메뉴 건너뛰기




Volumn 234, Issue 1, 2006, Pages 40-50

Single nucleotide polymorphisms in ABCC2 and ABCB1 genes and their clinical impact in physiology and drug response

Author keywords

ABC transporter; ABCB1; ABCC2; SNP; Tumorigenesis; Xenobiotics

Indexed keywords

ABC TRANSPORTER;

EID: 33644806448     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2005.06.050     Document Type: Review
Times cited : (39)

References (92)
  • 1
    • 0344927562 scopus 로고    scopus 로고
    • Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
    • J. Konig, A.T. Nies, Y. Cui, I. Leier, and D. Keppler Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity, and MRP2-mediated drug resistance Biochim. Biophys. Acta 1461 1999 377 394
    • (1999) Biochim. Biophys. Acta , vol.1461 , pp. 377-394
    • Konig, J.1    Nies, A.T.2    Cui, Y.3    Leier, I.4    Keppler, D.5
  • 2
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • M.M. Gottesman, T. Fojo, and S.E. Bates Multidrug resistance in cancer: role of ATP-dependent transporters Nat. Rev. Cancer 2 2002 48 58
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 3
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • P. Borst, R. Evers, M. Kool, and J. Wijnholds A family of drug transporters: the multidrug resistance-associated proteins J. Natl Cancer Inst. 92 2000 1295 1302
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 6
    • 0034674901 scopus 로고    scopus 로고
    • A family of drug transporters: The multidrug resistance-associated proteins
    • P. Borst, R. Evers, M. Kool, and J. Wijnholds A family of drug transporters: the multidrug resistance-associated proteins J. Natl Cancer Inst. 92 2000 1295 1302
    • (2000) J. Natl Cancer Inst. , vol.92 , pp. 1295-1302
    • Borst, P.1    Evers, R.2    Kool, M.3    Wijnholds, J.4
  • 7
    • 0033764825 scopus 로고    scopus 로고
    • The human multidrug resistance-associated protein (MRP) gene family: From biological function to drug molecular design
    • T. Ishikawa, M.T. Kuo, K. Furuta, and M. Suzuki The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design Clin. Chem. Lab. Med. 38 2000 893 897
    • (2000) Clin. Chem. Lab. Med. , vol.38 , pp. 893-897
    • Ishikawa, T.1    Kuo, M.T.2    Furuta, K.3    Suzuki, M.4
  • 9
    • 9544233652 scopus 로고    scopus 로고
    • A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation
    • K. Taniguchi, M. Wada, K. Kohno, T. Nakamura, T. Kawabe, and M. Kawakami A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation Cancer Res. 56 1996 4124 4129
    • (1996) Cancer Res. , vol.56 , pp. 4124-4129
    • Taniguchi, K.1    Wada, M.2    Kohno, K.3    Nakamura, T.4    Kawabe, T.5    Kawakami, M.6
  • 10
    • 0040761368 scopus 로고    scopus 로고
    • CDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
    • M. Buchler, J. Konig, M. Brom, J. Kartenbeck, H. Spring, and T. Horie cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats J. Biol. Chem. 271 1996 15091 15098
    • (1996) J. Biol. Chem. , vol.271 , pp. 15091-15098
    • Buchler, M.1    Konig, J.2    Brom, M.3    Kartenbeck, J.4    Spring, H.5    Horie, T.6
  • 11
    • 0031031247 scopus 로고    scopus 로고
    • Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR rats
    • K. Ito, H. Suzuki, T. Hirohashi, K. Kume, T. Shimizu, and Y. Sugiyama Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR rats Am. J. Physiol. 35 1997 G16 G22
    • (1997) Am. J. Physiol. , vol.35
    • Ito, K.1    Suzuki, H.2    Hirohashi, T.3    Kume, K.4    Shimizu, T.5    Sugiyama, Y.6
  • 12
    • 0029981430 scopus 로고    scopus 로고
    • Congenital jaundice in rats with a mutation in a multidrug resistanceassociated protein gene
    • C.C. Paulusma, P.J. Bosma, G.J. Zaman, C.T. Bakker, M. Otter, and G.L. Scheffer Congenital jaundice in rats with a mutation in a multidrug resistanceassociated protein gene Science 271 1996 1126 1128
    • (1996) Science , vol.271 , pp. 1126-1128
    • Paulusma, C.C.1    Bosma, P.J.2    Zaman, G.J.3    Bakker, C.T.4    Otter, M.5    Scheffer, G.L.6
  • 13
    • 0032577901 scopus 로고    scopus 로고
    • Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump
    • W. Priebe, M. Krawczyk, M.T. Kuo, Y. Yamane, N. Savaraj, and T. Ishikawa Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump Biochem. Biophys. Res. Commun. 247 1998 859 863
    • (1998) Biochem. Biophys. Res. Commun. , vol.247 , pp. 859-863
    • Priebe, W.1    Krawczyk, M.2    Kuo, M.T.3    Yamane, Y.4    Savaraj, N.5    Ishikawa, T.6
  • 14
    • 0032534064 scopus 로고    scopus 로고
    • Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): Evidence for cotransport with reduced glutathione
