Role of MD-2 in TLR2- and TLR4-mediated recognition of Gram-negative and Gram-positive bacteria and activation of chemokine genes

Journal of Endotoxin Research

Volumn 6, Issue 5, 2000, Pages 401-405

  Dziarski, R ^a   Gupta, D ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE NORTHWEST   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; BACTERIAL PROTEIN; BACTERIUM LIPOPOLYSACCHARIDE; CHEMOKINE; I KAPPA KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE; INTERLEUKIN 8; LIPID A; LIPOPEPTIDE; LIPOTEICHOIC ACID; MYELOID DIFFERENTIATION FACTOR 88; PEPTIDOGLYCAN; PROTEIN KINASE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN RECOGNITION; ARTICLE; BACTERIAL CELL WALL; CELL SURFACE; CONTROLLED STUDY; GENE ACTIVATION; GENE INDUCTION; GENETIC TRANSCRIPTION; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IMMUNE RESPONSE; MONOCYTE; MOUSE; NONHUMAN; PROTEIN DOMAIN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STIMULATION;

ANIMALS; ANTIGENS, SURFACE; CHEMOKINES; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; HUMANS; INTERLEUKIN-8; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE GLYCOPROTEINS; MICE; MICE, KNOCKOUT; MODELS, BIOLOGICAL; MONOCYTES; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TRANSFECTION;

ANIMALIA; BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 0034462136     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805100101532243     Document Type: Article

References (28)

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2. Recognition of Gram-negative bacteria and endotoxin by the innate immune system
3. Interactions of CD14 with components of Gram-positive bacteria
4. Endothelial and epithelial cells do not respond to complexes of peptidoglycan with soluble CD14, but are activated indirectly by peptidoglycan-induced tumor necrosis factor-α and interleukin-1 from monocytes
5. CD14 plays no major role in shock induced by Staphylococcus aureus but down-regulates TNF-α production
6. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signaling
7. Human Toll-like receptor 2 confers responsiveness to bacterial lipopolysaccharide
8. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
9. Recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
10. Host defense mechanisms triggered by microbial lipoproteins through Toll-like receptors
11. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products
12. Inflammatory signaling by Borrelia burgdorferi lipoproteins is mediated by Toll-like receptor 2
13. Human Toll-like receptors mediate cellular activation by Mycobacterium tuberculosis
14. Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages
15. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components
16. Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: Evidence for TLR4 as the Lps gene product
17. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
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19. Cells that carry a null allele for Toll-like receptor 2 are capable of responding to endotoxin
20. Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
21. MD-2 enables Toll-like receptor-2 (TLR2)-mediated responses to LPS and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components
22. Binding of bacterial peptidoglycan to CD14
23. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
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27. Chemokines are the main pro-inflammatory mediators in human monocytes activated by Staphylococcus aureus, peptidoglycan, and endotoxin
28. Micrococcus and peptidoglycan activate TLR2→MyD88→ IRAK→TRAF→NIK→IKK→NF→-κB signal transduction pathway that induces transcription of IL-8