Induction of chemokine and cytokine genes in astrocytes following infection with Theiler's murine encephalomyelitis virus is mediated by the toll-like receptor 3

GLIA

Volumn 53, Issue 8, 2006, Pages 858-867

  Eui, Young So ^a   Min, Hyung Kang ^a   Kim, Byung S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Astrocytes; Cytokines chemokines; TMEV; Toll like receptor

Indexed keywords

CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL LINE; CONTROLLED STUDY; ENCEPHALOMYELITIS; FIBROBLAST; GENE INDUCTION; GENETIC TRANSFECTION; INFLAMMATION; MOUSE; MURINE ENCEPHALOMYELITIS VIRUS; NEWBORN; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VIRUS REPLICATION; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; ASTROCYTES; CARDIOVIRUS INFECTIONS; CELL LINE; CENTRAL NERVOUS SYSTEM; CHEMOKINES; CYTOKINES; DISEASE MODELS, ANIMAL; ENCEPHALITIS, VIRAL; HUMANS; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; MYELOID DIFFERENTIATION FACTOR 88; SIGNAL TRANSDUCTION; THEILOVIRUS; TOLL-LIKE RECEPTOR 3; TRANS-ACTIVATION (GENETICS); UP-REGULATION; VIRUS REPLICATION;

EID: 33646516398     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20346     Document Type: Article

References (57)

