-
3
-
-
33646338189
-
Chronic obstructive pulmonary disease: Linking outcomes and pathobiology of disease modification
-
Rennard SI. Chronic obstructive pulmonary disease: linking outcomes and pathobiology of disease modification. Proc Am Thoracic Soc 2006; 3 (3): 276-80
-
(2006)
Proc Am Thoracic Soc
, vol.3
, Issue.3
, pp. 276-280
-
-
Rennard, S.I.1
-
4
-
-
26944489955
-
Exacerbations: The asthma paradox
-
Holgate ST. Exacerbations: the asthma paradox. Am J Resp Crit Care Med 2005; 172 (8): 941-3
-
(2005)
Am J Resp Crit Care Med
, vol.172
, Issue.8
, pp. 941-943
-
-
Holgate, S.T.1
-
5
-
-
0033940869
-
Outcome measures in asthma
-
Barnes N. Outcome measures in asthma. Thorax 2000; 55 Suppl.: 70S-74
-
(2000)
Thorax
, vol.55
, Issue.SUPPL.
-
-
Barnes, N.1
-
6
-
-
34247183129
-
-
Panettieri RA, Grunstein MM. Airway smooth muscle hyperplasia and hypertrophy. In: Barnes PJ, Grunstein MM, Leff AR, et al. editors. Asthma. Philadelphia (PA): Lippincott-Raven; 1997: 823-42
-
Panettieri RA, Grunstein MM. Airway smooth muscle hyperplasia and hypertrophy. In: Barnes PJ, Grunstein MM, Leff AR, et al. editors. Asthma. Philadelphia (PA): Lippincott-Raven; 1997: 823-42
-
-
-
-
7
-
-
14944346763
-
Airway remodeling in asthma: Therapeutic implications of mechanisms
-
Homer RJ, Elias JA. Airway remodeling in asthma: therapeutic implications of mechanisms. Physiology 2005; 20 (1): 28-35
-
(2005)
Physiology
, vol.20
, Issue.1
, pp. 28-35
-
-
Homer, R.J.1
Elias, J.A.2
-
8
-
-
0035891664
-
Remodeling in asthma and chronic obstructive lung disease
-
Jeffery PK. Remodeling in asthma and chronic obstructive lung disease. Am J Resp Crit Care Med 2001; 164 (10 Suppl.): 28S-38
-
(2001)
Am J Resp Crit Care Med
, vol.164
, Issue.10 SUPPL.
-
-
Jeffery, P.K.1
-
9
-
-
24944464002
-
Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease
-
Jeffery PK. Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thoracic Soc 2004; 1 (3): 176-83
-
(2004)
Proc Am Thoracic Soc
, vol.1
, Issue.3
, pp. 176-183
-
-
Jeffery, P.K.1
-
10
-
-
4644241215
-
Differences in airway remodeling between asthma and chronic obstructive pulmonary disease
-
Aoshiba K, Nagai A. Differences in airway remodeling between asthma and chronic obstructive pulmonary disease. Clin Rev Allergy Immunol 2004; 1: 35-43
-
(2004)
Clin Rev Allergy Immunol
, vol.1
, pp. 35-43
-
-
Aoshiba, K.1
Nagai, A.2
-
11
-
-
2142700884
-
Asthma: More muscle cells or more muscular cells?
-
Black JL. Asthma: more muscle cells or more muscular cells? Am J Respir Crit Care Med 2004; 169 (9): 980-1
-
(2004)
Am J Respir Crit Care Med
, vol.169
, Issue.9
, pp. 980-981
-
-
Black, J.L.1
-
12
-
-
0002543851
-
The pathology of asthma, with special reference to the changes in the bronchial mucosa
-
Dunnill MS. The pathology of asthma, with special reference to the changes in the bronchial mucosa. J Clin Pathol 1960; 13: 27-33
-
(1960)
J Clin Pathol
, vol.13
, pp. 27-33
-
-
Dunnill, M.S.1
-
13
-
-
0014491275
-
A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema
-
Dunnill MS, Massarella GR, Anderson JA. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969; 24: 176-9
-
(1969)
Thorax
, vol.24
, pp. 176-179
-
-
Dunnill, M.S.1
Massarella, G.R.2
Anderson, J.A.3
-
14
-
-
0015535510
-
Quantitative measurement of bronchial muscle in asthma
-
Hossain S. Quantitative measurement of bronchial muscle in asthma. Am Rev Resp Dis 1973; 107: 99-109
-
(1973)
Am Rev Resp Dis
, vol.107
, pp. 99-109
-
-
Hossain, S.1
-
15
-
-
0027181166
-
Cellular hypertrophy and hyperplasia of airway smooth muscle underlying bronchial asthma: A 3-D morphometric study
-
Ebina M, Takahashi T, Chiba T, et al. Cellular hypertrophy and hyperplasia of airway smooth muscle underlying bronchial asthma: a 3-D morphometric study. Am Rev Resp Dis 1993; 148: 720-6
-
(1993)
Am Rev Resp Dis
, vol.148
, pp. 720-726
-
-
Ebina, M.1
Takahashi, T.2
Chiba, T.3
-
16
-
-
0035376725
-
Airway smooth muscle as an immunomodulatory cell: A new target for pharmacotherapy?
-
Lazaar AL, Panettieri RA. Airway smooth muscle as an immunomodulatory cell: a new target for pharmacotherapy? Curr Opin Pharmacol 2001; 1: 259-64
-
(2001)
Curr Opin Pharmacol
, vol.1
, pp. 259-264
-
-
Lazaar, A.L.1
Panettieri, R.A.2
-
17
-
-
11144358047
-
Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression
-
Woodruff PG, Dolganov GM, Ferrando RE, et al. Hyperplasia of smooth muscle in mild to moderate asthma without changes in cell size or gene expression. Am J Resp Crit Care Med 2004; 169 (9): 1001-6
-
(2004)
Am J Resp Crit Care Med
, vol.169
, Issue.9
, pp. 1001-1006
-
-
Woodruff, P.G.1
Dolganov, G.M.2
Ferrando, R.E.3
-
19
-
-
0037952701
-
Airway structural alterations selectively associated with severe asthma
-
Benayoun L, Druilhe A, Dombret M-C, et al. Airway structural alterations selectively associated with severe asthma. Am J Resp Crit Care Med 2003; 167 (10): 1360-8
-
(2003)
Am J Resp Crit Care Med
, vol.167
, Issue.10
, pp. 1360-1368
-
-
Benayoun, L.1
Druilhe, A.2
Dombret, M.-C.3
-
20
-
-
0036907405
-
Airway smooth muscle: An immunomodulatory cell
-
Panettieri J, Reynold A. Airway smooth muscle: an immunomodulatory cell. J Allergy Clin Immunol 2002; 110 Suppl.: S269-74
-
(2002)
J Allergy Clin Immunol
, vol.110
, Issue.SUPPL.
