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Volumn 2, Issue 4, 2007, Pages 297-312

Toll-like receptors in defense and damage of the central nervous system

Author keywords

Astrocytes; CNS infections; Microglia; Pathogen associated molecular patterns; Toll like receptor

Indexed keywords

TOLL LIKE RECEPTOR;

EID: 35649003133     PISSN: 15571890     EISSN: 15571904     Source Type: Journal    
DOI: 10.1007/s11481-007-9071-5     Document Type: Article
Times cited : (147)

References (184)
  • 1
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K (2004) Toll-like receptor signalling. Nat Rev Immunol 4:499-511
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 2
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783-801
    • (2006) Cell , vol.124 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 3
    • 0034758046 scopus 로고    scopus 로고
    • Toll-like receptor-2 transduces signals for NF-kappa B activation, apoptosis and reactive oxygen species production
    • Aliprantis AO, Weiss DS, Zychlinsky A (2001) Toll-like receptor-2 transduces signals for NF-kappa B activation, apoptosis and reactive oxygen species production. J Endotoxin Res 7:287-291
    • (2001) J Endotoxin Res , vol.7 , pp. 287-291
    • Aliprantis, A.O.1    Weiss, D.S.2    Zychlinsky, A.3
  • 5
    • 0035152836 scopus 로고    scopus 로고
    • Immune function of microglia
    • Aloisi F (2001) Immune function of microglia. Glia 36:165-179
    • (2001) Glia , vol.36 , pp. 165-179
    • Aloisi, F.1
  • 6
    • 25444448498 scopus 로고    scopus 로고
    • Cutting Edge: TLR2-mediated production of proinflammatory cytokines and chemokines by microglial cells in response to herpes simplex virus
    • Aravalli RN, Hu S, Rowen TN, Palmquist J, Lokensgard JR (2005) Cutting Edge: TLR2-mediated production of proinflammatory cytokines and chemokines by microglial cells in response to herpes simplex virus. J Immunol 175:4189-4193
    • (2005) J Immunol , vol.175 , pp. 4189-4193
    • Aravalli, R.N.1    Hu, S.2    Rowen, T.N.3    Palmquist, J.4    Lokensgard, J.R.5
  • 7
    • 33845507853 scopus 로고    scopus 로고
    • Differential apoptotic signaling in primary glial cells infected with herpes simplex virus 1
    • Aravalli RN, Hu S, Rowen TN, Gekker G, Lokensgard JR (2006) Differential apoptotic signaling in primary glial cells infected with herpes simplex virus 1. J Neurovirol 12:501-510
    • (2006) J Neurovirol , vol.12 , pp. 501-510
    • Aravalli, R.N.1    Hu, S.2    Rowen, T.N.3    Gekker, G.4    Lokensgard, J.R.5
  • 10
    • 0037177825 scopus 로고    scopus 로고
    • Novel signal transduction pathway utilized by extracellular HSP70: Role of toll-like receptor (TLR) 2 and TLR4
    • Asea A, Rehli M, Kabingu E, Boch JA, Bare O, Auron PE, Stevenson MA, Calderwood SK (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277:15028-15034
    • (2002) J Biol Chem , vol.277 , pp. 15028-15034
    • Asea, A.1    Rehli, M.2    Kabingu, E.3    Boch, J.A.4    Bare, O.5    Auron, P.E.6    Stevenson, M.A.7    Calderwood, S.K.8
  • 13
    • 0038173259 scopus 로고    scopus 로고
    • Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis
    • Bannerman DD, Goldblum SE (2003) Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis. Am J Physiol Lung Cell Mol Physiol 284:L899-L914
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284
    • Bannerman, D.D.1    Goldblum, S.E.2
  • 14
    • 0029781523 scopus 로고    scopus 로고
    • Regulation of CD14 expression on human adult central nervous system-derived microglia
    • Becher B, Fedorowicz V, Antel JP (1996) Regulation of CD14 expression on human adult central nervous system-derived microglia. J Neurosci Res 45:375-381
    • (1996) J Neurosci Res , vol.45 , pp. 375-381
    • Becher, B.1    Fedorowicz, V.2    Antel, J.P.3
  • 16
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L, Hong JS (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57-69
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 17
    • 0042377367 scopus 로고    scopus 로고
    • Cultured astrocytes express toll-like receptors for bacterial products
    • Bowman CC, Rasley A, Tranguch SL, Marriott I (2003) Cultured astrocytes express toll-like receptors for bacterial products. Glia 43:281-291
    • (2003) Glia , vol.43 , pp. 281-291
    • Bowman, C.C.1    Rasley, A.2    Tranguch, S.L.3    Marriott, I.4
  • 18
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi M, Ravid R, Gveric D, van Noort JM (2002) Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 61:1013-1021
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Van Noort, J.M.4
  • 19
    • 33646258023 scopus 로고    scopus 로고
    • Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators
    • Bsibsi M, Persoon-Deen C, Verwer RW, Meeuwsen S, Ravid R, Van Noort JM (2006) Toll-like receptor 3 on adult human astrocytes triggers production of neuroprotective mediators. Glia 53:688-695
    • (2006) Glia , vol.53 , pp. 688-695
    • Bsibsi, M.1    Persoon-Deen, C.2    Verwer, R.W.3    Meeuwsen, S.4    Ravid, R.5    Van Noort, J.M.6
  • 20
    • 0036467447 scopus 로고    scopus 로고
    • Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway
    • Bulut Y, Faure E, Thomas L, Karahashi H, Michelsen KS, Equils O, Morrison SG, Morrison RP, Arditi M (2002) Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway. J Immunol 168:1435-1440
    • (2002) J Immunol , vol.168 , pp. 1435-1440
    • Bulut, Y.1    Faure, E.2    Thomas, L.3    Karahashi, H.4    Michelsen, K.S.5    Equils, O.6    Morrison, S.G.7    Morrison, R.P.8    Arditi, M.9
  • 22
    • 14044279966 scopus 로고    scopus 로고
    • Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines
    • Chakravarty S, Herkenham M (2005) Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines. J Neurosci 25:1788-1796
    • (2005) J Neurosci , vol.25 , pp. 1788-1796
    • Chakravarty, S.1    Herkenham, M.2
