메뉴 건너뛰기




Volumn 116, Issue 2, 2006, Pages 456-464

Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis

Author keywords

[No Author keywords available]

Indexed keywords

MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TOLL LIKE RECEPTOR 9;

EID: 32444443739     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI26078     Document Type: Article
Times cited : (326)

References (43)
  • 1
    • 0029939467 scopus 로고    scopus 로고
    • Multiple sclerosis: A coordinated immunological attack against myelin in the central nervous system
    • Steinman, L. 1996. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell. 85:299-302.
    • (1996) Cell , vol.85 , pp. 299-302
    • Steinman, L.1
  • 2
    • 0035128996 scopus 로고    scopus 로고
    • Genetic models for CNS inflammation
    • Owens, T., Wekerle, H., and Antel, J. 2001. Genetic models for CNS inflammation. Nat. Med. 7:161-166.
    • (2001) Nat. Med. , vol.7 , pp. 161-166
    • Owens, T.1    Wekerle, H.2    Antel, J.3
  • 3
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • Banchereau, J., and Steinman, R.M. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252.
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 4
    • 0034775153 scopus 로고    scopus 로고
    • Toll-like receptors control activation of adaptive immune responses
    • Schnare, M., et al. 2001. Toll-like receptors control activation of adaptive immune responses. Nat. Immunol. 2:947-950.
    • (2001) Nat. Immunol. , vol.2 , pp. 947-950
    • Schnare, M.1
  • 5
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • Takeda, K., and Akira, S. 2005. Toll-like receptors in innate immunity. Int. Immunol. 17:1-14.
    • (2005) Int. Immunol. , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 6
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signalling
    • Beutler, B. 2004. Inferences, questions and possibilities in Toll-like receptor signalling. Nature. 430:257-263.
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 7
    • 0028201732 scopus 로고
    • Tolerance, danger, and the extended family
    • Matzinger, P. 1994. Tolerance, danger, and the extended family. Annu. Rev. Immunol. 12:991-1045.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 991-1045
    • Matzinger, P.1
  • 8
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J.M., and Hoffmann, J.A. 1996. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 9
    • 0032133278 scopus 로고    scopus 로고
    • MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways
    • Medzhitov, R., et al. 1998. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell. 2:253-258.
    • (1998) Mol. Cell , vol.2 , pp. 253-258
    • Medzhitov, R.1
  • 10
    • 0030694108 scopus 로고    scopus 로고
    • IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling
    • Muzio, M., Ni, J., Feng, P., and Dixit, V.M. 1997. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science. 278:1612-1615.
    • (1997) Science , vol.278 , pp. 1612-1615
    • Muzio, M.1    Ni, J.2    Feng, P.3    Dixit, V.M.4
  • 11
    • 0037297956 scopus 로고    scopus 로고
    • Prion pathogenesis in the absence of Toll-like receptor signalling
    • Prinz, M., et al. 2003. Prion pathogenesis in the absence of Toll-like receptor signalling. EMBO Rep. 4:195-199.
    • (2003) EMBO Rep. , vol.4 , pp. 195-199
    • Prinz, M.1
  • 12
    • 0032127279 scopus 로고    scopus 로고
    • Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function
    • Adachi, O., et al. 1998. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity. 9:143-150.
    • (1998) Immunity , vol.9 , pp. 143-150
    • Adachi, O.1
  • 13
    • 0033166472 scopus 로고    scopus 로고
    • Unresponsiveness of MyD88-deficient mice to endotoxin
    • Kawai, T., Adachi, O., Ogawa, T., Takeda, K., and Akira, S. 1999. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity. 11:115-122.
    • (1999) Immunity , vol.11 , pp. 115-122
    • Kawai, T.1    Adachi, O.2    Ogawa, T.3    Takeda, K.4    Akira, S.5
  • 14
    • 0033968625 scopus 로고    scopus 로고
    • Cellular responses to bacterial cell wall components are mediated through MyD88dependent signaling cascades
    • Takeuchi, O., et al. 2000. Cellular responses to bacterial cell wall components are mediated through MyD88dependent signaling cascades. Int. Immunol. 12:113-117.
    • (2000) Int. Immunol. , vol.12 , pp. 113-117
    • Takeuchi, O.1
  • 15
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi, H., et al. 2002. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 3:196-200.
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1
  • 16
    • 0034698739 scopus 로고    scopus 로고
    • Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6
    • Hacker, H., et al. 2000. Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6. J. Exp. Med. 192:595-600.
    • (2000) J. Exp. Med. , vol.192 , pp. 595-600
    • Hacker, H.1
  • 17
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi, F., et al. 2001. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature. 410:1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1
  • 18
    • 0034043957 scopus 로고    scopus 로고
    • CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo
    • Segal, B.M., Chang, J.T., and Shevach, E.M. 2000. CpG oligonucleotides are potent adjuvants for the activation of autoreactive encephalitogenic T cells in vivo. J. Immunol. 164:5683-5688.
    • (2000) J. Immunol. , vol.164 , pp. 5683-5688
    • Segal, B.M.1    Chang, J.T.2    Shevach, E.M.3
  • 19
    • 4644232615 scopus 로고    scopus 로고
    • Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs
    • Olson, J.K., and Miller, S.D. 2004. Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs. J. Immunol. 173:3916-3924.
    • (2004) J. Immunol. , vol.173 , pp. 3916-3924
    • Olson, J.K.1    Miller, S.D.2
  • 20
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • Lehnardt, S., et al. 2003. Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway. Proc. Natl. Acad. Sci. U. S. A. 100:8514-8519.
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 8514-8519
    • Lehnardt, S.1
  • 21
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • Bsibsi, M., Ravid, R., Gveric, D., and van Noort, J.M. 2002. Broad expression of Toll-like receptors in the human central nervous system. J. Neuropathol. Exp. Neurol. 61:1013-1021.
    • (2002) J. Neuropathol. Exp. Neurol. , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Van Noort, J.M.4
  • 22
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare, C., and Medzhitov, R. 2004. Toll-dependent control mechanisms of CD4 T cell activation. Immunity. 21:733-741.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 23
    • 0035896737 scopus 로고    scopus 로고
    • The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system
    • Becher, B., Durell, B.G., Miga, A.V., Hickey, W.F., and Noelle, R.J. 2001. The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system. J. Exp. Med. 193:967-974.
    • (2001) J. Exp. Med. , vol.193 , pp. 967-974
    • Becher, B.1    Durell, B.G.2    Miga, A.V.3    Hickey, W.F.4    Noelle, R.J.5
  • 24
    • 0347357773 scopus 로고    scopus 로고
    • IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis
    • doi:10.1172/JCI200319079
    • Becher, B., Durell, B.G., and Noelle, R.J. 2003. IL-23 produced by CNS-resident cells controls T cell encephalitogenicity during the effector phase of experimental autoimmune encephalomyelitis. J. Clin. Invest. 112:1186-1191. doi:10.1172/JCI200319079.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1186-1191
    • Becher, B.1    Durell, B.G.2    Noelle, R.J.3
  • 25
    • 16244380177 scopus 로고    scopus 로고
    • Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis
    • Greter, M., et al. 2005. Dendritic cells permit immune invasion of the CNS in an animal model of multiple sclerosis. Nat. Med. 11:328-334.
    • (2005) Nat. Med. , vol.11 , pp. 328-334
    • Greter, M.1
  • 26
    • 0242499506 scopus 로고    scopus 로고
    • Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion
    • Prinz, M., et al. 2003. Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion. Nature. 425:957-962.
    • (2003) Nature , vol.425 , pp. 957-962
    • Prinz, M.1
  • 27
    • 1542618312 scopus 로고    scopus 로고
    • Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein
    • Asheuer, M., et al. 2004. Human CD34+ cells differentiate into microglia and express recombinant therapeutic protein. Proc. Natl. Acad. Sci. U. S. A. 101:3557-3562.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 3557-3562
    • Asheuer, M.1
  • 28
    • 0026755999 scopus 로고
    • Bone marrow-derived elements in the central nervous system: An immunohistochemical and ultrastructural survey of rat chimeras
    • Hickey, W.F., Vass, K., and Lassmann, H. 1992. Bone marrow-derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J. Neuropathol. Exp. Neurol. 51:246-256.
    • (1992) J. Neuropathol. Exp. Neurol. , vol.51 , pp. 246-256
    • Hickey, W.F.1    Vass, K.2    Lassmann, H.3
  • 29
    • 0035658031 scopus 로고    scopus 로고
    • Targeting gene-modified hematopoietic cells to the central nervous system: Use of green fluorescent protein uncovers microglial engraftment