-
-
Panettieri, J.1
Reynold, A.2
-
21
-
-
0033788441
-
Phosphatidylinositol kinase regulation of airway smooth muscle cell proliferation
-
Thomas CF, Limper AH. Phosphatidylinositol kinase regulation of airway smooth muscle cell proliferation. Am J Resp Cell Mol Biol 2000; 23 (4): 429-30
-
(2000)
Am J Resp Cell Mol Biol
, vol.23
, Issue.4
, pp. 429-430
-
-
Thomas, C.F.1
Limper, A.H.2
-
22
-
-
0034133112
-
Mitogen-activated signaling and cell cycle regulation in airway smooth muscle
-
Page K, Hershenson MB. Mitogen-activated signaling and cell cycle regulation in airway smooth muscle. Front Biosci 2000; 5: d258-67
-
(2000)
Front Biosci
, vol.5
-
-
Page, K.1
Hershenson, M.B.2
-
23
-
-
0034581626
-
Phosphoinositide 3-kinase: A critical signaling event in pulmonary cells
-
Condliffe AM, Cadwallader KA, Walker TR, et al. Phosphoinositide 3-kinase: a critical signaling event in pulmonary cells. Resp Res 2000; 1: 24-9
-
(2000)
Resp Res
, vol.1
, pp. 24-29
-
-
Condliffe, A.M.1
Cadwallader, K.A.2
Walker, T.R.3
-
24
-
-
4444302962
-
Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70s6k regulates contractile protein accumulation in airway myocyte differentiation
-
Halayko AJ, Kartha S, Stelmack GL, et al. Phophatidylinositol-3 kinase/mammalian target of rapamycin/p70s6k regulates contractile protein accumulation in airway myocyte differentiation. Am J Resp Cell Molec Biol 2004; 31 (3): 266-75
-
(2004)
Am J Resp Cell Molec Biol
, vol.31
, Issue.3
, pp. 266-275
-
-
Halayko, A.J.1
Kartha, S.2
Stelmack, G.L.3
-
25
-
-
0034911881
-
Synthesis and function of 3-phosphorylated inositol lipids
-
Vanhaesebroeck B, Leevers SJ, Ahmadi K, et al. Synthesis and function of 3-phosphorylated inositol lipids. Ann Rev Biochem 2001; 70 (1): 535-602
-
(2001)
Ann Rev Biochem
, vol.70
, Issue.1
, pp. 535-602
-
-
Vanhaesebroeck, B.1
Leevers, S.J.2
Ahmadi, K.3
-
26
-
-
0034912744
-
PTEN and myotubularin: Novel phosphoinositide phosphatases
-
Maehama T, Taylor GS, Dixon JE. PTEN and myotubularin: novel phosphoinositide phosphatases. Ann Rev Biochem 2001; 70 (1): 247-79
-
(2001)
Ann Rev Biochem
, vol.70
, Issue.1
, pp. 247-279
-
-
Maehama, T.1
Taylor, G.S.2
Dixon, J.E.3
-
27
-
-
16244393685
-
Signalling by PI3K isoforms: Insights from gene-targeted mice
-
Vanhaesebroeck B, Ali K, Bilancio A, et al. Signalling by PI3K isoforms: insights from gene-targeted mice. Trends Biochem Sci 2005; 30 (4): 194-204
-
(2005)
Trends Biochem Sci
, vol.30
, Issue.4
, pp. 194-204
-
-
Vanhaesebroeck, B.1
Ali, K.2
Bilancio, A.3
-
28
-
-
0030612144
-
p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes
-
Chantry D, Vojtek A, Kashishian A, et al. p110δ, a novel phosphatidylinositol 3-kinase catalytic subunit that associates with p85 and is expressed predominantly in leukocytes. J Biol Chem 1997; 272: 19236-41
-
(1997)
J Biol Chem
, vol.272
, pp. 19236-19241
-
-
Chantry, D.1
Vojtek, A.2
Kashishian, A.3
-
29
-
-
0029090212
-
Cloning and characterization of a G protein-activated human phosphoinositide 3-kinase
-
Stoyanov B, Volonia S, Hanck T, et al. Cloning and characterization of a G protein-activated human phosphoinositide 3-kinase. Science 1995; 269: 690-3
-
(1995)
Science
, vol.269
, pp. 690-693
-
-
Stoyanov, B.1
Volonia, S.2
Hanck, T.3
-
30
-
-
0034697119
-
The class II phosphoinositide 3-kinase PI3K-α is concentrated in the trans-Golgi network and present in clatrin-coated vesicles
-
Domin J, Gaidarov I, Smith MEK, et al. The class II phosphoinositide 3-kinase PI3K-α is concentrated in the trans-Golgi network and present in clatrin-coated vesicles. J Biol Chem 2000; 275: 11943-50
-
(2000)
J Biol Chem
, vol.275
, pp. 11943-11950
-
-
Domin, J.1
Gaidarov, I.2
Smith, M.E.K.3
-
31
-
-
0028981018
-
A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system
-
Volinia S, Dhand R, Vanhaesebroeck B, et al. A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system. EMBO J 1995; 14: 3339-48
-
(1995)
EMBO J
, vol.14
, pp. 3339-3348
-
-
Volinia, S.1
Dhand, R.2
Vanhaesebroeck, B.3
-
32
-
-
1342292522
-
Phosphoinositide 3-kinase: Diverse roles in immune cell activation
-
Deane JA, Fruman DA. Phosphoinositide 3-kinase: diverse roles in immune cell activation. Ann Rev Immunol 2004; 22 (1): 563-98
-
(2004)
Ann Rev Immunol
, vol.22
, Issue.1
, pp. 563-598
-
-
Deane, J.A.1
Fruman, D.A.2
-
33
-
-
0036007421
-
Regulation of cell size in growth, development and human disease
-
Kozma SC, Thomas G. Regulation of cell size in growth, development and human disease. BioEssays 2002; 24: 65-71
-
(2002)
BioEssays
, vol.24
, pp. 65-71
-
-
Kozma, S.C.1
Thomas, G.2
-
34
-
-
0035190026
-
Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer
-
Katso R, Okkenhaug K, Ahmadi K, et al. Cellular function of phosphoinositide 3-kinases: implications for development, homeostasis, and cancer. Ann Rev Cell Develop Biol 2001; 17 (1): 615-75
-
(2001)
Ann Rev Cell Develop Biol
, vol.17
, Issue.1
, pp. 615-675
-
-
Katso, R.1
Okkenhaug, K.2
Ahmadi, K.3
-
35
-
-
0033574429
-
Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase
-
Bi L, Okabe I, Bernard DJ, et al. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J Biol Chem 1999; 274: 10963-8
-
(1999)
J Biol Chem
, vol.274
, pp. 10963-10968
-
-
Bi, L.1
Okabe, I.2
Bernard, D.J.3
-
36
-
-
0033556333
-
Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α
-
Fruman DA, Snapper SB, Yballe CM, et al. Impaired B cell development and proliferation in absence of phosphoinositide 3-kinase p85α. Science 1999; 283: 393-7
-
(1999)
Science
, vol.283
, pp. 393-397
-
-
Fruman, D.A.1
Snapper, S.B.2
Yballe, C.M.3
-
37
-
-
0034213075
-
The conserved phosphoinositide 3-kinase pathway determines heart size in mice
-
Shioi T, Kang PM, Douglas PS, et al. The conserved phosphoinositide 3-kinase pathway determines heart size in mice. EMBO J 2000; 19: 2537-48
-
(2000)
EMBO J
, vol.19
, pp. 2537-2548
-
-
Shioi, T.1
Kang, P.M.2
Douglas, P.S.3
-
38
-
-
0034681264
-
The multiple roles of PTEN in tumor suppression
-
Di Cristofano A, Pandolfi PP. The multiple roles of PTEN in tumor suppression. Cell 2000; 100: 387-90
-
(2000)
Cell
