A role for α4-integrin in the pathology following Semliki Forest virus infection

Journal of Neuroimmunology

Volumn 106, Issue 1-2, 2000, Pages 60-68

  Smith, John Paul ^a   Morris Downes, M ^d   Brennan, Frank R ^b   Wallace, Graham J ^c   Amor, Sandra ^c  

^a U Med Dent Schools Guys C   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

^c IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Adhesion molecules; Demyelination; Immunocytochemistry; Semliki Forest virus; VLA 4

Indexed keywords

BETA1 INTEGRIN; CD18 ANTIGEN; CD56 ANTIGEN; CELL ADHESION MOLECULE; HERMES ANTIGEN; INTEGRIN; INTERCELLULAR ADHESION MOLECULE 1; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; VASCULAR CELL ADHESION MOLECULE 1; ALPHA4 INTEGRIN; ANTIBODY; LEUKOCYTE ANTIGEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL ADHESION; CELL INFILTRATION; CONTROLLED STUDY; DEMYELINATING DISEASE; DEMYELINATION; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; SEMLIKI FOREST ALPHAVIRUS; VIRUS INFECTION; ANIMAL; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MOUSE STRAIN; MYELIN SHEATH; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ALPHAVIRUS INFECTIONS; ANIMALS; ANTIBODIES; ANTIGENS, CD; CELL ADHESION MOLECULES; CENTRAL NERVOUS SYSTEM; IMMUNOHISTOCHEMISTRY; INTEGRIN ALPHA4; MICE; MICE, INBRED STRAINS; MYELIN SHEATH; SEMLIKI FOREST VIRUS;

EID: 0034214878     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(99)00235-0     Document Type: Article

References (35)

