메뉴 건너뛰기




Volumn 20, Issue 1, 2006, Pages 23-29

Efficacy and safety of memantine in moderate-to-severe Alzheimer disease: The evidence to date

Author keywords

Alzheimer disease; Caregiver burden; Costs; Efficacy; Institutionalization; Memantine; Safety

Indexed keywords

CHOLINESTERASE INHIBITOR; DONEPEZIL; GALANTAMINE; MEMANTINE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; RIVASTIGMINE; TACRINE; AMINO ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NOOTROPIC AGENT;

EID: 33745661717     PISSN: 08930341     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.wad.0000201847.29836.a5     Document Type: Review
Times cited : (78)

References (55)
  • 1
    • 0141594927 scopus 로고    scopus 로고
    • Realistic expectations: The management of severe Alzheimer disease
    • Bullock R, Hammond G. Realistic expectations: the management of severe Alzheimer disease. Alzheimer Dis Assoc Disord. 2003;17:S80-S85.
    • (2003) Alzheimer Dis Assoc Disord , vol.17
    • Bullock, R.1    Hammond, G.2
  • 2
    • 0037738829 scopus 로고    scopus 로고
    • Medical management of advanced dementia
    • Tariot PN. Medical management of advanced dementia. J Am Geriatr Soc. 2003;51:S305-S313.
    • (2003) J Am Geriatr Soc , vol.51
    • Tariot, P.N.1
  • 3
    • 0344896762 scopus 로고    scopus 로고
    • Number of dementia sufferers in Europe between the years 2000 and 2050
    • Wancata J, Musalek M, Alexandrowicz R, et al. Number of dementia sufferers in Europe between the years 2000 and 2050. Eur Psychiatry. 2003;18:306-313.
    • (2003) Eur Psychiatry , vol.18 , pp. 306-313
    • Wancata, J.1    Musalek, M.2    Alexandrowicz, R.3
  • 4
    • 0037042299 scopus 로고    scopus 로고
    • Alzheimer disease
    • Cummings JL, Cole G. Alzheimer disease. JAMA. 2002;287:2335-2338.
    • (2002) JAMA , vol.287 , pp. 2335-2338
    • Cummings, J.L.1    Cole, G.2
  • 5
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol. 2003;60:1119-1122.
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3
  • 6
    • 0002432482 scopus 로고    scopus 로고
    • Epidemiology of Alzheimer's disease
    • Wimo A, Jonsson B, Karlsson G, Winblad B, eds. Chichester, UK: John Wiley & Sons Ltd
    • Fratiglioni L. Epidemiology of Alzheimer's disease. In: Wimo A, Jonsson B, Karlsson G, Winblad B, eds. Health Economics of Dementia. Chichester, UK: John Wiley & Sons Ltd; 1998:13-31.
    • (1998) Health Economics of Dementia , pp. 13-31
    • Fratiglioni, L.1
  • 8
    • 0034071327 scopus 로고    scopus 로고
    • Patterns of care in the early stages of Alzheimer's disease: Impediments to timely diagnosis
    • Knopman D, Donohue JA, Gutterman EM. Patterns of care in the early stages of Alzheimer's disease: Impediments to timely diagnosis. J Am Geriatr Soc. 2000;48:300-304.
    • (2000) J Am Geriatr Soc , vol.48 , pp. 300-304
    • Knopman, D.1    Donohue, J.A.2    Gutterman, E.M.3
  • 9
    • 0023297731 scopus 로고
    • Institutionalisation of Alzheimer's disease patients: Reducing precipitating factors through family counselling
    • Ferris SH, Steinberg G, Shulman E, et al. Institutionalisation of Alzheimer's disease patients: reducing precipitating factors through family counselling. Home Health Care Serv Q. 1987;8:23-51.
    • (1987) Home Health Care Serv Q , vol.8 , pp. 23-51
    • Ferris, S.H.1    Steinberg, G.2    Shulman, E.3
  • 10
    • 2942535826 scopus 로고    scopus 로고
    • The needs of the caregiver in the long-term treatment of Alzheimer disease
    • Bullock R. The needs of the caregiver in the long-term treatment of Alzheimer disease. Alzheimer Dis Assoc Disord. 2004;18:S17-S23.
    • (2004) Alzheimer Dis Assoc Disord , vol.18
    • Bullock, R.1
  • 11
    • 0036046441 scopus 로고    scopus 로고
    • Clinical features and assessment of severe dementia. A review
    • Boller F, Verny M, Hugonot-Diener L, et al. Clinical features and assessment of severe dementia. A review. Eur J Neurol. 2002;9:125-136.
    • (2002) Eur J Neurol , vol.9 , pp. 125-136
    • Boller, F.1    Verny, M.2    Hugonot-Diener, L.3
  • 12
    • 0028903786 scopus 로고
    • Survival in institutionalized patients. Influence of dementia and loss of functional capacities
    • Hebert M, Parlato V, Lese GB, et al. Survival in institutionalized patients. Influence of dementia and loss of functional capacities. Arch Neurol. 1995;52:469-476.
    • (1995) Arch Neurol , vol.52 , pp. 469-476
    • Hebert, M.1    Parlato, V.2    Lese, G.B.3
  • 13
    • 0030630746 scopus 로고    scopus 로고
    • Activities of daily living as an outcome measure in clinical trials of dementia drugs
    • Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines
    • Gauthier S, Bodick N, Erzigkeit E, et al. Activities of daily living as an outcome measure in clinical trials of dementia drugs. Position paper from the International Working Group on Harmonization of Dementia Drug Guidelines. Alzheimer Dis Assoc Disord. 1997;11(Suppl 3):6-7.
    • (1997) Alzheimer Dis Assoc Disord , vol.11 , Issue.3 SUPPL. , pp. 6-7
    • Gauthier, S.1    Bodick, N.2    Erzigkeit, E.3
  • 14
    • 3242669518 scopus 로고    scopus 로고
    • What are the treatment options for patients with severe Alzheimer's disease?
    • Voisin T, Reynish E, Portet F, et al. What are the treatment options for patients with severe Alzheimer's disease? CNS Drugs. 2004;18:575-583.
    • (2004) CNS Drugs , vol.18 , pp. 575-583
    • Voisin, T.1    Reynish, E.2    Portet, F.3
  • 15
    • 0037387097 scopus 로고    scopus 로고
    • Cost of illness of Alzheimer's disease: How useful are current estimates?
    • Bloom BS, de Pouvourville N, Straus WL. Cost of illness of Alzheimer's disease: how useful are current estimates? Gerontologist. 2003;43:158-164.
    • (2003) Gerontologist , vol.43 , pp. 158-164
    • Bloom, B.S.1    De Pouvourville, N.2    Straus, W.L.3
  • 16
    • 0035679752 scopus 로고    scopus 로고
    • Alzheimer's disease in the UK: Comparative evidence on cost of illness and volume of health services research funding
    • Lowin A, Knapp M, McCrone P. Alzheimer's disease in the UK: comparative evidence on cost of illness and volume of health services research funding. Int J Geriatr Psychiatry. 2001;16:1143-1148.
    • (2001) Int J Geriatr Psychiatry , vol.16 , pp. 1143-1148
    • Lowin, A.1    Knapp, M.2    McCrone, P.3
  • 17
    • 0012785955 scopus 로고    scopus 로고
    • Health economic aspects of Alzheimer's disease and its treatment
    • Wimo A, Winblad B. Health economic aspects of Alzheimer's disease and its treatment. Psychogeriatrics. 2001;3:189-193.
    • (2001) Psychogeriatrics , vol.3 , pp. 189-193
    • Wimo, A.1    Winblad, B.2
  • 18
    • 3242710619 scopus 로고    scopus 로고
    • A dependency model for patients with Alzheimer's disease: Its validation and relationship to the costs of care - The LASER-AD Study
    • Livingston G, Katona C, Roch B, et al. A dependency model for patients with Alzheimer's disease: its validation and relationship to the costs of care - the LASER-AD Study. Curr Med Res Opin. 2004;S7:1007-1016.
    • (2004) Curr Med Res Opin , vol.S7 , pp. 1007-1016
    • Livingston, G.1    Katona, C.2    Roch, B.3
  • 19
    • 0345411353 scopus 로고    scopus 로고
    • The stress and psychological morbidity of the Alzheimer patient caregiver
    • Gonzalez-Salvador MT, Arango C, Lyketsos CG, et al. The stress and psychological morbidity of the Alzheimer patient caregiver. Int J Geriatr Psychiatry. 1999;14:701-710.
    • (1999) Int J Geriatr Psychiatry , vol.14 , pp. 701-710
    • Gonzalez-Salvador, M.T.1    Arango, C.2    Lyketsos, C.G.3
  • 20
    • 0033192597 scopus 로고    scopus 로고
    • Emotional and physical health of spouse caregivers of persons with Alzheimer's disease and stroke
    • Wright LK, Hickey JV, Buckwalter KC, et al. Emotional and physical health of spouse caregivers of persons with Alzheimer's disease and stroke. J Adv Nurs. 1999;30:552-563.
