatory responses can Be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes
-
Bouchon, A., Dietrich, J. & Colonna, M. Cutting edge: inflammatory responses can Be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. J. Immunol. 164, 4991-4995 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 4991-4995
-
-
Bouchon, A.1
Dietrich, J.2
Colonna, M.3
-
4
-
-
0035953547
-
TREM-1 amplifies inflammation and is a crucial mediator of septic shock
-
Bouchon, A., Facchetti, F., Weigand, M.A. & Colonna, M. TREM-1 amplifies inflammation and is a crucial mediator of septic shock. Nature 410, 1103-1107 (2001).
-
(2001)
Nature
, vol.410
, pp. 1103-1107
-
-
Bouchon, A.1
Facchetti, F.2
Weigand, M.A.3
Colonna, M.4
-
5
-
-
0035086799
-
Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family
-
Daws, M.R., Lanier, L.L., Seaman, W.E. & Ryan, J.C. Cloning and characterization of a novel mouse myeloid DAP12-associated receptor family. Eur. J. Immunol. 31, 783-791 (2001).
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 783-791
-
-
Daws, M.R.1
Lanier, L.L.2
Seaman, W.E.3
Ryan, J.C.4
-
6
-
-
0036149766
-
Characterization of TREM-3, an activating receptor on mouse macrophages: Definition of a family of single Ig domain receptors on mouse chromosome 17
-
Chung, D.H., Seaman, W.E. & Daws, M.R. Characterization of TREM-3, an activating receptor on mouse macrophages: definition of a family of single Ig domain receptors on mouse chromosome 17. Eur. J. Immunol. 32, 59-66 (2002).
-
(2002)
Eur. J. Immunol.
, vol.32
, pp. 59-66
-
-
Chung, D.H.1
Seaman, W.E.2
Daws, M.R.3
-
7
-
-
0042662883
-
Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation
-
Yotsumoto, K. et al. Paired activating and inhibitory immunoglobulin-like receptors, MAIR-I and MAIR-II, regulate mast cell and macrophage activation. J. Exp. Med. 198, 223-233 (2003).
-
(2003)
J. Exp. Med.
, vol.198
, pp. 223-233
-
-
Yotsumoto, K.1
-
8
-
-
0041832335
-
Characterization of the CD200 receptor family in mice and humans and their interactions with CD200
-
Wright, G.J. et al. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J. Immunol. 171, 3034-3046 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 3034-3046
-
-
Wright, G.J.1
-
9
-
-
0033981961
-
Cutting edge: Signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells
-
Dietrich, J., Cella, M., Seiffert, M., Buhring, H.J. & Colonna, M. Cutting edge: signal-regulatory protein β1 is a DAP12-associated activating receptor expressed in myeloid cells. J. Immunol. 164, 9-12 (2000).
-
(2000)
J. Immunol.
, vol.164
, pp. 9-12
-
-
Dietrich, J.1
Cella, M.2
Seiffert, M.3
Buhring, H.J.4
Colonna, M.5
-
10
-
-
0033842963
-
Association of signal-regulatory proteins β with KARAP/DAP-12
-
Tomasello, E. et al. Association of signal-regulatory proteins β with KARAP/DAP-12. Eur. J. Immunol. 30, 2147-2156 (2000).
-
(2000)
Eur. J. Immunol.
, vol.30
, pp. 2147-2156
-
-
Tomasello, E.1
-
11
-
-
1242343695
-
Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor
-
Shiratori, I., Ogasawara, K., Saito, T., Lanier, L.L. & Arase, H. Activation of natural killer cells and dendritic cells upon recognition of a novel CD99-like ligand by paired immunoglobulin-like type 2 receptor. J. Exp. Med. 199, 525-533 (2004).
-
(2004)
J. Exp. Med.
, vol.199
, pp. 525-533
-
-
Shiratori, I.1
Ogasawara, K.2
Saito, T.3
Lanier, L.L.4
Arase, H.5
-
12
-
-
0033578326
-
Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells
-
Bakker, A.B., Baker, E., Sutherland, G.R., Phillips, J.H. & Lanier, L.L. Myeloid DAP12-associating lectin (MDL)-1 is a cell surface receptor involved in the activation of myeloid cells. Proc. Natl. Acad. Sci. USA 96, 9792-9796 (1999).
