Differential regulation of interleukin-1 receptor associated kinase 1 (IRAK1) splice variants

Molecular Immunology

Volumn 44, Issue 5, 2007, Pages 900-905

  Su, Jianmin ^a   Richter, Kathleen ^a   Zhang, Chunxiao ^b   Gu, Qiang ^c   Li, Liwu ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b EDWARD VIA COLLEGE OF OSTEOPATHIC MEDICINE   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Innate immunity; IRAK1; IRAK1c; Regulation; Sumoylation

Indexed keywords

INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1C; UNCLASSIFIED DRUG;

ADULT; AGED; AGING; ARTICLE; BRAIN; BRAIN TISSUE; CELL NUCLEUS; CONTROLLED STUDY; CYTOPLASM; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RNA SPLICING;

ADULT; AGE FACTORS; AGED; BRAIN; CELL LINE; CELL NUCLEUS; HUMANS; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LEUKOCYTES, MONONUCLEAR; LIPOPOLYSACCHARIDES; MIDDLE AGED; PROTEIN ISOFORMS; PROTEIN TRANSPORT;

EID: 33748802777     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.03.021     Document Type: Article

References (21)

1. Bol G., Kreuzer O.J., and Brigelius-Flohe R. Translocation of the interleukin-1 receptor-associated kinase-1 (IRAK-1) into the nucleus. FEBS Lett. 477 (2000) 73-78
2. Bol G.F., Jurrmann N., and Brigelius-Flohe R. Cellular trafficking of the IL-1RI-associated kinase-1 requires intact kinase activity. Biochem. Biophys. Res. Commun. 332 (2005) 279-287
3. Cao Z., Henzel W.J., and Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 271 (1996) 1128-1131
4. Freiman R.N., and Tjian R. Regulating the regulators: lysine modifications make their mark. Cell 112 (2003) 11-17
5. Hu J., Jacinto R., McCall C., and Li L. Regulation of IL-1 receptor-associated kinases by lipopolysaccharide. J. Immunol. 168 (2002) 3910-3914
6. Huang T.T., Wuerzberger-Davis S.M., Wu Z.H., and Miyamoto S. Sequential modification of NEMO/IKKgamma by SUMO-1 and ubiquitin mediates NF-kappaB activation by genotoxic stress. Cell 115 (2003) 565-576
7. Huang Y., Li T., Sane D.C., and Li L. IRAK1 serves as a novel regulator essential for lipopolysaccharide-induced interleukin-10 gene expression. J. Biol. Chem. 279 (2004) 51697-51703
8. Jacinto R., Hartung T., McCall C., and Li L. Lipopolysaccharide- and lipoteichoic acid-induced tolerance and cross-tolerance: distinct alterations in IL-1 receptor-associated kinase. J. Immunol. 168 (2002) 6136-6141
9. Janssens S., and Beyaert R. Functional diversity and regulation of different interleukin-1 receptor-associated kinase (IRAK) family members. Mol. Cell 11 (2003) 293-302
10. Jensen L.E., and Whitehead A.S. IRAK1b, a novel alternative splice variant of interleukin-1 receptor-associated kinase (IRAK), mediates interleukin-1 signaling and has prolonged stability. J. Biol. Chem. 276 (2001) 29037-29044
11. Li L. Regulation of innate immunity signaling and its connection with human diseases. Curr. Drug Targets Inflamm. Allergy 3 (2004) 81-86
12. Li L., Cousart S., Hu J., and McCall C.E. Characterization of interleukin-1 receptor-associated kinase in normal and endotoxin-tolerant cells. J. Biol. Chem. 275 (2000) 23340-23345
13. Li T., Hu J., and Li L. Characterization of Tollip protein upon lipopolysaccharide challenge. Mol. Immunol. 41 (2004) 85-92
14. Li X., Commane M., Jiang Z., and Stark G.R. IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 4461-4465
15. Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., and Janeway Jr. C.A. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 2 (1998) 253-258
16. Moors M.A., Li L., and Mizel S.B. Activation of interleukin-1 receptor-associated kinase by gram-negative flagellin. Infect. Immun. 69 (2001) 4424-4429
17. Mueller L.P., Yoza B.K., Neuhaus K., Loeser C.S., Cousart S., Chang M.C., Meredith J.W., Li L., and McCall C.E. Endotoxin-adapted septic shock leukocytes selectively alter production of sIL-IRA and IL-1beta. Shock 16 (2001) 430-437
18. Rao N., Nguyen S., Ngo K., and Fung-Leung W.P. A novel splice variant of interleukin-1 receptor (IL-1R)-associated kinase 1 plays a negative regulatory role in Toll/IL-1R-induced inflammatory signaling. Mol. Cell Biol. 25 (2005) 6521-6532
19. Williams, K.L., Lich, J.D., Duncan, J.A., Reed, W., Rallabhandi, P., Moore, C., Kurtz, S., Coffield, V.M., Accavitti-Loper, M.A., Su, L., Vogel, S.N., Braunstein, M., Ting, J.P., 2005. The CATERPILLER protein Monarch-1 is an antagonist of TLR, TNFalpha, and M. tuberculosis-induced pro-inflammatory signals. J. Biol. Chem.
20. Wilson V.G., and Rangasamy D. Intracellular targeting of proteins by sumoylation. Exp. Cell Res. 271 (2001) 57-65
21. Yamin T.T., and Miller D.K. The interleukin-1 receptor-associated kinase is degraded by proteasomes following its phosphorylation. J. Biol. Chem. 272 (1997) 21540-21547