    • D.W. Loe, R.G. Deeley, and S.P. Cole Characterization of vincristine transport by the M(r) 190,000 multidrug resistance protein (MRP): evidence for cotransport with reduced glutathione Cancer Res. 58 1998 5130 5136
    • (1998) Cancer Res. , vol.58 , pp. 5130-5136
    • Loe, D.W.1    Deeley, R.G.2    Cole, S.P.3
  • 15
    • 0030063480 scopus 로고    scopus 로고
    • Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump
    • G. Jedlitschky, I. Leier, U. Buchholz, K. Barnouin, G. Kurz, and D. Keppler Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump Cancer Res. 56 1996 988 994
    • (1996) Cancer Res. , vol.56 , pp. 988-994
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Barnouin, K.4    Kurz, G.5    Keppler, D.6
  • 16
    • 0026459859 scopus 로고
    • The ATP-dependent glutathione S-conjugate export pump
    • T. Ishikawa The ATP-dependent glutathione S-conjugate export pump Trends Biochem. Sci. 17 1992 463 468
    • (1992) Trends Biochem. Sci. , vol.17 , pp. 463-468
    • Ishikawa, T.1
  • 17
    • 0034072174 scopus 로고    scopus 로고
    • Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions
    • E. Bakos, R. Evers, J.A. Sinkule, A. Varadi, P. Borst, and B. Sarkadi Interactions of the human multidrug resistance proteins MRP1 and MRP2 with organic anions Mol. Pharmacol. 57 2000 760 768
    • (2000) Mol. Pharmacol. , vol.57 , pp. 760-768
    • Bakos, E.1    Evers, R.2    Sinkule, J.A.3    Varadi, A.4    Borst, P.5    Sarkadi, B.6
  • 18
    • 0030009305 scopus 로고    scopus 로고
    • Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles: Demonstration of glutathione-dependent vincristine transport
    • D.W. Loe, K.C. Almquist, R.G. Deeley, and S.P.C. Cole Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles: demonstration of glutathione-dependent vincristine transport J. Biol. Chem. 271 1996 9675 9682
    • (1996) J. Biol. Chem. , vol.271 , pp. 9675-9682
    • Loe, D.W.1    Almquist, K.C.2    Deeley, R.G.3    Cole, S.P.C.4
  • 19
    • 0029918142 scopus 로고    scopus 로고
    • ATP-dependent 17-estradiol 17-(-D-glucuronide) transport by multidrug resistance protein: Inhibition by cholestatic steroids
    • D.W. Loe, K.C. Almquist, S.P.C. Cole, and R.G. Deeley ATP-dependent 17-estradiol 17-(-D-glucuronide) transport by multidrug resistance protein: inhibition by cholestatic steroids J. Biol. Chem. 271 1996 9683 9689
    • (1996) J. Biol. Chem. , vol.271 , pp. 9683-9689
    • Loe, D.W.1    Almquist, K.C.2    Cole, S.P.C.3    Deeley, R.G.4
  • 20
    • 0030962253 scopus 로고    scopus 로고
    • ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the MRP gene
    • D.W. Loe, R.K. Stewart, T.E. Massey, R.G. Deeley, and S.P.C. Cole ATP-dependent transport of aflatoxin B1 and its glutathione conjugates by the product of the MRP gene Mol. Pharmacol. 51 1997 1034 1041
    • (1997) Mol. Pharmacol. , vol.51 , pp. 1034-1041
    • Loe, D.W.1    Stewart, R.K.2    Massey, T.E.3    Deeley, R.G.4    Cole, S.P.C.5
  • 21
    • 0025132673 scopus 로고
    • ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates
    • T. Ishikawa, M. Müller, C. Klünemann, U. Berger, L. Lucka, and A. Schreyer ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates J. Biol. Chem. 265 1990 19279 19286
    • (1990) J. Biol. Chem. , vol.265 , pp. 19279-19286
    • Ishikawa, T.1    Müller, M.2    Klünemann, C.3    Berger, U.4    Lucka, L.5    Schreyer, A.6
  • 25
    • 0030668526 scopus 로고    scopus 로고
    • ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2
    • G. Jedlitschky, I. Leier, U. Buchholz, J. Hummel-Eisenbeiss, B. Burchell, and D. Keppler ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2 Biochem. J. 327 1997 305 310
    • (1997) Biochem. J. , vol.327 , pp. 305-310
    • Jedlitschky, G.1    Leier, I.2    Buchholz, U.3    Hummel-Eisenbeiss, J.4    Burchell, B.5    Keppler, D.6
  • 26
    • 0035958862 scopus 로고    scopus 로고
    • Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1), requirement for glutathione or a non-sulfur-containing analog
    • E.M. Leslie, K.-I. Ito, P. Upadhyaya, S.S. Hecht, R.G. Deeley, and S.P.C. Cole Transport of the β-O-glucuronide conjugate of the tobacco-specific carcinogen 4- (methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by the multidrug resistance protein 1 (MRP1), requirement for glutathione or a non-sulfur-containing analog J. Biol. Chem. 276 2001 27846 27854
    • (2001) J. Biol. Chem. , vol.276 , pp. 27846-27854
    • Leslie, E.M.1    Ito, K.-I.2    Upadhyaya, P.3    Hecht, S.S.4    Deeley, R.G.5    Cole, S.P.C.6
  • 27
    • 0001308329 scopus 로고    scopus 로고
    • Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    • R. Evers, M. Kool, L. Van, H. Jansen, J. Calafat, and L.C. Oomen Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA J. Clin. Invest. 101 1998 1310 1319