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9792-9796
-
-
Bakker, A.B.1
Baker, E.2
Sutherland, G.R.3
Phillips, J.H.4
Lanier, L.L.5
-
13
-
-
0036915968
-
Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D
-
Diefenbach, A. et al. Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D. Nat. Immunol. 3, 1142-1149 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 1142-1149
-
-
Diefenbach, A.1
-
14
-
-
0036910991
-
NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation
-
Gilfillan, S., Ho, E.L., Cella, M., Yokoyama, W.M. & Colonna, M. NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation. Nat. Immunol. 3, 1150-1155 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 1150-1155
-
-
Gilfillan, S.1
Ho, E.L.2
Cella, M.3
Yokoyama, W.M.4
Colonna, M.5
-
15
-
-
0033671748
-
DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming
-
Bakker, A.B. et al. DAP12-deficient mice fail to develop autoimmunity due to impaired antigen priming. Immunity 13, 345-353 (2000).
-
(2000)
Immunity
, vol.13
, pp. 345-353
-
-
Bakker, A.B.1
-
16
-
-
0033662295
-
Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice
-
Tomasello, E. et al. Combined natural killer cell and dendritic cell functional deficiency in KARAP/DAP12 loss-of-function mutant mice. Immunity 13, 355-364 (2000).
-
(2000)
Immunity
, vol.13
, pp. 355-364
-
-
Tomasello, E.1
-
17
-
-
0038687056
-
TREM-1 (triggering receptor expressed on myeloid cells): A new player in acute inflammatory responses
-
Colonna, M. & Facchetti, F. TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses. J. Infect. Dis. 187 (suppl. 2), S397-S401 (2003).
-
(2003)
J. Infect. Dis.
, vol.187
, Issue.SUPPL. 2
-
-
Colonna, M.1
Facchetti, F.2
-
18
-
-
0033997615
-
Tyrosine kinase SYK: Essential functions for immunoreceptor signalling
-
Turner, M., Schweighoffer, E., Colucci, F., Di Santo, J.P. & Tybulewicz, V.L. Tyrosine kinase SYK: essential functions for immunoreceptor signalling. Immunol. Today 21, 148-154 (2000).
-
(2000)
Immunol. Today
, vol.21
, pp. 148-154
-
-
Turner, M.1
Schweighoffer, E.2
Colucci, F.3
Di Santo, J.P.4
Tybulewicz, V.L.5
-
19
-
-
0038784517
-
Pattern recognition by TREM-2: Binding of anionic ligands
-
Daws, M.R. et al. Pattern recognition by TREM-2: binding of anionic ligands. J. Immunol. 171, 594-599 (2003).
-
(2003)
J. Immunol.
, vol.171
, pp. 594-599
-
-
Daws, M.R.1
-
20
-
-
0346665750
-
A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response
-
Bleharski, J.R. et al. A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response. J. Immunol. 170, 3812-3818 (2003).
-
(2003)
J. Immunol.
, vol.170
, pp. 3812-3818
-
-
Bleharski, J.R.1
-
21
-
-
1842424642
-
Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: Differential regulation of activation and survival
-
Radsak, M.P., Salih, H.R., Rammensee, H.G. & Schild, H. Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival. J. Immunol. 172, 4956-4963 (2004).
-
(2004)
J. Immunol.
, vol.172
, pp. 4956-4963
-
-
Radsak, M.P.1
Salih, H.R.2
Rammensee, H.G.3
Schild, H.4
-
22
-
-
11144355389
-
The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase
-
Mocsai, A. et al. The immunomodulatory adapter proteins DAP12 and Fc receptor γ-chain (FcRγ) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc. Natl. Acad. Sci. USA 101, 6158-6163 (2004).
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6158-6163
-
-
Mocsai, A.1
-
23
-
-
0028889302
-
Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk
-
Turner, M. et al. Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk. Nature 378, 298-302 (1995).
-
(1995)
Nature
, vol.378
, pp. 298-302
-
-
Turner, M.1
-
24
-
-
0036231179
-
Syk is required for integrin signaling in neutrophils
-
Mocsai, A., Zhou, M., Meng, F., Tybulewicz, V.L. & Lowell, C.A. Syk is required for integrin signaling in neutrophils. Immunity 16, 547-558 (2002).
-
(2002)
Immunity
, vol.16
, pp. 547-558
-
-
Mocsai, A.1
Zhou, M.2
Meng, F.3
Tybulewicz, V.L.4
Lowell, C.A.5
-
25
-
-
0029989339
-
Immune and inflammatory responses in TNF α-deficient mice: A critical requirement for TNF α in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
-
Pasparakis, M., Alexopoulou, L., Episkopou, V. & Kollias, G. Immune and inflammatory responses in TNF α-deficient mice: a critical requirement for TNF α in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response. J. Exp. Med. 184, 1397-1411 (1996).
