Circulating cell wall components derived from gram-negative, not gram-positive, bacteria cause a profound induction of the gene-encoding Toll-like receptor 2 in the CNS

Journal of Neurochemistry

Volumn 79, Issue 3, 2001, Pages 648-657

  Laflamme, Nathalie ^a   Soucy, Geneviève ^a   Rivest, Serge ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

Innate immune response; Lipopolysaccharide; Lipoteichoic acid; Microglia; NF B; Peptidoglycan

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOTEICHOIC ACID; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR 2;

ARTICLE; BACTERIAL CELL WALL; BLOOD BRAIN BARRIER; BRAIN REGION; BRAIN TISSUE; CENTRAL NERVOUS SYSTEM; CHOROID PLEXUS; CONTROLLED STUDY; GENETIC CODE; GENETIC TRANSCRIPTION; GENETIC TRANSDUCTION; IMMUNE RESPONSE; MALE; MICROGLIA; MODULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN CHEMISTRY; CELL WALL; CEREBROVASCULAR CIRCULATION; CHOROID PLEXUS; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION; GRAM-NEGATIVE BACTERIA; GRAM-POSITIVE BACTERIA; LIPOPOLYSACCHARIDES; MALE; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED STRAINS; MICROCIRCULATION; MICROGLIA; NF-KAPPA B; RECEPTORS, CELL SURFACE; RNA, MESSENGER; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTORS; TRANS-ACTIVATION (GENETICS);

BACTERIA (MICROORGANISMS); MAMMALIA; NEGIBACTERIA; POSIBACTERIA;

EID: 0034765855     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2001.00603.x     Document Type: Article

References (23)

1. Cell activation and apoptosis by bacterial lipoproteins through toll-like receptor-2
2. The apoptotic signaling pathway activated by Toll-like receptor-2
3. Toll signaling pathways in the innate immune response
4. Tlr4: Central component of the sole mammalian LPS sensor
5. Bacterial lipopolysaccharide and IFN-γ induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial ceils: Role of NF-κB activation
6. Cutting edge: Repurification of lipopolysaccharide eliminates signaling through both human and murine Toll-like receptor 2
7. Dendritic-cell function in toll-like receptor- and MyD88-knockout mice
8. The bacterial endotoxin lipopolysaccharide has the ability to target the brain in upregulating its membrane CD14 receptor within specific cellular populations
9. Effects of systemic immunogenic insults and circulating proinflammatory cytokines on the transcription of the inhibitory factor kappa B alpha within specific cellular populations of the rat brain
10. Toll-ike receptor 4: The missing link of the cerebral innate immune response triggered by circulating gram-negative bacterial cell wall components
11. An essential role of interleukin-1β in mediating NF-κB activity and COX-2 transcription in cells of the blood-brain barrier in response to systemic and localized inflammation, but not during endotoxemia
12. The role of Toll-like receptors (TLRs) in bacteria-induced maturation of murine dendritic cells (DCS). Peptidoglycan and lipoteichoic acid are inducers of DC maturation and require TLR2
13. Toll-like receptors: A growing family of immune receptors that are differentially expressed and regulated by different leukocytes
14. The complement system is an integrated part of the natural innate immune response in the brain
15. Toll-like receptor-2 mediates Treponema glycolipid and lipoteichoic acid-induced NF-κB translocation
16. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors
17. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
18. Induction of inhibitory factor κBα mRNA in the central nervous system after peripheral lipopolysaccharide administration: An in situ hybridization histochemistry study in the rat
19. PU1 and interferon consensus sequence-binding protein regulate the myeloid expression of the human Toll-like receptor 4 gene
20. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by Toll-like receptor 2
21. Differential roles of TLR2 and TLR4 in recognition of Gram-negative and gGam-positive bacterial cell wall components
22. Regulation of Toll-like receptor 2 expression by macrophages following Mycobacterium avium infection
23. Toll, a new piece in the puzzle of innate immunity