    • (1998) J. Clin. Invest. , vol.101 , pp. 1310-1319
    • Evers, R.1    Kool, M.2    Van, L.3    Jansen, H.4    Calafat, J.5    Oomen, L.C.6
  • 28
    • 0035034532 scopus 로고    scopus 로고
    • Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine in MRP2-deficient rats
    • C.G. Dietrich, D.R. De Waart, R. Ottenhoff, I.G. Schoots, and R.P. Elferink Increased bioavailability of the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine in MRP2-deficient rats Mol. Pharmacol. 59 2001 974 980
    • (2001) Mol. Pharmacol. , vol.59 , pp. 974-980
    • Dietrich, C.G.1    De Waart, D.R.2    Ottenhoff, R.3    Schoots, I.G.4    Elferink, R.P.5
  • 29
    • 0030814774 scopus 로고    scopus 로고
    • The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man
    • C.C. Paulusma, and R. Oude Elferink The canalicular multispecific organic anion transporter and conjugated hyperbilirubinemia in rat and man J. Mol. Med. 75 1997 420 428
    • (1997) J. Mol. Med. , vol.75 , pp. 420-428
    • Paulusma, C.C.1    Oude Elferink, R.2
  • 30
    • 0034721764 scopus 로고    scopus 로고
    • The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic
    • S.V. Kala, M.W. Neely, G. Kala, C.I. Prater, D.W. Atwood, and J.S. Rice The MRP2/cMOAT transporter and arsenic-glutathione complex formation are required for biliary excretion of arsenic J. Biol. Chem. 275 2000 33404 33408
    • (2000) J. Biol. Chem. , vol.275 , pp. 33404-33408
    • Kala, S.V.1    Neely, M.W.2    Kala, G.3    Prater, C.I.4    Atwood, D.W.5    Rice, J.S.6
  • 31
    • 0019278267 scopus 로고
    • Hepatocellular carcinoma in a case of Dubin-Johnson syndrome treated successfully with right extended lobectomy
    • J. Okamura, M. Monden, S. Horikawa, O. Sikujara, G. Kosaki, and K. Seki Hepatocellular carcinoma in a case of Dubin-Johnson syndrome treated successfully with right extended lobectomy Jpn. J. Surg. 10 1980 343 347
    • (1980) Jpn. J. Surg. , vol.10 , pp. 343-347
    • Okamura, J.1    Monden, M.2    Horikawa, S.3    Sikujara, O.4    Kosaki, G.5    Seki, K.6
  • 32
    • 0019941552 scopus 로고
    • A black hepatocellular carcinoma with Dubin-Johnson-like pigment and mallory bodies: A histochemical and ultrastructural study
    • J.A. Roth, E. Berman, D. Befeler, and F.B. Johnson A black hepatocellular carcinoma with Dubin-Johnson-like pigment and mallory bodies: a histochemical and ultrastructural study Am. J. Surg. Pathol. 6 1982 375 382
    • (1982) Am. J. Surg. Pathol. , vol.6 , pp. 375-382
    • Roth, J.A.1    Berman, E.2    Befeler, D.3    Johnson, F.B.4
  • 33
    • 0023407554 scopus 로고
    • Dubin-Johnson syndrome associated with hepatocellular carcinoma - Report of an autopsy case
    • A. Sakamoto, I. Mori, K. Kawai, and H. Tsuchiyama Dubin-Johnson syndrome associated with hepatocellular carcinoma - report of an autopsy case Gan No Rinsho (Jpn. J. Cancer Clin.) 33 1987 1361 1367
    • (1987) Gan No Rinsho (Jpn. J. Cancer Clin.) , vol.33 , pp. 1361-1367
    • Sakamoto, A.1    Mori, I.2    Kawai, K.3    Tsuchiyama, H.4
  • 35
    • 0026947534 scopus 로고
    • Japanese clinical statistical data of patients with constitutional jaundice
    • Y. Adachi, T. Nanno, and T. Yamamoto Japanese clinical statistical data of patients with constitutional jaundice Nippon Rinsho (Jpn. J. Clin. Med.) 50 1992 677 685 (in Japanese)
    • (1992) Nippon Rinsho (Jpn. J. Clin. Med.) , vol.50 , pp. 677-685
    • Adachi, Y.1    Nanno, T.2    Yamamoto, T.3
  • 36
    • 0032429384 scopus 로고    scopus 로고
    • Postoperative management following massive hepatectomy in a patient with Dubin-Johnson syndrome: Report of a case
    • S. Ueno, G. Tanabe, K. Hanazono, H. Ogawa, S. Yoshidome, and T. Aikou Postoperative management following massive hepatectomy in a patient with Dubin-Johnson syndrome: report of a case Surg. Today 28 1998 1274 1278
    • (1998) Surg. Today , vol.28 , pp. 1274-1278
    • Ueno, S.1    Tanabe, G.2    Hanazono, K.3    Ogawa, H.4    Yoshidome, S.5    Aikou, T.6
  • 37
    • 0017695106 scopus 로고
    • Clinical study of the constitutional hyperbilirubinemia in Japan. a nationwide survey between 1970 and 1974
    • T. Takino, T. Takahashi, and T. Okuno Clinical study of the constitutional hyperbilirubinemia in Japan. A nationwide survey between 1970 and 1974 Jpn. J. Gastroenterol. 74 1977 1518 1528
    • (1977) Jpn. J. Gastroenterol. , vol.74 , pp. 1518-1528
    • Takino, T.1    Takahashi, T.2    Okuno, T.3
  • 38
    • 0033361943 scopus 로고    scopus 로고
    • Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATPBinding-cassette region in Dubin-Johnson syndrome
