Toll-like receptor signaling is impaired in dendritic cells from patients with X-linked agammaglobulinemia

Clinical Immunology

Volumn 126, Issue 2, 2008, Pages 148-154

  Taneichi, Hiromichi ^a   Kanegane, Hirokazu ^a   Mohamed Sira, Mostafa ^a   Futatani, Takeshi ^a   Agematsu, Kazunaga ^b   Sako, Masahiro ^c   Kaneko, Hideo ^d   Kondo, Naomi ^d   Kaisho, Tsuneyasu ^e   Miyawaki, Toshio ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b SHINSHU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA CITY GENERAL HOSPITAL   (Japan)

^d GIFU UNIVERSITY   (Japan)

^e RIKEN Center for Integrative Medical Sciences   (Japan)

Author keywords

Bruton's tyrosine kinase; Dendritic cells; TNF ; Toll like receptor; X linked agammaglobulinemia

Indexed keywords

CD83 ANTIGEN; INTERLEUKIN 12P70; INTERLEUKIN 6; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; FLOW CYTOMETRY; HUMAN; HUMAN TISSUE; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; X LINKED AGAMMAGLOBULINEMIA;

AGAMMAGLOBULINEMIA; ANTIGENS, CD; CHILD; CHILD, PRESCHOOL; CHROMOSOMES, HUMAN, X; CYTOKINES; DENDRITIC CELLS; GENETIC DISEASES, X-LINKED; HUMANS; IMMUNOGLOBULINS; INFANT; LIGANDS; MEMBRANE GLYCOPROTEINS; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 37849005315     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2007.10.005     Document Type: Article

References (26)

