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Volumn 2, Issue 3, 2005, Pages 484-494

Toxin-induced models of Parkinson's disease

Author keywords

6 hydroxydopamine; Experimental models; MPTP; Neurodegeneration; Paraquat; Parkinson's disease; Pathogenesis; Rotenone

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; NEUROTOXIN; OXIDOPAMINE; PARAQUAT; ROTENONE; TOXIN;

EID: 26844505808     PISSN: 15455343     EISSN: 15455351     Source Type: Journal    
DOI: 10.1602/neurorx.2.3.484     Document Type: Article
Times cited : (611)

References (132)
  • 1
    • 0003148419 scopus 로고    scopus 로고
    • Parkinsonism
    • (Rowland LP, ed), Ed 10. New York: Lippincott Williams & Wilkins
    • Fahn S, Przedborski S. Parkinsonism. In: Merritt's neurology (Rowland LP, ed), Ed 10, pp 679-693. New York: Lippincott Williams & Wilkins, 2000.
    • (2000) Merritt's Neurology , pp. 679-693
    • Fahn, S.1    Przedborski, S.2
  • 2
    • 0141741347 scopus 로고    scopus 로고
    • Parkinson's disease: Mechanisms and models
    • Dauer W, Przedborski S. Parkinson's disease: mechanisms and models. Neuron 39:889-909, 2003.
    • (2003) Neuron , vol.39 , pp. 889-909
    • Dauer, W.1    Przedborski, S.2
  • 5
    • 10244222286 scopus 로고    scopus 로고
    • MPTP as a mitochondrial neurotoxic model of Parkinson's disease
    • Przedborski S, Tieu K, Perier C, Vila M. MPTP as a mitochondrial neurotoxic model of Parkinson's disease. J Bioenerg Biomembr 36:375-379, 2004.
    • (2004) J Bioenerg Biomembr , vol.36 , pp. 375-379
    • Przedborski, S.1    Tieu, K.2    Perier, C.3    Vila, M.4
  • 6
    • 17644413217 scopus 로고    scopus 로고
    • Reactive oxygen and nitrogen species: Weapons of neuronal destruction in models of Parkinson's disease
    • Przedborski S, Ischiropoulos H. Reactive oxygen and nitrogen species: weapons of neuronal destruction in models of Parkinson's disease. Antioxid Redox Signaling 7:685-693, 2005.
    • (2005) Antioxid Redox Signaling , vol.7 , pp. 685-693
    • Przedborski, S.1    Ischiropoulos, H.2
  • 7
    • 0001857180 scopus 로고
    • Chemical lesioning techniques: Monoamine neurotoxins
    • (Björklund A, Hökfelt T, eds), Ed 1, Amsterdam: Elsevier Science Publishers B.V.
    • Jonsson G. Chemical lesioning techniques: monoamine neurotoxins. In: Handbook of chemical neuroanatomy. Methods in chemical neuroanatomy (Björklund A, Hökfelt T, eds), Ed 1, Vol 1, pp 463-507. Amsterdam: Elsevier Science Publishers B.V., 1983.
    • (1983) Handbook of Chemical Neuroanatomy. Methods in Chemical Neuroanatomy , vol.1 , pp. 463-507
    • Jonsson, G.1
  • 8
    • 0028834711 scopus 로고
    • Effects of unilateral 6-hydroxydopamine lesions on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis
    • Reeling TA, Docter GJ, Voorn P, Melchers BP, Wolters EC, Groenewegen HJ. Effects of unilateral 6-hydroxydopamine lesions on neuropeptide immunoreactivity in the basal ganglia of the common marmoset, Callithrix jacchus, a quantitative immunohistochemical analysis. J Chem Neuroanat 9:155-164, 1995.
    • (1995) J Chem Neuroanat , vol.9 , pp. 155-164
    • Reeling, T.A.1    Docter, G.J.2    Voorn, P.3    Melchers, B.P.4    Wolters, E.C.5    Groenewegen, H.J.6
  • 9
    • 0031455188 scopus 로고    scopus 로고
    • Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age
    • Annett LE, Torres EM, Clarke DJ, Ishida Y, Barker RA, Ridley RM, et al. Survival of nigral grafts within the striatum of marmosets with 6-OHDA lesions depends critically on donor embryo age. Cell Transplant 6:557-569, 1997.
    • (1997) Cell Transplant , vol.6 , pp. 557-569
    • Annett, L.E.1    Torres, E.M.2    Clarke, D.J.3    Ishida, Y.4    Barker, R.A.5    Ridley, R.M.6
  • 10
    • 0034763094 scopus 로고    scopus 로고
    • Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set
    • Crofts HS, Dalley JW, Collins P, Van Denderen JC, Everitt BJ, Robbins TW, et al. Differential effects of 6-OHDA lesions of the frontal cortex and caudate nucleus on the ability to acquire an attentional set. Cereb Cortex 11:1015-1026, 2001.
    • (2001) Cereb Cortex , vol.11 , pp. 1015-1026
    • Crofts, H.S.1    Dalley, J.W.2    Collins, P.3    Van Denderen, J.C.4    Everitt, B.J.5    Robbins, T.W.6
  • 11
    • 0035999174 scopus 로고    scopus 로고
    • Dual SPECT of dopamine system using [99mTc]TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys
    • Ma KH, Huang WS, Chen CH, Lin SZ, Wey SP, Ting G, et al. Dual SPECT of dopamine system using [99mTc]TRODAT-1 and [123I]IBZM in normal and 6-OHDA-lesioned formosan rock monkeys. Nucl Med Biol 29:561-567, 2002.
    • (2002) Nucl Med Biol , vol.29 , pp. 561-567
    • Ma, K.H.1    Huang, W.S.2    Chen, C.H.3    Lin, S.Z.4    Wey, S.P.5    Ting, G.6
  • 12
    • 0023918244 scopus 로고
    • Differential effects of 6-hydroxydopamine on the two types of nerve vesicles and dopamine and noradrenaline content in mesenteric arterial vessels
    • Soares-da-Silva P, Azevedo I. Differential effects of 6-hydroxydopamine on the two types of nerve vesicles and dopamine and noradrenaline content in mesenteric arterial vessels. J Auton Pharmacol 8:1-10, 1988.
