Lipoteichoic acid (LTA) of Streptococcus pneumoniae and Staphylococcus aureus activates immune cells via Toll-like receptor (TLR)-2, lipopolysaccharide-binding protein (LBP), and CD14, whereas TLR-4 and MD-2 are not involved

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 15587-15594

  Schröder, Nicolas W J ^a   Morath, Siegfried ^b   Alexander, Christian ^c   Hamann, Lutz ^a   Hartung, Thomas ^b   Zähringer, Ulrich ^c   Göbel, Ulf B ^a   Weber, Joerg R ^a   Schumann, Ralf R ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF KONSTANZ   (Germany)

^c RESEARCH CENTER BORSTEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CELLS; CHEMICAL ACTIVATION; COMPLEXATION; ELECTROPHORESIS; IMMUNOLOGY; PATHOLOGY; POLYSACCHARIDES; PROTEINS;

PATHOGENS;

BIOCHEMISTRY;

BUTANOL; CD14 ANTIGEN; CELL PROTEIN; CHLOROFORM; LIPOPOLYSACCHARIDE BINDING PROTEIN; LIPOTEICHOIC ACID; METHANOL; PROTEIN MD 2; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ACUTE PHASE PROTEIN; CARRIER PROTEIN; CELL SURFACE RECEPTOR; LIPOPOLYSACCHARIDE; LIPOPOLYSACCHARIDE-BINDING PROTEIN; LY96 PROTEIN, HUMAN; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; TEICHOIC ACID; TLR2 PROTEIN, HUMAN; TLR4 PROTEIN, HUMAN; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; COMPLEX FORMATION; CYTOKINE PRODUCTION; GEL ELECTROPHORESIS; GENETIC TRANSFECTION; GRAM NEGATIVE INFECTION; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; MONONUCLEAR PHAGOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; ANIMAL; BIOSYNTHESIS; CELL CULTURE; CHO CELL; DRUG EFFECT; HAMSTER; IMMUNOLOGY; MONOCYTE; PATHOGENICITY; PHYSIOLOGY;

ANIMALIA; CRICETINAE; CRICETULUS GRISEUS; NEGIBACTERIA; POSIBACTERIA; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

ACUTE-PHASE PROTEINS; ANIMALS; ANTIGENS, CD14; ANTIGENS, SURFACE; CARRIER PROTEINS; CELLS, CULTURED; CHO CELLS; CRICETINAE; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTE ANTIGEN 96; MEMBRANE GLYCOPROTEINS; MONOCYTES; RECEPTORS, CELL SURFACE; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; TEICHOIC ACIDS; TOLL-LIKE RECEPTOR 2; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0038182550     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M212829200     Document Type: Article

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