Expression of the apical conjugate export pump, Mrp2, in the polarized hepatoma cell line, WIF-B

Hepatology

Volumn 28, Issue 5, 1998, Pages 1332-1340

  Nies, Anne T ^a   Cantz, Tobias ^a   Brom, Manuela ^a   Leier, Inka ^a   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN A; GLUCURONIDE; GLUTATHIONE; GLYCOPROTEIN; MULTIDRUG RESISTANCE PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL LINE; FIBROBLAST; GENE EXPRESSION; HEPATOMA CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE MICROSCOPY; LIVER CELL CARCINOMA; MALE; MEMBRANE PERMEABILITY; MEMBRANE VESICLE; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATE; ANILINE COMPOUNDS; ANIMALS; ANION TRANSPORT PROTEINS; BIOLOGICAL TRANSPORT, ACTIVE; CARRIER PROTEINS; CELL MEMBRANE; FIBROBLASTS; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; GENE EXPRESSION; HUMANS; HYBRID CELLS; IMMUNOBLOTTING; LIVER NEOPLASMS, EXPERIMENTAL; MALE; POLYMERASE CHAIN REACTION; RATS; RATS, WISTAR; RNA, MESSENGER; TUMOR CELLS, CULTURED; XANTHENES;

EID: 0031758818     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510280523     Document Type: Article

References (16)

1. Meier PJ, Eckhardt U, Schroeder A, Hagenbuch B, Stieger B. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. HEPATOLOGY 1997;26:1667-1677.
2. Keppler D, Arias IM. Introduction: transport across the hepatocyte canalicular membrane. FASEB J 1997;11:15-18.
3. Büchler M, König J, Brom M, Kartenbeck J, Spring H, Hone T, Keppler D. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats. J Biol Chem 1996;271:15091-15098.
4. Paulusma CC, Bosma PJ, Zaman GJR, Bakker CTM, Otter M, Scheffer GL, Scheper RJ, et al. Congenital jaundice in rats with a mutation in a multidrug resistance associated-protein gene. Science 1996;271:1126-1127.
5. Taniguchi K, Wada M, Kohno K, Nakamura T, Kawabe T, Kawakami M, Kagotani K, et al. A human canalicular multispecific organic anion transporter (cMOAT) overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation. Cancer Res 1996;56:4124-4129.
6. Ito K, Suzuki H, Hirohashi T, Kume K, Shimizu T, Sugiyama Y. Molecular cloning of canalicular multispecific organic anion transporter defective in EHBR. Am J Physiol 1997;272:G16-G22.
7. Keppler D, Kartenbeck J. The canalicular conjugate export pump encoded by the cmrp/cmoat gene. In: Boyer JL, Ockner RK, eds. Progress in Liver Diseases. Philadelphia: Saunders, 1996:55-67.
8. 4 and structurally related conjugates. J Biol Chem 1994;269:27807-27810.
9. Jedlitschky G, Leier I, Buchholz U, Barnouin K, Kurz G, Keppler D. Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump. Cancer Res 1996;56:988-994.
10. Jedlitschky G, Leier I, Buchholz U, Hummel-Eisenbeiss J, Burchell B, Keppler D. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem J 1997;327:305-310.
11. Cole SPC, Bhardwaj G, Gerlach JH, Mackie JE, Grant CE, Almquist KC, Stewart AJ, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 1992;258:1650-1654.
12. Schaub TP, Kartenbeck J, König J, Vogel O, Witzgall R, Kriz W, Keppler D. Expression of the conjugate export pump encoded by the mrp2 gene in the apical membrane of kidney proximal tubules. J Am Soc Nephrol 1997;8:1213-1221.
13. Jansen PLM, Peters WHM, Lamers WH. Hereditary chronic conjugated hyperbilirubinemia in mutants rats caused by defective hepatic anion transport. HEPATOLOGY 1985;5:573-579.
14. Kuipers F, Enserink M, Havinga R, van der Steen ABM, Hardonk MJ, Fevery J, Vonk RJ. Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat. J Clin Invest 1988;81:1593-1599.
15. Oude Elferink RPJ, Meijer DKF, Kuipers F, Jansen PLM, Groen AK, Groothuis GMM. Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport. Biochim Biophys Acta 1995;1241:215-268.
16. Takikawa H, Sano N, Narita T, Uchida Y, Yamanaka M, Horie T, Mikami T, et al. Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant Sprague-Dawley rat. HEPATOLOGY 1991;14:352-360.