Metal and inflammatory targets for Alzheimer's disease

Current Drug Targets

Volumn 5, Issue 6, 2004, Pages 535-551

  Rogers, Jack T ^a   Lahiri, Debomoy K ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIINFLAMMATORY AGENT; AZITHROMYCIN; BATIMASTAT; CHOLINERGIC RECEPTOR STIMULATING AGENT; CLIOQUINOL; COPPER; DEFERIPRONE; DEFEROXAMINE; DEFERRIFERRITHIOCIN; DIMERCAPROL; IBUPROFEN; INDOMETACIN; IRON; IRON CHELATING AGENT; MESSENGER RNA; METAL; METALLOPROTEIN; MINOCYCLINE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PAROXETINE; PHENSERINE; PIOGLITAZONE; ROSIGLITAZONE; UBIQUINONE; UNINDEXED DRUG; ZINC;

5' UNTRANSLATED REGION; ALLELE; ALZHEIMER DISEASE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; BRAIN CORTEX; CATALYSIS; CHELATION THERAPY; CLINICAL TRIAL; DOWNSTREAM PROCESSING; DRUG EFFICACY; DRUG MECHANISM; DRUG SCREENING; DRUG TARGETING; ENCEPHALITIS; ENZYME ACTIVATION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HEMOCHROMATOSIS; HUMAN; IMMUNOGENICITY; IRON CHELATION; IRON RESPONSIVE ELEMENT; MICROGLIA; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS; PROTEIN AGGREGATION; PROTEIN PHOSPHORYLATION; REPORTER GENE; REVIEW; RISK REDUCTION; RNA TRANSLATION; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; ANIMALS; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; HUMANS; INFLAMMATION MEDIATORS; METALS, HEAVY;

EID: 3442888291     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/1389450043345272     Document Type: Review

References (178)

1. Sampietro, M., Caputo, L., Casatta, A., Meregalli, M., Pellagatti, A., Tagliabue, J., Annoni, G. and Vergani, C. (2001) Neurobiol. Aging, 22, 563-568.
2. Lovell, M. A., Robertson, J. D., Teesdale, W. J., Campbell, J. L. and Markesbery, W. R. (1998) J. Neurol. Sci., 158, 47-52.
3. Rogers, J.T, Randall, J., Cahill, C.M., Eder, P.S., Huang, X., Gunshin, H., Leiter, L., McPhee, J., Sarang, S.S., Utsuki, T., Greig, N., Lahiri, D.K., Tanzi, R.E., Bush, A.I., Giordano, T., Gullans, S. (2002) J. Biol. Chem., 277, 45518-45528.
4. Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D., Hanson, G. R., Stokes, K. C., Leopold, M., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Saunders, A. J., Lim, J., Moir, R. D., Glabe, C., Bowden, E. F., Masters, C. L., Fairlie, D. P., Tanzi, R. E. and Bush, A. I. (1999) J. Biol. Chem., 274, 37111-37116.
5. Kosik, K., Ahn, J., Stein, R. and Yeh, L. (2002) J. Mol. Neurosci., 19, 261-266.
6. Lu, M. and Kosik, K. (2001) Mol. Biol. Cell, 12, 171-184.
7. Selkoe, D. J. (1996) J. Biol. Chem., 271, 18295-18298.
8. Shin, R., Kruck, T., Murayama, H. and Kitamoto, T. (2003) Brain Res., 961, 139-146.
9. Polizzi, S., Ppira, E., Ferrara, M., Bugiani, M., Papaleo, A., Albera, R. and Palmi, S. (2002) Neurotoxicology, 23, 761-774.
10. Griffin, W. S., Sheng, J. G., Roberts, G. W. and Mrak, R. E. (1995) J. Neuropathol. Exp. Neurol., 54, 276-281.
11. Nilsson, L., Rogers, J., Potter, H. (1998) Frontiers in Bioscience, 3, d436-446,
12. Wisniewski, K.E., Wisniewski, H., Wen, G. (1985) Ann. Neurol., 17, 278-282.
13. Shaw, K. T., Utsuki, T., Rogers, J., Yu, Q. S., Sambamurti, K., Brossi, A., Ge, Y. W., Lahiri, D. K. and Greig, N. H. (2001) Proc. Natl. Acad. Sci. USA, 98, 7605-7610.
14. Howlett, D., Cutler, P., Heales, S. and Camilleri, P. (1997) FEBS Lett., 417, 249-251.
15. Cherny, R., Atwood, C.S., Xilinas, M.E., Gray, D.N., Jones, W.D., McLean, C.A., Barnham, K.J., Volitakis, I., Fraser, F.W., Kim, Y., Huang, X., Goldstein, L.E., Moir, R.D., Lim, J.T., Beyreuther, K., Zheng, H., Tanzi, R.E., Masters, C.L., Bush, A.I. (2001) Neuron, 30, 641-642.
