ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity

Nature Immunology

Volumn 6, Issue 6, 2005, Pages 587-592

  Matsuzawa, Atsushi ^a,b   Saegusa, Kaoru ^a,b   Noguchi, Takuya ^a,b,c   Sadamitsu, Chiharu ^a,b   Nishitoh, Hideki ^a,b,c   Nagai, Shigenori ^b,d   Koyasu, Shigeo ^b,d   Matsumoto, Kunihiro ^b,e   Takeda, Kohsuke ^a,b   Ichijo, Hidenori ^a,b  

^a UNIVERSITY OF TOKYO   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e NAGOYA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APOPTOSIS SIGNAL REGULATING KINASE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; CYTOKINE; IMMUNOGLOBULIN RECEPTOR; LIPOPOLYSACCHARIDE; MAP3K5 PROTEIN, MOUSE; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; SEPTIC SHOCK; SIGNAL TRANSDUCTION; SPLEEN CELL; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL LINE; DRUG EFFECT; FEMALE; GENETICS; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOUSE MUTANT;

ANIMALS; CELL LINE; CYTOKINES; FEMALE; IMMUNITY, NATURAL; LIPOPOLYSACCHARIDES; MAP KINASE KINASE KINASE 5; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REACTIVE OXYGEN SPECIES; RECEPTORS, IMMUNOLOGIC; SHOCK, SEPTIC; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 4;

EID: 20644433073     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1200     Document Type: Article

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