    • S. Toh, M. Wada, T. Uchiumi, A. Inokuchi, Y. Makino, and Y. Horie Genomic structure of the canalicular multispecific organic anion-transporter gene (MRP2/cMOAT) and mutations in the ATPBinding-cassette region in Dubin-Johnson syndrome Am. J. Hum. Genet. 64 1999 739 746
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 739-746
    • Toh, S.1    Wada, M.2    Uchiumi, T.3    Inokuchi, A.4    Makino, Y.5    Horie, Y.6
  • 39
    • 0041668155 scopus 로고    scopus 로고
    • The role of pglycoprotein in intestinal tumorigenesis: Disruption of indula suppresses polyp formation in ApcMin,4 mice
    • Y. Mochida, K. Taguchi, S. Taniguchi, M. Tsuneyoshi, H. Kuwano, and T. Tsuzuki The role of pglycoprotein in intestinal tumorigenesis: disruption of indula suppresses polyp formation in ApcMin,4 mice Carcinogenesis 24 2003 1219 1224
    • (2003) Carcinogenesis , vol.24 , pp. 1219-1224
    • Mochida, Y.1    Taguchi, K.2    Taniguchi, S.3    Tsuneyoshi, M.4    Kuwano, H.5    Tsuzuki, T.6
  • 40
    • 0037373889 scopus 로고    scopus 로고
    • Suppression of intestinal polyposis in Mdrl-deficient ApcMin/_ mice
    • T. Yamada, Y. Mari, R. Hayashi, M. Takada, Y. Ino, and Y. Naishiao Suppression of intestinal polyposis in Mdrl-deficient ApcMin/_ mice Cancer Res. 63 2003 895 901
    • (2003) Cancer Res. , vol.63 , pp. 895-901
    • Yamada, T.1    Mari, Y.2    Hayashi, R.3    Takada, M.4    Ino, Y.5    Naishiao, Y.6
  • 41
    • 0025325922 scopus 로고
    • Carvalho: Diagnostic and pathogenetic implications of urinary coproporphyrin excretion in the Dubin-Johnson syndrome
    • M. Frank, M. Doss, and D.G. De Carvalho Carvalho: diagnostic and pathogenetic implications of urinary coproporphyrin excretion in the Dubin-Johnson syndrome Hepatogastroenterology 37 1990 147 151
    • (1990) Hepatogastroenterology , vol.37 , pp. 147-151
    • Frank, M.1    Doss, M.2    De Carvalho, D.G.3
  • 42
    • 0035103009 scopus 로고    scopus 로고
    • Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects
    • S. Ito, I. Ieiri, M. Tanabe, A. Suzuki, S. Higuchi, and K. Otsubo Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/cMOAT, in healthy Japanese subjects Pharmacogenetics 11 2001 175 184
    • (2001) Pharmacogenetics , vol.11 , pp. 175-184
    • Ito, S.1    Ieiri, I.2    Tanabe, M.3    Suzuki, A.4    Higuchi, S.5    Otsubo, K.6
  • 43
    • 0036246271 scopus 로고    scopus 로고
    • Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR)
    • S. Saito, A. Iida, A. Sekine, C. Ogawa, S. Kawauchi, and S. Higuchi Identification of 779 genetic variations in eight genes encoding members of the ATP-binding cassette, subfamily C (ABCC/MRP/CFTR) J. Hum. Genet. 47 2002 147 171
    • (2002) J. Hum. Genet. , vol.47 , pp. 147-171
    • Saito, S.1    Iida, A.2    Sekine, A.3    Ogawa, C.4    Kawauchi, S.5    Higuchi, S.6
  • 44
    • 0037131880 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): Its impact on drug disposition
    • H. Suzuki, and Y. Sugiyama Single nucleotide polymorphisms in multidrug resistance associated protein 2 (MRP2/ABCC2): its impact on drug disposition Adv. Drug Deliv. Rev. 54 2002 1311 1331
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1311-1331
    • Suzuki, H.1    Sugiyama, Y.2
  • 45
    • 0029986408 scopus 로고    scopus 로고
    • Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome
    • J. Kartenbeck, U. Leuschner, R. Mayer, and D. Keppler Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome Hepatology 23 1996 1061 1066
    • (1996) Hepatology , vol.23 , pp. 1061-1066
    • Kartenbeck, J.1    Leuschner, U.2    Mayer, R.3    Keppler, D.4
  • 46
    • 0029849789 scopus 로고    scopus 로고
    • The canalicular conjugate export pump encoded by the cmrp/cmoat gene
    • D. Keppler, and J. Kartenbeck The canalicular conjugate export pump encoded by the cmrp/cmoat gene Prog. Liver Dis. 14 1996 55 67
    • (1996) Prog. Liver Dis. , vol.14 , pp. 55-67
    • Keppler, D.1    Kartenbeck, J.2
  • 47
    • 0030994468 scopus 로고    scopus 로고
    • Mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    • C.C. Paulusma, M. Kool, P.J. Bosma, G.L. Scheffer, F. Ter Borg, and R.J. Scheper Mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome Hepatology 25 1997 1539 1542
    • (1997) Hepatology , vol.25 , pp. 1539-1542
    • Paulusma, C.C.1    Kool, M.2    Bosma, P.J.3    Scheffer, G.L.4    Ter Borg, F.5    Scheper, R.J.6
  • 48
    • 0032842748 scopus 로고    scopus 로고
    • Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome
    • H. Tsujii, J. Konig, D. Rost, B. Stockel, U. Leuschner, and D. Keppler Exon-intron organization of the human multidrug-resistance protein 2 (MRP2) gene mutated in Dubin-Johnson syndrome Gastroenterology 117 1999 653 660
    • (1999) Gastroenterology , vol.117 , pp. 653-660
    • Tsujii, H.1    Konig, J.2    Rost, D.3    Stockel, B.4    Leuschner, U.5    Keppler, D.6