  • 23
    • 33747877119 scopus 로고    scopus 로고
    • Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll-like receptor-2 and tumour necrosis factor-a dependent manner
    • Chan G, Guilbert LJ (2006) Ultraviolet-inactivated human cytomegalovirus induces placental syncytiotrophoblast apoptosis in a Toll-like receptor-2 and tumour necrosis factor-a dependent manner. J Pathol 210:111-120
    • (2006) J Pathol , vol.210 , pp. 111-120
    • Chan, G.1    Guilbert, L.J.2
  • 24
    • 0027197996 scopus 로고
    • Neuroprotective role of IL-4 against activated microglia
    • Chao CC, Molitor TW, Hu S (1993) Neuroprotective role of IL-4 against activated microglia. J Immunol 151:1473-1481
    • (1993) J Immunol , vol.151 , pp. 1473-1481
    • Chao, C.C.1    Molitor, T.W.2    Hu, S.3
  • 26
    • 0029991620 scopus 로고    scopus 로고
    • Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway
    • Cleveland MG, Gorham JD, Murphy TL, Tuomanen E, Murphy KM (1996) Lipoteichoic acid preparations of gram-positive bacteria induce interleukin-12 through a CD14-dependent pathway. Infect Immun 64:1906-1912
    • (1996) Infect Immun , vol.64 , pp. 1906-1912
    • Cleveland, M.G.1    Gorham, J.D.2    Murphy, T.L.3    Tuomanen, E.4    Murphy, K.M.5
  • 28
    • 0035653671 scopus 로고    scopus 로고
    • Genetics of susceptibility to human infectious disease
    • Cooke GS, Hill AV (2001) Genetics of susceptibility to human infectious disease. Nat Rev Genet 2:967-977
    • (2001) Nat Rev Genet , vol.2 , pp. 967-977
    • Cooke, G.S.1    Hill, A.V.2
  • 29
    • 33745847180 scopus 로고    scopus 로고
    • TLRs, NLRs and RLRs: A trinity of pathogen sensors that co-operate in innate immunity
    • Creagh EM, O'Neill LAJ (2006) TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol 27:352-357
    • (2006) Trends Immunol , vol.27 , pp. 352-357
    • Creagh, E.M.1    O'Neill, L.A.J.2
  • 31
    • 0037312886 scopus 로고    scopus 로고
    • Inflammatory mechanisms after ischemia and stroke
    • Danton GH, Dietrich WD (2003) Inflammatory mechanisms after ischemia and stroke. J Neuropathol Exp Neurol 62:127-136
    • (2003) J Neuropathol Exp Neurol , vol.62 , pp. 127-136
    • Danton, G.H.1    Dietrich, W.D.2
  • 32
    • 23244465355 scopus 로고    scopus 로고
    • TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFNbeta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo
    • De Trez C, Pajak B, Brait M, Glaichenhaus N, Urbain J, Moser M, Lauvau G, Muraille E (2005) TLR4 and Toll-IL-1 receptor domain-containing adapter-inducing IFNbeta, but not MyD88, regulate Escherichia coli-induced dendritic cell maturation and apoptosis in vivo. J Immunol 175:839-846
    • (2005) J Immunol , vol.175 , pp. 839-846
    • De Trez, C.1    Pajak, B.2    Brait, M.3    Glaichenhaus, N.4    Urbain, J.5    Moser, M.6    Lauvau, G.7    Muraille, E.8
  • 33
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis Sousa, E.C.5
  • 36
    • 0036067659 scopus 로고    scopus 로고
    • Toll receptors, CD14, and macrophage activation and deactivation by LPS
    • Dobrovolskaia MA, Vogel SN (2002) Toll receptors, CD14, and macrophage activation and deactivation by LPS. Microbes Infect 4:903-914
    • (2002) Microbes Infect , vol.4 , pp. 903-914
    • Dobrovolskaia, M.A.1    Vogel, S.N.2
  • 37
    • 30144442455 scopus 로고    scopus 로고
    • Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci
    • Draper DW, Bethea HN, He YW (2006) Toll-like receptor 2-dependent and -independent activation of macrophages by group B streptococci. Immunol Lett 102:202-214
    • (2006) Immunol Lett , vol.102 , pp. 202-214
    • Draper, D.W.1    Bethea, H.N.2    He, Y.W.3
  • 38
    • 0034462136 scopus 로고    scopus 로고
    • Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes
    • Dziarski R, Gupta D (2000) Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes. J Endotoxin Res 6:401-405
    • (2000) J Endotoxin Res , vol.6 , pp. 401-405
    • Dziarski, R.1    Gupta, D.2
  • 39
    • 0029836383 scopus 로고    scopus 로고
    • Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan
    • Dziarski R, Jin YP, Gupta D (1996) Differential activation of extracellular signal-regulated kinase (ERK) 1, ERK2, p38, and c-Jun NH2-terminal kinase mitogen-activated protein kinases by bacterial peptidoglycan. J Infect Dis 174:777-785
    • (1996) J Infect Dis , vol.174 , pp. 777-785
    • Dziarski, R.1    Jin, Y.P.2    Gupta, D.3
  • 40
    • 0035253732 scopus 로고    scopus 로고
    • MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components
    • Dziarski R, Wang Q, Miyake K, Kirschning CJ, Gupta D (2001) MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components. J Immunol 166:1938-1944
    • (2001) J Immunol , vol.166 , pp. 1938-1944
    • Dziarski, R.1    Wang, Q.2    Miyake, K.3    Kirschning, C.J.4    Gupta, D.5
  • 41
    • 12344322869 scopus 로고    scopus 로고
    • Dosedependent activation of microglial cells by Toll-like receptor agonists alone and in combination
    • Ebert S, Gerber J, Bader S, Muhlhauser F, Brechtel K, Mitchell TJ, Nau R (2005) Dosedependent activation of microglial cells by Toll-like receptor agonists alone and in combination. J Neuroimmunol 159:87-96
    • (2005) J Neuroimmunol , vol.159 , pp. 87-96
    • Ebert, S.1    Gerber, J.2    Bader, S.3    Muhlhauser, F.4    Brechtel, K.5    Mitchell, T.J.6    Nau, R.7
  • 43
    • 33645087923 scopus 로고    scopus 로고
    • Molecular mechanisms involved in T cell migration across the blood-brain barrier
    • Engelhardt B (2006) Molecular mechanisms involved in T cell migration across the blood-brain barrier. J Neural Transm 113:477-485
    • (2006) J Neural Transm , vol.113 , pp. 477-485
    • Engelhardt, B.1
  • 44
    • 28444498105 scopus 로고    scopus 로고
    • Recognition of Staphylococcus aureus-derived peptidoglycan (PGN) but not intact bacteria is mediated by CD14 in microglia