    • (1988) J Auton Pharmacol , vol.8 , pp. 1-10
    • Soares-Da-Silva, P.1    Azevedo, I.2
  • 13
    • 0028893619 scopus 로고
    • Canine myocardial beta-adrenergic, muscarinic receptor densities after denervation: A PET study
    • Valette H, Deleuze P, Syrota A, Delforge J, Crouzel C, Fuseau C, et al. Canine myocardial beta-adrenergic, muscarinic receptor densities after denervation: a PET study. J Nucl Med 36:140-146, 1995.
    • (1995) J Nucl Med , vol.36 , pp. 140-146
    • Valette, H.1    Deleuze, P.2    Syrota, A.3    Delforge, J.4    Crouzel, C.5    Fuseau, C.6
  • 14
    • 0031055873 scopus 로고    scopus 로고
    • Chemical cardiac sympathetic denervation hampers defibrillation in the dog
    • Ruffy R, Leonard M. Chemical cardiac sympathetic denervation hampers defibrillation in the dog. J Cardiovasc Electrophysiol 8:62-67, 1997.
    • (1997) J Cardiovasc Electrophysiol , vol.8 , pp. 62-67
    • Ruffy, R.1    Leonard, M.2
  • 15
    • 0018851399 scopus 로고
    • Chemical neurotoxins as denervation tools in neurobiology
    • Jonsson G. Chemical neurotoxins as denervation tools in neurobiology. Annu Rev Neurosci 3:169-187, 1980.
    • (1980) Annu Rev Neurosci , vol.3 , pp. 169-187
    • Jonsson, G.1
  • 16
    • 0021165054 scopus 로고
    • Oxy-radical toxicity in catecholamine neurons
    • Cohen G. Oxy-radical toxicity in catecholamine neurons. Neurotoxicology 5:77-82, 1984.
    • (1984) Neurotoxicology , vol.5 , pp. 77-82
    • Cohen, G.1
  • 17
    • 0015020955 scopus 로고
    • Model experiments on the molecular mechanism of action of 6- hydroxydopamine
    • Saner A, Thoenen H. Model experiments on the molecular mechanism of action of 6- hydroxydopamine. Mol Pharmacol 7:147-154, 1971.
    • (1971) Mol Pharmacol , vol.7 , pp. 147-154
    • Saner, A.1    Thoenen, H.2
  • 18
    • 0015231054 scopus 로고
    • Inhibition of biogenic amine uptake by hydrogen peroxide: A mechanism for toxic effects of 6-hydroxydopamine
    • Heikkila R, Cohen G. Inhibition of biogenic amine uptake by hydrogen peroxide: a mechanism for toxic effects of 6-hydroxydopamine. Science 172:1257-1258, 1971.
    • (1971) Science , vol.172 , pp. 1257-1258
    • Heikkila, R.1    Cohen, G.2
  • 19
    • 0021967159 scopus 로고
    • Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in mouse
    • Mandel RJ, Randall PK. Quantification of lesion-induced dopaminergic supersensitivity using the rotational model in mouse. Brain Res 330:358-363, 1985.
    • (1985) Brain Res , vol.330 , pp. 358-363
    • Mandel, R.J.1    Randall, P.K.2
  • 20
    • 0035800589 scopus 로고    scopus 로고
    • Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum
    • He Y, Appel S, Le W. Minocycline inhibits microglial activation and protects nigral cells after 6-hydroxydopamine injection into mouse striatum. Brain Res 909:187-193, 2001.
    • (2001) Brain Res , vol.909 , pp. 187-193
    • He, Y.1    Appel, S.2    Le, W.3
  • 21
    • 2342459797 scopus 로고    scopus 로고
    • A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: Relation to motor and cellular parameters of nigrostriatal function
    • Lundblad M, Picconi B, Lindgren H, Cenci MA. A model of L-DOPA-induced dyskinesia in 6-hydroxydopamine lesioned mice: relation to motor and cellular parameters of nigrostriatal function. Neurobiol Dis 16:110-123, 2004.
    • (2004) Neurobiol Dis , vol.16 , pp. 110-123
    • Lundblad, M.1    Picconi, B.2    Lindgren, H.3    Cenci, M.A.4
  • 22
    • 3242757365 scopus 로고    scopus 로고
    • Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone
    • Baker SA, Baker KA, Hagg T. Dopaminergic nigrostriatal projections regulate neural precursor proliferation in the adult mouse subventricular zone. Eur J Neurosci 20:575-579, 2004.
    • (2004) Eur J Neurosci , vol.20 , pp. 575-579
    • Baker, S.A.1    Baker, K.A.2    Hagg, T.3
  • 23
    • 0015182655 scopus 로고
    • Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system
    • Ungerstedt U. Adipsia and aphagia after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 367:95-122, 1971.
    • (1971) Acta Physiol Scand Suppl , vol.367 , pp. 95-122
    • Ungerstedt, U.1
  • 24
    • 0015422850 scopus 로고
    • Enhancement of audiogenic seizure by 6-hydroxydopamine
    • Bourn WM, Chin L, Picchioni AL. Enhancement of audiogenic seizure by 6-hydroxydopamine. J Pharm Pharmacol 24:913-914, 1972.
    • (1972) J Pharm Pharmacol , vol.24 , pp. 913-914
    • Bourn, W.M.1    Chin, L.2    Picchioni, A.L.3
  • 25
    • 0014376793 scopus 로고
    • 6-Hydroxydopamine induced degeneration of central monoamine neurons
    • Ungerstedt U. 6-Hydroxydopamine induced degeneration of central monoamine neurons. Eur J Pharmacol 5:107-110, 1968.
    • (1968) Eur J Pharmacol , vol.5 , pp. 107-110
    • Ungerstedt, U.1
  • 26
    • 0015164043 scopus 로고
    • Stereotaxic mapping of the monoamine pathways in the rat brain
    • Ungerstedt U. Stereotaxic mapping of the monoamine pathways in the rat brain. Acta Physiol Scand Suppl 367:1-48, 1971.
    • (1971) Acta Physiol Scand Suppl , vol.367 , pp. 1-48
    • Ungerstedt, U.1
  • 27
    • 0017281887 scopus 로고
    • Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system
    • Javoy F, Sotelo C, Herbert A, Agid Y. Specificity of dopaminergic neuronal degeneration induced by intracerebral injection of 6-hydroxydopamine in the nigrostriatal dopamine system. Brain Res 102:210-215, 1976.
    • (1976) Brain Res , vol.102 , pp. 210-215
    • Javoy, F.1    Sotelo, C.2    Herbert, A.3    Agid, Y.4
  • 28
    • 0029018424 scopus 로고
    • 6-Hydroxydopamine lesion of the rat substantia nigra: Time course and morphology of cell death
    • Jeon BS, Jackson-Lewis V, Burke RE. 6-Hydroxydopamine lesion of the rat substantia nigra: time course and morphology of cell death. Neurodegeneration 4:131-137, 1995.
