Directional trans-epithelial transport of organic anions in porcine LLC-PK1 cells that co-express human OATP1B1 (OATP-C) and MRP2

Biochemical Pharmacology

Volumn 69, Issue 3, 2005, Pages 415-423

  Spears, Kevin J ^a   Ross, Jillian ^a   Stenhouse, Alasdair ^a   Ward, Clive J ^a   Goh, Lay Beng ^a   Wolf, C Roland ^a   Morgan, Paul ^b   Ayrton, Andy ^c   Friedberg, Thomas H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Drug transport; Mutidrug resistance; Organic anion transport; Preclinical drug development

Indexed keywords

COMPLEMENTARY DNA; ESTRADIOL 17 GLUCURONIDE; ESTRONE SULFATE; HEMAGGLUTININ; MULTIDRUG RESISTANCE PROTEIN 2; OATP1B1 PROTEIN; ORGANIC ANION TRANSPORTER; ORGANIC COMPOUND; PRASTERONE; PROTEIN; PROTEIN ANTIBODY; RIFAMPICIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CELL TRANSPORT; CONTROLLED STUDY; KIDNEY CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL;

ANIMALS; BIOLOGICAL TRANSPORT; EPITHELIUM; ESTRADIOL; ESTRONE; MEMBRANE TRANSPORT PROTEINS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; ORGANIC ANION TRANSPORT POLYPEPTIDE C; RIFAMPIN; SWINE; TRANSFECTION;

EID: 11844279093     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2004.09.026     Document Type: Article

References (18)

1. A. Ayrton, and P. Morgan Role of transport proteins in drug absorption, distribution and excretion Xenobiotica 31 2001 469 497
2. B. Hagenbuch, and P.J. Meier The superfamily of organic anion transporting polypeptides Biochem Biophys Acta 1609 2003 1 18
3. Y. Nishizato, I. Ieiri, H. Suzuki, M. Kimura, K. Kawabata, and T. Hirota Polymorphisms of OATP-C (SLC21A6) and OAT3 (SLC22A8) genes: consequences for pravastatin pharmacokinetics Clin Pharmacol Ther 73 2003 554 565
4. H. Ishizuka, K. Konno, H. Naganuma, K. Nishimura, H. Kouzuki, and H. Suzuki Transport of temocaprilat into rat hepatocytes: role of organic anion transporting polypeptide J Pharmacol Exp Ther 287 1 1998 37 42
5. R.G. Tirona, B.F. Leake, A.W. Wolkoff, and R.B. Kim Human organic anion transporting polypeptide-C (SLC21A6) is a major determinant of rifampin-mediated pregnane X receptor activation J Pharmacol Exp Ther 304 2003 223 228
6. P. Borst, R. Evers, M. Kool, and J. Winjholds A family of drug transporters: the multidrug resistance-associated proteins J Natl Cancer Inst 92 2000 1295 1302
7. S.P. Cole, K.E. Sparks, K. Fraser, D.W. Loe, C.E. Grant, and G.M. Wilson Pharmacological characterization of multidrug resistance MEP-transfected human tumour cells Cancer Res 54 1994 5902 5910
8. R. Evers, M. Kool, A.J. Smith, L. van Deemter, M. de Hans, and P. Borst Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-MRP1- and MRP2-mediated transport Br J Cancer 83 2000 366 374
9. H. Suzuki, and Y. Sugiyama Transporters for bile acids and organic anions G.L. Amidon W. Sadee Membrane transporters as drug targets 1999 Kluwer Academic New York 387 439
10. S.J. Rippin, B. Hagenbuch, P.J. Meier, and B. Stieger Cholestatic expression pattern of sinusoidal and canalicular organic anion transport systems in primary cultured rat hepatocytes Hepatology 33 2001 776 782
11. T.K. Lee, C.L. Hammond, and N. Ballatori Intracellular glutathione regulates taurocholate transport in HepG2 cells Toxicol Appl Pharmacol 174 2001 207 215
12. J.M. Baron, L.B. Goh, D.G. Yao, C.R. Wolf, and T. Friedberg Modulation of P450CYP3A4-dependent metabolism by p-glycoprotein: Implications for P450 phenotyping J Pharmacol Exp Ther 296 2001 351 358
13. J. König, Y. Cui, and A.T. Nies A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am J Physiol Gastrointest Liver Physiol 278 2000 G156 G164
14. J.D. Irvine, L. Takahashi, K. Lockhart, J. Cheong, J.W. Tolan, and H.E. Selick MDCK cells: a tool for membrane permeability screening J Pharm Sci 88 1999 28 33
15. Y.H. Cui, J. König, and D. Keppler Vectorial transport by double transfected cells expressing the human uptake transporter SLC21A8 and the apical export pump ABCC2 Mol Pharmacol 60 2001 1866 1876
16. L.B. Goh, K.J. Spears, D. Yao, A. Ayrton, P. Morgan, and C.R. Wolf Endogenous drug transporters in in vitro and in vivo models for the prediction of drug disposition in man Biochem Pharmacol 64 2002 1569 1578
17. M. Sasaki, H. Suzuki, K. Ito, T. Abe, and Y. Sugiyama Transcellular transport of organic anions across a double-transfected Madin-Darby canine kidney II cell monolayer expressing both human organic anion-transporting polypeptide (OATP2/SLC21A6) and multidrug resistance-associated protein 2 (MRP2/ABCC2) J Biol Chem 277 2002 6497 6503
18. C. Kneuer, K.U. Honscha, and W. Honscha Sodium-dependent methotrexate carrier-1 is expressed in rat kidney: cloning and functional characterization Am J Physiol Renal Physiol 286 2004 F564 F572