Altered expression of bcl-2 and bax mRNA in amyotrophic lateral sclerosis spinal cord motor neurons

Annals of Neurology

Volumn 40, Issue 3, 1996, Pages 379-386

  Mu, Xiaojun ^a   He, Jin ^a   Anderson, David W ^a   Trojanowski, John Q ^b   Springer, Joe E ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA;

ADULT; AGED; AMYOTROPHIC LATERAL SCLEROSIS; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; ETIOLOGY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MOTONEURON; PRIORITY JOURNAL; SPINAL CORD;

EID: 0029787513     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410400307     Document Type: Article

References (44)

1. Hughes JT. Pathology of amyotrophic lateral sclerosis. In: Rowland LP, ed. Human motor neuron diseases. New York: Raven Press, 1982:61-74
2. Perry TL, Krieger C, Hansen S, et al. Amyotrophic lateral sclerosis: amino acid levels in plasma and cerebrospinal fluid. Ann Neurol 1990;28:12-17
3. Rothstein JD, Tsai G, Kuncl RW, et al. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Ann Neurol 1990;28:18-25
4. Ruthstein JD, Martin LJ, Kuncl RW. Decreased glutamate transporter in the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 1992;236:1464-1468
5. Rothstein JD, Van Kammen M, Levey AI, et al. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Ann Neurol 1995;38:73-84
6. Drachman DB, Kuncl RW. Amyotrophic lateral sclerosis: an unconventional autoimmune disease? Ann Neurol 1989;26: 269-274
7. Brown RH Jr. Amyotrophic lateral sclerosis: recent insights from genetics and transgenic mice. Cell 1995;80:687-692
8. Lee MK, Marszalek JR, Cleveland DW. A mutant neurofilament subunit causes massive, selective motor neuron death: implications for the pathogenesis of human motor neuron disease. Neuron 1994;13:975-988
9. Bowling AC, Barkowski EE, McKenna-Yasek D, et al. Superoxide dismutase concentration and activity in familial amyotrophic lateral sclerosis. J Neurochem 1995;64:2366-2369
10. Rosen DR, Bowling AC, Patterson D, et al. A frequent Ala 4 to Val superoxide dismutase-1 mutation is associated with a rapidly progressive familial amyotrophic lateral sclerosis. Hum Mol Genet 1994;3:981-987
11. Deng HX, Hentati A, Tainer JA, et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 1993;261:1047-1051
12. Jones CT, Brock DJ, Chancellor AM, et al. Cu/Zn superoxide dismutase (SOD1) mutations and sporadic amyotrophic lateral sclerosis. Lancet 1993;342:1050-1051
13. Rosen DR, Siddique T, Patterson D, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature 1993;362:59-62
14. Gurney ME, Pu H, Chiu AY, et al. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. Science 1994;264:1772-1775
15. Oppenheim RW. Cell death during the development of the nervous system. Annu Rev Neurosci 1991;14:453-502
16. Wyllie AH, Kerr JF, Currie AR. Cell death: the significance of apoptosis. Int Rev Cytol 1980;68:251-306
17. Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972;26:239-257
18. Sendtner M, Dittrich F, Hughes RA, et al. Actions of CNTF and neurotrophins on degenerating motor neurons: preclinical studies and clinical implications. J Neurol Sci 1994;124(suppl): 77-83
19. Merry DE, Veis DJ, Hickey WF, et al. bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 1994;120:301-311
20. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell 1993;74:609-619
21. Garcia I, Martinou I, Tsujimoto Y, et al. Prevention of programmed cell death of sympathetic neurons by the bcl-2 protooncogene. Science 1992;258:302-304
22. Zhong LT, Sarafian T, Kane DJ, et al. bcl-2 inhibits death of central neural cells induced by multiple agents. Proc Natl Acad Sci USA 1993;90:4533-4537
23. Zhong LT, Kane DJ, Bredesen DE. BCL-2 blocks glutamate toxicity in neural cell lines. Mol Brain Res 1993;19:353-355
