Glucocorticoids inhibit IRF3 phosphorylation in response to toll-like receptor-3 and -4 by targeting TBK1 activation

Journal of Biological Chemistry

Volumn 283, Issue 21, 2008, Pages 14277-14285

  McCoy, Claire E ^a   Carpenter, Susan ^a   Pålsson McDermott, Eva M ^a   Gearing, Linden J ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CHEMICAL REACTIONS; GLYCOPROTEINS; INTERFERONS; NUCLEIC ACIDS; PHOSPHORYLATION; POLYSACCHARIDES; RNA; TRANSCRIPTION; TRANSCRIPTION FACTORS;

C TERMINUSES; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOIDS; HUMAN PERIPHERAL BLOODS; INTERFERON REGULATORY FACTOR 3; KINASE ACTIVITIES; LIPOPOLYSACCHARIDE; N TERMINUSES; RESPONSE ELEMENTS; T CELLS;

DRUG PRODUCTS;

DEXAMETHASONE; INTERFERON REGULATORY FACTOR 3; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 7; POLYINOSINIC POLYCYTIDYLIC ACID; PROTEIN SERINE THREONINE KINASE; PROTEIN TBK1; RANTES; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; DEXAMPHETAMINE; GLUCOCORTICOID; LIPOPOLYSACCHARIDE; TBK1 PROTEIN, HUMAN;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; REPORTER GENE; CELL CULTURE; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PHOSPHORYLATION;

CELLS, CULTURED; CHEMOKINE CCL5; DEXTROAMPHETAMINE; DIMERIZATION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUCOCORTICOIDS; HUMANS; INTERFERON REGULATORY FACTOR-3; LIPOPOLYSACCHARIDES; PHOSPHORYLATION; POLY I-C; PROTEIN-SERINE-THREONINE KINASES; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4;

EID: 46749133303     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M709731200     Document Type: Article

References (34)

