Glutathione peroxidase overexpression inhibits cytochrome c release and proapoptotic mediators to protect neurons from experimental stroke

Stroke

Volumn 34, Issue 10, 2003, Pages 2489-2494

  Hoehn, B ^a   Yenari, M A ^a   Sapolsky, R M ^a   Steinberg, Gary K ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Cytochrome c; Gene therapy; Glutathione peroxidase; Ischemia; Neuroprotection

Indexed keywords

ANTIOXIDANT; APOPTOSIS INDUCING FACTOR; CASPASE 3; CYTOCHROME C; FREE RADICAL; GLUTATHIONE PEROXIDASE; PROAPOPTOSIS MEDIATOR; PROTEIN BAX; PROTEIN BCL 2; SCAVENGER; SUPEROXIDE; UNCLASSIFIED DRUG; VIRUS VECTOR;

AMPLICON; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NERVE CELL; CELL COUNT; CELL SURVIVAL; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME RELEASE; EXPERIMENTAL MODEL; GENE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; GPX GENE; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; IMMUNOFLUORESCENCE; INTRACELLULAR TRANSPORT; LACZ GENE; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REPERFUSION INJURY; STROKE; VIRAL GENE THERAPY;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASE 3; CASPASES; CELL SURVIVAL; CEREBROVASCULAR ACCIDENT; CORPUS STRIATUM; CYTOCHROME C GROUP; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; GENE THERAPY; GENETIC VECTORS; GLUTATHIONE PEROXIDASE; MALE; NEURONS; NEUROPROTECTIVE AGENTS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; SIMPLEXVIRUS; TIME FACTORS;

EID: 0141642104     PISSN: 00392499     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.STR.0000091268.25816.19     Document Type: Article

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