16. Selkoe, D. J. (2000) Curr. Opin. Neurobiol., 10, 50-57.
17. Hardy, J. (1992) Nature Genetics, 1, 233-234.
18. Goate, A., Chartier-Harlin, M.C., Mullan, M., Brown, J., Haynes, J., Irving, N., James, L., Mant, R., Newton, P., Rooke, K., Roques, P., Talbot, C., Pericak-Vance, M., Roses, A., Williamsion, R., Rossor, M., Owen, M., Hardy, J. (1991) Nature, 349, 704-6.
19. Games, D., Adams, D., Alessandrini, R., Barbour, R., Berthelette, P., Blackwell, C., Carr, T, Clemens, J., Donaldson, T., Gillespie, F., Guido, T., Hagoplan, S., Johnson-Wood, K., Kan, K., Lee, M., Leibowitz, P., Liberburg, I., Little, S., Masliah, E., McConlogue, L., Montoya-Zavala, M., Mucke, L., Pagannin, L., Penniman, E., Power, M., Schemnk, D., Seubert, P., Snyder, B., Soriano, F., Tan, H., Vitale, J., Wadsworth, S., Wolozin, B. and Zhao, J. (1995) Nature, 373, 523-527.
20. Mullan, M., Crawford, F., Axelman, K., Houlden, H., Lilius, L., Winblad, B., Lannfelt, L. (1992) Nature Genetics, 1, 345-347.
21. Citron, M., Oltersdorf, T., Haass, C., McConlogue, L., Hung, A.Y., Seubert, P., Vigo-Pelfrey, C., Lieberburg, I., Selkoe, D.J. (1992) Nature, 360, 672-674.
22. Melchor, J. P. and Van Nostrand, W. E. (2000) J. Biol. Chem., 275, 9782-9791.
23. Levy-Lahad, E., Wasco, W., Poorkaj, P., Romano, D.M., Oshima, J., Yu, C.E., Jondro, P.D., Schmidt, S.D., Wang, K. and Tanzi, R. (1995) Science, 269, 973-977.
24. Sherrington, R., Rogaev, E. I., Liang, Y., Rogaeva, E. A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Fonci, J.-F., Bruni, A. C., Montesi, M. P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R. J., Wasco, W., Da Silva, H. A. R., Haines, J. L., Pericak-Vance, M. A., Tanzi, R. E., Roses, A. D., Fraser, P. E., Rommens, J. M., St George-Hyslop, P. H. (1995) Nature, 375, 754-760.
25. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberly, W. T. and Selkoe, D. J. (1999) Nature, 398, 513-517.
26. De Strooper, B. (2003) Neuron, 38, 9-12.
27. Multhaup, G., Schlicksupp, A., Hesse, L., Beher, D., Ruppert, T., masters, C., Beyreuther, K. (1996) Science, 271, 1406-1409.
28. Haass, C., Schlossmacher, M.G., Hung, A.Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B.L., Liebhaber, I., Koo, E.H., Schenk, D., Teplow, D.B., Selkoe, D.J. (1992) Nature, 359, 322-325.
29. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J. C., Collins, F., Treanor, J., Rogers, G. and Citron, M. (1999) Science, 286, 735-741.
30. Huse, J. T., Pijak, D. S., Leslie, G. J., Lee, V. M. and Doms, R. W. (2000) J Biol. Chem., 275, 33729-33737.
31. Buxbaum, J. D., Liu, K. N., Luo, Y., Slack, J. L., Stocking, K. L., Peschon, J. J., Johnson, R. S., Castner, B. J., Cerretti, D. P. and Black, R. A. (1998) J. Biol. Chem., 273, 27765-27767.
32. Buxbaum, J. D., Oishi, M., Chen, H. I., Pinkas-Kramarski, R., Jaffe, E. A., Gandy, S. E. and Greengard, P. (1992) Proc. Natl. Acad. Sci. USA, 89, 10075-10078.
33. Nitsch, R. M., Slack, B. E., Wurtman, R. J. and Growdon, J. H. (1992) Science 258, 304-307.
34. Hooper, N. and Turner, A. (2002) Curr. Med. Chem., 9, 1107-1119.
35. Bush, A. I. (2003) Trends Neurosci., 26, 207-214.
36. Bodovitz, S., Falduto, MT., Frail, DE., Klein, WL. (1995) J. Neurochem., 64, 307-315.
37. Rich, J. B., Rasmusson, D. X., Folstein, M. F., Carson, K. A., Kawas, C. and Brandt, J. (1995) Neurology, 45, 51-55.
38. Rebeck, G. W. (2000) Neurosci. Lett., 293, 75-77.
39. Ujiie, M., Dickstein, D. and Jeffires, W. (2002) Front Biosci., 7, 42-47.
40. Jeffries, W., Dickstein, D. and Ujiie, M. (2001) J. Alzheimers Dis., 3, 339-344.
41. Sparks, D. and Schreurs, B. (2003) Proc. Natl. Acad. Sci. USA, 100, 11065-11069.
42. Thompson, K., Menzies, S., Muckenthaler, M., Torti, F., Wood, T., Torti, S., Hentze, M., Beard, M. and Connor, J. (2003) J. Neuroscie. Res., 71, 46-63.
