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Volumn 2, Issue 5, 2000, Pages 281-287

The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; EZRIN; GENE PRODUCT; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; HAMARTIN; LYSOPHOSPHATIDIC ACID; MOESIN; RADIXIN; RHO FACTOR; UNCLASSIFIED DRUG;

EID: 0033775869     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35010550     Document Type: Article
Times cited : (281)

References (44)
  • 2
  • 3
    • 0027770784 scopus 로고
    • Identification and characterization of the tuberous sclerosis gene on chromosome 16
    • (1993) Cell , vol.75 , pp. 1305-1315
  • 4
    • 0026922021 scopus 로고
    • Linkage of an important gene locus for tuberous sclerosis to a chromosome l6 marker for polycystic kidney disease
    • (1992) Nature Genet. , vol.2 , pp. 37-41
    • Kandt, R.S.1
  • 6
    • 0033582748 scopus 로고    scopus 로고
    • Gigas, a Drosophila homolog of tuberous sclerosis gene product-2, regulates the cell cycle
    • (1999) Cell , vol.96 , pp. 529-539
    • Ito, N.1    Rubin, G.M.2
  • 7
    • 0029814436 scopus 로고    scopus 로고
    • Suppression of tumorigenicity by the wild-type tuberous sclerosis 2 (Tsc2) gene and its C-terminal region
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9154-9159
    • Jin, F.1
  • 8
    • 0030696314 scopus 로고    scopus 로고
    • Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 2155-2161
    • Jones, A.C.1
  • 10
    • 0029121577 scopus 로고
    • Ezrin self-association involves binding of an N-terminal domain to a normally masked C-terminal domain that includes the F actin binding site
    • (1995) Mol. Biol. Cell , vol.6 , pp. 1061-1075
    • Gary, R.1    Bretscher, A.2
  • 12
    • 0032498528 scopus 로고    scopus 로고
    • Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association
    • (1998) J. Cell Biol. , vol.140 , pp. 647-657
    • Matsui, T.1
  • 13
    • 0029795488 scopus 로고    scopus 로고
    • Regulation mechanism of ERM (Ezrin/Radixin/Moesin) protein/plasma membrane association; possible involvement of phosphatidylinositol turnover and Rho-dependent signalling pathway
    • (1996) J. Cell Biol. , vol.135 , pp. 37-51
    • Hirao, M.1
  • 14
    • 0026778133 scopus 로고
    • The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
    • (1992) Cell , vol.70 , pp. 389-399
    • Ridley, A.J.1    Hall, A.2
  • 16
    • 0030846295 scopus 로고    scopus 로고
    • Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein
    • (1997) J. Biol. Chem. , vol.272 , pp. 23371-23375
    • Takahashi, K.1
  • 17
    • 0032566011 scopus 로고    scopus 로고
    • Interaction of radixin with rho small G protein GDP/GTP exchange factor Dbl
    • (1998) Oncogene , vol.16 , pp. 3279-3284
    • Takahashi, K.1
  • 18
    • 0027405720 scopus 로고
    • A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurifibromatosis 2 tumour suppressor
    • (1993) Cell , vol.72 , pp. 791-800
    • Trofatter, J.A.1
  • 19
    • 0028247080 scopus 로고
    • Perturbation of cell adhesion and microvilli formation by antisense oligonucleotides to ERM family members
    • (1994) J. Cell Biol. , vol.125 , pp. 1371-1384
    • Tacheuchi, K.1
  • 20
    • 0031240066 scopus 로고    scopus 로고
    • Essential functions of ezrin in maintenance of cell shape and lamellipodial extension in normal and transformed fibroblasts
    • (1997) Curr. Biol. , vol.7 , pp. 682-688
    • Lamb, R.F.1
  • 24
    • 0031683065 scopus 로고    scopus 로고
    • The FERM domain: A unique module involved in the linkage of cytoplasmic proteins to the membrane
    • (1998) Trends Biochem. Sci. , vol.23 , pp. 281-282
    • Chishti, A.H.1
  • 27
    • 0030297176 scopus 로고    scopus 로고
    • Chromophore-assisted laser inactivation (CALI): Probing protein function in situ with a high degree of spatial and temporal resolution
    • (1996) Trends Cell Biol. , vol.6 , pp. 442-445
    • Wang, F.-S.1    Jay, D.G.2
  • 31
    • 0032568868 scopus 로고    scopus 로고
    • Direct stimulation of the guanine nucleotide exchange activity of p 115 RhoGEF by Ga13
    • (1998) Science , vol.280 , pp. 2112-2114
    • Hart, M.J.1
  • 35
    • 0029931281 scopus 로고    scopus 로고
    • Neurofibromatosis 2 antisense oligodeoxynucleotides induce reversible inhibition of schwannomin synthesis and cell adhesion in STS26T and T98G cells
    • (1996) Oncogene , vol.13 , pp. 73-84
    • Huynh, D.P.1    Pulst, S.M.2
  • 36
    • 0032522603 scopus 로고    scopus 로고
    • Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    • (1998) Genes Dev. , vol.12 , pp. 1121-1133
    • McClatchey, A.I.1
  • 37
    • 0032551944 scopus 로고    scopus 로고
    • Impairment of cell adhesion by expression of the mutant neurofibromatosis type 2 (NF2) genes which lack exons in the ERM-homology domain
    • (1998) Oncogene , vol.17 , pp. 801-810
    • Koga, H.1
  • 38
    • 0032568370 scopus 로고    scopus 로고
    • E-cadherin germline mutations in familial gastric cancer
    • (1998) Nature , vol.392 , pp. 402-405
    • Guilford, P.1
  • 40
    • 0031033178 scopus 로고    scopus 로고
    • Ezrin is a cyclic AMP-dependent protein kinase anchoring protein
    • (1997) EMBO J. , vol.16 , pp. 35-430
    • Dransfield, D.T.1
  • 43
    • 0028961293 scopus 로고
    • Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
    • (1995) Cell , vol.81 , pp. 53-62
    • Nobes, C.D.1    Hall, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.