, vol.100
, pp. 387-390
-
-
Di Cristofano, A.1
Pandolfi, P.P.2
-
39
-
-
0037683087
-
Tumor suppressors hamartin and tuberin: Intracellular signaling
-
Krymskaya VP. Tumor suppressors hamartin and tuberin: intracellular signaling. Cell Signal 2003; 15: 729-39
-
(2003)
Cell Signal
, vol.15
, pp. 729-739
-
-
Krymskaya, V.P.1
-
40
-
-
0034705207
-
Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
-
Carsillo T, Astrinidis A, Henske EP. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A 2000; 97: 6085-90
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 6085-6090
-
-
Carsillo, T.1
Astrinidis, A.2
Henske, E.P.3
-
41
-
-
34247243645
-
-
Moses J. LAM and other diseases characterized by smooth muscle proliferation. New York: Marcel Dekker, Inc., 1999
-
Moses J. LAM and other diseases characterized by smooth muscle proliferation. New York: Marcel Dekker, Inc., 1999
-
-
-
-
43
-
-
0032246307
-
Lymphangioleiomyomatosis
-
Sullivan EJ. Lymphangioleiomyomatosis. Chest 1998; 114: 1689-703
-
(1998)
Chest
, vol.114
, pp. 1689-1703
-
-
Sullivan, E.J.1
-
44
-
-
0037732711
-
Lymphangioleiomyomatosis: A complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation
-
Krymskaya VP, Shipley JM. Lymphangioleiomyomatosis: a complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation. Am J Resp Cell Molec Biol 2003; 28 (5): 546-50
-
(2003)
Am J Resp Cell Molec Biol
, vol.28
, Issue.5
, pp. 546-550
-
-
Krymskaya, V.P.1
Shipley, J.M.2
-
45
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K, Corradetti MN, Guan K-L. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37 (1): 19-24
-
(2005)
Nat Genet
, vol.37
, Issue.1
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
46
-
-
12344279947
-
TSC1-2 tumor suppressor and regulation of mTOR signalling: Linking cell growth and proliferation?
-
Findlay GM, Harrington LS, Lamb RF. TSC1-2 tumor suppressor and regulation of mTOR signalling: linking cell growth and proliferation? Curr Opin Genet Develop 2005; 15 (1): 69-76
-
(2005)
Curr Opin Genet Develop
, vol.15
, Issue.1
, pp. 69-76
-
-
Findlay, G.M.1
Harrington, L.S.2
Lamb, R.F.3
-
47
-
-
27844562649
-
Tuberous sclerosis complex: Linking growth and energy signaling pathways with human disease
-
Astrinidis A, Henske EP. Tuberous sclerosis complex: linking growth and energy signaling pathways with human disease. Oncogene 2005; 24 (50): 7475-81
-
(2005)
Oncogene
, vol.24
, Issue.50
, pp. 7475-7481
-
-
Astrinidis, A.1
Henske, E.P.2
-
48
-
-
16544383044
-
The mTOR/S6K signaling pathway: The role of the TSC1/2 tumor suppressor complex and the proto-oncogene Rheb
-
Nobukini T, Thomas G. The mTOR/S6K signaling pathway: the role of the TSC1/2 tumor suppressor complex and the proto-oncogene Rheb. Novartis Foundation Symposium 2005; 262: 148-59
-
(2005)
Novartis Foundation Symposium
, vol.262
, pp. 148-159
-
-
Nobukini, T.1
Thomas, G.2
-
49
-
-
0033775869
-
The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
-
Lamb RF, Roy C, Diefenbach TJ, et al. The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol 2000; 2: 281-7
-
(2000)
Nat Cell Biol
, vol.2
, pp. 281-287
-
-
Lamb, R.F.1
Roy, C.2
Diefenbach, T.J.3
-
50
-
-
11244277987
-
TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
-
Goncharova E, Goncharov D, Noonan D, et al. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol 2004; 167 (6): 1171-82
-
(2004)
J Cell Biol
, vol.167
, Issue.6
, pp. 1171-1182
-
-
Goncharova, E.1
Goncharov, D.2
Noonan, D.3
-
51
-
-
0032741978
-
Tsc2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
-
Onda H, Lueck A, Marks PW, et al. Tsc2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 1999; 104: 687-95
-
(1999)
J Clin Invest
, vol.104
, pp. 687-695
-
-
Onda, H.1
Lueck, A.2
Marks, P.W.3
-
52
-
-
0033559663
-
Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
-
Kobayashi E, Minowa O, Kuno J, et al. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 1999; 59: 1206-11
-
(1999)
Cancer Res
, vol.59
, pp. 1206-1211
-
-
Kobayashi, E.1
Minowa, O.2
Kuno, J.3
-
53
-
-
0035902509
-
A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
-
Kobayashi T, Minowa O, Sugitani Y, et al. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 2001; 98 (15): 8762-7
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, Issue.15
, pp. 8762-8767
-
-
Kobayashi, T.1
Minowa, O.2
Sugitani, Y.3
-
54
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, et al. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 2002; 11: 525-34
-
(2002)
Hum Mol Genet
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
-
55
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis
-
Goncharova EA, Goncharov DA, Eszterhas A, et al. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis. J Biol Chem 2002; 277: 30958-67
-
(2002)
J Biol Chem
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.3
-
56
-
-
0036712741
-
-
McManus EJ, Alessi DR. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol 2002; 4: E214-6
-
McManus EJ, Alessi DR. TSC1-TSC2: a complex tale of PKB-mediated S6K regulation. Nat Cell Biol 2002; 4: E214-6
-
-
-
-
57
-
-
0036342294
-
Identification of the tuberous sclerosis scomplex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt/PKB pathway
-
Manning BD, Tee AR, Longdon MN, et al. Identification of the tuberous sclerosis scomplex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/Akt/PKB pathway. Mol Cell 2002; 10: 151-62
-
(2002)
Mol Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Longdon, M.N.3
-
58
-
-
0041356888
-
Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
Castro AF, Rebhun JF, Clark GG, et al. Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 2003; 278: 32493-6
-
(2003)
J Biol Chem
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.G.3
-
59
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami A, Zwartruis FJT, Nobukuni T, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol Cell 2003; 11: 1457-66
-
(2003)
Mol Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
Zwartruis, F.J.T.2
Nobukuni, T.3
-
60
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, et al. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Devel 2003; 17 (15): 1829-34