    • Esen N, Kielian T (2005) Recognition of Staphylococcus aureus-derived peptidoglycan (PGN) but not intact bacteria is mediated by CD14 in microglia. J Neuroimmunol 170:93-104
    • (2005) J Neuroimmunol , vol.170 , pp. 93-104
    • Esen, N.1    Kielian, T.2
  • 45
    • 33646860198 scopus 로고    scopus 로고
    • Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns
    • Esen N, Kielian T (2006) Central role for MyD88 in the responses of microglia to pathogen-associated molecular patterns. J Immunol 176:6802-6811
    • (2006) J Immunol , vol.176 , pp. 6802-6811
    • Esen, N.1    Kielian, T.2
  • 47
    • 0030831201 scopus 로고    scopus 로고
    • Seeking wisdom in innate immunity
    • Fearon DT (1997) Seeking wisdom in innate immunity. Nature 388:323-324
    • (1997) Nature , vol.388 , pp. 323-324
    • Fearon, D.T.1
  • 49
    • 0035895913 scopus 로고    scopus 로고
    • Role of TLR-2 in the activation of nuclear factor κb by oxidative stress in cardiac myocytes
    • Frantz S, Kelly RA, Bourcier T (2001) Role of TLR-2 in the activation of nuclear factor κB by oxidative stress in cardiac myocytes. J Biol Chem 276:5197-5203
    • (2001) J Biol Chem , vol.276 , pp. 5197-5203
    • Franyz, S.1    Kelly, R.A.2    Bourcier, T.3
  • 51
    • 5444251622 scopus 로고    scopus 로고
    • Genetics of infectious diseases
    • Spec No. 182
    • Frodsham AJ, Hill AV (2004) Genetics of infectious diseases. Human Mol Genet:R187-R194 (Spec No. 182)
    • (2004) Human Mol Genet
    • Frodsham, A.J.1    Hill, A.V.2
  • 52
    • 0035142605 scopus 로고    scopus 로고
    • Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro
    • Gao JJ, Xue Q, Zuvanich EG, Haghi KR, Morrison, DC (2001) Commercial preparations of lipoteichoic acid contain endotoxin that contributes to activation of mouse macrophages in vitro. Infect Immun 69:751-757
    • (2001) Infect Immun , vol.69 , pp. 751-757
    • Gao, J.J.1    Xue, Q.2    Zuvanich, E.G.3    Haghi, K.R.4    Morrison, D.C.5
  • 53
    • 27644561365 scopus 로고    scopus 로고
    • Genomics: Understanding human diversity
    • Goldstein DB, Cavalleri GL (2005) Genomics: understanding human diversity. Nature 437:1241-1242
    • (2005) Nature , vol.437 , pp. 1241-1242
    • Goldstein, D.B.1    Cavalleri, G.L.2
  • 54
    • 0037097672 scopus 로고    scopus 로고
    • Cutting edge: The immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4
    • Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, Si-Tahar M (2002) Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 168:5989-5992
    • (2002) J Immunol , vol.168 , pp. 5989-5992
    • Guillot, L.1    Balloy, V.2    Golenbock, D.T.3    Chignard, M.4    Si-Tahar, M.5
  • 55
    • 0029814185 scopus 로고    scopus 로고
    • CD14 is a cell-activating receptor for bacterial peptidoglycan
    • Gupta D, Kirkland TN, Viriyakosol S, Dziarski R (1996) CD14 is a cell-activating receptor for bacterial peptidoglycan. J Biol Chem 271:23310-23316
    • (1996) J Biol Chem , vol.271 , pp. 23310-23316
    • Gupta, D.1    Kirkland, T.N.2    Viriyakosol, S.3    Dziarski, R.4
  • 56
    • 33745013111 scopus 로고    scopus 로고
    • Oxidative stress and neurodegeneration: Where are we now?
    • Halliwell B (2006) Oxidative stress and neurodegeneration: where are we now? J Neurochem 97:1634-1658
    • (2006) J Neurochem , vol.97 , pp. 1634-1658
    • Halliwell, B.1
  • 57
    • 3042686382 scopus 로고    scopus 로고
    • The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory
    • Hardy MP, O'Neill LA (2004) The murine IRAK2 gene encodes four alternatively spliced isoforms, two of which are inhibitory. J Biol Chem 279:27699-27708
    • (2004) J Biol Chem , vol.279 , pp. 27699-27708
    • Hardy, M.P.1    O'Neill, L.A.2
  • 59
    • 0024299087 scopus 로고
    • The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein
    • Hashimoto C, Hudson KL, Anderson KV (1988) The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell 52:269-279
    • (1988) Cell , vol.52 , pp. 269-279
    • Hashimoto, C.1    Hudson, K.L.2    Anderson, K.V.3
  • 60
    • 29144528084 scopus 로고    scopus 로고
    • Profile of TOll-like receptor expressions and induction of nitric oxide synthesis by Toll-like receptor agonists in chicken monocytes
    • He H, Genovese KJ, Nisbet DJ, Kogut MH (2006) Profile of Toll-like receptor expressions and induction of nitric oxide synthesis by Toll-like receptor agonists in chicken monocytes. Mol Immunol 43:783-789
    • (2006) Mol Immunol , vol.43 , pp. 783-789
    • He, H.1    Genovese, K.J.2    Nisbet, D.J.3    Kogut, M.H.4
  • 63
    • 0033963108 scopus 로고    scopus 로고
    • Apoptosis and neurologic disease
    • Honig LS, Rosenberg RN (2000) Apoptosis and neurologic disease. Am J Med 108:317-330
    • (2000) Am J Med , vol.108 , pp. 317-330
    • Honig, L.S.1    Rosenberg, R.N.2
  • 64
    • 2342637023 scopus 로고    scopus 로고
    • Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells
    • Hosoi T, Suzuki S, Nomura J, Ono A, Okuma Y, Akira S, Nomura Y (2004) Bacterial DNA induced iNOS expression through MyD88-p38 MAP kinase in mouse primary cultured glial cells. Brain Res Mol Brain Res 124:159-164
    • (2004) Brain Res Mol Brain Res , vol.124 , pp. 159-164
    • Hosoi, T.1    Suzuki, S.2    Nomura, J.3    Ono, A.4    Okuma, Y.5    Akira, S.6    Nomura, Y.7
  • 66
    • 14044272143 scopus 로고    scopus 로고
    • Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) components of Neisseria meningitidis and is independent of Toll-like receptor 4 and TLR2 signaling
    • Humphries HE, Triantafilou M, Makepeace BL, Heckels JE, Triantafilou K, Christodoulides M (2005) Activation of human meningeal cells is modulated by lipopolysaccharide (LPS) and non-LPS components of Neisseria meningitidis and is independent of Toll-like receptor 4 and TLR2 signaling. Cell Microbiol 7:415-430
    • (2005) Cell Microbiol , vol.7 , pp. 415-430