    • (1995) Neurodegeneration , vol.4 , pp. 131-137
    • Jeon, B.S.1    Jackson-Lewis, V.2    Burke, R.E.3
  • 29
    • 0014481719 scopus 로고
    • Changes in dopamine levels in the corpus striatum following lesions in the substantia nigra
    • Faull RL, Laverty R. Changes in dopamine levels in the corpus striatum following lesions in the substantia nigra. Exp Neurol 23:332-340, 1969.
    • (1969) Exp Neurol , vol.23 , pp. 332-340
    • Faull, R.L.1    Laverty, R.2
  • 30
    • 3042845122 scopus 로고    scopus 로고
    • In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats
    • Sarre S, Yuan H, Jonkers N, Van HA, Ebinger G, Michotte Y. In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. J Neurochem 90:29-39, 2004.
    • (2004) J Neurochem , vol.90 , pp. 29-39
    • Sarre, S.1    Yuan, H.2    Jonkers, N.3    Van, H.A.4    Ebinger, G.5    Michotte, Y.6
  • 31
    • 0029015394 scopus 로고
    • Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine
    • Przedborski S, Levivier M, Jiang H, Ferreira M, Jackson-Lewis V, Donaldson D, et al. Dose-dependent lesions of the dopaminergic nigrostriatal pathway induced by intrastriatal injection of 6-hydroxydopamine. Neuroscience 67:631-647, 1995.
    • (1995) Neuroscience , vol.67 , pp. 631-647
    • Przedborski, S.1    Levivier, M.2    Jiang, H.3    Ferreira, M.4    Jackson-Lewis, V.5    Donaldson, D.6
  • 32
    • 0028220834 scopus 로고
    • Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: A combined retrograde tracing and immunocytochemical study in the rat
    • Sauer H, Oertel WH. Progressive degeneration of nigrostriatal dopamine neurons following intrastriatal terminal lesions with 6-hydroxydopamine: a combined retrograde tracing and immunocytochemical study in the rat. Neuroscience 59:401-415, 1994.
    • (1994) Neuroscience , vol.59 , pp. 401-415
    • Sauer, H.1    Oertel, W.H.2
  • 33
    • 0031027178 scopus 로고    scopus 로고
    • Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra
    • Marti MJ, James CJ, Oo TF, Kelly WJ, Burke RE. Early developmental destruction of terminals in the striatal target induces apoptosis in dopamine neurons of the substantia nigra. J Neurosci 17:2030-2039, 1997.
    • (1997) J Neurosci , vol.17 , pp. 2030-2039
    • Marti, M.J.1    James, C.J.2    Oo, T.F.3    Kelly, W.J.4    Burke, R.E.5
  • 34
    • 0022557583 scopus 로고
    • Astrocyte responses to dopaminergic denervations by 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as evidenced by glial fibrillary acidic protein immunohistochemistry
    • Stromberg I, Bjorklund H, Dahl D, Jonsson G, Sundstrom E, Olson L. Astrocyte responses to dopaminergic denervations by 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine as evidenced by glial fibrillary acidic protein immunohistochemistry. Brain Res Bull 17:225-236, 1986.
    • (1986) Brain Res Bull , vol.17 , pp. 225-236
    • Stromberg, I.1    Bjorklund, H.2    Dahl, D.3    Jonsson, G.4    Sundstrom, E.5    Olson, L.6
  • 35
    • 0038335842 scopus 로고    scopus 로고
    • Intranigral infusion of interleukin-1β activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
    • Saura J, Pares M, Bove J, Pezzi S, Alberch J, Marin C, et al. Intranigral infusion of interleukin-1β activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity. J Neurochem 85:651-661, 2003.
    • (2003) J Neurochem , vol.85 , pp. 651-661
    • Saura, J.1    Pares, M.2    Bove, J.3    Pezzi, S.4    Alberch, J.5    Marin, C.6
  • 36
    • 0035077354 scopus 로고    scopus 로고
    • Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: An animal model of Parkinson's disease
    • Rodriguez DM, Abdala P, Barroso-Chinea P, Obeso J, Gonzalez-Hernandez T. Motor behavioural changes after intracerebroventricular injection of 6-hydroxydopamine in the rat: an animal model of Parkinson's disease. Behav Brain Res 122:79-92, 2001.
    • (2001) Behav Brain Res , vol.122 , pp. 79-92
    • Rodriguez, D.M.1    Abdala, P.2    Barroso-Chinea, P.3    Obeso, J.4    Gonzalez-Hernandez, T.5
  • 37
    • 0036637271 scopus 로고    scopus 로고
    • Animal models of neurological deficits: How relevant is the rat?
    • Cenci MA, Whishaw IQ, Schallert T. Animal models of neurological deficits: how relevant is the rat? Nat Rev Neurosci 3:574-579, 2002.
    • (2002) Nat Rev Neurosci , vol.3 , pp. 574-579
    • Cenci, M.A.1    Whishaw, I.Q.2    Schallert, T.3
  • 38
    • 0014954436 scopus 로고
    • Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system
    • Ungerstedt U, Arbuthnott G. Quantitative recording of rotational behaviour in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res 24:485-493, 1970.
    • (1970) Brain Res , vol.24 , pp. 485-493
    • Ungerstedt, U.1    Arbuthnott, G.2
  • 39
    • 0018830236 scopus 로고
    • Partial lesions of the dopaminergic nigrostriatal system in rat brain: Biochemical characterization
    • Hefti F, Melamed E, Wurtman RJ. Partial lesions of the dopaminergic nigrostriatal system in rat brain: biochemical characterization. Brain Res 195:123-137, 1980.
    • (1980) Brain Res , vol.195 , pp. 123-137
    • Hefti, F.1    Melamed, E.2    Wurtman, R.J.3
  • 40
    • 0027195844 scopus 로고
    • Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats
    • Jiang H, Jackson-Lewis V, Muthane U, Dollison A, Ferreira M, Espinosa A, et al. Adenosine receptor antagonists potentiate dopamine receptor agonist-induced rotational behavior in 6-hydroxydopamine-lesioned rats. Brain Res 613:347-351, 1993.