-
(2003)
Genes Devel
, vol.17
, Issue.15
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
-
61
-
-
0042701991
-
Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb
-
Tee AR, Manning BD, Roux PP, et al. Tuberous sclerosis complex gene products, tuberin and hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003; 13 (15): 1259-68
-
(2003)
Curr Biol
, vol.13
, Issue.15
, pp. 1259-1268
-
-
Tee, A.R.1
Manning, B.D.2
Roux, P.P.3
-
62
-
-
0141733228
-
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase (PI3K)/Akt/PKB-dependent and -independent phosphorylation of tuberin
-
Tee AR, Anjum R, Blenis J. Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase (PI3K)/Akt/PKB-dependent and -independent phosphorylation of tuberin. J Biol Chem 2003; 278: 37288-96
-
(2003)
J Biol Chem
, vol.278
, pp. 37288-37296
-
-
Tee, A.R.1
Anjum, R.2
Blenis, J.3
-
63
-
-
18044381192
-
Rheb binds and regulates the mTOR kinase
-
Long X, Lin Y, Ortiz-Vega S, et al. Rheb binds and regulates the mTOR kinase. Curr Biol 2005; 15 (8): 702-13
-
(2005)
Curr Biol
, vol.15
, Issue.8
, pp. 702-713
-
-
Long, X.1
Lin, Y.2
Ortiz-Vega, S.3
-
64
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long X, Ortiz-Vega S, Lin Y, et al. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem 2005; 280 (25): 23433-6
-
(2005)
J Biol Chem
, vol.280
, Issue.25
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
-
65
-
-
0442323560
-
Tuberous sclerosis complex: From Drosophila to human disease
-
Pan D, Dong J, Zhang Y, et al. Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 2004; 14 (2): 78-85
-
(2004)
Trends Cell Biol
, vol.14
, Issue.2
, pp. 78-85
-
-
Pan, D.1
Dong, J.2
Zhang, Y.3
-
66
-
-
14844363721
-
Signaling by target of rapamycin proteins in cell growth control
-
Inoki K, Ouyang H, Li Y, et al. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 2005; 69 (1): 79-100
-
(2005)
Microbiol Mol Biol Rev
, vol.69
, Issue.1
, pp. 79-100
-
-
Inoki, K.1
Ouyang, H.2
Li, Y.3
-
67
-
-
0034644525
-
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103: 253-62
-
Schmelzle T, Hall MN. TOR, a central controller of cell growth. Cell 2000; 103: 253-62
-
-
-
-
69
-
-
0031453135
-
The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-pro motif and is activated by antibodies to a region near its COOH terminus
-
Brunn GJ, Fadden P, Haystead TAJ, et al. The mammalian target of rapamycin phosphorylates sites having a (Ser/Thr)-pro motif and is activated by antibodies to a region near its COOH terminus. J Biol Chem 1997; 272 (51): 32547-50
-
(1997)
J Biol Chem
, vol.272
, Issue.51
, pp. 32547-32550
-
-
Brunn, G.J.1
Fadden, P.2
Haystead, T.A.J.3
-
70
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R, Jacinto E, Wullschleger S, et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10 (3): 457-68
-
(2002)
Mol Cell
, vol.10
, Issue.3
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
-
71
-
-
3342895823
-
-
Sarbassov DD, Siraj MA, Kim D-H. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14 (14): 1296-302
-
Sarbassov DD, Siraj MA, Kim D-H. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14 (14): 1296-302
-
-
-
-
72
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6 (11): 1122-8
-
(2004)
Nat Cell Biol
, vol.6
, Issue.11
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
-
73
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB/PKB by the Rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, et al. Phosphorylation and regulation of Akt/PKB/PKB by the Rictor-mTOR complex. Science 2005; 307 (5712): 1098-101
-
(2005)
Science
, vol.307
, Issue.5712
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
-
74
-
-
33646485688
-
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
-
Yang Q, Inoki K, Kim E, et al. TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A 2006; 103 (18): 6811-6
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, Issue.18
, pp. 6811-6816
-
-
Yang, Q.1
Inoki, K.2
Kim, E.3
-
75
-
-
0025806666
-
Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A
-
Sigal NH, Lin CS, Siekierka JJ. Inhibition of human T-cell activation by FK 506, rapamycin, and cyclosporine A. Transplant Proc 1991; 23: 1-5
-
(1991)
Transplant Proc
, vol.23
, pp. 1-5
-
-
Sigal, N.H.1
Lin, C.S.2
Siekierka, J.J.3
-
76
-
-
0026659046
-
Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases
-
Chung J, Kuo CJ, Crabtree GR, et al. Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases. Cell 1992; 69: 1227-36
-
(1992)
Cell
, vol.69
, pp. 1227-1236
-
-
Chung, J.1
Kuo, C.J.2
Crabtree, G.R.3
-
77
-
-
0026721092
-
Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase
-
Kuo CJ, Chung J, Fiorentino DF, et al. Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase. Nature 1992; 358: 70-3
-
(1992)
Nature
, vol.358
, pp. 70-73
-
-
Kuo, C.J.1
Chung, J.2
Fiorentino, D.F.3
-
78
-
-
0026759874
-
Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase
-
Price DJ, Grove JR, Calvo V, et al. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 1992; 257: 973-7
-
(1992)
Science
, vol.257
, pp. 973-977
-
-
Price, D.J.1
Grove, J.R.2
Calvo, V.3
-
79
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett PE, Barrow RK, Cohen NA, et al. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A 1998; 95: 1432-7
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
-
80
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, et al. Phosphorylation of the translational repressor PHAS-I by mammalian target of rapamycin. Science 1997; 277: 99-101
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
-
81
-
-
0031919552
-
Insulin signal transduction through protein kinase cascades
-
Avruch J. Insulin signal transduction through protein kinase cascades. Mol Cell Biochem 1998; 182: 31-48
-
(1998)
Mol Cell Biochem
, vol.182
, pp. 31-48
-
-
Avruch, J.1
-
82
-
-
5044229348
-
Molecular mechanisms of translational control
-
Gebauer F, Hentze MW. Molecular mechanisms of translational control. Nat Rev Mol Cell Biol 2004; 5: 827-35
-
(2004)
Nat Rev Mol Cell Biol
, vol.5
, pp. 827-835
-
-
Gebauer, F.1
Hentze, M.W.2
-
83
-
-
2342545519
-
Target of rapamycin (TOR): An integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar DC, Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23: 3151-71
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
84
-
-
0032514924
-
Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase β containing proline-rich region
-
Gout I, Minami T, Hara K, et al. Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase β containing proline-rich region. J Biol Chem 1998; 273: 30061-4
-
(1998)
J Biol Chem
, vol.273
, pp. 30061-30064
-
-
Gout, I.1
Minami, T.2
Hara, K.3
-
85
-
-
0242432371
-
Cyclin dependent kinases and cell cycle control
-
Nurse P. Cyclin dependent kinases and cell cycle control. Biosci Rep 2002; 22: 487-99
-
(2002)
Biosci Rep
, vol.22
, pp. 487-499
-
-
Nurse, P.1
-
86
-
-
0016793098
-
Genetic control of cell size at cell division in yeast
-
Nurse P. Genetic control of cell size at cell division in yeast. Nature 1975; 256: 547-51
-
(1975)
Nature
, vol.256
, pp. 547-551
-
-
Nurse, P.1
-
87
-
-
0017581306
-
Coordination of growth with cell division in the yeast Sacchromyces cerevisiae
-
Johnston GC, Pringle JR, Hartwell LH. Coordination of growth with cell division in the yeast Sacchromyces cerevisiae. Exp Cell Res 1977; 105: 79-98
-
(1977)
Exp Cell Res
, vol.105
, pp. 79-98
-
-
Johnston, G.C.1
Pringle, J.R.2
Hartwell, L.H.3
-
88
-
-
0032568795
-
Coordination of growth and cell division in the Drosophila wing
-
Neufeld TP, de la Cruz AFA, Johnston LA, et al. Coordination of growth and cell division in the Drosophila wing. Cell 1998; 93 (7): 1183-93
-
(1998)
Cell
, vol.93
, Issue.7
, pp. 1183-1193
-
-
Neufeld, T.P.1
de la Cruz, A.F.A.2
Johnston, L.A.3
-
89
-
-
0030807904
-
Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase
-
Weigmann K, Cohen S, Lehner C. Cell cycle progression, growth and patterning in imaginal discs despite inhibition of cell division after inactivation of Drosophila Cdc2 kinase. Development 1997; 124 (18): 3555-63
-
(1997)
Development
, vol.124
, Issue.18
, pp. 3555-3563
-
-
Weigmann, K.1
Cohen, S.2
Lehner, C.3
-
90
-
-
0032843917
-
Drosophila S6 kinase: A regulator of cell size
-
Montagne J, Stewart MJ, Stocker H, et al. Drosophila S6 kinase: a regulator of cell size. Science 1999; 285: 2126-9
-
(1999)
Science
, vol.285
, pp. 2126-2129
-
-
Montagne, J.1
Stewart, M.J.2
Stocker, H.3
-
91
-
-
11144356304
-
S6K1-/-/S6K2-/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent s6 kinase pathway
-
Pende M, Um SH, Mieulet V, et al. S6K1-/-/S6K2-/- mice exhibit perinatal lethality and rapamycin-sensitive 5′-terminal oligopyrimidine mRNA translation and reveal a mitogen-activated protein kinase-dependent s6 kinase pathway. Mol Cell Biol 2004; 24 (8): 3112-24
-
(2004)
Mol Cell Biol
, vol.24
, Issue.8
, pp. 3112-3124
-
-
Pende, M.1
Um, S.H.2
Mieulet, V.3
-
92
-
-
20044392290
-
Atrophy of S6K1-/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control
-
Ohanna M, Sobering AK, Lapointe T, et al. Atrophy of S6K1-/- skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nat Cell Biol 2005; 7 (3): 286-94
-
(2005)
Nat Cell Biol
, vol.7
, Issue.3
, pp. 286-294
-
-
Ohanna, M.1
Sobering, A.K.2
Lapointe, T.3
-
93
-
-
27644491911
-
Cooperative regulation of p70s6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth
-
Billington CK, Kong KC, Bhattacharyya R, et al. Cooperative regulation of p70s6 kinase by receptor tyrosine kinases and G protein-coupled receptors augments airway smooth muscle growth. Biochemistry 2005; 44 (44): 14595-605
-
(2005)
Biochemistry
, vol.44
, Issue.44
, pp. 14595-14605
-
-
Billington, C.K.1
Kong, K.C.2
Bhattacharyya, R.3
-
94
-
-
25444440319
-
Signaling and regulation of G protein-coupled receptors in airway smooth muscle
-
Billington CK, Penn RB. Signaling and regulation of G protein-coupled receptors in airway smooth muscle. Resp Res 2003; 4 (2): 1-23
-
(2003)
Resp Res
, vol.4
, Issue.2
, pp. 1-23
-
-
Billington, C.K.1
Penn, R.B.2
-
95
-
-
0033604577
-
Signaling by distinct classes of phosphoinositide 3-kinases
-
Vanhaesebroeck B, Waterfield MD. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 1999; 253: 239-54
-
(1999)
Exp Cell Res
, vol.253
, pp. 239-254
-
-
Vanhaesebroeck, B.1
Waterfield, M.D.2
-
96
-
-
0032549177
-
Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of catalytic p110 subunit
-
Leopoldt D, Hanck T, Exner T, et al. Gβγ stimulates phosphoinositide 3-kinase-γ by direct interaction with two domains of catalytic p110 subunit. J Biol Chem 1998; 273: 7024-9
-
(1998)
J Biol Chem
, vol.273
, pp. 7024-7029
-
-
Leopoldt, D.1
Hanck, T.2
Exner, T.3
-
97
-
-
0031037296
-
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ
-
Lopez-Ilasaca M, Crespo P, Pellici PG, et al. Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase γ. Science 1997; 275: 394-7
-
(1997)
Science
, vol.275
, pp. 394-397
-
-
Lopez-Ilasaca, M.1
Crespo, P.2
Pellici, P.G.3
-
98
-
-
0034635259
-
Signals to move cells
-
Dekker LV, Segal AW. Signals to move cells. Science 2000; 287: 982-5
-
(2000)
Science
, vol.287
, pp. 982-985
-
-
Dekker, L.V.1
Segal, A.W.2
-
99
-
-
0032810950
-
Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation
-
Krymskaya VP, Penn RB, Orsini MJ, et al. Phosphatidylinositol 3-kinase mediates mitogen-induced human airway smooth muscle cell proliferation. Am J Physiol 1999; 277: L65-78
-
(1999)
Am J Physiol
, vol.277
-
-
Krymskaya, V.P.1
Penn, R.B.2
Orsini, M.J.3
-
100
-
-
0032997708
-
EGF activates ErbB2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells
-
Krymskaya VP, Hoffman R, Eszterhas A, et al. EGF activates ErbB2 and stimulates phosphatidylinositol 3-kinase in human airway smooth muscle cells. Am J Physiol 1999; 276: L246-55
-
(1999)
Am J Physiol
, vol.276
-
-
Krymskaya, V.P.1
Hoffman, R.2
Eszterhas, A.3
-
101
-
-
0032886631
-
MAPK superfamily activation in human airway smooth muscle cell: Mitogenesis requires prolonged p42/p44 activation
-
Orsini MJ, Krymskaya VP, Eszterhas AJ, et al. MAPK superfamily activation in human airway smooth muscle cell: mitogenesis requires prolonged p42/p44 activation. Am J Physiol 1999; 277: L479-88
-
(1999)
Am J Physiol
, vol.277
-
-
Orsini, M.J.1
Krymskaya, V.P.2
Eszterhas, A.J.3
-
102
-
-
0033257938
-
Activation of K-p21ras and N-p21ras, but not H-p21ras, is necessary for mitogen-induced human airway smooth-muscle proliferation
-
Ammit AJ, Kane SA, Panettieri RA. Activation of K-p21ras and N-p21ras, but not H-p21ras, is necessary for mitogen-induced human airway smooth-muscle proliferation. Am J Resp Cell Molec Biol 1999; 21: 719-27
-
(1999)
Am J Resp Cell Molec Biol
, vol.21
, pp. 719-727
-
-
Ammit, A.J.1
Kane, S.A.2
Panettieri, R.A.3
-
103
-
-
0029785079
-
A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells
-
Scott PH, Belham CM, Al-Hafidh J, et al. A regulatory role for cAMP in phosphatidylinositol 3-kinase/p70 ribosomal S6 kinase-mediated DNA synthesis in platelet-derived-growth-factor-stimulated bovine airway smooth-muscle cells. Biochem J 1996; 318: 965-71
-
(1996)
Biochem J
, vol.318
, pp. 965-971
-
-
Scott, P.H.1
Belham, C.M.2
Al-Hafidh, J.3
-
104
-
-
0033787918
-
Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle
-
Krymskaya VP, Orsini MJ, Eszterhas AJ, et al. Mechanisms of proliferation synergy by receptor tyrosine kinase and G protein-coupled receptor activation in human airway smooth muscle. Am J Resp Cell Molec Biol 2000; 23 (4): 546-54
-
(2000)
Am J Resp Cell Molec Biol
, vol.23
, Issue.4
, pp. 546-554
-
-
Krymskaya, V.P.1
Orsini, M.J.2
Eszterhas, A.J.3
-
105
-
-
0033618344
-
1 expression in airway smooth muscle cells
-
1 expression in airway smooth muscle cells. J Biol Chem 1999; 274: 22065-71
-
(1999)
J Biol Chem
, vol.274
, pp. 22065-22071
-
-
Page, K.1
Li, J.2
Hodge, J.A.3
-
106
-
-
0033791846
-
Regulation of cyclin D1 expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells
-
Page K, Li J, Wang Y, et al. Regulation of cyclin D1 expression and DNA synthesis by phosphatidylinositol 3-kinase in airway smooth muscle cells. Am J Resp Cell Molec Biol 2000; 23 (4): 436-43
-
(2000)
Am J Resp Cell Molec Biol
, vol.23
, Issue.4
, pp. 436-443
-
-
Page, K.1
Li, J.2
Wang, Y.3
-
107
-
-
14644426493
-
Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration
-
Krymskaya VP, Goncharova EA, Ammit AJ, et al. Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. FASEB J 2005; 19: 428-30
-
(2005)
FASEB J
, vol.19
, pp. 428-430
-
-
Krymskaya, V.P.1
Goncharova, E.A.2
Ammit, A.J.3
-
108
-
-
0035041349
-
Activation of class IA phosphatidylinositol 3-kinase stimulates DNA synthesis in human airway smooth muscle cells
-
Krymskaya VP, Ammit AJ, Hoffman RK, et al. Activation of class IA phosphatidylinositol 3-kinase stimulates DNA synthesis in human airway smooth muscle cells. Am J Physiol 2001; 280: L1009-18
-
(2001)
Am J Physiol
, vol.280
-
-
Krymskaya, V.P.1
Ammit, A.J.2
Hoffman, R.K.3
-
109
-
-
0028584245
-
The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors
-
Roche S, Koegl M, Courtneidge SA. The phosphatidylinositol 3-kinase α is required for DNA synthesis induced by some, but not all, growth factors. Proc Natl Acad Sci U S A 1994; 91: 9185-9
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 9185-9189
-
-
Roche, S.1
Koegl, M.2
Courtneidge, S.A.3
-
110
-
-
0027211693
-
Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal
-
Valius M, Kazlauskas A. Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal. Cell 1993; 73: 321-34
-
(1993)
Cell
, vol.73
, pp. 321-334
-
-
Valius, M.1
Kazlauskas, A.2
-
111
-
-
0031035636
-
Specific activation of p85-p110 phosphatidylinositol 3′-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways
-
McIlroy J, Chen D, Wjasow C, et al. Specific activation of p85-p110 phosphatidylinositol 3′-kinase stimulates DNA synthesis by ras- and p70 S6 kinase-dependent pathways. Mol Cell Biol 1997; 17: 248-55
-
(1997)
Mol Cell Biol
, vol.17
, pp. 248-255
-
-
McIlroy, J.1
Chen, D.2
Wjasow, C.3
-
112
-
-
0031708412
-
Activation of phosphatidyli-nositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation
-
Klippel A, Escobedo MA, Wachowicz MS, et al. Activation of phosphatidyli-nositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation. Mol Cell Biol 1998; 18: 5699-711
-
(1998)
Mol Cell Biol
, vol.18
, pp. 5699-5711
-
-
Klippel, A.1
Escobedo, M.A.2
Wachowicz, M.S.3
-
113
-
-
0028935995
-
Dissociation of phosphatidylinositol 3-kinase activity and mitogenic inhibition in vascular smooth muscle cells
-
Weiss RH, Apostolids A. Dissociation of phosphatidylinositol 3-kinase activity and mitogenic inhibition in vascular smooth muscle cells. Cell Signal 1995; 7: 113-22
-
(1995)
Cell Signal
, vol.7
, pp. 113-122
-
-
Weiss, R.H.1
Apostolids, A.2
-
114
-
-
0030858836
-
Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells
-
Saward L, Zahradka P. Angiotensin II activates phosphatidylinositol 3-kinase in vascular smooth muscle cells. Circ Res 1997; 81: 249-57
-
(1997)
Circ Res
, vol.81
, pp. 249-257
-
-
Saward, L.1
Zahradka, P.2
-
115
-
-
0032571084
-
Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: Effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1
-
Bacqueville D, Casagrande F, Perret B, et al. Phosphatidylinositol 3-kinase inhibitors block aortic smooth muscle cell proliferation in mid-late G1 phase: effect on cyclin-dependent kinase 2 and the inhibitory protein p27KIP1. Biochem Biophys Res Commun 1998; 244: 630-6
-
(1998)
Biochem Biophys Res Commun
, vol.244
, pp. 630-636
-
-
Bacqueville, D.1
Casagrande, F.2
Perret, B.3
-
116
-
-
0029664629
-
-
Hu ZW, Shi XY, Hoffman BB. ?1 Adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular muscle cells. J Biol Chem 1996; 271: 8977-82
-
Hu ZW, Shi XY, Hoffman BB. ?1 Adrenergic receptors activate phosphatidylinositol 3-kinase in human vascular muscle cells. J Biol Chem 1996; 271: 8977-82
-
-
-
-
117
-
-
0030982219
-
Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells
-
Takahashi T, Kawahara Y, Okuda M, et al. Angiotensin II stimulates mitogen-activated protein kinases and protein synthesis by a Ras-independent pathway in vascular smooth muscle cells. J Biol Chem 1997; 272: 16018-22
