Using Isoform-Specific Inhibitors to Target Lipid Kinases

Cell

Volumn 125, Issue 4, 2006, Pages 647-649

  Simon, Julian A ^a  

^a Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ATM PROTEIN; ATR PROTEIN; DNA DEPENDENT PROTEIN KINASE; INSULIN; ISOENZYME; KU 55933; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PI 103; PIK 108; PIK 39; PIK 90; PIK 93; PROTEIN KINASE B; PROTEIN P110; TGX 286; UNCLASSIFIED DRUG; WORTMANNIN;

CANCER GROWTH; CELL GROWTH; CELL SURVIVAL; DIABETES MELLITUS; DRUG BINDING; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE DELETION; GENE DISRUPTION; GENE MUTATION; GENE SEQUENCE; GENE SILENCING; GLIOMA; GLUCOSE INTOLERANCE; HUMAN; IC 50; KNOCKOUT GENE; NONHUMAN; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RNA INTERFERENCE; SHORT SURVEY;

MAMMALIA;

EID: 33646687962     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2006.05.008     Document Type: Short Survey

References (10)

1. Brachmann S.M., Ueki K., Engelman J.A., Kahn R.C., and Cantley L.C. Mol. Cell. Biol. 25 (2005) 1596-1607
2. Cully M., You H., Levine A.J., and Mak T.W. Nat. Rev. Cancer 6 (2006) 184-192
3. Fan Q.-W., Knight Z.A., Goldenberg D.D., Yu W., Mostov K.E., Stokoe D., Shokat K.M., and Weiss W.A. Cancer Cell 9 (2006) 341-349
4. Foukas L.C., Claret M., Pearce W., Okkenhaug K., Meek S., Peskett E., Sancho S., Smith A.J., Withers D.J., and Vanhaesebroeck B. Nature (2006) 10.1038/nature04694 Published online April 12, 2006
5. Hennessy B.T., Smith D.L., Ram P.T., Lu Y., and Mills G.B. Nat. Rev. Drug Discov. 4 (2005) 988-1004
6. Knight Z.A., Gonzalez B., Feldman M.E., Zunder E.R., Goldenberg D.D., Williams O., Loewith R., Stokoe D., Balla A., Toth B., et al. Cell (2006) 10.1016/j.cell.2006.03.035 this issue. Published online April 27, 2006
7. Lindsay M.A. Nat. Rev. Drug Discov. 2 (2003) 831-838
8. Patrucco E., Notte A., Barberis L., Selvetella G., Maffei A., Brancaccio M., Marengo S., Russo G., Azzolino O., Rybalkin S.D., et al. Cell 118 (2004) 375-387
9. Vanhaesebroeck B., Ali K., Bilancio A., Geering B., and Foukas L.C. Trends Biochem. Sci. 30 (2005) 194-204
10. White M.F. Science 302 (2003) 1710-1711