    • Humphries, H.E.1    Triantafilou, M.2    Makepeace, B.L.3    Heckels, J.E.4    Triantafilou, K.5    Christodoulides, M.6
  • 68
    • 0030941175 scopus 로고    scopus 로고
    • Secretory leukocyte protease inhibitor: A macrophage product induced by and antagonistic to bacterial lipopolysaccharide
    • Jin FY, Nathan C, Radzioch D, Ding A (1997) Secretory leukocyte protease inhibitor: a macrophage product induced by and antagonistic to bacterial lipopolysaccharide. Cell 88:417-426
    • (1997) Cell , vol.88 , pp. 417-426
    • Jin, F.Y.1    Nathan, C.2    Radzioch, D.3    Ding, A.4
  • 69
    • 0037094084 scopus 로고    scopus 로고
    • Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4
    • Johnson GB, Brunn GJ, Kodaira Y, Platt JL (2002) Receptor-mediated monitoring of tissue well-being via detection of soluble heparan sulfate by Toll-like receptor 4. J Immunol 168:5233-5239
    • (2002) J Immunol , vol.168 , pp. 5233-5239
    • Johnson, G.B.1    Brunn, G.J.2    Kodaira, Y.3    Platt, J.L.4
  • 70
    • 0038454645 scopus 로고    scopus 로고
    • Activation of mammalian Toll-like receptors by endogenous agonists
    • Johnson GB, Brunn GJ, Platt JL (2003) Activation of mammalian Toll-like receptors by endogenous agonists. Crit Rev Immunol 23:15-44
    • (2003) Crit Rev Immunol , vol.23 , pp. 15-44
    • Johnson, G.B.1    Brunn, G.J.2    Platt, J.L.3
  • 71
    • 18644376728 scopus 로고    scopus 로고
    • TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: A critical role of IFN-beta as a decision maker
    • Jung DY, Lee H, Jung BY, Ock J, Lee MS, Lee WH, Suk K (2005) TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol 174:6467-6476
    • (2005) J Immunol , vol.174 , pp. 6467-6476
    • Jung, D.Y.1    Lee, H.2    Jung, B.Y.3    Ock, J.4    Lee, M.S.5    Lee, W.H.6    Suk, K.7
  • 72
    • 0034891984 scopus 로고    scopus 로고
    • Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients
    • Kang TJ, Chae GT (2001) Detection of Toll-like receptor 2 (TLR2) mutation in the lepromatous leprosy patients. FEMS Immunol Med Microbiol 31:53-58
    • (2001) FEMS Immunol Med Microbiol , vol.31 , pp. 53-58
    • Kang, T.J.1    Chae, G.T.2
  • 77
    • 14844348476 scopus 로고    scopus 로고
    • Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia
    • Kielian T, Esen N, Bearden ED (2005) Toll-like receptor 2 (TLR2) is pivotal for recognition of S. aureus peptidoglycan but not intact bacteria by microglia. Glia 49:567-576
    • (2005) Glia , vol.49 , pp. 567-576
    • Kielian, T.1    Esen, N.2    Bearden, E.D.3
  • 78
    • 27744583563 scopus 로고    scopus 로고
    • Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess
    • Kielian T, Haney A, Mayes PM, Garg S, Esen N (2006) Toll-like receptor 2 modulates the proinflammatory milieu in Staphylococcus aureus-induced brain abscess. Infect Immun 73:7428-7435
    • (2006) Infect Immun , vol.73 , pp. 7428-7435
    • Kielian, T.1    Haney, A.2    Mayes, P.M.3    Garg, S.4    Esen, N.5
  • 79
    • 25444495866 scopus 로고    scopus 로고
    • Microglia in health and disease
    • Kim SU, de Vellis J (2005) Microglia in health and disease. J Neurosci Res 81:302-313
    • (2005) J Neurosci Res , vol.81 , pp. 302-313
    • Kim, S.U.1    De Vellis, J.2
  • 80
    • 0035877172 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia
    • Kitamura Y, Spleiss O, Li H, Taniguchi T, Kimura H, Nomura Y, Gebicke-Haerter PJ (2001) Lipopolysaccharide-induced switch between retinoid receptor (RXR) alpha and glucocorticoid attenuated response gene (GARG)-16 messenger RNAs in cultured rat microglia. J Neurosci Res 64:553-563
    • (2001) J Neurosci Res , vol.64 , pp. 553-563
    • Kitamura, Y.1    Spleiss, O.2    Li, H.3    Taniguchi, T.4    Kimura, H.5    Nomura, Y.6    Gebicke-Haerter, P.J.7
  • 83
    • 0034765855 scopus 로고    scopus 로고
    • Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS
    • Laflamme N, Soucy G, Rivest S (2001) Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS. J Neurochem 79:648-657
    • (2001) J Neurochem , vol.79 , pp. 648-657
    • Laflamme, N.1    Soucy, G.2    Rivest, S.3
  • 84
    • 0038744340 scopus 로고    scopus 로고
    • Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria
    • Laflamme N, Echchannaoui H, Landmann R, Rivest S (2003) Cooperation between toll-like receptor 2 and 4 in the brain of mice challenged with cell wall components derived from gram-negative and gram-positive bacteria. Eur J Immunol 33:1127-1138
    • (2003) Eur J Immunol , vol.33 , pp. 1127-1138
    • Laflamme, N.1    Echchannaoui, H.2    Landmann, R.3    Rivest, S.4
  • 85
    • 0142155221 scopus 로고    scopus 로고
    • Toll-like receptors and inflammation in the CNS
    • Lee SJ, Lee S (2002) Toll-like receptors and inflammation in the CNS. Curr Drug Targets Inflamm Allergy 1:181-191
    • (2002) Curr Drug Targets Inflamm Allergy , vol.1 , pp. 181-191
    • Lee, S.J.1    Lee, S.2
  • 86
    • 3242728422 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: The role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation
    • Lee S, Hong J, Choi SY, Oh SB, Park K, Kim JS, Karin M, Lee SJ (2004) CpG oligodeoxynucleotides induce expression of proinflammatory cytokines and chemokines in astrocytes: the role of c-Jun N-terminal kinase in CpG ODN-mediated NF-kappaB activation. J Neuroimmunol 153:50-63
    • (2004) J Neuroimmunol , vol.153 , pp. 50-63
    • Lee, S.1    Hong, J.2    Choi, S.Y.3    Oh, S.B.4    Park, K.5    Kim, J.S.6    Karin, M.7    Lee, S.J.8
  • 87
    • 33750024981 scopus 로고    scopus 로고
    • Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: Implication in Wallerian degeneration
    • Lee H, Jo EK, Choi SY, Oh SB, Park K, Soo Kim J, Lee SJ (2006) Necrotic neuronal cells induce inflammatory Schwann cell activation via TLR2 and TLR3: implication in Wallerian degeneration. Biochem Biophys Res Commun 350:742-747
