Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70(s6k)

EMBO Journal

Volumn 16, Issue 12, 1997, Pages 3693-3704

  Jefferies, Harold B J ^a   Fumagalli, Stefano ^a   Dennis, Patrick B ^a   Reinhard, Christoph ^b   Pearson, Richard B ^c   Thomas, George ^a  

^a FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH   (Switzerland)

^b NOVARTIS PHARMA AG   (Switzerland)

^c PETER MACCALLUM CANCER CENTRE   (Australia)

Author keywords

Mitogenesis; p70(s6k); Ribosome biogenesis; S6 phosphorylation; Translational control

Indexed keywords

ELONGATION FACTOR; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; MESSENGER RNA; PHOSPHOTRANSFERASE; PROTEIN P70; PYRIMIDINE; RAPAMYCIN; RIBOSOME PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHIMERA; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESISTANCE; ENZYME INHIBITION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RNA TRANSLATION; TRANSLATION REGULATION;

3T3 CELLS; ANIMALS; CELL LINE, TRANSFORMED; DRUG RESISTANCE; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMAN GROWTH HORMONE; HUMANS; MICE; MUTAGENESIS; POLYENES; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; PYRIMIDINES; RECOMBINANT FUSION PROTEINS; RIBOSOMAL PROTEIN S6 KINASES; RNA, MESSENGER; SIROLIMUS;

ANIMALIA; BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0030915898     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.12.3693     Document Type: Article

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