Competition for microtubule-binding with dual expression of tau missense and splice isoforms

Molecular Biology of the Cell

Volumn 12, Issue 1, 2001, Pages 171-184

  Lu, M ^a   Kosik, K S ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYAN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; ISOPROTEIN; MUTANT PROTEIN; TAU PROTEIN; UNCLASSIFIED DRUG; YELLOW FLUORESCENT PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EXON; FLUORESCENCE MICROSCOPY; GENE EXPRESSION; GENETIC TRANSFECTION; MICROTUBULE; MISSENSE MUTATION; MOUSE; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROCESSING;

ANIMALIA;

EID: 0035181835     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.12.1.171     Document Type: Article

References (32)

1. Characterization of posttranslational modifications in neuron-specific class III beta-tubulin by mass spectrometry
2. Polymerization of tau peptides into fibrillar structures. The effect of FTDP-17 mutations
3. Polyglutamylation of tubulin as a progressive regulator of in vitro interactions between the microtubule-associated protein Tau and tubulin
4. Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau
5. Pathogenic implications of mutations in the tau gene in pallido-ponto-nigral degeneration and related neurodegenerative disorders linked to chromosome 17
6. Missense and silent tau gene mutations cause frontotemporal dementia with parkinsonism-chromosome 17 type, by affecting multiple alternative R.N.A. splicing regulatory elements
7. Mutations in tan reduce its microtubule binding properties in intact cells and affect its phosphorylation
8. Vulnerable neuronal subsets in Alzheimer's and Pick's disease are distinguished by their tau isoform distribution and phosphorylation
9. The minimum GTP cap required to stabilize microtubules [published erratum appears in Curr. Biol. 1995, 5(2), 215]
10. Posttranslational glutamylation of alpha-tubulin
11. Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
12. Tau gene mutation in familial progressive subcortical gliosis
13. Multiple isoforms of human microtubule-associated protein tau: Sequences and localization in neurofibrillary tangles of Alzheimer's disease
14. Identification of a novel microtubule binding and assembly domain in the developmentally regulated inter-repeat region of tau
15. Tau proteins with FTDP-17 mutations have a reduced ability to promote microtubule assembly
16. FTDP-17 mutations N279K and S305N in tau produce increased splicing of exon 10
17. Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
18. Missense and splicing mutations in tau associated with FTDP-17: Multiple pathogenic mechanisms
19. Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
20. Cytoskeletal plasticity in cells expressing neuronal microtubule-associated proteins
21. Developmentally regulated expression of specific tau sequences
22. Tau: Structure and function
23. Expression of map cDNAs in eukaryotic cells
24. The microtubule binding domain of tau protein
25. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations
26. Structure of the alpha beta tubulin dimer by electron crystallography [see comments] [published erratum appears in Nature 1998 May 14, 393(6681),191]
27. Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau
28. Rapid treadmilling of brain microtubules free of microtubule-associated proteins in vitro and its suppression by tau [In Process Citation]
29. Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration
30. High prevalence of mutations in the microtubule-associated protein tau in a population study of frontotemporal dementia in the Netherlands
31. Tau protein pathology in neurodegenerative diseases
32. A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration