Can pure fruit and vegetable juices protect against cancer and cardiovascular disease too? A review of the evidence

International Journal of Food Sciences and Nutrition

Volumn 57, Issue 3-4, 2006, Pages 249-272

  Ruxton, Carrie H S ^a   Gardner, Elaine J ^b   Walker, Drew ^c  

^a Nutrition Communications   (United Kingdom)

^b Kings Cross Hospital ^*  (United Kingdom)

^c King's Cross Hospital   (United Kingdom)

Author keywords

Cancer risk; Cardiovascular disease risk; Pure juice

Indexed keywords

ALPHA TOCOPHEROL; ANTHOCYANIN; ANTIOXIDANT; ASCORBIC ACID; BETA CAROTENE; CAROTENOID; FLAVANOID; HOMOCYSTEINE; LIPOPROTEIN; LYCOPENE; POLYPHENOL; TOCOPHEROL; VITAMIN B GROUP;

APPLE JUICE; APRICOT; BIOAVAILABILITY; BREAST CANCER; BROCCOLI; CABBAGE; CANCER PREVENTION; CANCER RISK; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CARROT; CEREBROVASCULAR ACCIDENT; CHRONIC DISEASE; CLINICAL TRIAL; COLON CANCER; COLORECTAL CANCER; DIETARY FIBER; DIETARY INTAKE; FOOD COMPOSITION; FRUIT; FRUIT JUICE; GRAPE JUICE; GRAPEFRUIT JUICE; HUMAN; KIDNEY CARCINOMA; LIME (FRUIT); LIPOPROTEIN BLOOD LEVEL; MANGO; ORANGE JUICE; PLANT PRODUCT; POMEGRANATE; PROSTATE CANCER; REVIEW; RISK REDUCTION; SPINACH; THROMBOCYTE AGGREGATION INHIBITION; TOMATO; VEGETABLE JUICE;

ANTIOXIDANTS; BEVERAGES; CARDIOVASCULAR DISEASES; DIETARY FIBER; FRUIT; HUMANS; NEOPLASMS; RISK ASSESSMENT; VEGETABLES;

EID: 34247645662     PISSN: 09637486     EISSN: 14653478     Source Type: Journal    
DOI: 10.1080/09637480600858134     Document Type: Review

References (98)

1. Abbey, M and Noakes, M and Nestel, PJ. (1995) Dietary supplementation with orange and carrot juice in cigarette smokers lowers oxidation products in copper-oxidised low-density lipoproteins J Am Diet Assoc, 95, pp. 671-675.
2. Abu-Amsha, A and Croft, KD and Puddey, IB and Proudfoot, JM and Beilin, LJ. (1996) Phenolic content of various beverages determines the extent of inhibition of human serum and low-density lipoprotein oxidation in vitro: Identification and mechanism of action of some cinnamic acid derivatives from red wine Clin Sci, 91, pp. 449-458.
3. Agarwal, A and Shen, H and Agarwal, S and Rao, AV. (2001) Lycopene content of tomato products: Its stability, bioavailability and in vivo antioxidant properties J Med Food, 4, pp. 9-15.
4. Alexy, U and Sichert-Hellert, W and Kersting, M and Manz, F and Schoch, G. (1999) Fruit juice consumption and the prevalence of obesity and short stature in German preschool children: Results of the DONALD Study J Pediatr Gastroenterol Nutr, 29, pp. 343-349.
5. American Academy of Pediatrics: Committee on Nutrition. (2001) The use and misuse of fruit juice in pediatrics Pediatrics, 107, pp. 1210-1213.
6. Aviram, M and Rosenblat, M and Gaitini, D and Nitecki, S and Hoffman, A and Dornfield, L and Volkova, N and Presser, D and Atias, J and Lier, H and Hayek, T. (2004) Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation Clin Nutr, 23, pp. 423-433.
7. Bazzano, LA and Serdula, MK and Liu, S. (2002) Dietary intakes of F&V and risk of cardiovascular disease Curr Atheroscler Rep, 5, pp. 492-499.
8. Briviba, K and Schnabele, K and Rechkemmer, G and Bub, A. (2004) Supplementation of a diet low in carotenoids with tomato or carrot juice does not affect lipid peroxidation in plasma and faeces of healthy men J Nutr, 134, pp. 1081-1083.
9. Brouwer, IA and van Dusseldorp, M and West, CE and Meyboom, S and Thomas, CMG and Duran, M and van het Hof, KH and Eskes, T and Hautvast, J and Steegers-Theunissen, R. (1999) Dietary folate from vegetables and citrus fruit decreases plasma homocysteine concentrations in humans in a dietary controlled trial J Nutr, 129, pp. 1135-1139.
10. Bub, A and Watzl, B and Blockhaus, M and Briviba, K and Liegibel, U and Muller, H and Pool-Zobel, BL and Rechkemmer, G. (2003) Fruit juice consumption modulates antioxidative status, immune status and DNA damage J Nutr Biochem, 14, pp. 90-98.
11. Chou, EJ and Keevel, JG and Aeschlimann and Wiebe, DA and Folts, JD and Stein, JH. (2001) Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease Am J Cardiol, 88, pp. 553-555.
12. Collins, JK and Arjmandi, BH and Claypool, PL and Perkins-Veazie, P and Baker, RA and Clevidence, BA. (2004) Lycopene from two food sources does not affect antioxidant or cholesterol status of middle-aged adults Nutr J, 3, pp. 15.
13. Cordeiro, J and Matsudaira, F and Ozaki, F and Yanagida, A and Kitamura, C. (2000) Caries-protective effect of apple polyphenols on rampant caries of hamsters J Dental Res, 79, pp. 594.
14. Day, AP and Kemp, HJ and Bolton, C and Hartog, M and Stansbie, D. (1997) Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation Annals Nutr Metab, 41, pp. 353-357.
15. Department of Health, 1989. Dietary sugars and human disease. Report on Health and Social Subjects No 37. London: HMSO.
16. Department of Health and Human Services and the Department of Agriculture. 2005. Dietary guidelines for Americans 2005. Available online at: http://www.healthierus.gov/dietaryguidelines Accessed 1 September 2005.
17. Dutta-Roy, AK and Crosbie, L and Gordon, MJ. (2001) Effects of tomato extract on human platelet aggregation in vitro Platelets, 12, pp. 218-227.
18. Folts, JD. (1998) Antothrombotic potential of grape juice and red wine for preventing heart attacks Pharmacol Biol, 36, pp. S21-S27.
19. Folts, JD. (2002) Potential health benefits from the flavonoids in grape products on vascular disease Adv Exp Med Biol, 505, pp. 95-111.
20. Food and Agricultural Organisation. 1998. Carbohydrates in human nutrition. Report of a joint FAO/WHO expert consultation. Rome: FAO.
21. Frankel, EN and Bosanek, CA and Meyer, AS and Silliman, K and Kirk, LL. (1998) Commercial grape juices inhibit the in vitro oxidation of human low-density lipoproteins J Agric Food Chem, 46, pp. 834-838.
22. Freedman, JE and Parker, III C and Li, L and Perlman, JA and Frei, B and Ivanov, V and Deak, L and Iafrati, MD and Folts, JD. (2001) Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release Circulation, 103, pp. 2792-2798.
23. Gahler, S and Otto, K and Bohm, V. (2003) Alterations of vitamin C, total phenolics and antioxidant capacity as affected by processing tomatoes to different products J Agric Food Chem, 51, pp. 7962-7968.
24. Gil, MI and Tomas-Barberan, FA and Hess-Pierce, B and Holcroft, DM and Kader, AA. (2000) Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing J Agric Food Chem, 48, pp. 4581-4589.
25. Gil-Izquierdo, A and Gil, MI and Ferreres, F. (2002) Effect of processing techniques at industrial scale on orange juice antioxidant and beneficial health compounds J Agric Food Chem, 50, pp. 5107-5114.
26. Giovannucci, E and Ascherio, A and Rimm, EB and Stampfer, MJ and Colditz, GA and Willett, WC. (1995) J Natl Cancer Inst, 87, pp. 1767-1776.
27. Gorinstein, S and Caspi, A and Libman, I and Katrich, E and Lerner, HT and Trakhtenberg, S. (2004a) Fresh Israeli Jaffa Sweetie juice consumption improves lipid metabolism and increases antioxidant capacity in hypercholesterolemic patients suffering from coronary artery disease: Studies in vitro and in humans and positive changes in albumin and fibrinogen fractions J Agric Food Chem, 52, pp. 5215-5222.
28. Gorinstein, S and Caspi, A and Libman, I and Katrich, E and Lerner, HT and Trakhtenberg, S. (2004b) Preventative effects of diets supplemented with sweetie fruits in hypercholesterolemic patients suffering from coronary artery disease Prevent Med, 38, pp. 841-847.
29. Handa, K and Kreiger, N. (2002) Diet patterns and the risk of renal cell carcinoma Public Health Nutr, 5, pp. 757-767.
30. Harris, PJ and Ferguson, LR. (1993) Dietary fibre: Its composition and role in protection against colorectal cancer Mutat Res, 290, pp. 97-110.
31. Harris, PJ and Ferguson, LR. (1999) Dietary fibres may protect or enhance carcinogenesis Mutat Res, 443, pp. 95-110.
32. Heber, D and Lui, QY. (2002) Overview of mechanisms of action of lycopene Exp Biol Med, 227, pp. 920-923.
33. HendersonL, GregoryJ.2002. National diet and nutrition survey: Adults aged 19-64 years. Volume 1. Types and quantities of foods consumed. London: National Office for Statistics.
34. Hung, H-C and Joshipura, KJ and Jiang, R and Hu, FB and Hunter, D and Smith-Warner, SA and Colditz, GA and Rosner, B and Spiegelman, D and Willet, WC. (2004) Fruit and vegetable intake and risk of major chronic disease J Natl Cancer Inst, 98, pp. 1577-1584.
35. Hussein, I and Pollard, MA and Curzon, ME. (1996) A comparison of the effects of some extrinsic and intrinsic sugars on dental plaque pH Int J Paediatr Dent, 6, pp. 81-86.
36. Jenkins, DJ and Axelsen, M and Kendall, CW and Augustin, LS and Vuksan, V and Smith, U. (2000) Dietary fibre, lente carbohydrates and the insulin-resistant diseases Br J Nutr, 83, pp. S157-S163.
37. Johnsen, SP and Overvad, K and Stripp, C and Tjonneland, A and Husted, SE and Sorensen, H. (2003) Intake of fruit and vegetables and the risk of ischemic stroke in a cohort of Danish men and women Am J Clin Nutr, 78, pp. 57-64.
38. Johnston, CS and Dancho, CL and Strong, G. (2003) Orange juice ingestion and supplemental vitamin C are equally effective at reducing plasma lipid peroxidation in healthy adult women J Am Coll Nutr, 22, pp. 519-523.
39. Joshipura, KJ and Ascherio, A and Manson, JE and Stampfer, M and Rimm, E and Speizer, FE and Hennekens, CH and Spigelman, D and Willett, W. (1999) Fruit and vegetable intake in relation to risk of ischaemic stroke J Am Med Assoc, 282, pp. 1233-1239.
40. Keevil, JG and Osman, HE and Reed, JD and Folts, JD. (2000) Grape juice, but not orange juice or grapefruit juice inhibits human platelet aggregation J Nutr, 130, pp. 53-56.
41. Kiefer, I and Prock, P and Lawrence, C and Wise, J and Bieger, W and Bayer, P and Rathmanner, T and Kunze, M and Rieder, A. (2004) Supplementation with mixed fruit and vegetable juice concentrates increased serum antioxidants and folate in healthy adults J Am College Nutr, 23, pp. 205-211.
42. Kurowska, EM and Spence, JD and Jordan, J and Wetmore, S and Freeman, DJ and Piche, LA and Serratore, P. (2000) HDL-cholesterol-raising effect of orange juice in subjects with hypercholesterolemia Am J Clin Nutr, 72, pp. 1095-1100.
43. Lampe, JW. (1999) Health effects of vegetables and fruit: Assessing mechanisms of action in human experimental studies Am J Clin Nutr, 70, pp. 475S-490S.
44. Lanningham-Foster, L and Chen, C and Chance, DS and Loo, G. (1995) Grape extract inhibits lipid peroxidation of human low density lipoprotein Biol Pharmacol Bull, 18, pp. 1347-1351.
45. Law, MR and Morris, JK. (1998) By how much does fruit and vegetable consumption reduce the risk of ischaemic heart disease? Eur J Clin Nutr, 52, pp. 549-556.
46. Lazarus, SA and Garg, ML. (2004) Tomato extract inhibits human platelet aggregation in vitro without increasing basal camp levels Int J Food Sci Nutr, 3, pp. 249-256.
47. Lazarus, SA and Bowen, K and Garg, ML. (2004) Tomato juice and platelet aggregation in Type 2 diabetes J Am Med Assoc, 292, pp. 805-806.
48. Levine, RS and Stillman-Lowe, CR.(2004) The scientific basis of oral health education 2nd Ed. London: BDJ Books.
49. Lugasi, A and Hovari, J. (2003) Antioxidant properties of commercial alcoholic and non-alcoholic beverages Nahrung, 47, pp. 79-86.
50. McEligot, AJ and Rock, CL and Shanks, TG and Flatt, SW and Newman, V and Faerber, S and Pierce, JP. (1999) Comparison of serum carotenoid responses between women consuming vegetable juice and women consuming raw or cooked vegetables Cancer Epidemiol Biomarkers Prevent, 8, pp. 227-231.
51. Malinow, RM. (2001) Plasma concentrations of total homocysteine predict mortality risk Am J Clin Nutr, 74, pp. 3.
52. Marshall, TA and Eichenberger Gilmore, JM and Broffit, B and Stumbo, PJ and Levy, SM. (2005) Diet quality in young children is influenced by beverage consumption J Am Coll Nutr, 24, pp. 65-75.
53. Martinez-Gonzalez, MA and Fernandez-Jarne, E and Martinez-Losa, E and Prado-Santamaria, M and Brugarolas-Brufau, C and Serrano-Martinez, M. (2002) Role of fibre and fruit in the Mediterranean diet to protect against myocardial infarction: A case-control study in Spain Eur J Clin Nutr, 56, pp. 715-722.
54. Maruyama, C and Imamura, K and Oshima, S and Suzukawa, M and Egami, S and Tonomoto, M and Baba, N and Harada, M and Ayaori, M and Inakuma, T and Ishikawa, T. (2001) Effects of tomato juice consumption on plasma and lipoprotein carotenoid concentrations and the susceptibility of low density lipoprotein to oxidative modification J Nutr Sci Vitaminol, 47, pp. 213-221.
55. Miller, NJ and Rice-Evans, CA. (1997) The relative contributions of ascorbic acid and phenolic antioxidants to the total antioxidant activity of orange and apple fruit juices and blackcurrant drink Food Chem, 60, pp. 331-337.
56. MINTEL. 2004. Fruit juice and juice drinks - UK - November 2004. London: Mintel International Group Ltd.
57. Miyagi, Y and Miwa, K and Inoue, H. (1997) Inhibition of human low-density lipoprotein oxidation by flavonoids in red wine and grape juice Am J Cardiol, 80, pp. 1627-1631.
58. Mojzisova, G and Kuchta, M. (2001) Dietary flavonoids and risk of coronary heart disease Physiol Res, 50, pp. 529-535.
59. Newby, PK and Peterson, KE and Berkey, CS and Leppert, J and Willett, WC and Colditz, GA. (2004) Beverage consumption is not associated with changes in weight and body mass index among low-income preschool children in North Dakota J Am Diet Assoc, 104, pp. 1086-1094.
60. O'Byrne, DJ and Devaraj, S and Grundy, SM and Jialal, I. (2002) Comparison of the antioxidant effects of Concord grape juice flavonoids and alpha-tocopherol markers of oxidative stress in healthy adults Am J Clin Nutr, 76, pp. 1367-1374.
61. Olsen, A and Tjonneland, A and Thomsen, BL and Loft, S and Stripp, C and Overvad, K and Moller, S and Olsen, J. (2003) Fruit and vegetables intake differentially affects estrogen receptor negative and positive breast cancer incidence rates J Nutr, 133, pp. 2342-2347.
62. Pace-Asiak, CR and Rounova, O and Hahn, Se and Diamandis, EP and Goldberg, DM. (1996) Wines and grape juices as modulators of platelet aggregation in healthy human subjects Clin Chim Acta, 246, pp. 163-182.
63. Panunzio, MF and Pisano, A and Antoniciello, A and Di Martino, V and Frisoli, L and Cipriani, V and Mongelli, MA and Bronzetti, G. (2003) Supplementation with fruit and vegetable concentrate decreases plasma homocysteine levels in a dietary controlled trial Nutr Res, 23, pp. 1221-1228.
64. Park, YK and Park, E and Kim, J-S and Kang, M-H. (2003) Daily grape juice consumption reduces oxidative damage and plasma free radical levels in healthy Koreans Mutat Res, 529, pp. 77-86.
65. Park, YK and Kim, JS and Kang, MH. (2004) Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: Double blind, placebo controlled intervention trial Biofactors, 22, pp. 145-147.
66. Pearson, DA and Tan, CH and German, JB and Davis, PA and Gershwin, ME. (1999) Apple juice inhibits human low density lipoprotein oxidation Life Sci, 64, pp. 1913-1920.
67. Pederson, CB and Kyle, J and Jenkinsin, A and Gardner, PT and McPhail, DB and Duthie, GG. (2000) Effects of blueberry and cranberry juice consumption on the plasma antioxidant capacity of healthy female volunteers Eur J Clin Nutr, 54, pp. 405-408.
68. Pool-Zobel, BL and Bub, A and Muller, H and Wollowski, I and Rechkemmer, G. (1997) Consumption of vegetables reduces genetic damage in humans: First results of a human intervention trial with carotenoid-rich foods Carcinogenesis, 9, pp. 1847-1850.
69. Rashidkhani, B and Lindblad, P and Wolk, A. (2005) Fruits, vegetables and risk of renal cell carcinoma: A prospective study of Swedish women Int J Cancer, 113, pp. 451-455.
70. Samman, S and Sivarajah, G and Masn, JC and Ahmad, ZI and Petocz, P and Caterson, ID. (2003) A mixed fruit and vegetable concentrate increases plasma antioxidant vitamins and folate and lowers plasma homocysteine in men J Nutr, 133, pp. 2188-2193.
71. Scottish Intercollegiate Guidelines Network. 2005. A guideline developer's handbook. Edinburgh. Available online at www.sign.ac.uk
72. Skinner, JD and Carruth, BR. (2001) A longitudinal study of children's juice intake and growth: The fruit juice controversy revisited J Am Diet Assoc, 101, pp. 432-437.
73. Skinner, JD and Carruth, BR and Moran, III J and Houck, K and Coletta, F. (1999) Fruit juice intake is not related to children's growth Pediatrics, 103, pp. 58-64.
74. Smith, MJ and Inserra, PF and Watson, RR and Wise, JA and O'Neill, KL. (1999) Supplementation with fruit and vegetable extracts may decrease DNA damage in the peripheral lymphocytes of an elderly population Nutr Res, 19, pp. 1507-1518.
75. Smith-Warner, SA and Spiegelman, D and Yaun, SS and Adami, HO and Beeson, WL and van den Brandt, PA and Folsom, AR and Frase, GE and Frendenheim, JL and Goldbohm, RA and Graham, S and (2001) Intake of fruits and vegetables and risk of breast cancer J Am Med Assocx, 285, pp. 769-776.
76. Smith-Warner, SA and Elmer, PJ and Fosdick, L and Randall, B and Bostick, RM and Grandits, G and Grambsch, P and Louis, TA and Wood, JR and Potter, JD. (2002) Fruits, vegetables and adenomatous polyps: The Minnesota Cancer Prevention Research Unit case-control study Am J Epidemiol, 155, pp. 1104-1113.
77. Stanner, SA and Hughes, J and Kelly, CNM and Buttriss, J. (2003) A review of the epidemiological evidence for the 'antioxidant hypothesis' Public Health Nutr, 7, pp. 407-422.
78. Stein, JH and Keeveil, JG and Wiebe, DA and Aeschlimann, S and Folts, JD. (1999) Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease Circulation, 100, pp. 1050-1055.
79. Steinmetz, KA and Potter, JD. (1996) Vegetables, fruit and cancer prevention: A review J Am Diet Assoc, 96, pp. 1027-1039.
80. Strazzullo, P and Scalfi, L and Branca, F and Cairella, G and Garbagnati, F and Siani, A and Barba, G and Rubba, P and Mancia, G. (2004) Nutrition and prevention of ischaemic stroke: Present knowledge, limitations and future perspectives Nutr Metab Cardiovasc Dis, 14, pp. 97-114.
81. Suido, H and Tanaka, T and Tabei, T and Takeuchi, A and Okita, M and Kishimoto, T and Kasayama, S and Higashino, K. (2002) A mixed green vegetable and fruit beverage decreased the serum level of low-density lipoprotein cholesterol in hypercholesterolemic patients J Agric Food Chem, 50, pp. 3346-3350.
82. Sutherland, WH and Walker, RJ and De Jong, SA and Upritvhard, JE. (1999) Supplementation with tomato juice increases plasma lycopene and does not alter susceptibility to oxidation of low-density lipoproteins from renal transplant patients Clin Nephrol, 52, pp. 30-36.
83. Tahmassebi, JF and Duggal, MS. (1997) The effect of different methods of drinking on the pH of dental plaque in vivo Int J Paediatr Dent, 7, pp. 249-254.
84. TakaiM, SuidoH, TanakaT, KotaniM, FujitaA, TakeuchiA, MakinoT, SumikawaK, OrigasaH, TsujiK, NakashimaM. 2003. LDL-cholesterol-lowering effect of a mixed green vegetable and fruit beverage containing broccoli and cabbage in hypercholesterolemic subjects. Rinsho Byori 51:1073-1083[article in Japanese; abstract only reviewed].
85. Umar, S and Morris, AP and Kourouma, F and Sellin, JH. (2003) Dietary pectin and calcium inhibit colonic proliferation in vivo by differing mechanisms Cell Prolif, 36, pp. 361-375.
86. UK Food Standards Agency. 2004. Frequently asked questions. Available online at: http://www.eatwell.gov.uk/asksam/healthydiet/drinksq Accessed 6 September 2005.
87. US Food and Drug Administration. 2002a. Health claims: Fruits, vegetables, and grain products that contain fiber, particularly soluble fiber, and risk of coronary heart disease. Available online at: http://vm.cfsan.fda.gov/~lrd/CF101-77.html Accessed 7 July 2005.
88. US Food and Drug Administration. 2002b. Health claim notification for potassium containing foods. Available online at: http://vm.cfsan.fda.gov/ ~dms/hclm-k.html Accessed 6 September 2005.
89. Van der Sluis, AA and Dekker, M and Skrede, G and Jongen, WMF. (2002) Activity and concentration of polyphenolic antioxidants in apple juice. 1. Effect of existing production methods J Agric Food Chem, 50, pp. 7211-7219.
90. Van, Gils and Peeters, PH and Bueno de Mesquita, HB and Boshvizen, HC and Lahman, PH and Clavel-Chapelon, F and Thiebunt, A and Kesse, E and Sieri, S and Palli, D and (2005) Consumption of vegetables and fruits and risk of breast cancer J Am Med Assoc, 293, pp. 183-193.
91. Van't Veer, P and Jansen, M and Klerk, M and Kok, FJ. (2000) Fruits and vegetables in the prevention of cancer and cardiovascular disease Public Health Nutr 3, pp. 103-107.
92. Verhoeven, DT and Assen, N and Goldbohm, RA and Dorant, E and van't Veer, P and Sturmans, F and Hermus, RJ and van den Brandt, PA. (1997) Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: A prospective cohort study Br J Cancer, 75, pp. 149-155.
93. Vinson, JA and Liang, X and Proch, J and Hontz, BA and Dancel, J and Sandone, N. (2002) Polyphenol antioxidants in citrus juices: In vitro and in vivo studies relevant to heart disease Adv Exp Med Biol, 505, pp. 113-122.
94. Wilson, T and Porcari, JP and Harbin, D. (1998) Cranberry extract inhibits low density lipoprotein oxidation Life Sci, 62, pp. 381-386.
95. Wise, JA and Morin, RJ and Sanderson, R and Blum, K. (1996) Changes in plasma catotenoid, alpha-tocopherol, and lipid peroxide levels in response to supplementation with concentrated fruit and vegetable extracts: A pilot study Curr Ther Res, 57, pp. 687-690.
96. World Cancer Research Fund. 1997. Food, nutrition and the prevention of cancer: A global perspective. London: WCRF.
97. World Health Organisation. 2003. Diet, nutrition and the prevention of chronic diseases. Report of a Joint WHO/FAO Expert Consultation. WHO Technical Report Series, No. 916. Geneva: World Health Organization.
98. Yen, GC and Lin, HT. (1998) High pressure and heat treatments effects on pectic substances in guava juice Adv Exp Med Biol, 434, pp. 81-90.