The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5′ secondary structure

RNA

Volumn 7, Issue 3, 2001, Pages 382-394

  Svitkin, Yuri V ^a   Pause, Arnim ^a,d   Haghighat, Ashkan ^a,e   Pyronnet, Stéphane ^a   Witherell, Gary ^b   Belsham, Graham J ^c   Sonenberg, Nahum ^a  

^a MCGILL UNIVERSITY   (Canada)

^b Questcor Pharmaceuticals Inc   (United States)

^c INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^d BOEHRINGER INGELHEIM CANADA LTD   (Canada)

^e UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Dominant negative mutants; ElF4A; RNA helicases; RNA secondary structure; Translation initiation

Indexed keywords

ADENOSINE TRIPHOSPHATASE; INITIATION FACTOR; MESSENGER RNA; MUTANT PROTEIN; RNA HELICASE;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; CROSS LINKING; ENZYME ACTIVITY; EUKARYOTE; IN VITRO STUDY; NONHUMAN; PICORNAVIRUS; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN SECONDARY STRUCTURE; PROTEIN STABILITY; RIBOSOME; RNA BINDING; RNA STRUCTURE; RNA TRANSLATION; STOICHIOMETRY; TRANSLATION INITIATION; TRANSLATION REGULATION;

5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; EUKARYOTIC INITIATION FACTOR-4A; MICE; MOLECULAR SEQUENCE DATA; MUTATION; NUCLEAR CAP-BINDING PROTEIN COMPLEX; NUCLEIC ACID CONFORMATION; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PICORNAVIRIDAE; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA CAPS; RNA HELICASES; RNA, MESSENGER; RNA, VIRAL; SACCHAROMYCES CEREVISIAE PROTEINS;

EUKARYOTA; MAMMALIA; PICORNAVIRIDAE;

EID: 0035032444     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S135583820100108X     Document Type: Article

References (82)

