Tumour suppressors hamartin and tuberin: Intracellular signalling

Cellular Signalling

Volumn 15, Issue 8, 2003, Pages 729-739

  Krymskaya, Vera P ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

14 3 3; Ezrin radixin moezin proteins; Neurofilaments; Polycystin 1; Rab5; Rap1A; Rho

Indexed keywords

BINDING PROTEIN; GROWTH FACTOR; HAMARTIN; INITIATION FACTOR 4E; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; POLYCYSTIN; PROTEIN; PROTEIN 14 3 3; PROTEIN KINASE B; PROTEIN P27; RAB PROTEIN; RAP PROTEIN; RAPAMYCIN; S6 KINASE; TRANSCRIPTION FACTOR AP 1; TUBERIN; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; APOPTOSIS; ASTROCYTE; BINDING SITE; CELL ADHESION; CELL COMMUNICATION; CELL CYCLE; CELL FUNCTION; CELL GROWTH; CELL PROLIFERATION; CELL STRUCTURE; CHROMOSOME MAP; CYTOSKELETON; DISSOCIATION; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; ENZYME RELEASE; GENE FUNCTION; GENE LOCUS; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; HETEROZYGOSITY; HUMAN; INTRACELLULAR SPACE; LYMPHANGIOLEIOMYOMATOSIS; MOLECULAR CLONING; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PURKINJE CELL; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR GENE; UPREGULATION;

EUKARYOTA; MAMMALIA;

EID: 0037683087     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0898-6568(03)00040-8     Document Type: Review

References (127)