-
(1996)
J. Exp. Med.
, vol.184
, pp. 1397-1411
-
-
Pasparakis, M.1
Alexopoulou, L.2
Episkopou, V.3
Kollias, G.4
-
26
-
-
5044222206
-
Immune responses to Listeria monocytogenes
-
Pamer, E.G. Immune responses to Listeria monocytogenes. Nat. Rev. Immunol. 4, 812-823 (2004).
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 812-823
-
-
Pamer, E.G.1
-
27
-
-
0042470456
-
Positive and negative selection of T cells
-
Starr, T.K., Jameson, S.C. & Hogquist, K.A. Positive and negative selection of T cells. Annu. Rev. Immunol. 21, 139-176 (2003).
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 139-176
-
-
Starr, T.K.1
Jameson, S.C.2
Hogquist, K.A.3
-
28
-
-
19944430878
-
Identification of FcαRI as an inhibitory receptor that controls inflammation: Dual role of FcRγ ITAM
-
Pasquier, B. et al. Identification of FcαRI as an inhibitory receptor that controls inflammation: dual role of FcRγ ITAM. Immunity 22, 31-42 (2005).
-
(2005)
Immunity
, vol.22
, pp. 31-42
-
-
Pasquier, B.1
-
29
-
-
14244268775
-
Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2
-
Takahashi, K., Rochford, C.D. & Neumann, H. Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2. J. Exp. Med. 201, 647-657 (2005).
-
(2005)
J. Exp. Med.
, vol.201
, pp. 647-657
-
-
Takahashi, K.1
Rochford, C.D.2
Neumann, H.3
-
30
-
-
0035849495
-
CNS manifestations of Nasu-Hakola disease: A frontal dementia with bone cysts
-
Paloneva, J. et al. CNS manifestations of Nasu-Hakola disease: a frontal dementia with bone cysts. Neurology 56, 1552-1558 (2001).
-
(2001)
Neurology
, vol.56
, pp. 1552-1558
-
-
Paloneva, J.1
-
31
-
-
10644237032
-
A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis
-
Gibot, S. et al. A soluble form of the triggering receptor expressed on myeloid cells-1 modulates the inflammatory response in murine sepsis. J. Exp. Med. 200, 1419-1426 (2004).
-
(2004)
J. Exp. Med.
, vol.200
, pp. 1419-1426
-
-
Gibot, S.1
-
32
-
-
10344245540
-
Cutting edge: Expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia
-
Knapp, S. et al. Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia. J. Immunol. 173, 7131-7134 (2004).
-
(2004)
J. Immunol.
, vol.173
, pp. 7131-7134
-
-
Knapp, S.1
-
33
-
-
0035366156
-
Face off-the interplay between activating and inhibitory immune receptors
-
Lanier, L.L. Face off-the interplay between activating and inhibitory immune receptors. Curr. Opin. Immunol. 13, 326-331 (2001).
-
(2001)
Curr. Opin. Immunol.
, vol.13
, pp. 326-331
-
-
Lanier, L.L.1
-
34
-
-
2942721674
-
ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
-
Brint, E.K. et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat. Immunol. 5, 373-379 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 373-379
-
-
Brint, E.K.1
-
35
-
-
10344260656
-
TRAIL-R as a negative regulator of innate immune cell responses
-
Diehl, G.E. et al. TRAIL-R as a negative regulator of innate immune cell responses. Immunity 21, 877-889 (2004).
-
(2004)
Immunity
, vol.21
, pp. 877-889
-
-
Diehl, G.E.1
-
36
-
-
0036850946
-
SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
-
Kinjyo, I. et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17, 583-591 (2002).
-
(2002)
Immunity
, vol.17
, pp. 583-591
-
-
Kinjyo, I.1
-
37
-
-
18744371050
-
SOCS-1 participates in negative regulation of LPS responses
-
Nakagawa, R. et al. SOCS-1 participates in negative regulation of LPS responses. Immunity 17, 677-687 (2002).
-
(2002)
Immunity
, vol.17
, pp. 677-687
-
-
Nakagawa, R.1
-
38
-
-
0036707521
-
PI3K-mediated negative feedback regulation of IL-12 production in DCs
-
Fukao, T. et al. PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat. Immunol. 3, 875-881 (2002).
-
(2002)
Nat. Immunol.
, vol.3
, pp. 875-881
-
-
Fukao, T.1
-
39
-
-
0037454946
-
Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
-
Burns, K. et al. Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J. Exp. Med. 197, 263-268 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 263-268
-
-
Burns, K.1
-
40
-
-
4143102310
-
LPS-induced upregulation of SHIP is essential for endotoxin tolerance
-
Sly, L.M., Rauh, M.J., Kalesnikoff, J., Song, C.H. & Krystal, G. LPS-induced upregulation of SHIP is essential for endotoxin tolerance. Immunity 21, 227-239 (2004).