1. Translation initiation factor-dependent extracts from Saccharomyces cerevisiae
2. The 5′-leader sequence of tobacco mosaic virus RNA mediates initiation-factor-4E-independent, but still initiation-factor-4A-dependent translation in yeast extracts
3. mRNA structures influencing translation in the yeast Saccharomyces cerevisiae
4. RNA-protein interactions in regulation of picornavirus RNA translation
5. Purification and characterization of initiation factor IF-E2 from rabbit reticulocytes
6. Crystal structure of the ATPase domain of translation initiation factor 4A from Saccharomyces cerevisiae - The prototype of the DEAD box protein family
7. Interaction of initiation factors with the cap structure of chimaeric mRNA containing the 5′-untranslated regions of Semliki Forest virus RNA is related to translational efficiency
8. Functional identity of a mouse ascites and a rabbit reticulocyte initiation factor required for natural mRNA translation
9. ATP hydrolysis by initiation factor 4A is required for translation initiation in Saccharomyces cerevisiae
10. Evidence that the 5′-untranslated leader of mRNA affects the requirement for wheat germ initiation factors 4A, 4F, and 4G
11. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families
12. Involvement of eukaryotic initiation factor 4A in the cap recognition process
13. Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism
14. The absence of a m7G cap on beta-globin mRNA and alfalfa mosaic virus RNA 4 increases the amounts of initiation factor 4F required for translation
15. 5′-Conformation of capped alfalfa mosaic virus ribonucleic acid 4 may reflect its independence of the cap structure or of cap-binding protein for efficient translation
16. elF4 initiation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
17. Helicases: Amino acid sequence comparisons and structure-function relationships
18. Two related superfamilies of putative helicases involved in replication, recombination, repair and expression of DNA and RNA genomes
19. A novel functional human eukaryotic translation initiation factor 4G
20. New initiation factor activity required for globin mRNA translation
21. elF4G dramatically enhances the binding of elF4E to the mRNA 5′-cap structure
22. Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis
23. Pathway and mechanism of initiation of protein synthesis
24. unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA
25. A newly identified N-terminal amino acid sequence of human elF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation
26. Human eukaryotic translation initiation factor 4G (elF4G) possesses two separate and independent binding sites for elF4A
27. The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species
28. Comparative view of initiation site selection mechanisms
29. Internal initiation of translation in eukaryotes: The picornavirus paradigm and beyond
30. RNA unwinding in translation: Assembly of helicase complex intermediates comprising eukaryotic initiation factors elF-4F and elF-4B
31. Crystallographic structure of the amino terminal domain of yeast initiation factor 4A, a representative DEAD-box RNA helicase
32. Translation eukaryotic initiation factor 4G recognizes a specific structural element within the internal ribosome entry site of encephatomyocarditis virus RNA
33. mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor elF-4E
34. 7 l-capped inosine-substituted reovirus mRNA
35. Inactivation of cap-binding proteins accompanies the shut-off of host protein synthesis by poliovirus
36. Birth of the DEAD box
37. Physical association of eukaryotic initiation factor 4G (elF4G) with elF4A strongly enhances binding of elF4G to the internal ribosomal entry site of encephalomyocarditis virus and is required for internal initiation of translation
38. The DEAD box protein elF4A. 1. A minimal kinetic and thermodynamic framework reveals coupled binding of RNA and nucleotide
39. The DEAD box protein elF4A. 2. A cycle of nucleotide and RNA-dependent conformational changes
40. The protein family of RNA helicases
41. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure
42. La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate
43. Assays for eukaryotic translation factors that bind mRNA
44. Identification of the 80-kDa protein that crosslinks to the cap structure of eukaryotic mRNAs as initiation factor elF-4B
45. Alternative translation of the proto-oncogene c-myc by an internal ribosome entry site
46. Mutational analysis of the 5′ non-coding region of human immunodeficiency virus type 1: Effects of secondary structure on translation
47. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
48. The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis
49. Dominant negative mutants of mammalian translation initiation factor elF-4A define a critical role for elF-4F in cap-dependent and cap-independent initiation of translation
50. Mutational analysis of a DEAD box RNA helicase: The mammalian translation initiation factor elF-4A
51. Helicases and RNA unwinding in translation
52. Effects of oligonucleotide length and atomic composition on stimulation of the ATPase activity of translation initiation factor elF4A
53. Insertion mutagenesis to increase secondary structure within the 5′ noncoding region of a eukaryotic mRNA reduces translational efficiency
54. Photochemical cross-linking of cap binding proteins to eucaryotic mRNAs: Effect of mRNA 5′ secondary structure
55. A prokaryotic-like mode of cytoplasmic eukaryotic ribosome binding to the initiation codon during internal translation initiation of hepatitis C and classical swine fever virus RNAs
56. Functional dissection of eukaryotic initiation factor 4F: The 4A subunit and the central domain of the 4G subunit are sufficient to mediate internal entry of 43S preinitiation complexes
57. Human eukaryotic translation initiation factor 4G (elF4G) recruits Mnk1 to phosphorylate elF4E
58. Relief of ornithine decarboxylase messenger RNA translational repression induced by alternative splicing of its 5′ untranslated region
59. Regulation of ribosomal recruitment in eukaryotes
60. ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors
61. Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H
62. Biochemical and kinetic characterization of the RNA helicase activity of eukaryotic initiation factor 4A
63. Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F
64. Starting at the beginning, middle, and end: Translation initiation in eukaryotes
65. D-E-A-D protein family of putative RNA helicases
66. A 60-kDa protein from rabbit reticulocytes specifically recognizes the capped 5′ end of β-globin mRNA
67. ++-dependent cross-linking of cap binding proteins to the 5′ end of eukaryotic mRNA
68. Remarks on the mechanism of ribosome binding to eukaryotic mRNAs
69. mRNA 5′ cap-binding protein elF4E and control of cell growth
70. A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5′-terminal cap in mRNA
71. Use of T7 RNA polymerase to direct expression of cloned genes
72. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells
73. Differences between translation products of tick-borne encephalitis virus RNA in cell-free systems from Krebs-2 cells and rabbit reticulocytes: Involvement of membranes in the processing of nascent precursors of flavivirus structural proteins
74. General RNA binding proteins render translation cap-dependent
75. La autoantigen alleviates translational repression by the 5′ leader sequence of the human immunodeficiency virus type 1 mRNA
76. Association of the yeast poly(A) tail binding protein with translation initiation factor elF4G
77. Initiation of mammalian protein synthesis. II. The assembly of the initiation complex with purified initiation factors
78. Internal ribosome entry site within hepatitis C virus RNA
79. Rat ornithine decarboxylase gene. Nucleotide sequence, potential regulatory elements, and comparison to the mouse gene
80. Specificity in initiation of protein synthesis in a fractionated mammalian cell-free system
81. The p46 subunit of eukaryotic initiation factor (elF)-4F exchanges with elF-4A