    • (1999) J Adv Nurs , vol.30 , pp. 552-563
    • Wright, L.K.1    Hickey, J.V.2    Buckwalter, K.C.3
  • 21
    • 0032973081 scopus 로고    scopus 로고
    • The social consequences for families with Alzheimer's disease patients: Potential impact of new drug treatment
    • Wimo A, Winblad B, Grafstrom M. The social consequences for families with Alzheimer's disease patients: potential impact of new drug treatment. Int J Geriatr Psychiatry. 1999;14:338-347.
    • (1999) Int J Geriatr Psychiatry , vol.14 , pp. 338-347
    • Wimo, A.1    Winblad, B.2    Grafstrom, M.3
  • 22
    • 3042735566 scopus 로고    scopus 로고
    • What causes problems in Alzheimer's disease: Attributions by caregivers. A qualitative study
    • Paton J, Johnston K, Katona C, et al. What causes problems in Alzheimer's disease: attributions by caregivers. A qualitative study. Int J Geriatr Psychiatry. 2004;19:1-6.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 1-6
    • Paton, J.1    Johnston, K.2    Katona, C.3
  • 23
    • 0032910197 scopus 로고    scopus 로고
    • The cholinergic hypothesis of Alzheimer's disease: A review of progress
    • Francis PT, Palmer AM, Snape M, et al. The cholinergic hypothesis of Alzheimer's disease: a review of progress. J Neurol Neurosurg Psychiatry. 1999;66:137-147.
    • (1999) J Neurol Neurosurg Psychiatry , vol.66 , pp. 137-147
    • Francis, P.T.1    Palmer, A.M.2    Snape, M.3
  • 24
    • 0033806044 scopus 로고    scopus 로고
    • NMDA channel blockers: Memantine and amino-aklylcyclohexanes-in vivo characterization
    • Danysz W, Parsons CG, Quack G. NMDA channel blockers: memantine and amino-aklylcyclohexanes-in vivo characterization. Amino Acids. 2000;19:167-172.
    • (2000) Amino Acids , vol.19 , pp. 167-172
    • Danysz, W.1    Parsons, C.G.2    Quack, G.3
  • 25
    • 3042725543 scopus 로고    scopus 로고
    • NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease
    • Farlow MR. NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease. Geriatrics. 2004;59:22-27.
    • (2004) Geriatrics , vol.59 , pp. 22-27
    • Farlow, M.R.1
  • 27
    • 0141483376 scopus 로고    scopus 로고
    • Current treatment for Alzheimer disease and future prospects
    • Tariot PN, Federoff HJ. Current treatment for Alzheimer disease and future prospects. Alzheimer Dis Assoc Disord. 2003;17:S105-S113.
    • (2003) Alzheimer Dis Assoc Disord , vol.17
    • Tariot, P.N.1    Federoff, H.J.2
  • 28
    • 0028762647 scopus 로고
    • Excitatory amino acids as a final common pathway for neurologic disorders
    • Lipton SA, Rosenberg PA. Excitatory amino acids as a final common pathway for neurologic disorders. N Engl J Med. 1994;330:613-622.
    • (1994) N Engl J Med , vol.330 , pp. 613-622
    • Lipton, S.A.1    Rosenberg, P.A.2
  • 29
    • 0032892343 scopus 로고    scopus 로고
    • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist: A review of preclinical data
    • Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist: a review of preclinical data. Neuropharmacology. 1999;38:735-767.
    • (1999) Neuropharmacology , vol.38 , pp. 735-767
    • Parsons, C.G.1    Danysz, W.2    Quack, G.3
  • 30
    • 0012527706 scopus 로고    scopus 로고
    • Drugs in development and experimental approaches
    • Qizilbashi SL, Chui H, Tariot P, et al., eds. London: Blackwell
    • Emre M. Drugs in development and experimental approaches. In: Qizilbashi SL, Chui H, Tariot P, et al., eds. Evidence-Based Dementia Practice. London: Blackwell; 2002:447-457.
    • (2002) Evidence-Based Dementia Practice , pp. 447-457
    • Emre, M.1
  • 31
    • 0030497661 scopus 로고    scopus 로고
    • Apparent independent action of nimodipine and glutamate antagonists to protect cultured neurons against glutamate-induced damage
    • Krieglstein J, Lippert K, Poch G. Apparent independent action of nimodipine and glutamate antagonists to protect cultured neurons against glutamate-induced damage. Neuropharmacology. 1996;35:1737-1742.