  • 49
    • 6844250107 scopus 로고    scopus 로고
    • Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome
    • M. Wada, S. Toh, K. Taniguchi, T. Nakamura, T. Uchiumi, and K. Kohno Mutations in the canilicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia II/Dubin-Johnson syndrome Hum. Mol. Genet. 7 1998 203 207
    • (1998) Hum. Mol. Genet. , vol.7 , pp. 203-207
    • Wada, M.1    Toh, S.2    Taniguchi, K.3    Nakamura, T.4    Uchiumi, T.5    Kohno, K.6
  • 50
    • 0035989612 scopus 로고    scopus 로고
    • A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome
    • G. Tate, M. Li, T. Suzuki, and T. Mitsuya A new mutation of the ATP-binding cassette, sub-family C, member 2 (ABCC2) gene in a Japanese patient with Dubin-Johnson syndrome Genes Genet. Syst. 77 2002 117 121
    • (2002) Genes Genet. Syst. , vol.77 , pp. 117-121
    • Tate, G.1    Li, M.2    Suzuki, T.3    Mitsuya, T.4
  • 51
    • 0033652766 scopus 로고    scopus 로고
    • Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome
    • V. Keitel, J. Kartenbeck, A.T. Nies, H. Spring, M. Brom, and D. Keppler Impaired protein maturation of the conjugate export pump multidrug resistance protein 2 as a consequence of a deletion mutation in Dubin-Johnson syndrome Hepatology 32 2000 1317 1328
    • (2000) Hepatology , vol.32 , pp. 1317-1328
    • Keitel, V.1    Kartenbeck, J.2    Nies, A.T.3    Spring, H.4    Brom, M.5    Keppler, D.6
  • 52
    • 0035813178 scopus 로고    scopus 로고
    • Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome
    • R. Mor-Cohen, A. Zivelin, N. Rosenberg, M. Shani, S. Muallem, and U. Seligsohn Identification and functional analysis of two novel mutations in the multidrug resistance protein 2 gene in Israeli patients with Dubin-Johnson syndrome J. Biol. Chem. 276 2001 36923 36930
    • (2001) J. Biol. Chem. , vol.276 , pp. 36923-36930
    • Mor-Cohen, R.1    Zivelin, A.2    Rosenberg, N.3    Shani, M.4    Muallem, S.5    Seligsohn, U.6
  • 53
    • 0036830243 scopus 로고    scopus 로고
    • Trafficking-defect and functional-defect by mutations of the ATP-binding domains in multidrug resistance protein 2 in patients with Dubin-Johnson syndrome
    • K. Hashimoto, T. Uchiumi, T. Konno, T. Ebihara, T. Nakamura, and M. Wada Trafficking-defect and functional-defect by mutations of the ATP-binding domains in multidrug resistance protein 2 in patients with Dubin-Johnson syndrome Hepatology 36 2002 1236 1245
    • (2002) Hepatology , vol.36 , pp. 1236-1245
    • Hashimoto, K.1    Uchiumi, T.2    Konno, T.3    Ebihara, T.4    Nakamura, T.5    Wada, M.6
  • 54
    • 0033016291 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway and pathogenesis of human diseases
    • A.L. Schwartz, and A. Ciechanover The ubiquitin-proteasome pathway and pathogenesis of human diseases Ann. Rev. Med. 50 1999 57 74
    • (1999) Ann. Rev. Med. , vol.50 , pp. 57-74
    • Schwartz, A.L.1    Ciechanover, A.2
  • 56
    • 0029124166 scopus 로고
    • P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site
    • I.L. Urbatsch, B. Sankaran, J. Weber, and A.E. Senior P-glycoprotein is stably inhibited by vanadate-induced trapping of nucleotide at a single catalytic site J. Biol. Chem. 270 1995 19383 19390
    • (1995) J. Biol. Chem. , vol.270 , pp. 19383-19390
    • Urbatsch, I.L.1    Sankaran, B.2    Weber, J.3    Senior, A.E.4
  • 57
    • 0034724680 scopus 로고    scopus 로고
    • Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1
    • M. Gao, H.R. Cui, D.W. Loe, C.E. Grant, K.C. Almquist, and S.P.C. Cole Comparison of the functional characteristics of the nucleotide binding domains of multidrug resistance protein 1 J. Biol. Chem. 275 2000 13098 13108
    • (2000) J. Biol. Chem. , vol.275 , pp. 13098-13108
    • Gao, M.1    Cui, H.R.2    Loe, D.W.3    Grant, C.E.4    Almquist, K.C.5    Cole, S.P.C.6
  • 58
    • 0034625350 scopus 로고    scopus 로고
    • Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1
    • K. Nagata, M. Nishitani, M. Matsuo, N. Kioka, T. Amachi, and K. Ueda Nonequivalent nucleotide trapping in the two nucleotide binding folds of the human multidrug resistance protein MRP1 J. Biol. Chem. 275 2000 17626 17630
    • (2000) J. Biol. Chem. , vol.275 , pp. 17626-17630
    • Nagata, K.1    Nishitani, M.2    Matsuo, M.3    Kioka, N.4    Amachi, T.5    Ueda, K.6
  • 59
    • 0032542358 scopus 로고    scopus 로고
    • Crystal structure of the ATP-binding subunit of an ABC transporter
    • L.W. Hung, I.X. Wang, K. Nikaido, P.Q. Liu, G.F. Ames, and S.H. Kim Crystal structure of the ATP-binding subunit of an ABC transporter Nature 396 1998 703 707
    • (1998) Nature , vol.396 , pp. 703-707