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 742-747
    • Lee, H.1    Jo, E.K.2    Choi, S.Y.3    Oh, S.B.4    Park, K.5    Soo Kim, J.6    Lee, S.J.7
  • 91
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart J-M, Hoffmann JA (1996) The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86:973-983
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.-M.4    Hoffmann, J.A.5
  • 92
    • 0034922931 scopus 로고    scopus 로고
    • Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus
    • Lokensgard JR, Hu S, Sheng W, van Oijen M, Cox D, Cheeran MC, Peterson PK (2001) Robust expression of TNF-alpha, IL-1beta, RANTES, and IP-10 by human microglial cells during nonproductive infection with herpes simplex virus. J Neurovirol 7:208-219
    • (2001) J Neurovirol , vol.7 , pp. 208-219
    • Lokensgard, J.R.1    Hu, S.2    Sheng, W.3    Van Oijen, M.4    Cox, D.5    Cheeran, M.C.6    Peterson, P.K.7
  • 93
    • 0036716761 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide
    • Lorenz E, Patel DD, Hartung T, Schwartz DA (2002) Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. Infect Immun 70:4892-4896
    • (2002) Infect Immun , vol.70 , pp. 4892-4896
    • Lorenz, E.1    Patel, D.D.2    Hartung, T.3    Schwartz, D.A.4
  • 95
    • 0027252052 scopus 로고
    • Microbial cell wall contaminants in peptides: A potential source of physiological artifacts
    • Majde JA (1993) Microbial cell wall contaminants in peptides: a potential source of physiological artifacts. Peptides 14:629-632
    • (1993) Peptides , vol.14 , pp. 629-632
    • Majde, J.A.1
  • 96
    • 17144400786 scopus 로고    scopus 로고
    • TLR2 Arg677Trp polymorphism in leprosy: Revisited
    • Malhotra D, Relhan V, Reddy BS, Bamezai R (2005) TLR2 Arg677Trp polymorphism in leprosy: revisited. Hum Genet 116:413-415
    • (2005) Hum Genet , vol.116 , pp. 413-415
    • Malhotra, D.1    Relhan, V.2    Reddy, B.S.3    Bamezai, R.4
  • 100
    • 25144479446 scopus 로고    scopus 로고
    • In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression
    • McKimmie CS, Fazakerley JK (2005) In response to pathogens, glial cells dynamically and differentially regulate Toll-like receptor gene expression. J Neuroimmunol 169:116-125
    • (2005) J Neuroimmunol , vol.169 , pp. 116-125
    • Fazakerley, J.K.1
  • 101
    • 0032080865 scopus 로고    scopus 로고
    • Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls
    • Medvedev AE, Flo T, Ingalls RR, Golenbock DT, Teti G, Vogel SN, Espevik T (1998) Involvement of CD14 and complement receptors CR3 and CR4 in nuclear factor-kappaB activation and TNF production induced by lipopolysaccharide and group B streptococcal cell walls. J Immunol 160:4535-4542
    • (1998) J Immunol , vol.160 , pp. 4535-4542
    • Medvedev, A.E.1    Flo, T.2    Ingalls, R.R.3    Golenbock, D.T.4    Teti, G.5    Vogel, S.N.6    Espevik, T.7
  • 102
    • 33745945755 scopus 로고    scopus 로고
    • Tolerance to microbial TLR ligands: Molecular mechanisms and relevance to disease
    • Medvedev AE, Sabroe I, Hasday JD, Vogel SN (2006) Tolerance to microbial TLR ligands: molecular mechanisms and relevance to disease. J Endotoxin Res 12:133-150
    • (2006) J Endotoxin Res , vol.12 , pp. 133-150
    • Medvedev, A.E.1    Sabroe, I.2    Hasday, J.D.3    Vogel, S.N.4
  • 103
    • 0030831210 scopus 로고    scopus 로고
    • A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    • Medzhitov R, Preston-Hurlburt P, Janeway CA, Jr (1997) A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 388:394-397
    • (1997) Nature , vol.388 , pp. 394-397
    • Medzhitov, R.1    Preston-Hurlburt, P.2    Janeway Jr., C.A.3
  • 104
    • 33748871535 scopus 로고    scopus 로고
    • New insights into the regulation of TLR signaling
    • Miggin SM, O'Neill LA (2006) New insights into the regulation of TLR signaling. J Leukoc Biol 80:220-226
    • (2006) J Leukoc Biol , vol.80 , pp. 220-226
    • Miggin, S.M.1    O'Neill, L.A.2
  • 106
    • 33748846770 scopus 로고    scopus 로고
    • Live Streptococcus penumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns
    • Mogensen TH, Paludan SR, Kilian M, Ostergaard L (2006a) Live Streptococcus penumoniae, Haemophilus influenzae, and Neisseria meningitidis activate the inflammatory response through Toll-like receptors 2, 4, and 9 in species-specific patterns. J Leukoc Biol 80:267-277
    • (2006) J Leukoc Biol , vol.80 , pp. 267-277
    • Mogensen, T.H.1    Paludan, S.R.2    Kilian, M.3    Ostergaard, L.4
  • 107
    • 33750711337 scopus 로고    scopus 로고
    • Two neisseria meningitidis strains with different ability to stimulate Toll-like receptor 4 through the MyD88-independent pathway
    • Mogensen TH, Paludan SR, Kilian M, Ostergaard L (2006b) Two neisseria meningitidis strains with different ability to stimulate Toll-like receptor 4 through the MyD88-independent pathway. Scan J Immunol 64:646-654
    • (2006) Scan J Immunol , vol.64 , pp. 646-654
    • Mogensen, T.H.1    Paludan, S.R.2    Kilian, M.3    Ostergaard, L.4
  • 112
    • 0842320917 scopus 로고    scopus 로고
    • Evidence that lipopolysaccharideinduced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus
    • Nolan Y, Vereker E, Lynch AM, Lynch MA (2003) Evidence that lipopolysaccharide-induced cell death is mediated by accumulation of reactive oxygen species and activation of p38 in rat cortex and hippocampus. Exp Neurol 184:794-804
    • (2003) Exp Neurol , vol.184 , pp. 794-804
    • Nolan, Y.1    Vereker, E.2    Lynch, A.M.3    Lynch, M.A.4
  • 115
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K, Burkart V, Flohe S, Kolb H (2000) Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 164:558-561
    • (2000) J Immunol , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 116
    • 33746047516 scopus 로고    scopus 로고
    • Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide
    • Ohya M, Nishitani C, Sano H, Yamada C, Mitsuzawa H, Shimizu T, Saito T, Smith K, Crouch E, Kuroki Y (2006) Human pulmonary surfactant protein D binds the extracellular domains of Toll-like receptors 2 and 4 through the carbohydrate recognition domain by a mechanism different from its binding to phosphatidylinositol and lipopolysaccharide. Biochemistry 45:8657-8664
    • (2006) Biochemistry , vol.45 , pp. 8657-8664
    • Ohya, M.1    Nishitani, C.2    Sano, H.3    Yamada, C.4    Mitsuzawa, H.5    Shimizu, T.6    Saito, T.7    Smith, K.8    Crouch, E.9    Kuroki, Y.10
  • 118
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • Olson JK, Miller SD (2004) Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J Immunol 173:3916-3924
    • (2004) J Immunol , vol.173 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 120
    • 1542380035 scopus 로고    scopus 로고
    • Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein
    • Park JS, Svetkauskaite D, He Q, Kim JY, Strassheim D, Ishizaka A, Abraham E (2004) Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. J Biol Chem 279:7370-7377
    • (2004) J Biol Chem , vol.279 , pp. 7370-7377
    • Park, J.S.1    Svetkauskaite, D.2    He, Q.3    Kim, J.Y.4    Strassheim, D.5    Ishizaka, A.6    Abraham, E.7
  • 121
    • 32344437590 scopus 로고    scopus 로고
    • TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: Differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression
    • Park C, Lee S, Cho IH, Lee HK, Kim D, Choi SY, Oh SB, Park K, Kim JS, Lee SJ (2006) TLR3-mediated signal induces proinflammatory cytokine and chemokine gene expression in astrocytes: differential signaling mechanisms of TLR3-induced IP-10 and IL-8 gene expression. Glia 53:248-256
    • (2006) Glia , vol.53 , pp. 248-256
    • Park, C.1    Lee, S.2    Cho, I.H.3    Lee, H.K.4    Kim, D.5    Choi, S.Y.6    Oh, S.B.7    Park, K.8    Kim, J.S.9    Lee, S.J.10
  • 122
    • 0004257938 scopus 로고    scopus 로고
    • 4 Lippincott-Raven Publishers Philadelphia
    • Paul WE (1998) Fundamental immunology, 4th edn. Lippincott-Raven Publishers, Philadelphia
    • (1998) Fundamental Immunology
    • Paul, W.E.1
  • 124
    • 26444552110 scopus 로고    scopus 로고
    • Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon
    • Prehaud C, Megret F, Lafage M, Lafon M (2005) Virus infection switches TLR-3-positive human neurons to become strong producers of beta interferon. J Virol 79:12893-12904
    • (2005) J Virol , vol.79 , pp. 12893-12904
    • Prehaud, C.1    Megret, F.2    Lafage, M.3    Lafon, M.4
  • 126
    • 27444443028 scopus 로고    scopus 로고
    • Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation
    • Qin L, Li G, Qian X, Liu Y, Wu X, Liu B, Hong JS, Block ML (2005) Interactive role of the toll-like receptor 4 and reactive oxygen species in LPS-induced microglia activation. Glia 52:78-84
    • (2005) Glia , vol.52 , pp. 78-84
    • Qin, L.1    Li, G.2    Qian, X.3    Liu, Y.4    Wu, X.5    Liu, B.6    Hong, J.S.7    Block, M.L.8
  • 128
    • 22544451204 scopus 로고    scopus 로고
    • A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling
    • Rao N, Nguyen S, Ngo K, Fung-Leung WP (2005) A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol Cell Biol 25:6521-6532
    • (2005) Mol Cell Biol , vol.25 , pp. 6521-6532
    • Rao, N.1    Nguyen, S.2    Ngo, K.3    Fung-Leung, W.P.4
  • 129
    • 0036709022 scopus 로고    scopus 로고
    • Borrelia burgdorferi induces inflammatory mediator production by murine microglia
    • Rasley A, Anguita J, Marriott I (2002) Borrelia burgdorferi induces inflammatory mediator production by murine microglia. J Neuroimmunol 130:22-31
    • (2002) J Neuroimmunol , vol.130 , pp. 22-31
    • Rasley, A.1    Anguita, J.2    Marriott, I.3
  • 131
    • 0042357122 scopus 로고    scopus 로고
    • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production
    • Reed RC, Berwin B, Baker JP, Nicchitta CV (2003) GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. J Biol Chem 278:31853-31860
    • (2003) J Biol Chem , vol.278 , pp. 31853-31860
    • Reed, R.C.1    Berwin, B.2    Baker, J.P.3    Nicchitta, C.V.4
  • 134
    • 28844454323 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: Effects of dexamethasone
    • Rock RB, Hu S, Gekker G, Sheng WS, May B, Kapur V, Peterson PK (2005) Mycobacterium tuberculosis-induced cytokine and chemokine expression by human microglia and astrocytes: effects of dexamethasone. J Infect Dis 192:2054-2058
    • (2005) J Infect Dis , vol.192 , pp. 2054-2058
    • Rock, R.B.1    Hu, S.2    Gekker, G.3    Sheng, W.S.4    May, B.5    Kapur, V.6    Peterson, P.K.7
  • 135
    • 0346971400 scopus 로고    scopus 로고
    • Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell mediated Trypanosoma cruzi-elicited meningoencephalitis
    • Roffe E, Silva AA, Marino AP, dos Santos PV, Lannes-Vieira J (2003) Essential role of VLA-4/VCAM-1 pathway in the establishment of CD8+ T-cell mediated Trypanosoma cruzi-elicited meningoencephalitis. J Neuroimmunol 142:17-30
    • (2003) J Neuroimmunol , vol.142 , pp. 17-30
    • Roffe, E.1    Silva, A.A.2    Marino, A.P.3    Dos Santos, P.V.4    Lannes-Vieira, J.5
  • 136
    • 0032522116 scopus 로고    scopus 로고
    • In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection
    • Rubin SA, Yednock TA, Carbone KM (1998) In vivo treatment with anti-alpha4 integrin suppresses clinical and pathological evidence of Borna disease virus infection. J Neuroimmunol 84:158-163
    • (1998) J Neuroimmunol , vol.84 , pp. 158-163
    • Rubin, S.A.1    Yednock, T.A.2    Carbone, K.M.3
  • 137
    • 1842588614 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-κB and interleukin-8 expression
    • Ryan KA, Smith MF Jr, Sanders MK, Ernst PB (2004) Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-κB and interleukin-8 expression. Infect Immun 72:2123-2130
    • (2004) Infect Immun , vol.72 , pp. 2123-2130
