Modulating autoimmunity: Pick your PI3 kinase. Small molecules that specifically inhibit PI3Kγ block disease in mouse models of arthritis and lupus

Nature Medicine

Volumn 11, Issue 9, 2005, Pages 924-925

  Ohashi, Pamela S ^a   Woodgett, James R ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; AS 604850; AS 605240; CYCLOOXYGENASE 2 INHIBITOR; ETANERCEPT; G PROTEIN COUPLED RECEPTOR; INFLIXIMAB; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ARTHRITIS; AUTOIMMUNITY; DISEASE MODEL; DISEASE SEVERITY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; KNOCKOUT MOUSE; LEUKOCYTE MIGRATION; NONHUMAN; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SHORT SURVEY; SYSTEMIC LUPUS ERYTHEMATOSUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ARTHRITIS; AUTOIMMUNE DISEASES; CELL LINE; ENZYME ACTIVATION; ENZYME INHIBITORS; ISOENZYMES; QUINOXALINES; THIAZOLIDINEDIONES;

EID: 24744448647     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0905-924     Document Type: Short Survey

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