43. Wong, P. C., Zheng, H., Chen, H., Becher, M. W., Sirinathsinghji, D. J., Trumbauer, M. E., Chen, H. Y., Price, D. L., Van der Ploeg, L. H. and Sisodia, S. S. (1997) Nature, 387, 288-292.
44. Corder, E., Saunders, A.M., Strittmatter, M.D., Schmechel, D.E., Gaskell, P.C., Rimmler., M.S., Locke, B.A., Conneally, P.M., Schmader, K.E., Tanzi, R.E., Gusella, J., Small, G.W., Roses, A.D., Pericak-Vance, M.A., Haines, J.L. (1995) Neurology, 45, 1323-1328.
45. Qiu, Z., Strickland, D. K., Hyman, B. T. and Rebeck, G. W. (1999) J. Neurochem., 73, 1393-1398.
46. Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J. and Guenette, S. (2003) Proc. Natl. Acad. Sci. USA, 100, 4162-4167.
47. Nilsson, L.N., Bales, K.R., DiCarlo, G., Gordon, M.N., Morgan, D., Paul, S.M., Potter, H. (2001) J. Neurosci., 21, 1444-1451.
48. Crapper McLachlan, D., Dalton, A.J., Kruck, T.P.A., Bell, M.Y., Smith, W.L., Kalow, W., Andrews, D.F. (1991) Lancet, 337, 1304-1308.
49. Ritchie, C. W., Bush, A. I., Mackinnon, A., Macfarlane, S., Mastwyk, M., MacGregor, L., Kiers, L., Cherny, R. A., Li, Q. X., Tammer, A., Carrington, D., Mavros, C., Volitakis, I., Xilinas, M., Ames, D., Davis, S., Beyreuther, K., Tanzi, R. E. and Masters, C. L. (2003) Archives of Neurology 60, 1685-1691.
50. Bartzokis, G., Sultzer, D., Cummings, J., Holt, L. E., Hance, D. B., Henderson, V. W. and Mintz, J. (2000) Arch. Gen. Psychiatry 57, 47-53.
51. Yankner, B. A., Duffy, L. K. and Kirschner, D. A. (1990) Science, 250, 279-282.
52. Schubert, D. and Chevion, M. (1995) Biochem. Biophys. Res. Commun., 216, 702-707.
53. Bishop, G. and Robinson, S. (2003) J. Neuroscie. Res., 73, 316-323.
54. Bishop, G., Robinson, S., Liu, Q., Perry, G., Atwood, C. and Smith, M. (2002) Dev. Neurosci., 24, 184-187.
55. Connor, J. R., Snyder, B. S., Beard, J. L., Fine, R. E. and Mufson, E. J. (1992) J. Neurosci. Res., 31, 327-335.
56. Thomson, A. M., Rogers, J. T. and Leedman, P. J. (1999) Int. J. Biochem. Cell Biol., 31, 1139-1152.
57. Pinero, D. J., Hu, J. and Connor, J. R. (2000) Cell Mol. Biol. (Noisy-Le-Grand), 46, 761-776.
58. Grundke-Iqbal, I., Fleming, J., Tung, Y. C., Lassmann, H., Iqbal, K. and Joshi, J. G. (1990) Acta Neuropathol., 81, 105-110.
59. Rogers, J. T., Leiter, L. M., McPhee, J., Cahill, C. M., Zhan, S. S., Potter, H. and Nilsson, L. N. (1999) J. Biol. Chem., 274, 6421-6431.
60. Mbella, E. G., Bertrand, S., Huez, G. and Octave, J. N. (2000) Mol. Cell Biol., 20, 4572-4579.
61. Tanzi, R. E. and Hyman, B. T. (1991) Nature, 350, 564.
62. Lai, A., Sisodia, SS., Trowbridge, IS. (1995) J. Biol. Chem., 270, 3565-3573.
63. Rogers, J.T., Randall, J., Eder, P.S., Huang, X., Bush, A.I., Tanzi, R.E., Venti, A., Payton, S.M., Giordano, T., Nagano, S., Cahill, C.M., Moir, R., Lahiri, D.K., Greig, N., Sarang, S.S., Gullans, S.R. (2002) J. Mol. Neurosci., 19, 77-82.