    • (1996) Neuropharmacology , vol.35 , pp. 1737-1742
    • Krieglstein, J.1    Lippert, K.2    Poch, G.3
  • 32
    • 2442465965 scopus 로고    scopus 로고
    • Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration
    • Li L, Sengupta A, Haque N, et al. Memantine inhibits and reverses the Alzheimer type abnormal hyperphosphorylation of tau and associated neurodegeneration. FEBS Lett. 2004;566:261-269.
    • (2004) FEBS Lett , vol.566 , pp. 261-269
    • Li, L.1    Sengupta, A.2    Haque, N.3
  • 33
    • 0035964226 scopus 로고    scopus 로고
    • A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease
    • Feldman H, Gauthier S, Hecker J, et al. A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease. Neurology. 2001;57:613-620.
    • (2001) Neurology , vol.57 , pp. 613-620
    • Feldman, H.1    Gauthier, S.2    Hecker, J.3
  • 34
    • 7644237621 scopus 로고    scopus 로고
    • Long-term effects of rivastigmine treatment on neuropsychiatric and behavioral disturbances in nursing home residents with moderate to severe Alzheimer's disease: Results of a 52-week open-label study
    • Aupperle PM, Koumaras B, Chen M, et al. Long-term effects of rivastigmine treatment on neuropsychiatric and behavioral disturbances in nursing home residents with moderate to severe Alzheimer's disease: results of a 52-week open-label study. Curr Med Res Opin. 2004;20:1605-1612.
    • (2004) Curr Med Res Opin , vol.20 , pp. 1605-1612
    • Aupperle, P.M.1    Koumaras, B.2    Chen, M.3
  • 35
    • 0037417238 scopus 로고    scopus 로고
    • Memantine in moderate-to-severe Alzheimer's disease
    • Reisberg B, Doody R, Stoffler A, et al. Memantine in moderate-to-severe Alzheimer's disease. N Engl J Med. 2003;348:1333-1341.
    • (2003) N Engl J Med , vol.348 , pp. 1333-1341
    • Reisberg, B.1    Doody, R.2    Stoffler, A.3
  • 36
    • 0345872128 scopus 로고    scopus 로고
    • Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: A randomized controlled trial
    • Tariot PN, Farlow MR, Grossberg GT, et al. Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 2004;291:317-324.
    • (2004) JAMA , vol.291 , pp. 317-324
    • Tariot, P.N.1    Farlow, M.R.2    Grossberg, G.T.3
  • 37
    • 0032983786 scopus 로고    scopus 로고
    • Memantine in severe dementia: Results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine)
    • Winblad B, Poritis N. Memantine in severe dementia: results of the 9M-Best Study (Benefit and efficacy in severely demented patients during treatment with memantine). Int J Geriatr Psychiatry. 1999;14:135-146.
    • (1999) Int J Geriatr Psychiatry , vol.14 , pp. 135-146
    • Winblad, B.1    Poritis, N.2
  • 38
    • 0141644654 scopus 로고    scopus 로고
    • Long-term treatment with the NMDA antagonist, memantine: Results of a 24-week, open-label extension study in advanced Alzheimer's disease
    • Ferris SH, Schmidt F, Doody R, et al. Long-term treatment with the NMDA antagonist, memantine: results of a 24-week, open-label extension study in advanced Alzheimer's disease [abstract]. Neurology. 2003;60(suppl 1):A414.
    • (2003) Neurology , vol.60 , Issue.1 SUPPL.
    • Ferris, S.H.1    Schmidt, F.2    Doody, R.3
  • 39
    • 5744242292 scopus 로고    scopus 로고
    • The place of memantine in the treatment of Alzheimer's disease: A number needed to treat analysis
    • Livingston G, Katona C. The place of memantine in the treatment of Alzheimer's disease: a number needed to treat analysis. Int J Geriatr Psychiatry. 2004;19:919-925.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 919-925
    • Livingston, G.1    Katona, C.2
  • 44
    • 0034027804 scopus 로고    scopus 로고
    • How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis
    • Livingston G, Katona C. How useful are cholinesterase inhibitors in the treatment of Alzheimer's disease? A number needed to treat analysis. Int J Geriatr Psychiatry. 2000;15:203-207.
    • (2000) Int J Geriatr Psychiatry , vol.15 , pp. 203-207
    • Livingston, G.1    Katona, C.2
  • 45
    • 0141763668 scopus 로고    scopus 로고
    • Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: A meta-analysis
    • Lanctôt KL, Herrmann N, Yau KK, et al. Efficacy and safety of cholinesterase inhibitors in Alzheimer's disease: a meta-analysis. Can Med Assoc J. 2003;169:557-564.