    • Ryan, K.A.1    Smith Jr., M.F.2    Sanders, M.K.3    Ernst, P.B.4
  • 138
    • 33751206873 scopus 로고    scopus 로고
    • Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells
    • Sato A, Linehan MM, Iwasaki A (2006) Dual recognition of herpes simplex viruses by TLR2 and TLR9 in dendritic cells. Proc Natl Acad Sci U S A 103:17343-17348
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17343-17348
    • Sato, A.1    Linehan, M.M.2    Iwasaki, A.3
  • 140
    • 33644872282 scopus 로고    scopus 로고
    • Toll-like receptor therapies compete to reduce side effects
    • Schmidt C (2006) Toll-like receptor therapies compete to reduce side effects. Nat Biotechnol 24:230-231
    • (2006) Nat Biotechnol , vol.24 , pp. 230-231
    • Schmidt, C.1
  • 141
    • 0033810469 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms and the future of genetic epidemiology
    • Schork NJ, Fallin D, Lanchbury JS (2000) Single nucleotide polymorphisms and the future of genetic epidemiology. Clin Genet 58:250-264
    • (2000) Clin Genet , vol.58 , pp. 250-264
    • Schork, N.J.1    Fallin, D.2    Lanchbury, J.S.3
  • 142
    • 0038182550 scopus 로고    scopus 로고
    • Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved
    • Schroder NW, Morath S, Alexander C, Hamann L, Hartung T, Zahringer U, Gobel UB, Weber JR, Schumann RR (2003) Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved. J Biol Chem 278:15587-15594
    • (2003) J Biol Chem , vol.278 , pp. 15587-15594
    • Schroder, N.W.1    Morath, S.2    Alexander, C.3    Hamann, L.4    Hartung, T.5    Zahringer, U.6    Gobel, U.B.7    Weber, J.R.8    Schumann, R.R.9
  • 144
    • 27844507557 scopus 로고    scopus 로고
    • Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes
    • Scumpia PO, Kelly KM, Reeves WH, Stevens BR (2005) Double-stranded RNA signals antiviral and inflammatory programs and dysfunctional glutamate transport in TLR3-expressing astrocytes. Glia 52:153-162
    • (2005) Glia , vol.52 , pp. 153-162
    • Scumpia, P.O.1    Kelly, K.M.2    Reeves, W.H.3    Stevens, B.R.4
  • 145
    • 0041823868 scopus 로고    scopus 로고
    • Genetic susceptibility to infectious disease
    • Segal S, Hill AV (2003) Genetic susceptibility to infectious disease. Trends Microbiol 11:445-448
    • (2003) Trends Microbiol , vol.11 , pp. 445-448
    • Segal, S.1    Hill, A.V.2
  • 146
    • 33744512819 scopus 로고    scopus 로고
    • Central role of endogenous Toll-like receptor 2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury
    • Shishido T, Nozaki N, Takahashi H, Arimoto T, Niizeki T, Koyama Y, Abe J, Takeishi Y, Kubota I (2006) Central role of endogenous Toll-like receptor 2 activation in regulating inflammation, reactive oxygen species production, and subsequent neointimal formation after vascular injury. Biochem Biophys Res Commun 345:1446-1453
    • (2006) Biochem Biophys Res Commun , vol.345 , pp. 1446-1453
    • Shishido, T.1    Nozaki, N.2    Takahashi, H.3    Arimoto, T.4    Niizeki, T.5    Koyama, Y.6    Abe, J.7    Takeishi, Y.8    Kubota, I.9
  • 147
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167:2887-2894
    • (2001) J Immunol , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 148
    • 0037947560 scopus 로고    scopus 로고
    • Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility
    • Smirnova I, Mann N, Dols A, Derkx HH, Hibberd ML, Levin M, Beutler B (2003) Assay of locus-specific genetic load implicates rare Toll-like receptor 4 mutations in meningococcal susceptibility. Proc Natl Acad Sci U S A 100:6075-6080
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 6075-6080
    • Smirnova, I.1    Mann, N.2    Dols, A.3    Derkx, H.H.4    Hibberd, M.L.5    Levin, M.6    Beutler, B.7
  • 149
    • 0032190281 scopus 로고    scopus 로고
    • Nitric oxide causes apoptosis in pulmonary vascular smooth muscle cells
    • Smith JD, McLean SD, Nakayama DK (1998) Nitric oxide causes apoptosis in pulmonary vascular smooth muscle cells. J Surg Res 79:121-127
    • (1998) J Surg Res , vol.79 , pp. 121-127
    • Smith, J.D.1    Nakayama, D.K.2
  • 150
    • 0034214878 scopus 로고    scopus 로고
    • A role for alpha4-integrin in the pathology following Semliki Forest virus infection
    • Smith JP, Morris-Downes M, Brennan FR, Wallace GJ, Amor S (2000) A role for alpha4-integrin in the pathology following Semliki Forest virus infection. J Neuroimmunol 106:60-68
    • (2000) J Neuroimmunol , vol.106 , pp. 60-68
    • Smith, J.P.1    Morris-Downes, M.2    Brennan, F.R.3    Wallace, G.J.4    Amor, S.5
  • 151
    • 33646516398 scopus 로고    scopus 로고
    • Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3
    • So EY, Kang MH, Kim BS (2006) Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the Toll-like receptor 3. Glia 53:858-867
    • (2006) Glia , vol.53 , pp. 858-867
    • So, E.Y.1    Kang, M.H.2    Kim, B.S.3
  • 152
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer TA (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76:301-314
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 153
    • 0036130317 scopus 로고    scopus 로고
    • Degeneration and regeneration of the peripheral nervous system: From Augustus Waller's observations to neuroinflammation
    • Stoll G, Jander S, Myers RR (2002) Degeneration and regeneration of the peripheral nervous system: from Augustus Waller's observations to neuroinflammation. J Peripher Nerv Syst 7:13-27
    • (2002) J Peripher Nerv Syst , vol.7 , pp. 13-27
    • Stoll, G.1    Jander, S.2    Myers, R.R.3
  • 154
    • 0036847816 scopus 로고    scopus 로고
    • Microglia as neuroprotective, immunocompetent cells of the CNS
    • Streit WJ (2002) Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139
    • (2002) Glia , vol.40 , pp. 133-139
    • Streit, W.J.1
  • 155
  • 157
    • 33748802777 scopus 로고    scopus 로고
    • Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants
    • Su J, Richter K, Zhang C, Gu Q, Li L. (2007) Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants. Mol Immunol 44:900-905
    • (2007) Mol Immunol , vol.44 , pp. 900-905
    • Su, J.1    Richter, K.2    Zhang, C.3    Gu, Q.4    Li, L.5
  • 159
    • 33748866473 scopus 로고    scopus 로고
    • Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner
    • Sweet L, Schorey JS (2006) Glycopeptidolipids from Mycobacterium avium promote macrophage activation in a TLR2- and MyD88-dependent manner. J Leukoc Biol 80:415-423
    • (2006) J Leukoc Biol , vol.80 , pp. 415-423
    • Sweet, L.1    Schorey, J.S.2
  • 163
    • 0031608167 scopus 로고    scopus 로고
    • Infections of the central nervous system
    • Townsend GC, Scheld WM (1998) Infections of the central nervous system. Adv Intern Med 43:403-447
    • (1998) Adv Intern Med , vol.43 , pp. 403-447
    • Townsend, G.C.1    Scheld, W.M.2
  • 164
    • 33846294353 scopus 로고    scopus 로고
    • Deciphering immunology's dirty little secret
    • Travis K (2007) Deciphering immunology's dirty little secret. The Scientist 21:46-49
    • (2007) The Scientist , vol.21 , pp. 46-49
    • Travis, K.1
  • 165
    • 4344627821 scopus 로고    scopus 로고
    • Endogenous ligands of Toll-like receptors
    • Tsan MF, Gao B (2004) Endogenous ligands of Toll-like receptors. J Leukoc Biol 76:514-519
    • (2004) J Leukoc Biol , vol.76 , pp. 514-519
    • Tsan, M.F.1    Gao, B.2
  • 168
    • 9144241212 scopus 로고    scopus 로고
    • IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection
    • Verdrengh M, Thomas JA, Hultgren O (2004) IL-1 receptor-associated kinase 1 mediates protection against Staphylococcus aureus infection. Microbes Infect 6:1268-1272
    • (2004) Microbes Infect , vol.6 , pp. 1268-1272
    • Verdrengh, M.1    Thomas, J.A.2    Hultgren, O.3
  • 170
    • 33644986066 scopus 로고    scopus 로고
    • Trigeminal nociceptors express TLR-4 and CD14: A mechanism for pain due to infection
    • Wadachi R, Hargreaves KM (2006) Trigeminal nociceptors express TLR-4 and CD14: a mechanism for pain due to infection. J Dent Res 85:49-53
    • (2006) J Dent Res , vol.85 , pp. 49-53
    • Wadachi, R.1    Hargreaves, K.M.2
  • 173
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA (2004) Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nature Med 10:1366-1373
    • (2004) J Neurochem , vol.88 , pp. 939-947
    • Wang, T.1    Town, T.2    Alexopoulou, L.3    Anderson, J.F.4    Fikrig, E.5    Flavell, R.A.6
  • 175
    • 27144528203 scopus 로고    scopus 로고
    • The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung
    • Wieland CW, Florquin S, Maris NA, Hoebe K, Beutler B, Takeda K, Akira S, van der Poll T (2005) The MyD88-dependent, but not the MyD88-independent, pathway of TLR4 signaling is important in clearing nontypeable haemophilus influenzae from the mouse lung. J Immunol 175:6042-6049
    • (2005) J Immunol , vol.175 , pp. 6042-6049
    • Wieland, C.W.1    Florquin, S.2    Maris, N.A.3    Hoebe, K.4    Beutler, B.5    Takeda, K.6    Akira, S.7    Van Der Poll, T.8
  • 177
    • 33644761926 scopus 로고    scopus 로고
    • The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans
    • Yim JJ, Lee HW, Lee HS, Kim YW, Han SK, Shim YS, Holland SM (2006a) The association between microsatellite polymorphisms in intron II of the human Toll-like receptor 2 gene and tuberculosis among Koreans. Genes Immun 7:150-155
    • (2006) Genes Immun , vol.7 , pp. 150-155
    • Yim, J.J.1    Lee, H.W.2    Lee, H.S.3    Kim, Y.W.4    Han, S.K.5    Shim, Y.S.6    Holland, S.M.7
  • 178
    • 33748439127 scopus 로고    scopus 로고
    • Evolution of an intronic microsatellite polymorphism in Toll-like receptor 2 among primates
    • Yim JJ, Adams AA, Kim JH, Holland SM (2006b) Evolution of an intronic microsatellite polymorphism in Toll-like receptor 2 among primates. Immunogenetics 58:740-745
    • (2006) Immunogenetics , vol.58 , pp. 740-745
    • Yim, J.J.1    Adams, A.A.2    Kim, J.H.3    Holland, S.M.4
  • 180
    • 0036019158 scopus 로고    scopus 로고
    • The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS
    • Zekki H, Feinstein DL, Rivest S (2002) The clinical course of experimental autoimmune encephalomyelitis is associated with a profound and sustained transcriptional activation of the genes encoding toll-like receptor 2 and CD14 in the mouse CNS. Brain Pathol 12:308-319
    • (2002) Brain Pathol , vol.12 , pp. 308-319
    • Zekki, H.1    Feinstein, D.L.2    Rivest, S.3
  • 182
    • 20444495564 scopus 로고    scopus 로고
    • Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists
    • Zhang Z, Trautmann K, Schluesener HJ (2005a) Microglia activation in rat spinal cord by systemic injection of TLR3 and TLR7/8 agonists. J Neuroimmunol 164:154-160
    • (2005) J Neuroimmunol , vol.164 , pp. 154-160
    • Zhang, Z.1    Trautmann, K.2    Schluesener, H.J.3
  • 183
    • 14844300873 scopus 로고    scopus 로고
    • The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif
    • Zhang Z, Guo K, Schluesener HJ (2005b) The immunostimulatory activity of CpG oligonucleotides on microglial N9 cells is affected by a polyguanosine motif. J Neuroimmunol 161:68-77
    • (2005) J Neuroimmunol , vol.161 , pp. 68-77
    • Zhang, Z.1    Guo, K.2    Schluesener, H.J.3
  • 184
    • 16444373989 scopus 로고    scopus 로고
    • Heat shock up-regulates expression of Toll-like receptor-2 and Toll-like receptor-4 in human monocytes via p38 kinase signal pathway
    • Zhou J, An H, Xu H, Liu S, Cao X (2005) Heat shock up-regulates expression of Toll-like receptor-2 and Toll-like receptor-4 in human monocytes via p38 kinase signal pathway. Immunology 114:522-530
    • (2005) Immunology , vol.114 , pp. 522-530
    • Zhou, J.1    An, H.2    Xu, H.3    Liu, S.4    Cao, X.5


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