64. Payton, S., Cahill, C., Randall, J., Gullans, S. and Rogers, J. (2003) J. Mol. Neurosci., 20, 267-275.
65. Campbell, A. and Bondy, S. C. (2000) Cell Mol. Biol. (Noisy-Le-Grand), 46, 721-730.
66. Halliwell, B. and Hedlund, B. (1992) Iron and Human Disease, 477-500.
67. Brittenham, G. (2003) Alcohol, 30, 151-158.
68. Brittenham, G., Nathan, D., Oliveieri, N., Pippard, M. and Weatherall, D. (2003) The Lancet, 361, 183-4.
69. Brittenham, G., Nathan, D., Olivieri, N., Porter, J., Pippard, M., Vichinsky, E. and Weatherall, D. (2003) Blood, 101, 5089-5091.
70. Konoghiorghes, G., Neocleous, K. and Kolnagou, A. (2003) Drug Safety, 26, 553-584.
71. Atwood, C. S., Moir, R. D., Huang, X., Scarpa, R. C., Bacarra, N. M., Romano, D. M., Hartshorn, M. A., Tanzi, R. E. and Bush, A. I. (1998) J. Biol. Chem., 273, 12817-12826.
72. Atwood, C., Huang, X., Khatri, A., Scarpa, R., Kim, Y-S., Moir, R.D., Tanzi, R.E., Roher, A.E., Bush, A.I. (2000) Cell. Mol. Biol., 46, 777-783.
73. Bush, A., Pettingell, W.H., Multhaup, G., Paradis, D., Vonsattel, Gusella, J.F., Beyreuther, K., Masters, C.L., Tanzi, R.E. (1994) Science, 265, 1464-1467.
74. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L. and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. USA, 82, 4245-4249.
75. Smith, M. A., Richey Harris, P. L., Sayre, L. M., Beckman, J. S. and Perry, G. (1997) J. Neurosci., 17, 2653-2657.
76. Smith, M. A., Kutty, R. K., Richey, P. L., Yan, S. D., Stern, D., Chader, G. J., Wiggert, B., Petersen, R. B. and Perry, G. (1994) Am. J. Pathol., 145, 42-47.
77. Smith, C. D., Carney, J. M., Starke-Reed, P. E., Oliver, C. N., Stadtman, E. R., Floyd, R. A. and Markesbery, W. R. (1991) Proc. Natl. Acad. Sci. USA, 88, 10540-10543.
78. Celsi, F., Ferri, A., D'Amrosi, N., Rotliiio, G., Costa, A., Volonte, C. and Carri, M. (2004) Neurochem. Int., 44, 25-33.
79. Beal, M. F. (2003) Ann. N. Y. Acad. Sci., 991, 120-131.
80. Huang, X., Atwood, C. S., Hartshorn, M. A., Multhaup, G., Goldstein, L. E., Scarpa, R. C., Cuajungco, M. P., Gray, D. N., Lim, J., Moir, R. D., Tanzi, R. E. and Bush, A. I. (1999) Biochemistry, 38, 7609-7616.
81. Opazo, C., Huang, X., Cherny, R. A., Moir, R. D., Rolier, A. E., White, A. R., Cappai, R., Masters, C. L., Tanzi, R. E., Inestrosa, N. C. and Bush, A. I. (2002) J. Biol. Chem., 277, 40302-40308.
82. Yatin, S. M., Aksenova, M., Aksenov, M., Markesbery, W. R., Aulick, T. and Butterfield, D. A. (1998) J. Mol. Neurosci., 11, 183-197.
83. Halliwell, B. and Gutteridge, JMC. (1984) Biochem. J., 219, 1-14.
84. Gutteridge, J. M. (1994) Ann. N. Y. Acad. Sci., 738, 201-213.
85. Curtain, C. C., Ali, F., Volitakis, I., Cherny, R. A., Norton, R. S., Beyreuther, K., Barrow, C. J., Masters, C. L., Bush, A. I. and Barnham, K. J. (2001) J. Biol. Chem., 276, 20466-20473.
86. Cuajungco, M. P., Goldstein, L. E., Nunomura, A., Smith, M. A., Lim, J. T., Atwood, C. S., Huang, X., Farrag, Y. W., Perry, G. and Bush, A. I. (2000) J. Biol. Chem., 275, 19439-19442.