    • Hung, L.W.1    Wang, I.X.2    Nikaido, K.3    Liu, P.Q.4    Ames, G.F.5    Kim, S.H.6
  • 60
    • 0027995444 scopus 로고
    • Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients
    • T. Dork, F. Mekus, K. Schmidt, J. Bosshammer, R. Fislage, and T. Heuer Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients Hum. Genet. 94 1994 533 542
    • (1994) Hum. Genet. , vol.94 , pp. 533-542
    • Dork, T.1    Mekus, F.2    Schmidt, K.3    Bosshammer, J.4    Fislage, R.5    Heuer, T.6
  • 61
    • 0034669176 scopus 로고    scopus 로고
    • Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon thermococcus litoralis
    • K. Diederichs, J. Diez, G. Greller, C. Muller, J. Breed, and C. Schrell Crystal structure of MalK, the ATPase subunit of the trehalose/maltose ABC transporter of the archaeon thermococcus litoralis Eur. Mol. Biol. Org. J. 19 2000 5951 5961
    • (2000) Eur. Mol. Biol. Org. J. , vol.19 , pp. 5951-5961
    • Diederichs, K.1    Diez, J.2    Greller, G.3    Muller, C.4    Breed, J.5    Schrell, C.6
  • 62
    • 0032545447 scopus 로고    scopus 로고
    • A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome
    • S. Kajihara, A. Hisatomi, T. Mizuta, T. Hara, I. Ozaki, and I. Wada A splice mutation in the human canalicular multispecific organic anion transporter gene causes Dubin-Johnson syndrome Biochem. Biophys. Res. Commun. 253 1998 454 457
    • (1998) Biochem. Biophys. Res. Commun. , vol.253 , pp. 454-457
    • Kajihara, S.1    Hisatomi, A.2    Mizuta, T.3    Hara, T.4    Ozaki, I.5    Wada, I.6
  • 63
    • 16944363733 scopus 로고    scopus 로고
    • Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression
    • R.C. Bargou, K. Jurchott, C. Wagener, S. Bergmann, S. Metzner, and K. Bommert Nuclear localization and increased levels of transcription factor YB-1 in primary human breast cancers are associated with intrinsic MDR1 gene expression Nat. Med. 3 1997 447 450
    • (1997) Nat. Med. , vol.3 , pp. 447-450
    • Bargou, R.C.1    Jurchott, K.2    Wagener, C.3    Bergmann, S.4    Metzner, S.5    Bommert, K.6
  • 64
    • 0032513246 scopus 로고    scopus 로고
    • Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene
    • T. Ohga, T. Uchiumi, Y. Makino, K. Koike, M. Wada, and M. Kuwano Direct involvement of the Y-box binding protein YB-1 in genotoxic stress-induced activation of the human multidrug resistance 1 gene J. Biol. Chem. 273 1998 5997 6000
    • (1998) J. Biol. Chem. , vol.273 , pp. 5997-6000
    • Ohga, T.1    Uchiumi, T.2    Makino, Y.3    Koike, K.4    Wada, M.5    Kuwano, M.6
  • 65
    • 0034021716 scopus 로고    scopus 로고
    • Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines
    • T. Harada, J. Nagayama, K. Kohno, L.A. Mickley, T. Fojo, and M. Kuwano Alu-associated interstitial deletions and chromosomal re-arrangement in 2 human multidrug-resistant cell lines Int. J. Cancer 86 2000 506 511
    • (2000) Int. J. Cancer , vol.86 , pp. 506-511
    • Harada, T.1    Nagayama, J.2    Kohno, K.3    Mickley, L.A.4    Fojo, T.5    Kuwano, M.6
  • 66
    • 0033564370 scopus 로고    scopus 로고
    • Association of 5′ CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells
    • H. Kusaba, M. Nakayama, T. Harada, M. Nomoto, K. Kohno, and M. Kuwano Association of 5′ CpG demethylation and altered chromatin structure in the promoter region with transcriptional activation of the multidrug resistance 1 gene in human cancer cells Eur. J. Biochem. 262 1999 924 932
    • (1999) Eur. J. Biochem. , vol.262 , pp. 924-932
    • Kusaba, H.1    Nakayama, M.2    Harada, T.3    Nomoto, M.4    Kohno, K.5    Kuwano, M.6
  • 67
    • 0032403478 scopus 로고    scopus 로고
    • Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias
    • M. Nakayama, M. Wada, T. Harada, J. Nagayama, H. Kusaba, and K. Ohshima Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias Blood 92 1998 4296 4307
    • (1998) Blood , vol.92 , pp. 4296-4307
    • Nakayama, M.1    Wada, M.2    Harada, T.3    Nagayama, J.4    Kusaba, H.5    Ohshima, K.6
  • 68
    • 0034351878 scopus 로고    scopus 로고
    • MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment
    • Y. Tada, M. Wada, K. Kuroiwa, N. Kinugawa, T. Harada, and J. Nagayama MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment Clin. Cancer Res. 6 2000 4618 4627
    • (2000) Clin. Cancer Res. , vol.6 , pp. 4618-4627
    • Tada, Y.1    Wada, M.2    Kuroiwa, K.3    Kinugawa, N.4    Harada, T.5    Nagayama, J.6
  • 70
    • 0023889448 scopus 로고
    • Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16
    • I. Sugawara, I. Kataoka, Y. Morishita, H. Hamada, T. Tsuruo, and S. Itoyama Tissue distribution of P-glycoprotein encoded by a multidrug-resistant gene as revealed by a monoclonal antibody, MRK 16 Cancer Res. 48 1988 1926 1929