    • (1993) Brain Res , vol.613 , pp. 347-351
    • Jiang, H.1    Jackson-Lewis, V.2    Muthane, U.3    Dollison, A.4    Ferreira, M.5    Espinosa, A.6
  • 41
    • 0037007106 scopus 로고    scopus 로고
    • Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer
    • Kirik D, Georgievska B, Burger C, Winkler C, Muzyczka N, Mandel RJ, et al. Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer. Proc Natl Acad Sci USA 99:4708-4713, 2002.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4708-4713
    • Kirik, D.1    Georgievska, B.2    Burger, C.3    Winkler, C.4    Muzyczka, N.5    Mandel, R.J.6
  • 43
    • 0028046229 scopus 로고
    • Motor fluctuations in levodopa treated parkinsonian rats: Relation to lesion extent and treatment duration
    • Papa SM, Engber TM, Kask AM, Chase TN. Motor fluctuations in levodopa treated parkinsonian rats: relation to lesion extent and treatment duration. Brain Res 662:69-74, 1994.
    • (1994) Brain Res , vol.662 , pp. 69-74
    • Papa, S.M.1    Engber, T.M.2    Kask, A.M.3    Chase, T.N.4
  • 44
    • 0037114028 scopus 로고    scopus 로고
    • Adenosine A2A antagonism reverses levodopa-induced motor alterations in hemiparkinsonian rats
    • Bove J, Marin C, Bonastre M, Tolosa E. Adenosine A2A antagonism reverses levodopa-induced motor alterations in hemiparkinsonian rats. Synapse 46:251-257, 2002.
    • (2002) Synapse , vol.46 , pp. 251-257
    • Bove, J.1    Marin, C.2    Bonastre, M.3    Tolosa, E.4
  • 45
    • 0029064091 scopus 로고
    • Forelimb akinesia in the rat Parkinson model: Differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test
    • Olsson M, Nikkhah G, Bentlage C, Bjorklund A. Forelimb akinesia in the rat Parkinson model: differential effects of dopamine agonists and nigral transplants as assessed by a new stepping test. J Neurosci 15:3863-3875, 1995.
    • (1995) J Neurosci , vol.15 , pp. 3863-3875
    • Olsson, M.1    Nikkhah, G.2    Bentlage, C.3    Bjorklund, A.4
  • 47
    • 3042829625 scopus 로고    scopus 로고
    • No evidence for new dopaminergic neurons in the adult mammalian substantia nigra
    • Frielingsdorf H, Schwarz K, Brundin P, Mohapel P. No evidence for new dopaminergic neurons in the adult mammalian substantia nigra. Proc Natl Acad Sci USA 101:10177-10182, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 10177-10182
    • Frielingsdorf, H.1    Schwarz, K.2    Brundin, P.3    Mohapel, P.4
  • 48
    • 0025949580 scopus 로고
    • Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats
    • Aebischer P, Tresco PA, Sagen J, Winn SR. Transplantation of microencapsulated bovine chromaffin cells reduces lesion-induced rotational asymmetry in rats. Brain Res 560:43-49, 1991.
    • (1991) Brain Res , vol.560 , pp. 43-49
    • Aebischer, P.1    Tresco, P.A.2    Sagen, J.3    Winn, S.R.4
  • 49
    • 0027280869 scopus 로고
    • Transplantation of fetal nigral cells reverses the increase of preproenkephalin mRNA levels in the rat striatum caused by 6-OHDA lesion of the dopaminergic nigrostriatal pathway: A quantitative in situ hybridization study
    • Bal A, Savasta M, Chritin M, Mennicken F, Abrous DN, Le Moal M, et al. Transplantation of fetal nigral cells reverses the increase of preproenkephalin mRNA levels in the rat striatum caused by 6-OHDA lesion of the dopaminergic nigrostriatal pathway: a quantitative in situ hybridization study. Mol Brain Res 18:221-227, 1993.
    • (1993) Mol Brain Res , vol.18 , pp. 221-227
    • Bal, A.1    Savasta, M.2    Chritin, M.3    Mennicken, F.4    Abrous, D.N.5    Le Moal, M.6
  • 50
    • 0028270292 scopus 로고
    • 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra
    • Venero JL, Beck KD, Hefti F. 6-Hydroxydopamine lesions reduce BDNF mRNA levels in adult rat brain substantia nigra. Neuroreport 5:429-432, 1994.
    • (1994) Neuroreport , vol.5 , pp. 429-432
    • Venero, J.L.1    Beck, K.D.2    Hefti, F.3
  • 51
    • 0028027183 scopus 로고
    • Intranigral but not intrastriatal microinjection of the NMDA antagonist MK-801 induces contralateral circling in the 6-OHDA rat model
    • St-Pierre JA, Bédard PJ. Intranigral but not intrastriatal microinjection of the NMDA antagonist MK-801 induces contralateral circling in the 6-OHDA rat model. Brain Res 660:255-260, 1994.
    • (1994) Brain Res , vol.660 , pp. 255-260
    • St.-Pierre, J.A.1    Bédard, P.J.2
  • 52
    • 0030774588 scopus 로고    scopus 로고
    • GDNF protection against 6-OHDA: Time dependence and requirement for protein synthesis
    • Kearns CM, Cass WA, Smoot K, Kryscio R, Gash DM. GDNF protection against 6-OHDA: time dependence and requirement for protein synthesis. J Neurosci 17:7111-7118, 1997.
    • (1997) J Neurosci , vol.17 , pp. 7111-7118
    • Kearns, C.M.1    Cass, W.A.2    Smoot, K.3    Kryscio, R.4    Gash, D.M.5
  • 53
    • 0032964444 scopus 로고    scopus 로고
    • Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid
    • Nakao N, Nakai E, Nakai K, Itakura T. Ablation of the subthalamic nucleus supports the survival of nigral dopaminergic neurons after nigrostriatal lesions induced by the mitochondrial toxin 3-nitropropionic acid. Ann Neural 45:640-651, 1999.
    • (1999) Ann Neural , vol.45 , pp. 640-651
    • Nakao, N.1    Nakai, E.2    Nakai, K.3    Itakura, T.4
  • 54
    • 0034562426 scopus 로고    scopus 로고
    • Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions
    • Chen L, Liu Z, Tian Z, Wang Y, Li S. Prevention of neurotoxin damage of 6-OHDA to dopaminergic nigral neuron by subthalamic nucleus lesions. Stereotact Funct Neurosurg 75:66-75, 2000.