87. Beal, M. F. and Shults, C. W. (2003) Biofactors, 18, 153-161.
88. Harper, J. D. and Lansbury, P. T., Jr. (1997) Annu. Rev. Biochem., 66, 385-407.
89. Priola, S. A., Raines, A. and Caughey, W. S. (2000) Science. 287, 1503-1506.
90. Caughey, W. S., Raymond, L. D., Horiuchi, M. and Caughey, B. (1998) Proc. Natl. Acad. Sci. USA, 95, 12117-12122.
91. Walsh, D. M., Tseng, B. P., Rydel, R. E., Podlisny, M. B. and Selkoe, D. J. (2000) Biochemistry, 39, 10831-10839.
92. Phinney, A., Drisaldi, B., Schmidt, S., Lugowski, S., Coronado, V., Liang, Y., Horne, P., Yang, J., Sekoulidis, J., Coomaraswarmy, J., Chisti, M., Cox, D., Mathews, P., Nixon, R., Carlson, A., St. George-Hyslop, P. and Westaway, D. (2003) Proc. Natl. Acad. Sci. USA, 100, 14193-14198.
93. Bayer, T., Schafer, S., Simons, A., Kemmling, A., Kamer, T., Tepests, R., Eckert, A., Schussel, K., Eikenberg, O., Sturchler-Pierrat, C., Abramowski, M. and Multhaup, G. (2003) Proc. Natl. Acad. Sci. USA, 100, 14187-14192.
94. Connor, J. R., Snyder, B. S., Arosio, P., Loeffler, D. A. and LeWitt, P. (1995) J. Neurochem., 65, 717-724.
95. Robinson, S., Noone, DF., Kril, J., Haliday, GM. (1995) Alzheimer's Research, 1, 191-193.
96. Connor, J. R., Menzies, S. L., St. Martin, S. M. and Mufson, E. J. (1992) J. Neurosci. Res., 31. 75-83.
97. Shohum, S., Youdim, M.B.H. (2000) Cell. Mol. Biol., 46, 743-760.
98. Frautschy, S. A., Yang, F., Irrizarry, M., Hyman, B., Saido, T. C., Hsiao, K. and Cole, G. M. (1998) Am. J. Pathol., 152, 307-317.
99. McGeer, P. L. and McGeer, E. G. (1999) J. Leukoc. Biol., 65, 409-415.
100. McGeer, P. L., Itagaki, S., Boyes, B. E. and McGeer, E. G. (1988) Neurology, 38, 1285-1291.
101. Itagaki, S., McGeer, PL., Akiyama, H., Zhu, S., Selkoe, D. (1989) J. Neuroimmunology, 24, 173-182.
102. Yan, S. D., Chen, X., Fu, J., Chen, M., Zhu, H., Roher, A., Slattery, T., Zhao, L., Nagashima, M., Morser, J., Migheli, A., Nawroth, P., Stern, D. and Schmidt, A. M. (1996) Nature 382, 685-691.
103. El Khoury, J., Hickman, S. E., Thomas, C. A., Can, L., Silverstein, S. C. and Loike, J. D. (1996) Nature, 382, 716-719.
104. Giulian, D. (1999) Am. J. Hum. Genet., 65, 13-18.
105. Culpan, D., MacGowan, S. H., Ford, J. M., Nicoll, J. A., Griffin, W. S., Dewar, D., Cairns, N. J., Hughes, A., Kehoe, P. G. and Wilcock, G. K. (2003) Neurosci. Lett., 350, 61-65.
106. Dziedzic, T., Wybranska, I., Dembinska-Kiec, A., Klimkowicz, A., Slowik, A., Pankiewicz, J., Zdzienicka, A. and Szczudlik, A. (2003) Dement. Geriatr. Cogn. Disord., 16, 283-286.
107. Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V., Perrot, L. J., White, C. L., 3rd, and Araoz, C. (1989) Proc. Natl. Acad. Sci. USA, 86, 7611-7615.
108. Giulian, D., Johnson, B., Krebs, J. F., George, J. K. and Tapscott, M. (1991) J. Cell Biol., 112, 323-333.
109. Roberts, G. W., Gentleman, S. M., Lynch, A. and Graham, D. I. (1991) Lancet, 338, 1422-1423.
110. Sheng, J. G., Ito, K., Skinner, R. D., Mrak, R. E., Rovnaghi, C. R., Van Eldik, L. J. and Griffin, W. S. (1996) Neurobiol. Aging, 17, 761-766.
111. Goldgaber, D., Harris, H. W., Hla, T., Maciag, T., Donnelly, R. J., Jacobsen, J. S., Vitek, M. P. and Gajdusek, D. C. (1989) Proc. Natl. Acad. Sci. USA, 86, 7606-7610.
112. Lahiri DK, N. C. (1995) Brain Res. Mol. Brain Res., 32, 233-240.
113. Nicoll, J. A., Mrak, R. E., Graham, D. I., Stewart, J., Wilcock, G., MacGowan, S., Esiri, M. M., Murray, L. S., Dewar, D., Love, S., Moss, T. and Griffin, W. S. (2000) Ann. Neurol., 47, 365-368,
114. Papassotiropoulos, A., Hock, C. and Nitsch, R. M. (2001) Neurobiol. Aging, 22, 863-871.
115. McCusker, S., Curran, M., Dynan, K., McCullagh, C., Urquhart, D., Middleton, D., Patterson, C., McIlroy, S. and Passmore, A.P. (2001) Lancet, 357, 436-439.
116. Kamboh, M., Sanghera, DK., Ferrell, RE., Dekosky, ST. (1995) Nature Genetics. 10, 486-488.
117. Rogers, J. T. ( 1996) Blood, 87, 2525-2537.
118. Giulian, D., Haverkamp, L. J., Yu, J., Karshin, W., Tom, D., Li, J., Kazanskaia, A., Kirkpatrick, J. and Roher, A. E. ( 1999) J. Biol. Chem., 273, 29719-29726.
119. Das, S., Potter, H. (1995) Neuron, 14, 447-456.
120. Eisenhauer, P. B., Wells, J. M., McKenna, D. C., Shanmugaratnam, J., Fine, R. E., Billingslea, A. M., Long, H. J., Simons, E. R. and Davies, T. A. (1998) Alzheimers Reports, 1, 241-249.
121. Mucke, L., Masliah, E., Johnson, W. B., Ruppe, M. D., Alford, M., Rockenstein, E. M., Forss-Petter, S., Pietropaolo, M., Mallory, M. and Abraham, C. R. (1994) Brain Res., 666, 151-167.
122. Mucke, L., Abraham, C. R., Ruppe, M. D., Rockenstein, E. M., Toggas, S. M., Mallory, M., Alford, M. and Masliah, E. (1995) J. Exp. Med., 181, 1551-1556.
123. Rogers, J., Huang, X. and Bush, A. (2002) in Neuroprotection Eng Lo & Joseph Martwah, Eds.
124. Komori, N., Kittel, A., Kang, D., Shackelford, D., Masliah, E., Zivin, J. A. and Saitoh, T. (1997) Brain Res. Mol. Brain Res., 49, 103-112.
125. Lesne, S., Docagne, F., Gabriel, C., Liot, G., Lahiri, D. K., Buee, L., Plawinski, L., Delacourte, A., MacKenzie, E. T., Buisson, A. and Vivien, D. (2003) J. Biol. Chem., 278, 18408-18418.
126. Lahiri, D., Chen, D., Vivien, D., Ge, Y.-W., Greig, N. and Rogers, J. (2003) J. Alzheimers Dis., 5, 81-90.
127. Crawford, F., Suo, Z., Fang, C., Sawar, A., Su, G., Arendash, G. and Mullan, M. (1997) Ann. N. Y. Acad. Sci., 826, 35-46.
128. Thomas, T., Thomas, G., McLendon, C., Sutton, T. and Mullan, M. (1996) Nature, 380, 168-171.
129. Koistinaho, M. and Koistinaho, J. (2003) Glia, 40, 175-183.
130. Koistinaho, M., Kettunen, M., Goldsteins, G., Keinanen, R., Salminen, A., Liu, D., Kauppinen, M., Ort, J., Bures, R., Higgins, L. and Koistinaho, J. (2002) Proc. Natl. Acad. Sci. USA, 99, 1610-1615.
131. Higgins, L., Rodems, J., Catalano, R., Quon, D. and Cordell, B. (1995) Proc. Natl. Acad. Sci. USA, 92, 4402-4406.
132. Tikka, T., Fiebich, G., Goldsteins, R., Keianen, R. and Koistinaho, J. (2001) J. Neuroscience., 21, 2580-2588.
133. Webster, S., Lue, L. F., Brachova, L., Tenner, A. J., McGeer, P. L., Terai, K., Walker, D. G., Bradt, B., Cooper, N. R. and Rogers, J. (1997) Neurobiol. Aging, 18, 415-421.
134. Rogers, J., Cooper, NR., Webster, S., Schultz, J., McGreer, PL., Styren, SD., Civin, WH., Brachova, L., Bradt, B., Ward, P., Lieberburg, I. (1992) Proc. Natl. Acad. Sci. USA, 89, 10016-10020.
135. Stoltzner, S. E., Grenfell, T. J., Mori, C., Wisniewski, K. E., Wisniewski, T. M., Selkoe, D. J. and Lemere, C. A. (2000) Am. J. Pathol., 156, 489-499.