    • (1988) Cancer Res. , vol.48 , pp. 1926-1929
    • Sugawara, I.1    Kataoka, I.2    Morishita, Y.3    Hamada, H.4    Tsuruo, T.5    Itoyama, S.6
  • 72
    • 4243801613 scopus 로고    scopus 로고
    • Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
    • A.H. Schinkel, U. Mayer, E. Wagenaar, C.A. Mol, L. Van Deemter, and J.J. Smit Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins Proc. Natl Acad. Sci. USA 94 1997 4028 4033
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 4028-4033
    • Schinkel, A.H.1    Mayer, U.2    Wagenaar, E.3    Mol, C.A.4    Van Deemter, L.5    Smit, J.J.6
  • 73
    • 0031982725 scopus 로고    scopus 로고
    • Pharmacological insights from P-glycoprotein knockout mice
    • A.H. Schinkel Pharmacological insights from P-glycoprotein knockout mice Int. J. Clin. Pharmacol. Ther. 36 1998 9 13
    • (1998) Int. J. Clin. Pharmacol. Ther. , vol.36 , pp. 9-13
    • Schinkel, A.H.1
  • 75
    • 0342762062 scopus 로고    scopus 로고
    • The barrier function of CYP3A4 and P-glycoprotein in the small bowel
    • P.B. Watkins The barrier function of CYP3A4 and P-glycoprotein in the small bowel Adv. Drug Deliv. Rev. 27 1997 161 170
    • (1997) Adv. Drug Deliv. Rev. , vol.27 , pp. 161-170
    • Watkins, P.B.1
  • 76
    • 0037131893 scopus 로고    scopus 로고
    • The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans
    • M.F. Fromm The influence of MDR1 polymorphisms on P-glycoprotein expression and function in humans Adv. Drug Deliv. Rev. 54 2002 1295 1310
    • (2002) Adv. Drug Deliv. Rev. , vol.54 , pp. 1295-1310
    • Fromm, M.F.1
  • 78
    • 0029916534 scopus 로고    scopus 로고
    • P-glycoprotein: A major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans
    • E.G. Schuetz, A.H. Schinkel, M.V. Relling, and J.D. Schuetz P-glycoprotein: a major determinant of rifampicin-inducible expression of cytochrome P4503A in mice and humans Proc. Natl Acad. Sci. USA 93 1996 4001 4005
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4001-4005
    • Schuetz, E.G.1    Schinkel, A.H.2    Relling, M.V.3    Schuetz, J.D.4
  • 80
    • 0030838009 scopus 로고    scopus 로고
    • The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain
    • U. Schumacher, and K. Mollgard The multidrug-resistance P-glycoprotein (Pgp, MDR1) is an early marker of blood-brain barrier development in the microvessels of the developing human brain Histochem. Cell Biol. 108 1997 179 182
    • (1997) Histochem. Cell Biol. , vol.108 , pp. 179-182
    • Schumacher, U.1    Mollgard, K.2
  • 81
    • 0033616684 scopus 로고    scopus 로고
    • Choroid plexus epithelialexpression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal fluid drug-permeability barrier
    • V.V. Rao, J.L. Dahlheimer, M.E. Bardgett, A.Z. Snyder, R.A. Finch, and A.C. Sartorelli Choroid plexus epithelialexpression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal fluid drug-permeability barrier Proc. Natl Acad. Sci. USA 96 1999 3900 3905
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 3900-3905
    • Rao, V.V.1    Dahlheimer, J.L.2    Bardgett, M.E.3    Snyder, A.Z.4    Finch, R.A.5    Sartorelli, A.C.6
  • 82
    • 0024576304 scopus 로고
    • Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: Evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
    • F. Thiebaut, T. Tsuruo, H. Hamada, M.M. Gottesman, I. Pastan, and M.C. Willingham Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein J. Histochem. Cytochem. 37 1989 159 164
    • (1989) J. Histochem. Cytochem. , vol.37 , pp. 159-164
    • Thiebaut, F.1    Tsuruo, T.2    Hamada, H.3    Gottesman, M.M.4    Pastan, I.5    Willingham, M.C.6
  • 83
    • 0034046035 scopus 로고    scopus 로고
    • Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas
    • E. Hinoshita, T. Uchiumi, K. Taguchi, N. Kinukawa, M. Tsuneyoshi, and Y. Maehara Increased expression of an ATP-binding cassette superfamily transporter, multidrug resistance protein 2, in human colorectal carcinomas Clin. Cancer Res. 6 2000 2401 2407
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2401-2407
    • Hinoshita, E.1    Uchiumi, T.2    Taguchi, K.3    Kinukawa, N.4    Tsuneyoshi, M.5    Maehara, Y.6
  • 84
    • 0026500180 scopus 로고
    • The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa
    • S. Hsing, Z. Gatmaitan, and I.M. Arias The function of Gp170, the multidrug-resistance gene product, in the brush border of rat intestinal mucosa Gastroenterology 102 1992 879 885
    • (1992) Gastroenterology , vol.102 , pp. 879-885
    • Hsing, S.1    Gatmaitan, Z.2    Arias, I.M.3
  • 85
    • 0033958086 scopus 로고    scopus 로고
    • Multiple physiological functions for multidrug transporter P-glycoprotein?
