β-amyloid precursor protein transgenic mice that harbor diffuse Aβ deposits but do not form plaques show increased ischemic vulnerability: Role of inflammation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 99, Issue 3, 2002, Pages 1610-1615

  Koistinaho, Milla ^a   Kettunen, Mikko I ^a   Goldsteins, Gundars ^a   Keinänen, Riitta ^a   Salminen, Antero ^a   Ort, Michael ^c,d   Bures, Jan ^c   Liu, David ^e   Kauppinen, Risto A ^a   Higgins, Linda S ^e   Koistinaho, Jari ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^d CHARLES UNIVERSITY   (Czech Republic)

^e SCIOS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID BETA PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; NITRIC OXIDE SYNTHASE; PROTEIN PRECURSOR; TRANSCRIPTION FACTOR AP 1;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; COGNITIVE DEFECT; CONTROLLED STUDY; EFFECTOR CELL; ENZYME ACTIVATION; INFLAMMATION; MALE; MICROGLIA; MOUSE; NERVE CELL NECROSIS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; SENILE PLAQUE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ASPIRIN; BLOOD PRESSURE; BRAIN; BRAIN ISCHEMIA; CARBON DIOXIDE; ENZYME INHIBITORS; HUMANS; INDOLES; INFLAMMATION; MAGNETIC RESONANCE IMAGING; MICE; MICE, TRANSGENIC; MICROGLIA; MITOGEN-ACTIVATED PROTEIN KINASES; OXYGEN; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PARTIAL PRESSURE; PROTEIN-SERINE-THREONINE KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION FACTOR AP-1;

ANIMALIA; MUS MUSCULUS; RODENTIA;

EID: 0037022288     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.032670899     Document Type: Article

References (52)