    • (2003) Can Med Assoc J , vol.169 , pp. 557-564
    • Lanctôt, K.L.1    Herrmann, N.2    Yau, K.K.3
  • 46
    • 4344660060 scopus 로고    scopus 로고
    • Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer's disease
    • Doody R, Wirth Y, Schmitt F, et al. Specific functional effects of memantine treatment in patients with moderate to severe Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;18:227-232.
    • (2004) Dement Geriatr Cogn Disord , vol.18 , pp. 227-232
    • Doody, R.1    Wirth, Y.2    Schmitt, F.3
  • 47
    • 0037247048 scopus 로고    scopus 로고
    • Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease
    • Wimo A, Winblad B, Stoffler A, et al. Resource utilisation and cost analysis of memantine in patients with moderate to severe Alzheimer's disease. Pharmacoeconomics. 2003;21:327-340.
    • (2003) Pharmacoeconomics , vol.21 , pp. 327-340
    • Wimo, A.1    Winblad, B.2    Stoffler, A.3
  • 48
    • 2542582291 scopus 로고    scopus 로고
    • Memantine enhances autonomy in moderate to severe Alzheimer's disease
    • Rive B, Vercelletto M, Damier F, et al. Memantine enhances autonomy in moderate to severe Alzheimer's disease. Int J Geriatr Psychiatry. 2004;19:1-7.
    • (2004) Int J Geriatr Psychiatry , vol.19 , pp. 1-7
    • Rive, B.1    Vercelletto, M.2    Damier, F.3
  • 49
    • 0037425565 scopus 로고    scopus 로고
    • Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: A meta-analysis
    • Trinh NH, Hoblyn J, Mohanty S, et al. Efficacy of cholinesterase inhibitors in the treatment of neuropsychiatric symptoms and functional impairment in Alzheimer disease: a meta-analysis. JAMA. 2003;289:210-216.
    • (2003) JAMA , vol.289 , pp. 210-216
    • Trinh, N.H.1    Hoblyn, J.2    Mohanty, S.3
  • 50
    • 10744226999 scopus 로고    scopus 로고
    • Role of behavioural disturbance in the loss of autonomy for activities of daily in Alzheimer patients
    • Lechowski L, Dieudonne B, Tortrat D, et al. Role of behavioural disturbance in the loss of autonomy for activities of daily in Alzheimer patients. Int J Geriatr Psychiatry. 2003;18:977-982.
    • (2003) Int J Geriatr Psychiatry , vol.18 , pp. 977-982
    • Lechowski, L.1    Dieudonne, B.2    Tortrat, D.3
  • 51
    • 33748482352 scopus 로고    scopus 로고
    • Effect of memantine on behavioral outcomes in moderate to severe Alzheimer's disease
    • Cummings J, Tariot P, Graham SM, et al. Effect of memantine on behavioral outcomes in moderate to severe Alzheimer's disease. Neurobiol Aging. 2004;25(Suppl 1).
    • (2004) Neurobiol Aging , vol.25 , Issue.1 SUPPL.
    • Cummings, J.1    Tariot, P.2    Graham, S.M.3
  • 52
    • 19144372322 scopus 로고    scopus 로고
    • Effects of memantine on behavioural symptoms in Alzheimer's disease patients: An analysis of the Neuropsychiatric Inventory (NPI) data of two randomised controlled trials
    • Gauthier S, Wirth Y, Mobius HJ. Effects of memantine on behavioural symptoms in Alzheimer's disease patients: an analysis of the Neuropsychiatric Inventory (NPI) data of two randomised controlled trials. Int J Geriatr Psychiatry. 2005;20:459-464.
    • (2005) Int J Geriatr Psychiatry , vol.20 , pp. 459-464
    • Gauthier, S.1    Wirth, Y.2    Mobius, H.J.3
  • 53
    • 0034635589 scopus 로고    scopus 로고
    • No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use
    • Wenk GL, Quack G, Moebius HJ, et al. No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life Sci. 2000;66:1079-1083.
    • (2000) Life Sci , vol.66 , pp. 1079-1083
    • Wenk, G.L.1    Quack, G.2    Moebius, H.J.3
  • 55
    • 3042567016 scopus 로고    scopus 로고
    • Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): Randomised double-blind trial
    • Courtney C, Farrell D, Gray R, et al. Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet. 2004;363:2105-2115.
    • (2004) Lancet , vol.363 , pp. 2105-2115
    • Courtney, C.1    Farrell, D.2    Gray, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.