    • R.W. Johnstone, A.A. Ruefli, and M.J. Smyth Multiple physiological functions for multidrug transporter P-glycoprotein? Trends Biochem. Sci. 25 2000 1 6
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 1-6
    • Johnstone, R.W.1    Ruefli, A.A.2    Smyth, M.J.3
  • 86
    • 0025739785 scopus 로고
    • Relationship of the expression of the multidrug resistance gene product (P- glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis
    • R.S. Weinstein, S.M. Jakate, J.M. Dominguez, M.D. Lebovitz, G.K. Koukoulis, and J.R. Kuszak Relationship of the expression of the multidrug resistance gene product (P- glycoprotein) in human colon carcinoma to local tumor aggressiveness and lymph node metastasis Cancer Res. 51 1991 2720 2726
    • (1991) Cancer Res. , vol.51 , pp. 2720-2726
    • Weinstein, R.S.1    Jakate, S.M.2    Dominguez, J.M.3    Lebovitz, M.D.4    Koukoulis, G.K.5    Kuszak, J.R.6
  • 87
    • 1542399109 scopus 로고    scopus 로고
    • Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N- nitrosourea induced mammary carcinogenesis in rats
    • J. Kankesan, R. Vanama, A. Yusuf, J.J. Thiessen, V. Ling, and P.M. Rao Effect of PSC 833, an inhibitor of P-glycoprotein on N-methyl-N-nitrosourea induced mammary carcinogenesis in rats Carcinogenesis 25 2004 425 430
    • (2004) Carcinogenesis , vol.25 , pp. 425-430
    • Kankesan, J.1    Vanama, R.2    Yusuf, A.3    Thiessen, J.J.4    Ling, V.5    Rao, P.M.6
  • 88
    • 10744231610 scopus 로고    scopus 로고
    • Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats
    • J. Kankesan, A. Yusuf, E. Laconi, R. Vanama, G. Bradley, and J.J. Thiessen Effect of PSC 833, an inhibitor of P-glycoprotein, on 1,2-dimethylhydrazine-induced liver carcinogenesis in rats Carcinogenesis 24 2003 1977 1984
    • (2003) Carcinogenesis , vol.24 , pp. 1977-1984
    • Kankesan, J.1    Yusuf, A.2    Laconi, E.3    Vanama, R.4    Bradley, G.5    Thiessen, J.J.6
  • 89
    • 0034724324 scopus 로고    scopus 로고
    • Functional polymorphisms of the human multidrugresistance gene: Multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    • S. Hoffmeyer, O. Burk, O. Von Richter, H.P. Arnold, J. Brockmoller, and A. Johne Functional polymorphisms of the human multidrugresistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo Proc. Natl Acad. Sci. USA 97 2000 3473 3478
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 3473-3478
    • Hoffmeyer, S.1    Burk, O.2    Von Richter, O.3    Arnold, H.P.4    Brockmoller, J.5    Johne, A.6
  • 90
    • 1942467691 scopus 로고    scopus 로고
    • Genetic polymorphism at the 5′ regulatory region of MDR1 and its association with inter-individual variation of expression level in colon
    • S. Taniguchi, Y. Mochida, T. Uchiumi, T. Tahira, K. Hayashi, and K. Takagi Genetic polymorphism at the 5′ regulatory region of MDR1 and its association with inter-individual variation of expression level in colon Mol. Cancer Ther. 2 2003 1351 1359
    • (2003) Mol. Cancer Ther. , vol.2 , pp. 1351-1359
    • Taniguchi, S.1    Mochida, Y.2    Uchiumi, T.3    Tahira, T.4    Hayashi, K.5    Takagi, K.6
  • 91
    • 0142024010 scopus 로고    scopus 로고
    • Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a caucasian patient
    • V. Materna, and H. Lage Homozygous mutation Arg768Trp in the ABC-transporter encoding gene MRP2/cMOAT/ABCC2 causes Dubin-Johnson syndrome in a caucasian patient J. Hum. Genet. 48 2003 484 486
    • (2003) J. Hum. Genet. , vol.48 , pp. 484-486
    • Materna, V.1    Lage, H.2
  • 92
    • 0141867789 scopus 로고    scopus 로고
    • Identification of a novel 2026G→C mutation of the MRP2 gene in a Japanese patient with Dubin-Johnson syndrome
    • S. Wakusawa, I. Machida, S. Suzuki, H. Hayashi, M. Yano, and K. Yoshioka Identification of a novel 2026G→C mutation of the MRP2 gene in a Japanese patient with Dubin-Johnson syndrome J. Hum. Genet. 48 2003 425 429
    • (2003) J. Hum. Genet. , vol.48 , pp. 425-429
    • Wakusawa, S.1    MacHida, I.2    Suzuki, S.3    Hayashi, H.4    Yano, M.5    Yoshioka, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.