    • (2000) Stereotact Funct Neurosurg , vol.75 , pp. 66-75
    • Chen, L.1    Liu, Z.2    Tian, Z.3    Wang, Y.4    Li, S.5
  • 55
    • 1642346342 scopus 로고    scopus 로고
    • Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: Neuroprotection of dopaminergic neurons
    • Maesawa S, Kaneoke Y, Kajita Y, Usui N, Misawa N, Nakayama A, et al. Long-term stimulation of the subthalamic nucleus in hemiparkinsonian rats: neuroprotection of dopaminergic neurons. J Neurosurg 100:679-687, 2004.
    • (2004) J Neurosurg , vol.100 , pp. 679-687
    • Maesawa, S.1    Kaneoke, Y.2    Kajita, Y.3    Usui, N.4    Misawa, N.5    Nakayama, A.6
  • 56
    • 0023405118 scopus 로고
    • Selective Dl and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions
    • Trugman JM, Wooten GF. Selective Dl and D2 dopamine agonists differentially alter basal ganglia glucose utilization in rats with unilateral 6-hydroxydopamine substantia nigra lesions. J Neurosci 7:2927-2935, 1987.
    • (1987) J Neurosci , vol.7 , pp. 2927-2935
    • Trugman, J.M.1    Wooten, G.F.2
  • 57
    • 0006453844 scopus 로고
    • The neostriatal mosaic: Comparmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey
    • Gerfen CR, Baimbridge KG, Miller JJ. The neostriatal mosaic: Comparmental distribution of calcium-binding protein and parvalbumin in the basal ganglia of the rat and monkey. Proc Natl Acad Sci USA 82:8780-8784, 1985.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8780-8784
    • Gerfen, C.R.1    Baimbridge, K.G.2    Miller, J.J.3
  • 58
    • 0023521580 scopus 로고
    • The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix nigrostriatal system
    • Gerfen CR, Baimbridge KG, Thibault J. The neostriatal mosaic: III. Biochemical and developmental dissociation of patch-matrix nigrostriatal system. J Neurosci 7:3935-3944, 1987.
    • (1987) J Neurosci , vol.7 , pp. 3935-3944
    • Gerfen, C.R.1    Baimbridge, K.G.2    Thibault, J.3
  • 59
    • 0023481972 scopus 로고
    • The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems
    • Gerfen CR, Herkenham M, Thibault J. The neostriatal mosaic: II. Patch- and matrix-directed mesostriatal dopaminergic and non-dopaminergic systems. J Neurosci 7:3915-3934, 1987.
    • (1987) J Neurosci , vol.7 , pp. 3915-3934
    • Gerfen, C.R.1    Herkenham, M.2    Thibault, J.3
  • 60
    • 0025572196 scopus 로고
    • D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons
    • Gerfen CR, Engber TM, Mahan LC, Susel Z, Chase TN, Monsma FJ, et al. D1 and D2 dopamine receptor-regulated gene expression of striatonigral and striatopallidal neurons. Science 250:1429-1432, 1990.
    • (1990) Science , vol.250 , pp. 1429-1432
    • Gerfen, C.R.1    Engber, T.M.2    Mahan, L.C.3    Susel, Z.4    Chase, T.N.5    Monsma, F.J.6
  • 61
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, et al. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65:135-172, 2001.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6
  • 62
    • 0020680904 scopus 로고
    • Chronic parkinsonism in humans due to a product of meperidine-analog synthesis
    • Langston JW, Ballard P, Irwin I. Chronic parkinsonism in humans due to a product of meperidine-analog synthesis. Science 219:979-980, 1983.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Irwin, I.3
  • 63
    • 0023610067 scopus 로고
    • MPTP: An industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease
    • Kopin IJ. MPTP: an industrial chemical and contaminant of illicit narcotics stimulates a new era in research on Parkinson's disease. Environ Health Perspect 75:45-51, 1987.
    • (1987) Environ Health Perspect , vol.75 , pp. 45-51
    • Kopin, I.J.1
  • 64
    • 0031665702 scopus 로고    scopus 로고
    • Protective effect of talipexole on MPTP-treated planarian, a unique parkinsonian worm model
    • Kitamura Y, Kakimura J, Taniguchi T. Protective effect of talipexole on MPTP-treated planarian, a unique parkinsonian worm model. Jpn J Pharmacol 78:23-29, 1998.
    • (1998) Jpn J Pharmacol , vol.78 , pp. 23-29
    • Kitamura, Y.1    Kakimura, J.2    Taniguchi, T.3
  • 65
    • 0035091767 scopus 로고    scopus 로고
    • The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety
    • Przedborski S, Jackson-Lewis V, Naini A, Jakowec M, Petzinger G, Miller R, et al. The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): a technical review of its utility and safety. J Neurochem 76:1265-1274, 2001.
    • (2001) J Neurochem , vol.76 , pp. 1265-1274
    • Przedborski, S.1    Jackson-Lewis, V.2    Naini, A.3    Jakowec, M.4    Petzinger, G.5    Miller, R.6
  • 66
    • 0001485756 scopus 로고    scopus 로고
    • MPTP: A review of its mechanisms of neurotoxicity
    • Przedborski S, Vila M. MPTP: a review of its mechanisms of neurotoxicity. Clin Neurosci Res 1:407-418, 2001.
    • (2001) Clin Neurosci Res , vol.1 , pp. 407-418
    • Przedborski, S.1    Vila, M.2
  • 68
    • 0025135495 scopus 로고
    • MPTP-induced parkinsonism
    • Stern Y. MPTP-induced parkinsonism. Prog Neurobiol 34:107-114, 1990.
    • (1990) Prog Neurobiol , vol.34 , pp. 107-114
    • Stern, Y.1
  • 70
    • 4544368233 scopus 로고    scopus 로고
    • Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates
    • Decamp E, Schneider JS. Attention and executive function deficits in chronic low-dose MPTP-treated non-human primates. Eur J Neurosci 20:1371-1378, 2004.
    • (2004) Eur J Neurosci , vol.20 , pp. 1371-1378
    • Decamp, E.1    Schneider, J.S.2
  • 71
    • 84938465236 scopus 로고
    • Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease
    • Kostic V, Przedborski S, Flaster E, Sternic N. Early development of levodopa-induced dyskinesias and response fluctuations in young-onset Parkinson's disease. Neurology 41:202-205, 1991.
    • (1991) Neurology , vol.41 , pp. 202-205
    • Kostic, V.1    Przedborski, S.2    Flaster, E.3    Sternic, N.4
  • 72
    • 0021239393 scopus 로고
    • Parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): Implications for treatment and the pathogenesis of Parkinson's disease
    • Langston JW, Ballard P. Parkinsonism induced by 1-methyl-4-phenyl-1,2,3, 6-tetrahydropyridine (MPTP): implications for treatment and the pathogenesis of Parkinson's disease. Can J Neurol Sci 11:160-165, 1984.
