Temocaprilat, a novel angiotensin-converting enzyme inhibitor, is excreted in bile via an ATP-dependent active transporter (cMOAT) that is deficient in Eisai hyperbilirubinemic mutant rats (EHBR)

Journal of Pharmacology and Experimental Therapeutics

Volumn 280, Issue 3, 1997, Pages 1304-1311

  Ishizuka, Hitoshi ^a   Konno, Kumiko ^a   Naganuma, Hideo ^a   Sasahara, Kunihiro ^a   Kawahara, Yukinori ^a   Niinuma, Kayoko ^b   Suzuki, Hiroshi ^b   Sugiyama, Yuichi ^b  

^a DAIICHI SANKYO CO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; BENAZEPRIL; CILAZAPRIL; DELAPRIL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRIL; IMIDAPRIL; TEMOCAPRILAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MONITORING; DISEASE MODEL; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EXCRETION; DRUG HYDROLYSIS; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HYPERBILIRUBINEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ADENOSINE TRIPHOSPHATE; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ANION TRANSPORT PROTEINS; BILE; BILE CANALICULI; CARRIER PROTEINS; HYPERBILIRUBINEMIA, HEREDITARY; RATS; RATS, MUTANT STRAINS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; THIAZEPINES;

EID: 0030951558     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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