    • Priller, J., et al. 2001. Targeting gene-modified hematopoietic cells to the central nervous system: use of green fluorescent protein uncovers microglial engraftment. Nat. Med. 7:1356-1361.
    • (2001) Nat. Med. , vol.7 , pp. 1356-1361
    • Priller, J.1
  • 30
    • 0037029424 scopus 로고    scopus 로고
    • Multiple sclerosis
    • Compston, A., and Coles, A. 2002. Multiple sclerosis. Lancet. 359:1221-1231.
    • (2002) Lancet , vol.359 , pp. 1221-1231
    • Compston, A.1    Coles, A.2
  • 31
    • 0034566306 scopus 로고    scopus 로고
    • Prognosis of multiple sclerosis:environmental factors
    • Casetta, I., and Granieri, E. 2000. Prognosis of multiple sclerosis:environmental factors. Neurol. Sci. 21:S839-S842.
    • (2000) Neurol. Sci. , vol.21
    • Casetta, I.1    Granieri, E.2
  • 32
    • 0036237054 scopus 로고    scopus 로고
    • Prospective study on the relationship between infections and multiple sclerosis exacerbations
    • Buljevac, D., et al. 2002. Prospective study on the relationship between infections and multiple sclerosis exacerbations. Brain. 125:952-960.
    • (2002) Brain , vol.125 , pp. 952-960
    • Buljevac, D.1
  • 33
    • 0027406406 scopus 로고
    • Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis
    • Oksenberg, J.R., et al. 1993. Selection for T-cell receptor Vβ-Dβ-Jβ gene rearrangements with specificity for a myelin basic protein peptide in brain lesions of multiple sclerosis. Nature. 362:68-70.
    • (1993) Nature , vol.362 , pp. 68-70
    • Oksenberg, J.R.1
  • 34
    • 20044376483 scopus 로고    scopus 로고
    • Experimental autoimmune encephalomyelitis repressed by microglial paralysis
    • Heppner, F.L., et al. 2005. Experimental autoimmune encephalomyelitis repressed by microglial paralysis. Nat. Med. 11:146-152.
    • (2005) Nat. Med. , vol.11 , pp. 146-152
    • Heppner, F.L.1
  • 35
    • 4043171986 scopus 로고    scopus 로고
    • Toll-like receptor pathways in the immune responses to mycobacteria
    • Quesniaux, V., et al. 2004. Toll-like receptor pathways in the immune responses to mycobacteria. Microbes Infect. 6:946-959.
    • (2004) Microbes Infect. , vol.6 , pp. 946-959
    • Quesniaux, V.1
  • 36
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C., and Medzhitov, R. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science. 299:1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 37
    • 0034619794 scopus 로고    scopus 로고
    • A Toll-like receptor recognizes bacterial DNA
    • Hemmi, H., et al. 2000. A Toll-like receptor recognizes bacterial DNA. Nature. 408:740-745.
    • (2000) Nature , vol.408 , pp. 740-745
    • Hemmi, H.1
  • 38
    • 18644383289 scopus 로고    scopus 로고
    • Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways
    • Yasuda, K., et al. 2005. Endosomal translocation of vertebrate DNA activates dendritic cells via TLR9-dependent and -independent pathways. J. Immunol. 174:6129-6136.
    • (2005) J. Immunol. , vol.174 , pp. 6129-6136
    • Yasuda, K.1
  • 39
    • 0031715518 scopus 로고    scopus 로고
    • T-cell apoptosis in inflammatory brain lesions. Destruction of T cells does not depend on antigen recognition
    • Bauer, J., et al. 1998. T-cell apoptosis in inflammatory brain lesions. Destruction of T cells does not depend on antigen recognition. Am. J. Pathol. 153:715-724.
    • (1998) Am. J. Pathol. , vol.153 , pp. 715-724
    • Bauer, J.1
  • 40
    • 0037061453 scopus 로고    scopus 로고
    • Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors
    • Leadbetter, E.A., et al. 2002. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature. 416:603-607.
    • (2002) Nature , vol.416 , pp. 603-607
    • Leadbetter, E.A.1
  • 41
    • 9144247024 scopus 로고    scopus 로고
    • TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease
    • Kerfoot, S.M., et al. 2004. TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease. J. Immunol. 173:7070-7077.
    • (2004) J. Immunol. , vol.173 , pp. 7070-7077
    • Kerfoot, S.M.1
  • 42
    • 5944225473 scopus 로고    scopus 로고
    • Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism
    • Werts, C., et al. 2001. Leptospiral lipopolysaccharide activates cells through a TLR2-dependent mechanism. Nat. Immunol. 2:346-352.
    • (2001) Nat. Immunol. , vol.2 , pp. 346-352
    • Werts, C.1
  • 43
    • 0037220060 scopus 로고    scopus 로고
    • Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis
    • Koedel, U., et al. 2003. Toll-like receptor 2 participates in mediation of immune response in experimental pneumococcal meningitis. J. Immunol. 170:438-444.
    • (2003) J. Immunol. , vol.170 , pp. 438-444
    • Koedel, U.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.