-
(1997)
J Biol Chem
, vol.272
, pp. 16018-16022
-
-
Takahashi, T.1
Kawahara, Y.2
Okuda, M.3
-
118
-
-
0030575539
-
Phosphoinositide 3-kinase and the regulation of cell growth
-
Carpenter CL, Cantley LC. Phosphoinositide 3-kinase and the regulation of cell growth. Biochim Biophys Acta 1996; 1288: M11-6
-
(1996)
Biochim Biophys Acta
, vol.1288
-
-
Carpenter, C.L.1
Cantley, L.C.2
-
119
-
-
0029356279
-
α-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation
-
Panettieri RA, Hall IP, Maki CS, et al. α-Thrombin increases cytosolic calcium and induces human airway smooth muscle cell proliferation. Am J Resp Cell Molec Biol 1995; 13: 205-16
-
(1995)
Am J Resp Cell Molec Biol
, vol.13
, pp. 205-216
-
-
Panettieri, R.A.1
Hall, I.P.2
Maki, C.S.3
-
120
-
-
0031439247
-
Cellular functions regulated by Src family kinases
-
Thomas SM, Brugge JS. Cellular functions regulated by Src family kinases. Ann Rev Cell Develop Biol 1997; 13: 513-609
-
(1997)
Ann Rev Cell Develop Biol
, vol.13
, pp. 513-609
-
-
Thomas, S.M.1
Brugge, J.S.2
-
121
-
-
0029896163
-
Regulation, substrates and functions of Src
-
Brown MT, Cooper JA. Regulation, substrates and functions of Src. Biochim Biophys Acta 1996; 1287: 121-49
-
(1996)
Biochim Biophys Acta
, vol.1287
, pp. 121-149
-
-
Brown, M.T.1
Cooper, J.A.2
-
122
-
-
0036290485
-
Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation
-
Tsang F, Hwa Choo H, Dawe GS, et al. Inhibitors of the tyrosine kinase signaling cascade attenuated thrombin-induced guinea pig airway smooth muscle cell proliferation. Biochem Biophys Res Commun 2002; 293 (1): 72-8
-
(2002)
Biochem Biophys Res Commun
, vol.293
, Issue.1
, pp. 72-78
-
-
Tsang, F.1
Hwa Choo, H.2
Dawe, G.S.3
-
123
-
-
0042704808
-
The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation
-
Sayeski PP, Ali MS. The critical role of c-Src and the Shc/Grb2/ERK2 signaling pathway in angiotensin II-dependent VSMC proliferation. Exp Cell Res 2003; 287 (2): 339-49
-
(2003)
Exp Cell Res
, vol.287
, Issue.2
, pp. 339-349
-
-
Sayeski, P.P.1
Ali, M.S.2
-
124
-
-
0033613938
-
β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes
-
Luttrell LM, Ferguson SSG, Daaka Y, et al. β-Arrestin-dependent formation of β2 adrenergic receptor-Src protein kinase complexes. Science 1999; 283: 655-61
-
(1999)
Science
, vol.283
, pp. 655-661
-
-
Luttrell, L.M.1
Ferguson, S.S.G.2
Daaka, Y.3
-
125
-
-
0035398487
-
G-protein-coupled receptors and signaling networks: Emerging paradigms
-
Marinissen MJ, Gutkind JS. G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci 2001; 22 (7): 368-76
-
(2001)
Trends Pharmacol Sci
, vol.22
, Issue.7
, pp. 368-376
-
-
Marinissen, M.J.1
Gutkind, J.S.2
-
126
-
-
0027374488
-
Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
-
Yano H, Nakanashi S, Kimura K, et al. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells. J Biol Chem 1993; 268: 25846-56
-
(1993)
J Biol Chem
, vol.268
, pp. 25846-25856
-
-
Yano, H.1
Nakanashi, S.2
Kimura, K.3
-
127
-
-
0025860067
-
Demethoxyviridin and wortmannin block phospholipase C and D activation in human neutrophil
-
Bonser RW, Thompson NT, Randall RW, et al. Demethoxyviridin and wortmannin block phospholipase C and D activation in human neutrophil. Br J Pharmacol 1991; 103: 1237-41
-
(1991)
Br J Pharmacol
, vol.103
, pp. 1237-1241
-
-
Bonser, R.W.1
Thompson, N.T.2
Randall, R.W.3
-
128
-
-
0027968536
-
Wortmannin inhibits serum-induced activation of phosphoinositide 3-kinase and proliferation of CHRF-288 cells
-
Vemuri GS, Rittenhouse SE. Wortmannin inhibits serum-induced activation of phosphoinositide 3-kinase and proliferation of CHRF-288 cells. Biochem Biophys Res Commun 1994; 202: 1619-23
-
(1994)
Biochem Biophys Res Commun
, vol.202
, pp. 1619-1623
-
-
Vemuri, G.S.1
Rittenhouse, S.E.2
-
129
-
-
0028486018
-
Phosphatidylinositol 3-kinase
-
Kapeller R, Cantley LC. Phosphatidylinositol 3-kinase. BioEssays 1994; 16: 565-76
-
(1994)
BioEssays
, vol.16
, pp. 565-576
-
-
Kapeller, R.1
Cantley, L.C.2
-
130
-
-
0028918408
-
Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase
-
Hu Q, Klippel A, Muslin AJ, et al. Ras-dependent induction of cellular responses by constitutively active phosphatidylinositol-3 kinase. Science 1995; 268: 100-2
-
(1995)
Science
, vol.268
, pp. 100-102
-
-
Hu, Q.1
Klippel, A.2
Muslin, A.J.3
-
131
-
-
0029943605
-
Membrane localization of phospha-tidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways
-
Klippel A, Reinhard C, Kavanaugh WM, et al. Membrane localization of phospha-tidylinositol 3-kinase is sufficient to activate multiple signal-transducing kinase pathways. Mol Cell Biol 1996; 16: 4117-27
-
(1996)
Mol Cell Biol
, vol.16
, pp. 4117-4127
-
-
Klippel, A.1
Reinhard, C.2
Kavanaugh, W.M.3
-
132
-
-
0028178928
-
S6k activation mediated by phosphatidylinositol-3-OH kinase
-
S6k activation mediated by phosphatidylinositol-3-OH kinase. Nature 1994; 370: 71-5
-
(1994)
Nature
, vol.370
, pp. 71-75
-
-
Chung, J.1
Grammer, T.C.2
Lemon, K.P.3
-
134
-
-
0028908804
-
Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP
-
Monfar M, Lemon KP, Grammer TC, et al. Activation of pp70/85 S6 kinases in interleukin-2-responsive lymphoid cells is mediated by phosphatidylinositol 3-kinase and inhibited by cyclic AMP. Mol Cell Biol 1995; 15: 326-37
-
(1995)
Mol Cell Biol
, vol.15
, pp. 326-337
-
-
Monfar, M.1
Lemon, K.P.2
Grammer, T.C.3
-
137
-
-
0032518467
-
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
-
Alessi DR, Kozlowski MT, Weng Q, et al. 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro. Curr Biol 1997; 8: 69-81
-
(1997)
Curr Biol
, vol.8
, pp. 69-81
-
-
Alessi, D.R.1
Kozlowski, M.T.2
Weng, Q.3
-
138
-
-
33745218112
-
Muscarinic receptor signaling in the pathophysiology of asthma and COPD
-
Gosens R, Zaagsma J, Meurs H, et al. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Resp Res 2006; 9: 73
-
(2006)
Resp Res
, vol.9
, pp. 73
-
-
Gosens, R.1
Zaagsma, J.2
Meurs, H.3
-
139
-
-
27644589238
-
Phosphodiesterase-4: Selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease
-