1. Consortium Cell. 75:1993;1305-1315.
2. van Slegtenhorst M., Hoogt Rd., Hermans C., Nellist M., Janssen B., Verhoef S.et al. Science. 277:1997;805-808.
3. Crino P.B., Henske E.P. Neurology. 53:1999;1384-1390.
4. Cheadle J.P., Reeve M.P., Sampson J.R., Kwiatkowski D.J. Hum. Genet. 107:2000;97-114.
5. Sparagana S.P., Roach E.S. Curr. Opin. Neurol. 13:2000;115-119.
6. Hino O., Majima S., Kobayashi T., Honda S., Momose S., Kikuchi Y.et al. Mutat. Res. 477:2001;155-164.
7. Mizuguchi M., Takashima S. Brain Dev. 23:2001;508-515.
8. Gomez R.M., Sampson J.R., Whittemore V.H. Harris J.C. Tuberous sclerosis complex. Developmental perspectives in psychiatry. 1999;Oxford Univ. Press, Oxford.
9. Halley D.J.J. Acta Genet. Med. Gemellol. 45:1996;63-75.
10. Carsillo T., Astrinidis A., Henske E.P. Proc. Natl. Acad. Sci. U. S. A. 97:2000;6085-6090.
11. Moss J. LAM and other diseases characterized by smooth muscle proliferation. 1999;Marcel Dekker, New York.
12. Johnson S. Thorax. 54:1999;254-264.
13. Sato T., Seyama K., Fujii H., Maruyama H., Setoguchi Y., Iwakami S.et al. J. Hum. Genet. 47:2002;20-28.
14. Sullivan E.J. Chest. 114:1998;1689-1703.
15. Johnson S.R., Tattersfield A.E. Sem. Resp. Crit. Care Med. 23:2002;85-92.
16. Tapon N., Moberg K.H., Hariharan I.K. Curr. Opin. Cell Biol. 13:2001;731-737.
17. Montagne J., Radimerski T., Thomas G. Science's STKE. 105:2001;PE36.
18. Hengstschlager M., Rodman D.M., Miloloza A., Hengstschlager-Ottnad E., Rosner M., Kubista M. Mutat. Res. 488:2001;233-239.
19. Hengstschlager M. Arch. Dermatol. Res. 293:2001;383-386.
20. Onda H., Lueck A., Marks P.W., Warren H.B., Kwiatkowski D.J. J. Clin. Invest. 104:1999;687-695.
21. Kobayashi E., Minowa O., Kuno J., Mitani H., Hino O., Noda T. Cancer Res. 59:1999;1206-1211.
22. Kobayashi T., Minowa O., Sugitani Y., Takai S., Mitani H., Kobayashi E.et al. Proc. Natl. Acad. Sci. U. S. A. 98:2001;8762-8767.
23. Kwiatkowski D.J., Zhang H., Bandura J.L., Heiberger K.M., Glogauer M., el-Hashemite N.et al. Hum. Mol. Genet. 11:2002;525-534.
24. Potter C.J., Huang H., Xu T. Cell. 105:2001;357-368.
25. Gao X., Pan D. Gene Dev. 15:2001;1383-1392.
26. Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S.et al. Nat. Cell Biol. 4:2002;699-704.
27. Lamb R.F., Roy C., Diefenbach T.J., Vinters H.V., Johnson M.W., Jay D.G.et al. Nat. Cell Biol. 2:2000;281-287.
28. Haddad L.A., Smith N., Bowser M., Niida Y., Murthy V., Gonzalez-Agosti C.et al. J. Biol. Chem. 277:2002;44180-44186.
29. Consortium Cell. 77:1994;881-894.
30. Consortium Cell. 81:1995;289-298.
31. Maheshwar M.M., Sandford R., Nellist M., Cheadle J.P., Sgotto B., Vauldin M.et al. Hum. Mol. Genet. 5:1996;131-137.
32. Rubinfeld B., Munemitsu S., Clark R., Conroy L., Watt K., Crosier W.J.et al. Cell. 65:1991;1033-1042.
33. Rubinfeld B., Crosier W.J., Albert I., Conroy L., Clark R., McCormack F.et al. Mol. Cell Biol. 12:1992;4634-4642.
34. Maheshwar M.M., Cheadle J.P., Jones A.C., Myring J., Fryer A.E., Harris P.C.et al. Hum. Mol. Genet. 6:1997;1991-1996.
35. Manning B.D., Tee A.R., Longdon M.N., Blenis J., Cantley L.C. Mol. Cell. 10:2002;151-162.