1. Akira S, Takeda K. 2004. Toll-like receptor signalling. Nat Rev Immunol 4:499-511.
2. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. 2001. Recognition of double-stranded RNA, activation of NF-κB by Toll-like receptor 3. Nature 413:732-738.
3. Bartosik-Psujek H, Belniak E, Mitosek-Szewczyk K, Dobosz B, Stelmasiak Z. 2004. Interleukin-8 and RANTES levels in patients with relapsing-remitting multiple sclerosis (RR-MS) treated with cladribine. Acta Neurol Scand 109:390-392.
4. Bowman CC, Rasley A, Tranguch SL, Marriott I. 2003. Cultured astrocytes express toll-like receptors for bacterial products. Glia 43:281-291.
5. Bsibsi M, Ravid R, Gveric D, van Noort JM. 2002. Broad expression of Toll-like receptors in the human central nervous system. J Neuropathol Exp Neurol 61:1013-1021.
6. Carpentier PA, Begolka WS, Olson JK, Elhofy A, Karpus WJ, Miller SD. 2005. Differential activation of astrocytes by innate and adaptive immune stimuli. Glia 49:360-374.
7. Clatch RJ, Miller SD, Metzner R, Dal Canto MC, Lipton HL. 1990. Monocytes/macrophages isolated from the mouse central nervous system contain infectious Theiler's murine encephalomyelitis virus (TMEV). Virology 176:244-254.
8. Compton T, Kurt-Jones EA, Boehme KW, Belko J, Latz E, Golenbock DT, Finberg RW. 2003. Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2. J Virol 77:4588-4596.
9. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis SC. 2004. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303:1529-1531.
10. Du W, Thanos D, Maniatis T. 1993. Mechanisms of transcriptional synergism between distinct virus-inducible enhancer elements. Cell 74:887-898.
11. Dunne A, O'Neill LA. 2005. Adaptor usage and Toll-like receptor signaling specificity. FEBS Lett 579:3330-3335.
12. Elco CP, Guenther JM, Williams BR, Sen GC. 2005. Analysis of genes induced by Sendai virus infection of mutant cell lines reveals essential roles of interferon regulatory factor 3, NF-κB, and interferon but not toll-like receptor 3. J Virol 79:3920-3929.
13. Esen N, Tanga FY, DeLeo JA, Kielian T. 2004. Toll-like receptor 2 (TLR2) mediates astrocyte activation in response to the Gram-positive bacterium Staphylococcus aureus. J Neurochem 88:746-758.
14. Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM, Maniatis T. 2003. IKK and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol 4:491-496.
15. Friedmann A, Frankel G, Lorch Y, Steinman L. 1987. Monoclonal anti-I-A antibody reverses chronic paralysis and demyelination in Theiler's virus-infected mice: Critical importance of timing of treatment. J Virol 61:898-903.
16. Guillot L, Le Goffic R, Bloch S, Escriou N, Akira S, Chignard M, Si-Tahar M. 2005. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA, influenza A virus. J Biol Chem 280:5571-5580.
17. Hardy MP, McGGettrick AF, O'Neill LA. 2004. Transcriptional regulation of the human TRIF (TIR domain-containing adaptor protein inducing interferon β) gene. Biochem J 380:83-93.
18. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S. 2004. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303:1526-1529.
19. Hemmi H, Takeuchi O, Sato S, Yamamoto M, Kaisho T, Sanjo H, Kawai T, Hoshino K, Takeda K, Akira S. 2004. The roles of two IκB kinase-related kinases in lipopolysaccharide and double stranded RNA signaling and viral infection. J Exp Med 199:1641-1650.
20. Iordanov MS, Wong J, Bell JC, Magun BE. 2001. Activation of NF-κB by double-stranded RNA (dsRNA) in the absence of protein kinase R, RNase L demonstrates the existence of two separate dsRNA-triggered antiviral programs. Mol Cell Biol 21(1):61-72.
21. Jacobs BL, Langland JO. 1996. When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA. Virology 219:339-349.
22. Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X. 2003. Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFκ B, MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR. J Biol Chem 278:16713-16719.
23. Kariko K, Ni H, Capodici J, Lamphier M, Weissman D. 2004. mRNA is an endogenous ligand for Toll-like receptor 3. J Biol Chem 279:12542-12550.
24. Kim BS, Palma JP, Inoue A, Koh CS. 2000. Pathogenic immunity in Theiler's virus-induced demyelinating disease: A viral model for multiple sclerosis. Arch Immunol Ther Exp 48:373-379.
25. Kim BS, Palma JP, Kwon D, Fuller AC. 2005. Innate immune response induced by Theiler's murine encephalomyelitis virus infection. Immunol Res 31(1):1-12.
26. Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, Walsh EE, Freeman MW, Golenbock DT, Anderson LJ, Finberg RW. 2000. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 1:398-401.
27. Kwon D, Fuller AC, Palma JP, Choi IH, Kim BS. 2004. Induction of chemokines in human astrocytes by picornavirus infection requires activation of both AP-1 and NF-κ B. Glia 45:287-296.
28. Latz E, Visintin A, Lien E, Fitzgerald KA, Monks BG, Kurt-Jones EA, Golenbock DT, Espevik T. 2002. Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction. J Biol Chem 277:47834-47843.
29. Lipton HL, Dal Canto MC. 1979. Susceptibility of inbred mice to chronic central nervous system infection by Theiler's murine encephalomyelitis virus. Infect Immun 26:369-374.
30. Lipton HL, Twaddle G, Jelachich ML. 1995. The predominant virus antigen burden is present in macrophages in Theiler's murine encephalomyelitis virus-induced demyelinating disease. J Virol 69:2525-2533.