Giembycz MA. Phosphodiesterase-4: selective and dual-specificity inhibitors for the therapy of chronic obstructive pulmonary disease. Proc Am Thoracic Soc 2005; 2 (4): 326-33
-
(2005)
Proc Am Thoracic Soc
, vol.2
, Issue.4
, pp. 326-333
-
-
Giembycz, M.A.1
-
140
-
-
4444330207
-
The potential of PDE4 inhibitors in respiratory disease
-
Spina D. The potential of PDE4 inhibitors in respiratory disease. Curr Drug Targets Inflam Allergy 2004; 3: 231-6
-
(2004)
Curr Drug Targets Inflam Allergy
, vol.3
, pp. 231-236
-
-
Spina, D.1
-
141
-
-
2542575493
-
PDE4 inhibitors in COPD: A more selective approach to treatment
-
Vignola AM. PDE4 inhibitors in COPD: a more selective approach to treatment. Resp Med 2004; 98 (6): 495-503
-
(2004)
Resp Med
, vol.98
, Issue.6
, pp. 495-503
-
-
Vignola, A.M.1
-
142
-
-
18144429417
-
Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features
-
Leung SY, Eynott P, Nath P, et al. Effects of ciclesonide and fluticasone propionate on allergen-induced airway inflammation and remodeling features. J Allergy Clin Immunol 2005; 115 (5): 989-96
-
(2005)
J Allergy Clin Immunol
, vol.115
, Issue.5
, pp. 989-996
-
-
Leung, S.Y.1
Eynott, P.2
Nath, P.3
-
143
-
-
33645280326
-
Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade
-
Henderson WR Jr, Chiang GKS, Tien Y-T, et al. Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Am J Resp Crit Care Med 2006; 173 (7): 718-28
-
(2006)
Am J Resp Crit Care Med
, vol.173
, Issue.7
, pp. 718-728
-
-
Henderson Jr, W.R.1
Chiang, G.K.S.2
Tien, Y.-T.3
-
144
-
-
0034932164
-
Airway wall remodelling and hyperresponsiveness: Modelling remodelling in vitro and in vivo
-
Stewart AG. Airway wall remodelling and hyperresponsiveness: modelling remodelling in vitro and in vivo. Pulmon Pharmacol Ther 2001; 14 (3): 255-65
-
(2001)
Pulmon Pharmacol Ther
, vol.14
, Issue.3
, pp. 255-265
-
-
Stewart, A.G.1
-
145
-
-
33644504507
-
Difficult asthma
-
Strek ME. Difficult asthma. Proc Am Thoracic Soc 2006; 3 (1): 116-23
-
(2006)
Proc Am Thoracic Soc
, vol.3
, Issue.1
, pp. 116-123
-
-
Strek, M.E.1
-
146
-
-
0037162039
-
Lysophosphatidic acid in airway function and disease
-
Toews ML, Ediger TL, Romberger DJ, et al. Lysophosphatidic acid in airway function and disease. Biochim Biophys Acta 2002; 1582 (1-3): 240-50
-
(2002)
Biochim Biophys Acta
, vol.1582
, Issue.1-3
, pp. 240-250
-
-
Toews, M.L.1
Ediger, T.L.2
Romberger, D.J.3
-
147
-
-
32044466838
-
Exploiting the PI3K/AKT/PKB pathway for cancer drug discovery
-
Hennessy BT, Smith DL, Ram PT, et al. Exploiting the PI3K/AKT/PKB pathway for cancer drug discovery. Nat Rev Drug Discov 2005; 4 (12): 988-1004
-
(2005)
Nat Rev Drug Discov
, vol.4
, Issue.12
, pp. 988-1004
-
-
Hennessy, B.T.1
Smith, D.L.2
Ram, P.T.3
-
148
-
-
33646687962
-
Using isoform-specific inhibitors to target lipid kinases
-
Simon JA. Using isoform-specific inhibitors to target lipid kinases. Cell 2006; 125 (4): 647-9
-
(2006)
Cell
, vol.125
, Issue.4
, pp. 647-649
-
-
Simon, J.A.1
-
149
-
-
28844448182
-
Oncogenic PI3K deregulates transcription and translation
-
Bader AG, Kang S, Zhao L, et al. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005; 5 (12): 921-9
-
(2005)
Nat Rev Cancer
, vol.5
, Issue.12
, pp. 921-929
-
-
Bader, A.G.1
Kang, S.2
Zhao, L.3
-
150
-
-
0036632368
-
The phosphatidylinositol 3-kinase-Akt/PKB pathway in human cancer
-
Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase-Akt/PKB pathway in human cancer. Nat Rev Cancer 2002; 2: 489-501
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
151
-
-
33646383684
-
A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling
-
Knight ZA, Gonzalez B, Feldman ME, et al. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling. Cell 2006; 125 (4): 733-47
-
(2006)
Cell
, vol.125
, Issue.4
, pp. 733-747
-
-
Knight, Z.A.1
Gonzalez, B.2
Feldman, M.E.3
-
152
-
-
33744990592
-
Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
-
Foukas LC, Claret M, Pearce W, et al. Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation. Nature 2006; 441 (7091): 366-70
-
(2006)
Nature
, vol.441
, Issue.7091
, pp. 366-370
-
-
Foukas, L.C.1
Claret, M.2
Pearce, W.3
-
153
-
-
33646382364
-
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma
-
Fan Q-W, Knight ZA, Goldenberg DD, et al. A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma. Cancer Cell 2006; 9 (5): 341-9
-
(2006)
Cancer Cell
, vol.9
, Issue.5
, pp. 341-349
-
-
Fan, Q.-W.1
Knight, Z.A.2
Goldenberg, D.D.3
-
155
-
-
24744449495
-
PI3Kγ inhibition blocks glomerulo-nephritis and extends lifespan in a mouse model of systemic lupus
-
Barber DF, Bartolome A, Hernandez C, et al. PI3Kγ inhibition blocks glomerulo-nephritis and extends lifespan in a mouse model of systemic lupus. Nat Med 2005; 11 (9): 933-5
-
(2005)
Nat Med
, vol.11
, Issue.9
, pp. 933-935
-
-
Barber, D.F.1
Bartolome, A.2
Hernandez, C.3
-
156
-
-
24744448647
-
Modulating autoimmunity: Pick your PI3 kinase
-
Ohashi PS, Woodgett JR. Modulating autoimmunity: pick your PI3 kinase. Nat Med 2005; 11 (9): 924-5
-
(2005)
Nat Med
, vol.11
, Issue.9
, pp. 924-925
-
-
Ohashi, P.S.1
Woodgett, J.R.2
-
157
-
-
0036909260
-
Protein tyrosine kinases: Autoregulation and small-molecule inhibition
-
Hubbard SR. Protein tyrosine kinases: autoregulation and small-molecule inhibition. Curr Opin Struct Biol 2002; 12 (6): 735-41
-
(2002)
Curr Opin Struct Biol
, vol.12
, Issue.6
, pp. 735-741
-
-
Hubbard, S.R.1
-
158
-
-
2342559981
-
The TOR pathway: A target for cancer therapy
-
Bjornsti M-A, Houghton PJ. The TOR pathway: a target for cancer therapy. Nat Rev Cancer 2004; 4 (5): 335-48
-
(2004)
Nat Rev Cancer
, vol.4
, Issue.5
, pp. 335-348
-
-
Bjornsti, M.-A.1
Houghton, P.J.2
-
159
-
-
24344471377
-
4E-Binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy
-
Zhou L, Goldsmith AM, Bentley JK, et al. 4E-Binding protein phosphorylation and eukaryotic initiation factor-4E release are required for airway smooth muscle hypertrophy. Am J Resp Cell Molec Biol 2005; 33 (2): 195-202
-
(2005)
Am J Resp Cell Molec Biol
, vol.33
, Issue.2
, pp. 195-202
-
-
Zhou, L.1
Goldsmith, A.M.2
Bentley, J.K.3
|