36. Dan H.C., Sun M., Yang L., Feldman R.I., Sui X.-M., Yeung R.S.et al. J. Biol. Chem. 2002;277.
37. Inoki K., Li Y., Zhu T., Wu J., Guan K.L. Nat. Cell Biol. 4:2002;648-657.
38. Potter C.J., Pedraza L.G., Xu T. Nat. Cell Biol. 4:2002;658-665.
39. Liu M.Y., Cai S., Espejo A., Bedford M.T., Walker C.L. Cancer Res. 62:2002;6475-6480.
40. Nellist M., Goedbloed M.A., de Winter C., Verhaaf B., Jankie A., Reuser A.J.J.et al. J. Biol. Chem. 2002;39417-39424.
41. Li Y., Inoki K., Yeung R., Guan K.-L. J. Biol. Chem. 277:2002;44593-44596.
42. Olsson P.G., Schofield J.N., Edwards Y.H., Frischaut A.M. Mamm. Genome. 7:1996;212-215.
43. Aicher L.D., Campbell J.S., Yeung R.S. J. Biol. Chem. 276:2001;21017-21021.
44. Tsuchiya H., Orimoto K., Kobayashi K., Hino O. Cancer Res. 56:1996;429-433.
45. Lou D., Griffith N., Noonan D. Mol. Cell Biol. Res. Commun. 4:2001;374-380.
46. Henry K.W., Yuan X., Koszewski N.J., Onda H., Kwiatkowski D.J., Noonan D.J. J. Biol. Chem. 273:1998;20535-20539.
47. Noonan D.J., Lou D., Griffith N., Vanaman T.C. Arch. Biochem. Biophys. 398:2002;132-140.
48. Matsumoto S., Bandyopadhyay A., Kwiatkowski D.J., Maitra U., Matsumoto T. Genetics. 161:2002;1053-1063.
49. Ito M., Rubin G.M. Cell. 96:1999;529-539.
50. Yeung R., Xiao G., Jin F., Lee W., Testa J., Knudson A. Proc. Natl. Acad. Sci. U. S. A. 91:1994;11413-11416.
51. Kobayashi S., Okumura T., Okada M., Hirai H., Nagai K. J. Biol. Chem. 272:1997;16262-16267.
52. Xu L., Sterner C., Maheshwar M.M., Wilson P.J., Nellist M., Short P.M.et al. Genomics. 27:1995;475-480.
53. Kim K.K., Pajak L., Wang H., Field L.J. Cel. Mol. Biol. Res. 41:1995;515-526.
54. Fukuda T., Kobayashi T., Momose S., Yasui H., Hino O. Lab. Invest. 80:2000;1347-1359.
55. Johnson M.W., Emelin J.K., Park S.H., Vinters H.V. Brain Pathol. 9:1999;45-54.
56. Murthy V., Haddad L.A., Smith N., Pinney D., Tyszkowski R., Brown D.et al. Am. J. Physiol., Renal Physiol. 278:2000;F737-F746.
57. Mizuguchi M., Ikeda K., Takashima S. Acta Neuropathol. 99:2000;503-510.
58. Catania M.G., Johnson M.W., Liau L.M., Kremen T.J., deVellis J.S., Vinters H.V. J. Neurosci. Res. 63:2001;276-283.
59. Johnson M.W., Kerfoot C., Bushnell T., Li M., Vinters H.V. Mod. Path. 14:2001;202-210.
60. Murthy V., Stemmer-Rachaminov A.O., Haddad L.A., Roy J.E., Cutone A.N., Beauchamp R.L.et al. Acta Neuropathol. 101:2001;202-210.
61. Nellist M., van Slegtenhorst M.A., Goedbloed M., van den Ouweland A.M.W., Halley D.J.J., van der Sluijs P. J. Biol. Chem. 274:1999;35647-35652.
62. Yamamoto Y., Jones K.A., Mak B.C., Muehlenbachs A., Yeung R.S. Arch. Biochem. Biophys. 404:2002;210-217.
63. Plank T.L., Yeung R.S., Henske E.P. Cancer Res. 58:1998;4766-4770.
64. Hodges A.K., Li S., Maynard J., Parry L., Braverman R., Cheadle J.P.et al. Hum. Mol. Genet. 10:2001;2899-2905.
65. van Slegtenhorst M.A., Nellist M., Nagelkerken B., Cheadle J.P., Snell R.G., van der Ouweland A.M.W.et al. Hum. Mol. Genet. 7:1998;1053-1057.
66. Benvenuto G., Li S., Brown S.J., Braverman R., Vass W.C., Cheadle J.P.et al. Oncogene. 19:2000;6306-6316.