1. Lin, R., Heylbroeck, C., Pitha, P. M., and Hiscott, J. (1998) Mol. Cell. Biol. 18, 2986-2996
2. Yoneyama, M., Suhara, W., Fukuhara, Y., Fukuda, M., Nishida, E., and Fujita, T. (1998) EMBO J. 17, 1087-1095
3. Weaver, B. K., Kumar, K. P., and Reich, N. C. (1998) Mol. Cell. Biol. 18, 1359-1368
4. Servant, M. J., ten Oever, B., LePage, C., Conti, L., Gessani, S., Julkunen, I., Lin, R., and Hiscott, J. (2001) J. Biol. Chem. 276, 355-363
5. Iwamura, T., Yoneyama, M., Yamaguchi, K., Suhara, W., Mori, W., Shiota, K., Okabe, Y., Namiki, H., and Fujita, T. (2001) Genes Cells 6, 375-388
6. Navarro, L., and David, M. (1999) J. Biol. Chem. 274, 35535-35538
7. Sakaguchi, S., Negishi, H., Asagiri, M., Nakajima, C., Mizutani, T., Takaoka, A., Honda, K., and Taniguchi, T. (2003) Biochem. Biophys. Res. Commun. 306, 860-866
8. Solis, M., Romieu-Mourez, R., Goubau, D., Grandvaux, N., Mesplede, T., Julkunen, I., Nardin, A., Salcedo, M., and Hiscott, J. (2007) Eur. J. Immunol. 37, 528-539
9. Servant, M. J., Grandvaux, N., tenOever, B. R., Duguay, D., Lin, R., and Hiscott, J. (2003) J. Biol. Chem. 278, 9441-9447
10. Schafer, S. L., Lin, R., Moore, P. A., Hiscott, J., and Pitha, P. M. (1998) J. Biol. Chem. 273, 2714-2720
11. Lin, R., Heylbroeck, C., Genin, P., Pitha, P. M., and Hiscott, J. (1999) Mol. Cell. Biol. 19, 959-966
12. Sing, A., Merlin, T., Knopf, H. P., Nielsen, P. J., Loppnow, H., Galanos, C., and Freudenberg, M. A. (2000) Infect. Immun. 68, 1600-1607
13. Honda, K., and Taniguchi, T. (2006) Nat. Rev. Immunol. 6, 644-658
14. Clement, J. F., Bibeau-Poirier, A., Gravel, S. P., Grandvaux, N., Bonneil, E., Thibault, P., Meloche, S., and Servant, M. J. (2008) J. Virol. 82, 3984-3996
15. Mori, M., Yoneyama, M., Ito, T., Takahashi, K., Inagaki, F., and Fujita, T. (2004) J. Biol. Chem. 279, 9698-9702
16. Fitzgerald, K. A., McWhirter, S. M., Faia, K. L., Rowe, D. C., Latz, E., Golenbock, D. T., Coyle, A. J., Liao, S. M., and Maniatis, T. (2003) Nat. Immunol. 4, 491-496
17. Sharma, S., tenOever, B. R., Grandvaux, N., Zhou, G. P., Lin, R., and Hiscott, J. (2003) Science 300, 1148-1151
18. McWhirter, S. M., Fitzgerald, K. A., Rosains, J., Rowe, D. C., Golenbock, D. T., and Maniatis, T. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 233-238
19. Perry, A. K., Chow, E. K., Goodnough, J. B., Yeh, W. C., and Cheng, G. (2004) J. Exp. Med. 199, 1651-1658
20. Hemmi, H., Takeuchi, O., Sato, S., Yamamoto, M., Kaisho, T., Sanjo, H., Kawai, T., Hoshino, K., Takeda, K., and Akira, S. (2004) J. Exp. Med. 199, 1641-1650
21. Wietek, C., Miggin, S. M., Jefferies, C. A., and O'Neill, L. A. (2003) J. Biol. Chem. 278, 50923-50931
22. Ogawa, S., Lozach, J., Benner, C., Pascual, G., Tangirala, R. K., Westin, S., Hoffmann, A., Subramaniam, S., David, M., Rosenfeld, M. G., and Glass, C. K. (2005) Cell 122, 707-721
23. Reily, M. M., Pantoja, C., Hu, X., Chinenov, Y., and Rogatsky, I. (2006) EMBO J. 25, 108-117
24. Kang, Y. J., Kusler, B., Otsuka, M., Hughes, M., Suzuki, N., Suzuki, S., Yeh, W. C., Akira, S., Han, J., and Jones, P. P. (2007) J. Immunol. 179, 4598-4607
25. Lasa, M., Abraham, S. M., Boucheron, C., Saklatvala, J., and Clark, A. R. (2002) Mol. Cell. Biol. 22, 7802-7811
26. Franklin, C. C., and Kraft, A. S. (1997) J. Biol. Chem. 272, 16917-16923
27. Kishore, N., Huynh, Q. K., Mathialagan, S., Hall, T., Rouw, S., Creely, D., Lange, G., Caroll, J., Reitz, B., Donnelly, A., Boddupalli, H., Combs, R. G., Kretzmer, K., and Tripp, C. S. (2002) J. Biol. Chem. 277, 13840-13847
28. Chen, Z. J. (2005) Nat. Cell. Biol. 7, 758-765
29. Lowe, E. L., Doherty, T. M., Karahashi, H., and Arditi, M. (2006) J. Endotoxin Res. 12, 337-345
30. Saitoh, T., Tun-Kyi, A., Ryo, A., Yamamoto, M., Finn, G., Fujita, T., Akira, S., Yamamoto, N., Lu, K. P., and Yamaoka, S. (2006) Nat. Immunol. 7, 598-605
31. Bibeau-Poirier, A., Gravel, S. P., Clement, J. F., Rolland, S., Rodier, G., Coulombe, P., Hiscott, J., Grandvaux, N., Meloche, S., and Servant, M. J. (2006) J. Immunol. 177, 5059-5067
32. Ishii, K. J., Coban, C., Kato, H., Takahashi, K., Torii, Y., Takeshita, F., Ludwig, H., Sutter, G., Suzuki, K., Hemmi, H., Sato, S., Yamamoto, M., Uematsu, S., Kawai, T., Takeuchi, O., and Akira, S. (2006) Nat. Immunol. 7, 40-48
33. Ishii, K. J., Kawagoe, T., Koyama, S., Matsui, K., Kumar, H., Kawai, T., Uematsu, S., Takeuchi, O., Takeshita, F., Coban, C., and Akira, S. (2008) Nature 451, 725-729
34. Chinenov, Y., and Rogatsky, I. (2007) Mol. Cell. Endocrinol. 275, 30-42