136. Andersen, K., Launer, LT., Ott, A., Hoess., AW., Breteler, MM., Hofman, A. (1995) Neurology, 45, 1441-1445.
137. Eikelenboom, P., Zhan, S. S., van Gool, W. A. and Allsop, D. (1994) Trends Pharmacol. Sci., 15, 447-450,
138. Eikelenboom, P. and Veerhuis, R. (1996) Neurobiol. Aging, 17, 673-680.
139. Eikelenboom, P., Rozemuller, A. J., Hoozemans, J. J., Veerhuis, R. and van Gool, W. A. (2000) Alzheimer Dis. Assoc. Disord., 14, S54-61.
140. Blom, M., van Twillert, MG., de Vries SC., Engels, F., Engels, Finch, CE., Veerhuis, R., Eikelenboom, P. (1997) Brain Res., 777, 210-218.
141. Vane, J. R., Bakhle, Y. S. and Botting, R. M. (1998) Annu. Rev. Pharmacol. Toxicol., 38, 97-120.
142. McGeer, P. L. (2000) Drugs Aging, 17, 1-11.
143. Weggen, S., Eriksen, J. L., Das, P., Sagi, S. A., Wang, R., Pietrzik, C. U., Findlay, K. A., Smith, T. E., Murphy, M. P., Bulter, T., Kang, D. E., Marquez-Sterling, N., Golde, T. T., and Koo, E. H. (2001) Nature, 414, 212-216.
144. Lim, G. P., Yang, F., Chu, T., Chen, P., Beech, W., Teter, B., Tran, T., Ubeda, O., Ashe, K. H., Frautschy, S. A. and Cole, G. M. (2000) J. Neurosci., 20, 5709-5714.
145. Wyss-Coray T, Mucke, L. (2000) Nat. Med., 6, 973-974.
146. Jantzen, P., Connor, K., Di Carlo, G., Wenk, G., Wallace, J., Rojiani, A., Coppola, D., Morgan, D. and Gordon. M. (2002) J. Neuroscience, 22, 2246-2254.
147. Lee, J., Laydon, J.T., McDonnell, P.C., Gallagher, T.F., Kumar, S., Green, D., McNulty, D., Blumenthal, M.J., Heys, J.R., Landvattrer, S.W., Stickler, J.E., McLaughlin, M.M., Siemens, I.R., Fisher, S.M., Livi, G.P., White, J.R., Adams, J.L., Young, P.R. (1994) Nature, 372, 739-745.
148. Han, J., Brown, T. and Buetler, B. (1990) J. Exp. Med., 171, 465-475.
149. Blasko I, M. F., Steiner E, Hartmann T, Grubeck-Loebenstein B. (1999) FASEB J., 13. 63-68.
150. Blasko, I, V. R., Stampfer-Kountchev, M, Saurwein-Teissl, M, Eikelenboom, P, Grubeck-Loebenstein, B. (2000) Neurobiol. Disease, 7, 682-689.
151. Blasko I, A. A., Boeck G, Hartmann T, Grubeck-Loebenstein B, Ransmayr G. (2001) Neurobiol. Dis., 8, 1094-1101.
152. Sastre, M., Dewachter, I., Landreth, G. E., Willson, T. M., Klockgether, T., van Leuven, F. and Heneka, M. T. (2003) J. Neurosci., 23, 9796-9804.
153. Heneka, M., Landreth, G. and DL, F. (2001) Annals of Neurology, 49, 279.
154. Heneka, M., Klockgether, T. and DL., F. (2000) J. Neurosci., 20, 6862-6867.
155. Heneka, M., Feinstein, D., E, Gleichmann, M., Wullner, U. and T., K. (1999) J. Neuroimmunol., 100, 156-168.
156. Schenk, D., Barbour, R., Dunn, W., Gordon, G., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Liao, Z., Lieberburg, I., Motter, R., Mutter, L., Soriano, F., Shopp, G., Vasquez, N., Vandevert, C., Walker, S., Wogulis, M., Yednock, T., Games, D. and Seubert, P. (1999) Nature, 400, 173-177.
157. Morgan, D., Diamond, D.M., Gottschall, P.E., Ugen, K.F., Dickey, C., Hardy, J., Duff, K., Jantzen, P., DiCarlo, G., Wilcock, D., Connor, K., Hatcher, J., Hope, C., Gordon, M., Arendash, G.W. (2000) Nature, 408, 982-985.
158. Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., Mount, H. T., Nixon, R. A., Mercken, M., Bergeron, C., Fraser, P. E., St George-Hyslop, P. and Westaway, D. (2000) Nature, 408, 979-982.
159. Nicoll, J.A., Wilkinson, D., Holmes, C., Steart, P., Markham, H. and Weller, R.O. (2003) Nat. Med., 9, 389-390.
160. Sergeant, N., Bombois, S., Ghestem, A., Drobecq, H., Kostanjevecki, V., Missiaen, C., Wattez, A., David, J.P., Vanmechelen, E., Sergheraert, C. and Delacourte, A. (2003) J. Neurochem., 85, 1581-1591.