67. Nellist M., Verhaaf B., Goedbloed M.A., Reuser A.J.J., van der Ouweland A.M.W., Halley D.J.J. Hum. Mol. Genet. 10:2001;2889-2898.
68. McManus E.J., Alessi D.R. Nat. Cell Biol. 4:2002;E214-E216.
69. Gutmann D.H., Zhang Y., Hasbani M.J., Goldberg M.P., Plank T.L., Henske E.P. Acta Neuropathol. 99:2000;223-230.
70. Miloloza A., Kubista M., Rosner M., Hengstschlager M. J. Neuropathol. Exp. Neurol. 61:2002;154-163.
71. Goncharova E.A., Goncharov D.A., Eszterhas A., Hunter D.S., Glassberg M.K., Yeung R.S.et al. J. Biol. Chem. 277:2002;30958-30967.
72. Jaeschke A., Hartkamp J., Saitoh M., Roworth W., Nobukuni T., Hodges A.et al. J. Cell Biol. 159:2002;217-224.
73. Gingras A.C., Raught B., Sonenberg N. Annu. Rev. Biochem. 68:1999;913-963.
74. Schmelzle T., Hall M.N. Cell. 103:2000;253-262.
75. Volarevic S., Thomas G. Prog. Nucleic Acid Res. Mol. Biol. 65:2001;101-127.
76. Volarevic S., Steward M.J., Lefderman B., Zilberman F., Terracciano L., Montini E.et al. Science. 288:2000;2045-2047.
77. Price D.J., Grove J.R., Calvo V., Avruch J., Bierer B.E. Science. 257:1992;973-977.
78. Brown E.J., Albers M.W., Shin T.B., Ichikawa K., Keith C.T., Lane W.S.et al. Nature. 369:1994;756-758.
79. Sabatini D.M., Erjument-Bromage H., Lui M., Tempst P., Snyder S.H. Cell. 78:1994;35-43.
80. Tapon N., Ito N., Dickson B.J., Treisman J.E., Hariharan I.K. Cell. 105:2001;345-355.
81. Wienkove D., Neufeld T., Twardzik T., Waterfield M., Leevers S. Curr. Biol. 9:1999;1019-1029.
82. Verdu J., Buratovich M.A., Wilder E.L., Birnbaum M.J. Nat. Cell Biol. 1:1999;500-506.
83. Montagne J., Stewart M.J., Stocker H., Hafen E., Kozma S.C., Thomas G. Science. 285:1999;2126-2129.
84. Goberdhan D.C.I., Paricio N., Goodman E.C., Mlodzik M., Wilson C. Gene Dev. 13:1999;3244-3258.
85. Kenerson H.L., Aicher L.D., True L.D., Yeung R.S. Cancer Res. 62:2002;5645-5650.
86. Tee A.R., Fingar D.C., Manning B.D., Kwiatkowski D.J., Cantley L.C., Blenis J. Proc. Natl. Acad. Sci. U. S. A. 2002;202476899.
87. Dufner A., Thomas G. Exp. Cell Res. 253:1999;100-109.
88. Proud C.G. Trends Biochem. Sci. 21:1996;181-185.
89. Maeshima Y., Sudhakar A., Lively J.C., Ueki K., Kharbanda S., Kahn C.R.et al. Science. 295:2002;140-143.
90. Dennis P.B., Jaeschke A., Saitoh M., Fowler B., Kozma S.C., Thomas G. Science. 294:2001;1102-1105.
91. Raught B., Gingras A.-C., Sonenberg N. Proc. Natl. Acad. Sci. U. S. A. 98:2001;7037-7044.
92. Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S.et al. Cell. 110:2002;177-189.
93. Kim D.H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H.et al. Cell. 110:2002;163-175.
94. Nave B.T., Ouwens D.M., Withers D.J., Alessi D.R., Shepherd P.R. Biochem. J. 344:1999;427-431.
95. Peterson R.T., Desai B.N., Hardwick J.S., Schreiber S.L. Proc. Natl. Acad. Sci. U. S. A. 96:1999;4438-4442.
96. Westphal R.S., Coffee R.L. Jr., Marotta A., Pelech S.L., Wadzinski B.E. J. Biol. Chem. 274:1999;687-692.
97. Dennis P.B., Pullen N., Kozma S.C., Thomas J.W. Mol. Cell Biol. 16:1996;6241-6242.
98. Ballou L.M., Jeno P., Thomas J.W. J. Biol. Chem. 263:1988;1188-1194.