31. Lund JM, Alexopoulou L, Sato A, Karow M, Adams NC, Gale NW, Iwasaki A, Flavell RA. 2004. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc Natl Acad Sci USA 101:5598-5603.
32. Majde JA. 2000. Viral double-stranded RNA, cytokines, and the flu. J Interferon Cytokine Res 20:259-272.
33. McWhirter SM, Fitzgerald KA, Rosains J, Rowe DC, Golenbock DT, Maniatis T. 2004. IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts. Proc Natl Acad Sci USA 101(1):233-238.
34. Oleszak EL, Chang JR, Friedman H, Katsetos CD, Platsoucas CD. 2004. Theiler's virus infection: A model for multiple sclerosis. Clin Microbiol Rev 17(1):174-207.
35. Olson JK, Girvin AM, Miller SD. 2001. Direct activation of innate and antigen-presenting functions of microglia following infection with Theiler's virus. J Virol 75:9780-9789.
36. Palma JP, Kim BS. 2001. Induction of selected chemokines in glial cells infected with Theiler's virus. J Neuroimmunol 117(1/2):166-170.
37. Palma JP, Kim BS. 2004. The scope and activation mechanisms of chemokine gene expression in primary astrocytes following infection with Theiler's virus. J Neuroimmunol 149(1/2):121-129.
38. Palma JP, Kwon D, Clipstone NA, Kim BS. 2003. Infection with Theiler's murine encephalomyelitis virus directly induces proinflammatory cytokines in primary astrocytes via NF-κB activation: Potential role for the initiation of demyelinating disease. J Virol 77:6322-6331.
39. Palma JP, Yauch RL, Kang HK, Lee HG, Kim BS. 2002. Preferential induction of IL-10 in APC correlates with a switch from Th1 to Th2 response following infection with a low pathogenic variant of Theiler's virus. J Immunol 168:4221-4230.
40. Perry AK, Chow EK, Goodnough JB, Yeh WC, Cheng G. 2004. Differential requirement for TANK-binding kinase-1 in type I interferon responses to toll-like receptor activation and viral infection. J Exp Med 199:1651-1658.
41. Pevear DC, Calenoff M, Rozhon E, Lipton HL. 1987. Analysis of the complete nucleotide sequence of the picornavirus Theiler's murine encephalomyelitis virus indicates that it is closely related to cardioviruses. J Virol 61:1507-1516.
42. Pullen LC, Park SH, Miller SD, Dal Canto MC, Kim BS. 1995. Treatment with bacterial LPS renders genetically resistant C57BL/6 mice susceptible to Theiler's virus-induced demyelinating disease. J Immunol 155:4497-1503.
43. Qureshi ST, Medzhitov R. 2003. Toll-like receptors and their role in experimental models of microbial infection. Genes Immun 4:87-94.
44. Rassa JC, Meyers JL, Zhang Y, Kudaravalli R, Ross SR. 2002. Murine retroviruses activate B cells via interaction with toll-like receptor 4. Proc Natl Acad Sci USA 99:2281-2286.
45. Reiss CS, Chesler DA, Hodges J, Ireland DD, Chen N. 2002. Innate immune responses in viral encephalitis. Curr Top Microbiol Immunol 265:63-94.
46. Rodriguez M, Lafuse WP, Leibowitz J, David CS. 1986. Partial suppression of Theiler's virus-induced demyelination in vivo by administration of monoclonal antibodies to immune-response gene products (Ia antigens). Neurology 36:964-970.
47. Rudd BD, Burstein E, Duckett CS, Li X, Lukacs NW. 2005. Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. J Virol 79:3350-3357.
48. Sharma S, tenOever BR, Grandvaux N, Zhou GP, Lin R, Hiscott J. 2003. Triggering the interferon antiviral response through an IKK-related pathway. Science 300:1148-1151.
49. Skias DD, Kim DK, Reder AT, Antel JP, Lancki DW, Fitch FW. 1987. Susceptibility of astrocytes to class I MHC antigen-specific cytotoxicity. J Immunol 138:3254-3258.
50. Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, Mudd S, Shamel L, Sovath S, Goode J, Alexopoulu L, Flavell RA, Beutler B. 2004. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 101:3516-3521.
51. tenOever BR, Sharma S, Zou W, Sun Q, Grandvaux N, Julkunen I, Hemmi H, Yamamoto M, Akira S, Yeh WC, Lin R, Hiscott J. 2004. Activation of TBK1 and IKKvarepsilon kinases by vesicular stomatitis virus infection and the role of viral ribonucleoprotein in the development of interferon antiviral immunity. J Virol 78:10636-10649.
52. Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, Williams BR, Major J, Hamilton TA, Fenton MJ, Vogel SN. 2002. TLR4, but not TLR2, mediates IFN-β-induced STAT1α/β-dependent gene expression in macrophages. Nat Immunol 3:392-398.
53. Triantafilou K, Triantafilou M. 2004. Coxsackievirus B4-induced cytokine production in pancreatic cells is mediated through toll-like receptor 4. J Virol 78:11313-11320.
54. Yamamoto M, Takeda K, Akira S. 2004. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 40:861-868.
55. Yauch RL, Palma JP, Yahikozawa H, Koh CS, Kim BS. 1998. Role of individual T-cell epitopes of Theiler's virus in the pathogenesis of demyelination correlates with the ability to induce a Th1 response. J Virol 72:6169-6174.
56. Zhang D, Zhang G, Hayden MS, Greenblatt MB, Bussey C, Flavell RA, Ghosh S. 2004. A toll-like receptor that prevents infection by uropathogenic bacteria. Science 303:1522-1526.
57. Zheng L, Calenoff MA, Dal Canto MC. 2001. Astrocytes, not microglia, are the main cells responsible for viral persistence in Theiler's murine encephalomyelitis virus infection leading to demyelination. J Neuroimmunol 118:256-267.