161. Bard, F., Cannon, C., Barbour, R., Burke, R. L., Gaines, D., Grajeda, H., Guido, T., Hu, K., Huang, J., Johnson-Wood, K., Khan, K., Kholodenko, D., Lee, M., Lieberburg, I., Motter, R., Nguyen, M., Soriano, F., Vasquez, N., Weiss, K., Welch, B., Seubert, P., Schenk, D. and Yednock, T. (2000) Nat. Med., 6, 916-919.
162. Morgan, D. (2003) Expert Rev. Vaccines, 2, 53-59.
163. Zuker, M. (1989) Science. 244, 48-52.
164. Feng, Y., Zhang, F., Lokey, L. K., Chastain, J. L., Lakkis, L., Eberhart, D. and Warren, S. T. (1995) Science, 268, 731-734.
165. Svitkin, Y. V., Pause, A., Haghighat, A., Pyronnet, S., Witherell, G., Belsham, G. J. and Sonenberg, N. (2001) RNA, 7, 382-394.
166. Morse, L., Payton, S., Cuny, G. and Rogers, J. (2004) J. Mol. Neuroscience, In Press.
167. Mandinov, L., Mandinova, A., Kyurkehiev, S., Kyurkchiev, D., Kehayov, I., Kolev, V., Soldi, R., Bagala, C., de Muinck, E. D., Lindner, V., Post, M. J., Simons, M., Bellum, S., Prudovsky, I. and Maciag, T. (2003) Proc. Natl. Acad. Sci. USA 100, 6700-6705.
168. Klausner, R., Rouault, TA., Harford, JB. (1993) Cell, 72, 19-28.
169. Wasco, W., Gurubhagavatula, S., Paradis, M. D., Romano, D. M., Sisodia, S. S., Hyman, B. T., Neve, R. L. and Tanzi, R. E. (1993) Nat. Genet., 5, 95-100.
170. von Koch, C. S., Zheng, H., Chen, H., Trumbauer, M., Thinakaran, G., van der Ploeg, L. H., Price, D. L. and Sisodia, S. S. (1997) Neurobiol. Aging, 18, 661-669.
171. Chishti, M. A., Yang, D. S., Janus, C., Phinney, A. L., Horne, P., Pearson, J., Strome, R., Zuker, N., Loukides, J., French, J., Turner, S., Lozza, G., Grilli, M., Kunicki, S., Morissette, C., Paquette, J., Gervais, F., Bergeron, C., Fraser, P. E., Carlson, G. A., George-Hyslop, P. S. and Westaway, D. (2001) J. Biol. Chem., 276, 21562-21570.
172. Tanzi, R. E., McClatchey, A. I., Lamperti, E. D., Villa-Komaroff, L., Gusella, J. F. and Neve, R. L. (1988) Nature, 331, 528-530.
173. Van Broeckhoven, C., Haan, J., Bakker, E., Hardy, J. A,, Van Hul, W., Wehnert, A., Vegter-Van der Vlis, M. and Roos, R. A. (1990) Science, 248, 1120-1122.
174. Seiffert, D., Bradley, J. D., Rominger, C. M., Rominger, D. H., Yang, F., Meredith, J. E., Jr., Wang, Q., Roach, A. H., Thompson, L. A., Spitz, S. M., Higaki, J. N., Prakash, S. R., Combs, A. P., Copeland, R. A., Arneric, S. P., Hartig, P. R., Robertson, D. W., Cordell, B., Stern, A. M., Olson, R. E. and Zaczek, R. (2000) J. Biol. Chem., 275, 34086-34091.
175. Harper, J. D., Wong, S. S., Lieber, C. M. and Lansbury, P. T., Jr. (1999) Biochemistry, 38, 8972-8980.
176. Cherny, R., Legg, J.T., McLean, C.A., Fairlie, D.P., Huang, X., Atwood, C.S., Beyreuther K., Tanzi, R., Masters, C.L., Bush, A.I. (1999) J. Biol. Chem., 274, 23223-23228.
177. Rogers, J. T., Randall, J. D., Eder, P. S., Huang, X., Bush, A. I., Tanzi, R. E., Venti, A., Payton, S. M., Giordano, T., Nagano, S., Cahill, C. M., Moir, R., Lahiri, D. K., Greig, N., Sarang, S. S. and Gullans, S. R. (2002) J. Mol. Neurosci., 19, 77-82.
178. Squitti, R., Pasqualetti, P., Cassetta, E., Dal Forno, G., Cesaretti, S., Pedace, F., Finazzi-Agro, A. and Rossini, P. (2003) Neurology, 60. 2013-2014.