    • (1984) Can J Neurol Sci , vol.11 , pp. 160-165
    • Langston, J.W.1    Ballard, P.2
  • 74
    • 0038579160 scopus 로고    scopus 로고
    • Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function
    • Bézard E, Ferry S, Mach U, Stark H, Leriche L, Boraud T, et al. Attenuation of levodopa-induced dyskinesia by normalizing dopamine D3 receptor function. Nat Med 9:762-767, 2003.
    • (2003) Nat Med , vol.9 , pp. 762-767
    • Bézard, E.1    Ferry, S.2    Mach, U.3    Stark, H.4    Leriche, L.5    Boraud, T.6
  • 76
    • 0027343340 scopus 로고
    • Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease: Neuropathologic considerations
    • Forno LS, DeLanney LE, Irwin I, Langston JW. Similarities and differences between MPTP-induced parkinsonism and Parkinson's disease: Neuropathologic considerations. Adv Neurol 60: 600-608, 1993.
    • (1993) Adv Neurol , vol.60 , pp. 600-608
    • Forno, L.S.1    DeLanney, L.E.2    Irwin, I.3    Langston, J.W.4
  • 77
    • 0000595601 scopus 로고
    • Biochemistry of neurotransmitters in Parkinson's disease
    • (Marsden CD, Fahn S, eds). London: Butterworths
    • Agid Y, Javoy-Agid F, Ruberg M. Biochemistry of neurotransmitters in Parkinson's disease. In: Movement disorders 2 (Marsden CD, Fahn S, eds), pp 166-230. London: Butterworths, 1987.
    • (1987) Movement Disorders 2 , pp. 166-230
    • Agid, Y.1    Javoy-Agid, F.2    Ruberg, M.3
  • 78
    • 0025074518 scopus 로고
    • Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP
    • Seniuk NA, Tatton WG, Greenwood CE. Dose-dependent destruction of the coeruleus-cortical and nigral-striatal projections by MPTP. Brain Res 527:7-20, 1990.
    • (1990) Brain Res , vol.527 , pp. 7-20
    • Seniuk, N.A.1    Tatton, W.G.2    Greenwood, C.E.3
  • 79
    • 0028302235 scopus 로고
    • Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1mice
    • Muthane U, Ramsay KA, Jiang H, Jackson-Lewis V, Donaldson D, Fernando S, et al. Differences in nigral neuron number and sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in C57/bl and CD-1mice. Exp Neurol 126:195-204, 1994.
    • (1994) Exp Neurol , vol.126 , pp. 195-204
    • Muthane, U.1    Ramsay, K.A.2    Jiang, H.3    Jackson-Lewis, V.4    Donaldson, D.5    Fernando, S.6
  • 80
    • 0026587806 scopus 로고
    • Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Moratalla R, Quinn B, DeLanney LE, Irwin I, Langston JW, Graybiel AM. Differential vulnerability of primate caudate-putamen and striosome-matrix dopamine systems to the neurotoxic effects of 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine. Proc Natl Acad Sci USA 89:3859-3863, 1992.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 3859-3863
    • Moratalla, R.1    Quinn, B.2    DeLanney, L.E.3    Irwin, I.4    Langston, J.W.5    Graybiel, A.M.6
  • 83
    • 0009510430 scopus 로고
    • Lack of progression of MPTP-induced parkinsonism during long-term treatment with L-DOPA
    • Burns RS, Pakkenberg H, Kopin IJ. Lack of progression of MPTP-induced parkinsonism during long-term treatment with L-DOPA. Ann Neurol 18:117, 1985.
    • (1985) Ann Neurol , vol.18 , pp. 117
    • Burns, R.S.1    Pakkenberg, H.2    Kopin, I.J.3
  • 84
  • 85
    • 0032829070 scopus 로고    scopus 로고
    • Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure
    • Langston JW, Forno LS, Tetrud J, Reeves AG, Kaplan JA, Karluk D. Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann Neurol 46:598-605, 1999.
    • (1999) Ann Neurol , vol.46 , pp. 598-605
    • Langston, J.W.1    Forno, L.S.2    Tetrud, J.3    Reeves, A.G.4    Kaplan, J.A.5    Karluk, D.6
  • 86
    • 0242384667 scopus 로고    scopus 로고
    • Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration
    • McGeer PL, Schwab C, Parent A, Doudet D. Presence of reactive microglia in monkey substantia nigra years after 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine administration. Ann Neurol 54: 599-604, 2003.
    • (2003) Ann Neurol , vol.54 , pp. 599-604
    • McGeer, P.L.1    Schwab, C.2    Parent, A.3    Doudet, D.4
  • 87
    • 0025169590 scopus 로고
    • Reversal of experimental parkinsonism by lesions of the subthalamic nucleus
    • Bergman H, Wichmann T, DeLong MR. Reversal of experimental parkinsonism by lesions of the subthalamic nucleus. Science 249:1436-1438, 1990.
    • (1990) Science , vol.249 , pp. 1436-1438
    • Bergman, H.1    Wichmann, T.2    DeLong, M.R.3
  • 88
    • 0032531683 scopus 로고    scopus 로고
    • Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease
    • Limousin P, Krack P, Pollak P, Benazzouz A, Ardouin C, Hoffmann D, et al. Electrical stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 339:1105-1111, 1998.
    • (1998) N Engl J Med , vol.339 , pp. 1105-1111
    • Limousin, P.1    Krack, P.2    Pollak, P.3    Benazzouz, A.4    Ardouin, C.5    Hoffmann, D.6
  • 89
  • 90
    • 0034721690 scopus 로고    scopus 로고
    • Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease
    • Kordower JH, Emborg ME, Bloch J, Ma SY, Chu Y, Leventhal L, et al. Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science 290:767-773, 2000.
    • (2000) Science , vol.290 , pp. 767-773
    • Kordower, J.H.1    Emborg, M.E.2    Bloch, J.3    Ma, S.Y.4    Chu, Y.5    Leventhal, L.6
  • 94
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • Gorell JM, Johnson CC, Rybicki BA, Peterson EL, Richardson RJ. The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50:1346-1350, 1998.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, J.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 95
    • 0024233594 scopus 로고
    • Oral toxicity of rotenone to mammals
    • Marking L. Oral toxicity of rotenone to mammals. Investig Fish Control, Issue No. 94, 1988.
    • (1988) Investig Fish Control , Issue.94
    • Marking, L.1
  • 96
  • 97
    • 0033773407 scopus 로고    scopus 로고
    • In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone
    • Talpade DJ, Greene JG, Higgins DS Jr, Greenamyre JT. In vivo labeling of mitochondrial complex I (NADH:ubiquinone oxidoreductase) in rat brain using [(3)H]dihydrorotenone. J Neurochem 75:2611-2621, 2000.
    • (2000) J Neurochem , vol.75 , pp. 2611-2621
    • Talpade, D.J.1    Greene, J.G.2    Higgins Jr., D.S.3    Greenamyre, J.T.4
  • 98
    • 0035796952 scopus 로고    scopus 로고
    • Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling
    • Schuler F, Casida JE. Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling. Biochim Biophys Acta 1506:79-87, 2001.
    • (2001) Biochim Biophys Acta , vol.1506 , pp. 79-87
    • Schuler, F.1    Casida, J.E.2
  • 99
    • 0018176775 scopus 로고
    • Rotenone inhibition of tubulin self-assembly
    • Marshall LE, Himes RH. Rotenone inhibition of tubulin self-assembly. Biochim Biophys Acta 543:590-594, 1978.
    • (1978) Biochim Biophys Acta , vol.543 , pp. 590-594
    • Marshall, L.E.1    Himes, R.H.2
  • 100
    • 0016367228 scopus 로고
    • Rotenone inhibition of spindle microtubule assembly in mammalian cells
    • Brinkley BR, Barham SS, Barranco SC, Fuller GM. Rotenone inhibition of spindle microtubule assembly in mammalian cells. Exp Cell Res 85:41-46, 1974.
    • (1974) Exp Cell Res , vol.85 , pp. 41-46
    • Brinkley, B.R.1    Barham, S.S.2    Barranco, S.C.3    Fuller, G.M.4
  • 101
    • 0024582786 scopus 로고
    • Dominant effects of tubulin overexpression in Saccharomyces cerevisiae
    • Burke D, Gasdaska P, Hartwell L. Dominant effects of tubulin overexpression in Saccharomyces cerevisiae. Mol Cell Biol 9:1049-1059, 1989.
    • (1989) Mol Cell Biol , vol.9 , pp. 1049-1059
    • Burke, D.1    Gasdaska, P.2    Hartwell, L.3
  • 102
    • 0025075301 scopus 로고
    • Phenotypic consequences of tubulin overproduction in Saccharomyces cerevisiae: Differences between α-tubulin and β-tubulin
    • Weinstein B, Solomon F. Phenotypic consequences of tubulin overproduction in Saccharomyces cerevisiae: differences between α-tubulin and β-tubulin. Mol Cell Biol 10:5295-5304, 1990.
    • (1990) Mol Cell Biol , vol.10 , pp. 5295-5304
    • Weinstein, B.1    Solomon, F.2
  • 103
    • 0037738525 scopus 로고    scopus 로고
    • Parkin binds to α/β tubulin and increases their ubiquitination and degradation
    • Ren Y, Zhao J, Feng J. Parkin binds to α/β tubulin and increases their ubiquitination and degradation. J Neurosci 23:3316-3324, 2003.
    • (2003) J Neurosci , vol.23 , pp. 3316-3324
    • Ren, Y.1    Zhao, J.2    Feng, J.3
  • 104
    • 0029052829 scopus 로고
    • A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation
    • Marey-Semper I, Gelman M, Lévi-Strauss M. A selective toxicity toward cultured mesencephalic dopaminergic neurons is induced by the synergistic effects of energetic metabolism impairment and NMDA receptor activation. J Neurosci 15:5912-5918, 1995.
    • (1995) J Neurosci , vol.15 , pp. 5912-5918
    • Marey-Semper, I.1    Gelman, M.2    Lévi-Strauss, M.3
  • 105
    • 0036470165 scopus 로고    scopus 로고
    • Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons
    • Gao HM, Hong JS, Zhang W, Liu B. Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 22:782-790, 2002.
    • (2002) J Neurosci , vol.22 , pp. 782-790
    • Gao, H.M.1    Hong, J.S.2    Zhang, W.3    Liu, B.4
  • 106
    • 0022403289 scopus 로고
    • Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: Implication for the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity
    • Heikkila RE, Nicklas WJ, Vyas I, Duvoisin RC. Dopaminergic toxicity of rotenone and the 1-methyl-4-phenylpyridinium ion after their stereotaxic administration to rats: implication for the mechanism of 1-methyl-4-phenyl-1,2, 3,6-tetrahydropyridine toxicity. Neurosci Lett 62:389-394, 1985.
    • (1985) Neurosci Lett , vol.62 , pp. 389-394
    • Heikkila, R.E.1    Nicklas, W.J.2    Vyas, I.3    Duvoisin, R.C.4
  • 107
    • 0031005815 scopus 로고    scopus 로고
    • Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra
    • Ferrante RJ, Schulz JB, Kowall NW, Beal MF. Systemic administration of rotenone produces selective damage in the striatum and globus pallidus, but not in the substantia nigra. Brain Res 753:157-162, 1997.
    • (1997) Brain Res , vol.753 , pp. 157-162
    • Ferrante, R.J.1    Schulz, J.B.2    Kowall, N.W.3    Beal, M.F.4
  • 108
    • 0034624274 scopus 로고    scopus 로고
    • Increased striatal dopamine turnover following acute administration of rotenone to mice
    • Thiffault C, Langston JW, Di Monte DA. Increased striatal dopamine turnover following acute administration of rotenone to mice. Brain Res 885:283-288, 2000.
    • (2000) Brain Res , vol.885 , pp. 283-288
    • Thiffault, C.1    Langston, J.W.2    Di Monte, D.A.3
  • 109
    • 0037229425 scopus 로고    scopus 로고
    • Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and α-synuclein aggregation
    • Sherer TB, Kim JH, Betarbet R, Greenamyre JT. Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and α-synuclein aggregation. Exp Neurol 179:9-16, 2003.
    • (2003) Exp Neurol , vol.179 , pp. 9-16
    • Sherer, T.B.1    Kim, J.H.2    Betarbet, R.3    Greenamyre, J.T.4
  • 110
    • 0037314540 scopus 로고    scopus 로고
    • Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats
    • Hoglinger GU, Feger J, Annick P, Michel PP, Karine P, Champy P, et al. Chronic systemic complex I inhibition induces a hypokinetic multisystem degeneration in rats. J Neurochem 84:1-12, 2003.