-
(2004)
Immunity
, vol.21
, pp. 227-239
-
-
Sly, L.M.1
Rauh, M.J.2
Kalesnikoff, J.3
Song, C.H.4
Krystal, G.5
-
41
-
-
0036510366
-
Negative regulation of toll-like receptor-mediated signaling by Tollip
-
Zhang, G. & Ghosh, S. Negative regulation of toll-like receptor-mediated signaling by Tollip. J. Biol. Chem. 277, 7059-7065 (2002).
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 7059-7065
-
-
Zhang, G.1
Ghosh, S.2
-
42
-
-
2442643942
-
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
-
Chuang, T.H. & Ulevitch, R.J. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5, 495-502 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 495-502
-
-
Chuang, T.H.1
Ulevitch, R.J.2
-
43
-
-
5444223519
-
The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses
-
Boone, D.L. et al. The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat. Immunol. 5, 1052-1060 (2004).
-
(2004)
Nat. Immunol.
, vol.5
, pp. 1052-1060
-
-
Boone, D.L.1
-
44
-
-
0037178785
-
IRAK-M is a negative regulator of Toll-like receptor signaling
-
Kobayashi, K. et al. IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110, 191-202 (2002).
-
(2002)
Cell
, vol.110
, pp. 191-202
-
-
Kobayashi, K.1
-
45
-
-
14444279642
-
DAP12-mediated signal transduction in natural killer cells, a dominant role for the syk protein-tyrosine kinase
-
McVicar, D.W. et al. DAP12-mediated signal transduction in natural killer cells, a dominant role for the syk protein-tyrosine kinase. J. Biol. Chem. 273, 32934-32942 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32934-32942
-
-
McVicar, D.W.1
-
46
-
-
0037450682
-
Selective activation of the c-Jun NH(2)-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4(+) T Cells
-
Snyder, M.R., Lucas, M., Vivier, E., Weyand, C.M. & Goronzy, J.J. Selective activation of the c-Jun NH(2)-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4(+) T Cells. J. Exp. Med. 197, 437-449 (2003).
-
(2003)
J. Exp. Med.
, vol.197
, pp. 437-449
-
-
Snyder, M.R.1
Lucas, M.2
Vivier, E.3
Weyand, C.M.4
Goronzy, J.J.5
-
47
-
-
0035887503
-
DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells
-
Bouchon, A., Hernandez-Munain, C., Cella, M. & Colonna, M.A. DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. J. Exp. Med. 194, 1111-1122 (2001).
-
(2001)
J. Exp. Med.
, vol.194
, pp. 1111-1122
-
-
Bouchon, A.1
Hernandez-Munain, C.2
Cella, M.3
Colonna, M.A.4
-
48
-
-
17744371331
-
TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
Dumitru, C.D. et al. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103, 1071-1083 (2000).
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
-
49
-
-
0033945864
-
Loss-of-function mutations in TYROBP(DAP12) result in a presenile dementia with bone cysts
-
Paloneva, J. et al. Loss-of-function mutations in TYROBP(DAP12) result in a presenile dementia with bone cysts. Nat. Genet. 25, 357-361 (2000).
-
(2000)
Nat. Genet.
, vol.25
, pp. 357-361
-
-
Paloneva, J.1
-
50
-
-
1642526619
-
The signaling adapter protein DAP12 regulates multinucleation during osteoclast development
-
Humphrey, M.B. et al. The signaling adapter protein DAP12 regulates multinucleation during osteoclast development. J. Bone Miner. Res. 19, 224-234 (2004).
-
(2004)
J. Bone Miner. Res.
, vol.19
, pp. 224-234
-
-
Humphrey, M.B.1
-
51
-
-
0037314230
-
Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice
-
Kaifu, T. et al. Osteopetrosis and thalamic hypomyelinosis with synaptic degeneration in DAP12-deficient mice. J. Clin. Invest. 111, 323-332 (2003).
-
(2003)
J. Clin. Invest.
, vol.111
, pp. 323-332
-
-
Kaifu, T.1
-
52
-
-
2442565738
-
Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors
-
Nishiya, T. & DeFranco, A.L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem. 279, 19008-19017 (2004).
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 19008-19017
-
-
Nishiya, T.1
DeFranco, A.L.2
-
53
-
-
0033012030
-
An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow
-
Lutz, M.B. et al. An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 223, 77-92 (1999).
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(1999)
J. Immunol. Methods
, vol.223
, pp. 77-92
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Lutz, M.B.1
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