1. Lederman H.M., and Winkelstein J.A. X-linked agammaglobulinemia: an analysis of 96 patients. Medicine 64 (1985) 145-156
2. Ochs H.D., and Smith C.I. X-linked agammaglobulinemia. Medicine 75 (1996) 287-299
3. Tsukada S., Saffran D.C., Rawlings D.J., Parolini O., Allen R.C., Klisak I., Sparkes R.S., Kubagawa H., Mohandas T., Quan S., Belmont J.W., Cooper M.D., Conley M.E., and Witte O.N. Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia. Cell 72 (1993) 279-290
4. Vetrie D., Vorechovsky I., Sideras P., Holland J., Davies A., Flinter F., Hammarstrom L., Kinnon C., Levinsky R., Bobrow M., Smith C.I.E., and Bentley D.R. The gene involved in X-linked agammaglobulinemia is a member of the src family of protein-tyrosine kinases. Nature 361 (1993) 226-233
5. Futatani T., Miyawaki T., Tsukada S., Hashimoto S., Kunitaka T., Arai S., Kurimoto M., Niida Y., Matsuoka H., Sakiyama Y., Iwata T., Tsuchiya S., Tatsuzawa O., Yoshizaki K., and Kishimoto T. Deficient expression of Bruton's tyrosine kinase in monocytes from X-linked agammaglobulinemia as evaluated by a flow cytometric analysis and its clinical application to carrier detection. Blood 91 (1998) 595-602
6. Gagliardi M.C., Finocchi A., Orlandi P., Cursi L., Cancrini C., Moschese V., Miyawaki T., and Rossi P. Bruton's tyrosine kinase defect in dendritic cells from X-linked agammaglobulinaemia patients does not influence their differentiation, maturation and antigen-presenting cell function. Clin. Exp. Immunol. 133 (2003) 115-122
7. Rudge P., Webster A.D., Revesz T., Warner T., Espanol T., Cunningham-Rundles C., and Hyman T. Encephalomyelitis in primary hypogammaglobulinaemia. Brain 119 (1996) 1-15
8. Wilfert C.M., Buckley R.H., Mohanakumar T., Griffith J.F., Katz S.L., Whisnant J.K., Eggleston P.A., Moore M., Treadwell E., Oxman M.N., and Rosen F.S. Persistent and fatal central-nervous-system ECHO virus infections in patients with agammaglobulinemia. N. Engl. J. Med. 296 (1977) 1485-1489
9. Horwood N.J., Mahon T., McDaid J.P., Campbell J., Mano H., Brennan F.M., Webster D., and Foxwell B.M.J. Bruton's tyrosine kinase is required for lipopolysaccharide-induced tumor necrosis factor α production. J. Exp. Med. 197 (2003) 1603-1611
10. Kaisho T., and Akira S. Toll-like receptor function and signaling. J. Allergy Clin. Immunol. 117 (2006) 979-987
11. Jefferies C.A., Doyle S., Brunner C., Dunne A., Brint E., Wietek C., Walch E., Wirth T., and O'Neill L.A.J. Bruton's tyrosine kinase is Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor κB activation by Toll-like receptor 4. J. Biol. Chem. 278 (2003) 26258-26264
12. Doyle S.L., Jefferies C.A., and O'Neill L.A. Bruton's tyrosine kinase is involved in p65-mediated transactivation and phosphorylation of p65 on serine 536 during NFκB activation by lipopolysaccharide. J. Biol. Chem. 280 (2005) 23496-23501
13. Hashimoto S., Tsukada S., Matsushita M., Miyawaki T., Niida Y., Yachie A., Kobayashi S., Iwata T., Hayakawa H., Matsuoka H., Tsuge I., Yamadori T., Kunikata T., Arai S., Yoshizaki K., Taniguchi N., and Kishimoto T. Identification of Bruton's tyrosine kinase (Btk) gene mutations and characterization of the derived proteins in 35 X-linked agammaglobulinemia families: a nationwide study of Btk deficiency in Japan. Blood 88 (1998) 561-573
14. Kanegane H., Futatani T., Wang Y., Nomura K., Shinozaki K., Matsukura H., Kubota T., Tsukada S., and Miyawaki T. Clinical and mutational characteristics of X-linked agammaglobulinemia and its carrier identified by flow cytometric assessment combined with genetic analysis. J. Allergy Clin. Immunol. 108 (2001) 1012-1020
15. + dendritic cells. Proc. Natl. Acad. Sci.U. S. A. 93 (1996) 2588-2592
16. Visintin A., Mazzoni A., Spitzer J.H., Willie D.H., Dower S.K., and Segal D.M. Regulation of Toll-like receptors in human monocytes and dendritic cells. J. Immunol. 166 (2001) 249-255
17. Sochorova K., Horvath R., Rozkova D., Litzman J., Bartunkova J., Sediva A., and Spisek R. Impaired Toll-like receptor 8-mediated IL-6 and TNF-α production in antigen presenting cells from patients with X-linked agammaglobulinemia. Blood 109 (2006) 2553-2556
18. de Diego R.P., Lopez-Granados E., Pozo M., Rodriguez C., Sabina P., Ferreira A., Fontan G., Gracia-Rodriguez M.C., and Alemany S. Bruton's tyrosine kinase is not essential for LPS-induced activation of human monocytes. J. Allergy Clin. Immunol. 117 (2006) 1462-1469
19. Jiang A., Craxton A., Kurosaki T., and Clark E.A. Different protein tyrosine kinases are required for B cell antigen receptor-mediated activation of extracellular signal-regulated kinase, c-Jun NH2-terminal kinase 1, and p38 mitogen-activated protein kinase. J. Exp. Med. 188 (1998) 1297-1306
20. Mukhopadhyay S., George A., Bal V., Ravindran B., and Rath S. Bruton's tyrosine kinase deficiency in macrophage inhibits nitric oxide generation leading to enhancement of IL-12 induction. J. Immunol. 163 (1999) 1786-1792
21. Schmidt N.W., Thieu V.T., Mann B.A., Ahyi A.N.N., and Kaplan M.H. Bruton's tyrosine kinase is required for TLR-induced IL-10 production. J. Immunol. 177 (2006) 7203-7210
22. Horwood N.J., Page T.H., McDaid J.P., Palmer C.D., Campbell J., Mahon T., Brennan F.M., Webster D., and Foxwell B.M.J. Bruton's tyrosine kinase is required for TLR2 and TLR4-induced TNF, but not IL-6, production. J. Immunol. 176 (2006) 3635-3641
23. Hemmi H., Kaisyo T., Takeuchi O., Sato S., Sanjo H., Hoshino K., Horiuchi T., Tomizawa H., Takeda K., and Akira S. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3 (2003) 196-200
24. Jurk M., Heil F., Vollmer J., Shetter C., Krieg A.M., Wagner H., Lipford G., and Bauer S. Human TLR7 or TLR8 independently confer responsiveness to the antiviral compound R-848. Nat. Immunol. 3 (2002) 499
25. Heil F., Hemmi H., Hochrein H., Ampenberger F., Kirschning C., Akira S., Lipford G., Wagner H., and Bauer S. Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8. Science 303 (2004) 1526-1529
26. Lund J.M., Alexopoulou L., Sato A., Karow M., Adams N.C., Gale N.W., Iwasaki A., and Flavell R.A. Recognition of single-strand RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci.U. S. A. 101 (2004) 5598-5603