99. Mills G.B., Lu Y., Kohn E.C. Proc. Natl. Acad. Sci. U. S. A. 98:2001;10031-10033.
100. Di Cristofano A., Pandolfi P.P. Cell. 100:2000;387-390.
101. Tzivion G., Avruch J. J. Biol. Chem. 277:2002;3061-3064.
102. Yaffe M.B., Leparc G.G., Lai J., Obata T., Volinia S., Cantley L.C. Nat. Biotechnol. 19:2001;348-353.
103. Olashaw N., Pledger W.J. Science's STKE. 134:2002;re7.
104. Miloloza A., Rosner M., Nellist M., Halley D., Bernaschek G., Hengstschlager M. Hum. Mol. Genet. 9:2000;1721-1727.
105. Pasumarthi K.B.S., Nakajima H., Nakajima H.O., Jing S., Field L.J. Circ. Res. 86:2000;1069-1077.
106. Soucek T., Yeung R.S., Hengstschlager M. Proc. Natl. Acad. Sci. U. S. A. 95:1998;15653-15658.
107. Catania M.G., Mischel P.S., Vinters H.V. J. Neuropathol. Exp. Neurol. 60:2001;711-723.
108. Wataya-Kaneda M., Kaneda Y., Hino O., Adachi H., Hirayama Y., Seyama K.et al. Arch. Dermatol. Res. 293:2001;460-469.
109. Uhlmann E.J., Apicelli A.J., Baldwin R.L., Burke S.P., Bajenaru M.L., Onda H.et al. Oncogene. 21:2002;4050-4059.
110. Wienecke R., Konig A., DeClue J.E. J. Biol. Chem. 270:1995;16409-16414.
111. Xiao G.H., Shoarinejad F., Jin F., Golemis E.A., Yeung R.S. J. Biol. Chem. 272:1997;6097-6100.
112. Xiao G.-H., Jeffers M., Bellacosa A., Mitsuuchi Y., Vande Woude G.F., Testa J.R. Proc. Natl. Acad. Sci. U. S. A. 98:2001;247-252.
113. Khare L., Strizheva G.D., Bailey J.N., Au K.S., Northrup H., Smith M.et al. J. Med. Genet. 38:2001;347-349.
114. Jin F., Wienecke R., Guang-Hui X., Maize J.C., DeClue J.E., Yeung R.S. Proc. Natl. Acad. Sci. U. S. A. 93:1996;9154-9159.
115. Urakami S., Tsuchiya H., Orimoto K., Kobayashi K., Igawa M., Hino O. Biochem. Biophys. Res. Commun. 241:1997;24-30.
116. Orimoto K., Tsuchiya H., Sakurai J., Nishizawa M., Hino O. Biochem. Biophys. Res. Commun. 247:1998;728-733.
117. Kleymenova E., Ibragimov-Beskrovnaya O., Kugoh H., Everitt J., Xu H., Kiguchi K.et al. Mol. Cell. 7:2001;823-832.
118. Brook-Carter P.T., Peral B., Ward C.J., Thompson P., Hughes J., Maheshwar M.M.et al. Nat. Genet. 8:1994;328-332.
119. Ibraghimov-Beskrovnaya O., Bukanov N.O., Donohue L.C., Dackowski W.R., Klinger K.W., Landes G.M. Hum. Mol. Genet. 9:2000;1641-1649.
120. Hanaoka K., Qian F., Boletta A., Bhunia A.K., Piontek K., Tsiokas L.et al. Nature. 408:2002;990-994.
121. Huan Y., van Adelsberg J. J. Clin. Invest. 104:1999;1459-1468.
122. Kim E., Arnould T., Sellin L.K., Benzing T., Fan M.J., Gruning W.et al. J. Biol. Chem. 274:1999;4947-4953.
123. Yu J., Astrinidis A., Henske E.P. Am. J. Respir. Crit. Care Med. 164:2001;1537-1540.
124. Karbowniczek M., Astrindis A., Balsara B.R., Testa J.R., Lium J.H., Colby T.V.et al. Am. J. Respir. Crit. Care Med. 2002;200208-200969OC. [Published On Line].
125. Irani C., Goncharova E., Hunter D., Walker C.L., Panettieri R.A., Krymskaya V.P. Am. J. Physiol. 282:2001;L854-L862.
126. Astrindis A., Cash T.P., Hunter D.S., Walker C.L., Chernoff J., Henske E.P. Oncogene. 21:2002;8470-8476.
127. Bretscher A., Edwards K., Fehon R.G. Nat. Rev., Mol. Cell Biol. 3:2002;586-599.