    • (2003) J Neurochem , vol.84 , pp. 1-12
    • Hoglinger, G.U.1    Feger, J.2    Annick, P.3    Michel, P.P.4    Karine, P.5    Champy, P.6
  • 112
    • 4644263680 scopus 로고    scopus 로고
    • Variable effects of chronic subcutaneous administration of rotenone on striatal histology
    • Zhu C, Vourc'h P, Fernagut PO, Fleming SM, Lacan S, Dicarlo CD, et al. Variable effects of chronic subcutaneous administration of rotenone on striatal histology. J Comp Neurol 478:418-426, 2004.
    • (2004) J Comp Neurol , vol.478 , pp. 418-426
    • Zhu, C.1    Vourc'h, P.2    Fernagut, P.O.3    Fleming, S.M.4    Lacan, S.5    Dicarlo, C.D.6
  • 113
    • 0037126181 scopus 로고    scopus 로고
    • Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats
    • Alam M, Schmidt WJ. Rotenone destroys dopaminergic neurons and induces parkinsonian symptoms in rats. Behav Brain Res 136:317-324, 2002.
    • (2002) Behav Brain Res , vol.136 , pp. 317-324
    • Alam, M.1    Schmidt, W.J.2
  • 114
    • 16544391570 scopus 로고    scopus 로고
    • The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA
    • Alam M, Mayerhofer A, Schmidt WJ. The neurobehavioral changes induced by bilateral rotenone lesion in medial forebrain bundle of rats are reversed by L-DOPA. Behav Brain Res 151: 117-124, 2004.
    • (2004) Behav Brain Res , vol.151 , pp. 117-124
    • Alam, M.1    Mayerhofer, A.2    Schmidt, W.J.3
  • 115
    • 2342662120 scopus 로고    scopus 로고
    • Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone
    • Fleming SM, Zhu C, Fernagut PO, Mehta A, Dicarlo CD, Seaman RL, et al. Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone. Exp Neurol 187:418-429, 2004.
    • (2004) Exp Neurol , vol.187 , pp. 418-429
    • Fleming, S.M.1    Zhu, C.2    Fernagut, P.O.3    Mehta, A.4    Dicarlo, C.D.5    Seaman, R.L.6
  • 117
    • 84965935742 scopus 로고
    • Paraquat poisoning by skin absorption: A review
    • Smith JG. Paraquat poisoning by skin absorption: a review. Hum Toxicol 7:15-19, 1988.
    • (1988) Hum Toxicol , vol.7 , pp. 15-19
    • Smith, J.G.1
  • 119
    • 0023690250 scopus 로고
    • Brain damage due to paraquat poisoning: A fatal case with neuropathological examination of the brain
    • Hughes JT. Brain damage due to paraquat poisoning: a fatal case with neuropathological examination of the brain. Neurotoxicology 9:243-248, 1988.
    • (1988) Neurotoxicology , vol.9 , pp. 243-248
    • Hughes, J.T.1
  • 120
    • 0035816365 scopus 로고    scopus 로고
    • Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat
    • Shimizu K, Ohtaki K, Matsubara K, Aoyama K, Uezono T, Saito O, et al. Carrier-mediated processes in blood-brain barrier penetration and neural uptake of paraquat. Brain Res 906:135-142, 2001.
    • (2001) Brain Res , vol.906 , pp. 135-142
    • Shimizu, K.1    Ohtaki, K.2    Matsubara, K.3    Aoyama, K.4    Uezono, T.5    Saito, O.6
  • 121
    • 0030878320 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: A case-control study in Taiwan
    • Liou HH, Tsai MC, Chen CJ, Jeng JS, Chang YC, Chen SY, et al. Environmental risk factors and Parkinson's disease: a case-control study in Taiwan. Neurology 48:1583-1588, 1997.
    • (1997) Neurology , vol.48 , pp. 1583-1588
    • Liou, H.H.1    Tsai, M.C.2    Chen, C.J.3    Jeng, J.S.4    Chang, Y.C.5    Chen, S.Y.6
  • 123
    • 0037380982 scopus 로고    scopus 로고
    • Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration
    • McCormack AL, Di Monte DA. Effects of L-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J Neurochem 85:82-86, 2003.
    • (2003) J Neurochem , vol.85 , pp. 82-86
    • McCormack, A.L.1    Di Monte, D.A.2
  • 124
    • 0034637267 scopus 로고    scopus 로고
    • Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: Environmental risk factors for Parkinson's disease?
    • Thiruchelvam M, Brockel BJ, Richfield EK, Baggs RB, Cory-Slechta DA. Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain Res 873:225-234, 2000.
    • (2000) Brain Res , vol.873 , pp. 225-234
    • Thiruchelvam, M.1    Brockel, B.J.2    Richfield, E.K.3    Baggs, R.B.4    Cory-Slechta, D.A.5
  • 125
    • 0034671469 scopus 로고    scopus 로고
    • The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: Implications for Parkinson's disease
    • Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci 20:9207-9214, 2000.
    • (2000) J Neurosci , vol.20 , pp. 9207-9214
    • Thiruchelvam, M.1    Richfield, E.K.2    Baggs, R.B.3    Tank, A.W.4    Cory-Slechta, D.A.5
  • 126
    • 0036075892 scopus 로고    scopus 로고
    • Environmental risk factors and Parkinson's disease: Selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat
    • McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, Cory-Slechta DA, et al. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis 10:119-127, 2002.
    • (2002) Neurobiol Dis , vol.10 , pp. 119-127
    • McCormack, A.L.1    Thiruchelvam, M.2    Manning-Bog, A.B.3    Thiffault, C.4    Langston, J.W.5    Cory-Slechta, D.A.6
  • 127
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: Paraquat and α-synuclein
    • Manning-Bog AB, McCormack AL, Li J, Uversky VN, Fink AL, Di Monte DA. The herbicide paraquat causes up-regulation and aggregation of alpha-synuclein in mice: paraquat and α-synuclein. J Biol Chem 277:1641-1644, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1    McCormack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.A.6
  • 130
    • 3543011314 scopus 로고    scopus 로고
    • The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway
    • Peng J, Mao XO, Stevenson FF, Hsu M, Andersen JK. The herbicide paraquat induces dopaminergic nigral apoptosis through sustained activation of the JNK pathway. J Biol Chem 279:32626-32632, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 32626-32632
    • Peng, J.1    Mao, X.O.2    Stevenson, F.F.3    Hsu, M.4    Andersen, J.K.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.