1. Amor S., Scallan M.F., Morris M.M., Dyson H., Fazakerley J.K. Role of immune responses in protection and pathogenesis during Semliki Forest virus encephalitis. J. Gen. Virol. 77:1996;281-291.
2. Archelos J.J., Jung S., Maurer M., Schmied M., Lassmann H., Tamatani T., Miyasaka M., Toyka K.V., Hartung H.P. Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. Ann. Neurol. 34:1993;145-154.
3. Baker D., O'Neill J.K., Gschmeissner S.E., Wilcox C.E., Butter C., Turk J.L. Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. J. Neuroimmunol. 28:1990;261-270.
4. Baker D., O'Neill J.K., Turk J.L. Cytokines in the central nervous system of mice during chronic relapsing experimental allergic encephalomyelitis. Cell. Immunol. 134:1991;505-510.
5. Baron J.L., Madri J.A., Ruddle N.H., Hashim G., Janeway C.A. Surface expression of α4-integrin by CD4 T cells is required for their entry into brain parenchyma. J. Exp. Med. 177:1993;57-68.
6. Barten D.M., Ruddle N.H. Vascular cell adhesion molecule-1 modulation by tumor necrosis factor in experimental allergic encephalomyelitis. J. Neuroimmunol. 51:1994;123-133.
7. Brennan F.R., Mikecz K., Glant T.T., Jobanputra P., Pinder S., Bavington C., Morrison P., Nuki G. CD44 expression by leukocytes in rheumatoid arthritis and modulation by specific antibody: implications for lymphocyte adhesion to endothelial cells and synoviocytes in vitro. Scand. J. Immunol. 45:1997;213-220.
8. Brocke S., Piercy C., Steinman L., Weissman I.L., Veromaa T. Antibodies to CD44 and integrin α4, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment. Proc. Natl. Acad. Sci. U.S.A. 96:1999;6896-6901.
9. Burkly L.C., Jakubowski A., Hattori M. Protection against adoptive transfer of autoimmune diabetes mediated through very late antigen-4 integrin. Diabetes. 43:1994;529-534.
10. Cannella B., Cross A.H., Raine C. Adhesion-related molecules in the central nervous system. Upregulation correlates with inflammatory cell influx during relapsing experimental autoimmune encephalomyelitis. Lab. Invest. 65:1991;23-31.
11. + T cells to sites of infection. J. Immunol. 154:1995;5293-5301.
12. Fazakerley J.K., Amor S., Webb H.E. Reconstitution of Semliki Forest virus infected mice induces immune mediated pathological changes in the CNS. Clin. Exp. Immunol. 52:1983;115-120.
13. Fazakerley J.K., Pathak S., Scallan M., Amor S., Dyson H. Replication of the A7(74) strain of Semliki Forest virus is restricted in neurons. Virology. 195:1993;627-637.
14. Fazakerley J.K., Webb H.E. Semliki Forest virus-induced, immune-mediated demyelination: adoptive transfer studies and viral persistence in nude mice. J. Gen. Virol. 68:1987;377-385.
15. Gordon E.J., Myers K.J., Dougherty J.P., Rosen H., Ron Y. Both anti-CD11a (LFA-1) and anti-CD11b (MAC-1) therapy delay the onset and diminish the severity of experimental autoimmune encephalomyelitis. J. Neuroimmunol. 62:1995;153-160.
16. Inoue A., Koh C.S., Yamazaki M., Ichikawa M., Isobe M., Ishihara Y., Yagita H., Kim B.S. Anti-adhesion molecule therapy in Theiler's murine encephalomyelitis virus-induced demyelinating disease. Int. Immunol. 9:1997;1837-1847.
17. Irani D.N., Griffin D.E. Regulation of lymphocyte homing into the brain during viral encephalitis at various stages of infection. J. Immunol. 156:1996;3850-3857.
18. Jagelman S., Suckling A.J., Webb H.E., Bowen F.T. The pathogenesis of avirulent Semliki Forest virus infections in athymic nude mice. J. Gen. Virol. 41:1978;599-607.
19. Kent S.J., Karlik S.J., Cannon C., Hines D.K., Yednock T.A., Fritz L.C., Horner H.C. A monoclonal antibody to α4-integrin suppresses and reverses active experimental allergic encephalomyelitis. J. Neuroimmunol. 58:1995;1-10.
20. Kelly W.R., Blakemore W.F., Jagelman S., Webb H.E. Demyelination induced in mice by avirulent Semliki Forest virus: II. An ultrastructural study of focal demyelination in the brain. Neuropathol. Appl. Neurobiol. 8:1982;43-53.
21. Leger O.J., Yednock T.A., Tanner L., Horner H.C., Hines D.K., Keen S., Saldanha J., Jones S.T., Fritz L.C., Bendig M.M. Humanization of a mouse antibody against human α4-integrin: a potential therapeutic for the treatment of multiple sclerosis. Hum. Antibodies. 8:1997;3-16.
22. Male D., Rahman J., Pryce G., Tamatani T., Miyasaka M. Lymphocyte migration into the CNS modelled in vitro: roles of LFA-1, ICAM-1 and VLA-4. Immunology. 81:1994;366-372.
23. Mikecz K., Brennan F.R., Kim J.H., Glant T.T. Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat. Med. 1:1995;558-563.
24. Morris M.M., Dyson H., Baker D., Harbige L.S., Fazakerley J.K., Amor S. Characterization of the cellular and cytokine response in the central nervous system following Semliki Forest virus infection. J. Neuroimmunol. 74:1997;185-197.
25. O'Neill J.K., Butter C., Baker D., Gschmeissner S.E., Kraal G., Butcher E.C., Turk J.L. Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse. Immunology. 72:1991;520-525.
26. Parsons L.M., Webb H.E. Virus titres and persistently raised white cell counts in cerebrospinal fluid in mice after peripheral infection with demyelinating Semliki Forest virus. Neuropathol. Appl. Neurobiol. 8:1982;395-401.
27. Pryce G., Male D., Campbell I., Greenwood J. Factors controlling T cell migration across rat cerebral endothelium in vitro. J. Neuroimmunol. 75:1997;84-94.
28. Rubin S.A., Yednock T.A., Carbone K.M. In vivo treatment with anti-α4 integrin suppresses clinical and pathological evidence of Borna disease virus infection. J. Neuroimmunol. 84:1998;158-163.
29. Shen J., Devery J.M., King N.J. Early induction of interferon-independent virus-specific ICAM-1 (CD54) expression by flavivirus in quiescent but not proliferating fibroblasts: implications for virus-host interactions. Virology. 208:1995;437-449.
30. Shrikant P., Chung I.Y., Ballestas M.E., Benveniste E.N. Regulation of intercellular adhesion molecule-1 gene expression by tumor necrosis factor-α, interleukin-1β, and interferon-γ in astrocytes. J. Neuroimmunol. 51:1994;209-220.
31. Soilu-Hänninen M., Erälinna J.P., Hukkanen V., Röyttä M., Salmi A.A., Salonen R. Semliki Forest virus infects mouse brain endothelial cells and causes blood-brain barrier damage. J. Virol. 68:1994;6291-6298.
32. Soilu-Hänninen M., Röyttä M., Salmi A.A., Salonen R. Semliki Forest virus infection leads to increased expression of adhesion molecules on splenic T cells and on brain vascular endothelium. J. Neurovirol. 3:1997;350-360.
33. + T cells prevents lesions of demyelination in Semliki Forest virus infection. J. Virol. 67:1993;7629-7633.
34. Verdrengh M., Holmdahl R., Tarkowski A. Administration of antibodies to hyaluronanreceptor (CD44) delays the start and ameliorates the severity of collagen II arthritis. Scand. J. Immunol. 42:1995;353-358.
35. Yednock T.A., Cannon C., Fritz L.C., Sanchez-Madrid F., Steinman L., Karin N. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature. 356:1992;63-66.