24. Allsopp TE, Wyatt S, Paterson HF, et al. The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993;73:295-307
25. Hockenbery DM, Oltvai ZN, Yin XM, et al. Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 1993;75: 241-251
26. Chao DT, Linette GP, Boise LH, et al. Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med 1995;182: 821-828
27. Korsmeyer SJ, Shutter JR, Veis DJ, et al. Bcl-2/Bax: a rheostat that regulates an anti-oxidant pathway and cell death. Semin Cancer Biol 1993;4:327-332
28. Yin XM, Oltvai ZN, Korsmeyer SJ. Heterodimerization with Bax is required for Bcl-2 to repress cell death. Curr Top Microbiol Immunol 1995;194:331-338
29. Itoh T, Sobue G, Ken E, et al. Phosphorylated high molecular weight neurofilament protein in the peripheral motor, sensory and sympathetic neuronal perikarya: system-dependent normal variations and changes in amyotrophic lateral sclerosis and multiple system atrophy. Acta Neuropathol (Berl) 1992;83:240-245
30. Schmidt ML, Carden MJ, Lee VM, et al. Phosphate dependent and independent neurofilament epitopes in the axonal swellings of patients with motor neuron disease and controls. Lab Invest 1987;56:282-294
31. Sobue G, Hashizume Y, Yasuda T, et al. Phosphorylated high molecular weight neurofilament protein in lower motor neurons in amyotrophic lateral sclerosis and other neurodegenerative diseases involving ventral horn cells. Acta Neuropathol (Berl) 1990;79:402-408
32. Cleary ML, Smith SD, Sklar J. Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation. Cell 1986;47: 19-28
33. Yin XM, Oltval ZN, Korsmeyer SJ. BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax. Nature 1994;369:321-323
34. Springer JE, Robbins E, Gwag BJ, et al. Non-radioactive detection of nerve growth factor receptor (NGFR) mRNA in rat brain using in situ hybridization histochemistry. J Histochem Cytochem 1991;39:231-234
35. Springer JE, Robbins E, Meyer S, et al. Localization of nerve growth factor receptor mRNA in the rat basal forebrain with in situ hybridization histochemistry. Cell Mol Neurobiol 1990; 10:33-39
36. Gwag BJ, Sessler FM, Waterhouse BD, et al. Regulation of nerve growth factor mRNA in the hippocampal formation effects of N-methyl-D-aspartate receptor activation. Exp Neurol 1993;121:160-171
37. Seeburger JL, Tarras S, Natter H, et al. Spinal cord motor neurons express p75NGFR and p145trkB mRNA in amyotrophic lateral sclerosis. Brain Res 1993;621:111-115
38. Takahashi H, Oyanagi K, Ohama E, et al. Clarke's column in sporadic amyotrophic lateral sclerosis. Acta Neuropathol (Berl) 1992;84:465-470
39. Portera-Cailliau C, Hedreen JC, Price DL, et al. Evidence for apoptotic cell death in Huntington disease and excitotoxic animal models. J Neurosci 1995;15:3775-3787
40. Migheli A, Cavalla P, Marino S, et al. A study of apoptosis in normal and pathological tissue after in situ end-labeling of DNA strand breaks. J Neuropathol Exp Neurol 1994;53:606-616
41. Greenland LJ, Deckwerth TL, Johnson EM Jr. Superoxide dismutase delays neuronal apoptosis: a role for reactive oxygen species in programmed neuronal death. Neuron 1995;14:303-315
42. Rabizadeh S, Gralla EB, Borchelt DR, et al. Mutations associated with amyotrophic lateral sclerosis convert superoxide dismutase from an antiapoptotic gene to a proapoptotic gene: studies in yeast and neural cells. Proc Natl Acad Sci USA 1995; 92:3024-3028
43. Rothstein JD, Bristol LA, Hosler B, et al. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proc Natl Acad Sci USA 1994;91:4155-4159
44. Troy CM, Shelanski ML. Down-regulation of copper/zinc superoxide dismutase causes apoptotic death in PC12 neuronal cells. Proc Natl Acad Sci USA 1994;91:6384-6387