Ibuprofen, inflammation and Alzheimer disease

Nature Medicine

Volumn 6, Issue 9, 2000, Pages 973-974

  Wyss Coray, Tony ^a   Mucke, Lennart ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; AMYLOID; CYTOKINE; IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; CYTOKINE RELEASE; INFLAMMATION; NERVE CELL DEGENERATION; NONHUMAN; PAIN; PATHOGENESIS; PRIORITY JOURNAL;

ALZHEIMER DISEASE; ANIMAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DISEASE MODELS, ANIMAL; IBUPROFEN; MICE; MICE, TRANSGENIC;

EID: 0033830795     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/79661     Document Type: Article

References (15)

1. Akiyama, H. et al. Inflammation and Alzheimer's disease. Neuroinflammation working group. Neurobiol. Aging 21, 383-421 (2000).
2. Lim, G.P. et al. Ibuprofen suppresses plaque pathology and inflammation in a mouse model for Alzheimer's disease J. Neurosci. 20, 5709-5714 (2000).
3. Kisilevsky, R. & Fraser, P. E. Aβ amyloidogenesis: unique, or variation on a systemic theme? Crit. Rev. Biochem. Mol. Biol. 32, 361-404 (1997).
4. Younkin, S.G. Evidence that Aβ42 is the real culprit in Alzheimer's disease. Ann. Neurol. 37, 287-288 (1995).
5. Yankner, B.A. Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron 16, 921-932 (1996).
6. Selkoe, D.J. Translating cell biology into therapeutic advances in Alzheimer's disease. Nature 399 (Suppl), A23-31 (1999).
7. Kaufmann, W.E., Andreasson, K.I., Isakson, P.C. & Worley, P.F. Cyclooxygenases and the central nervous system. Prostaglandins 54, 601-624 (1997).
8. Lehmann, J.M., Lenhard, J.M., Oliver, B.B., Ringold, G.M. & Kliewer, S.A. Peroxisome proliferator-activated receptors α and γ are activated by indomethacin and other non-steroidal anti-inflammatory drugs. J. Biol. Chem. 272, 3406-3410 (1997).
9. 1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J. Neurosci. 20, 4050-4058 (2000).
10. Bales, K.R. et al. Lack of apolipoprotein E dramatically reduces amyloid β-peptide deposition. Nature Genet. 17, 263-264 (1997).
11. Van, S.D., Roher, A., Schmidt, A.M. & Stern, D.M. Cellular cofactors for amyloid β-peptide-induced cell stress. Moving from cell culture to in vivo. Am. J. Pathol. 155, 1403-1411 (1999).
12. Schenk, D. et al. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400, 173-177 (1999).
13. Flaris, N.A., Densmore, T.L., Molleston, M.C. & Hickey, W.F. Characterization of microglia and macrophages in the central nervous system of rats: definition of the differential expression of molecules using standard and novel monoclonal antibodies in the normal CNS and in four models of parenchymal reaction. Glia 7, 34-40 (1993).
14. Hsia, A. et al. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl. Acad. Sci. USA 96, 3228-3233 (1999).
15. Lue, L.-F. et al. Soluble amyloid β peptide concentration as a predictor of synaptic change in Alzheimer's disease. Am. J. Pathol. 155, 853-862 (1999).