Regulation of the multidrug resistance protein 2 in the rat liver by lipopolysaccharide and dexamethasone

Gastroenterology

Volumn 116, Issue 2, 1999, Pages 401-410

  Kubitz, R ^a   Wettstein, M ^a   Warskulat, U ^a   Haussinger, D ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BROMSULFOPHTHALEIN; DEXAMETHASONE; DIPEPTIDYL PEPTIDASE IV; LIPOPOLYSACCHARIDE; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILIARY EXCRETION; CELLULAR DISTRIBUTION; CHOLESTASIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; INTRAHEPATIC BILE DUCT; LIVER PERFUSION; MALE; NONHUMAN; NORTHERN BLOTTING; OSMOLARITY; PRIORITY JOURNAL; RAT;

EID: 0032944048     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0016-5085(99)70138-1     Document Type: Article

References (41)

1. D Keppler J. König Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAT) gene in liver FASEB J 11 1997 509 516
2. D Keppler J. Kartenbeck The canalicular conjugate export pump encoded by the cmrp/cmoat gene Prog Liver Dis 14 1996 55 67
3. M Büchler J König M Brom J Kartenbeck H Spring T Horie D. Keppler cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMRP, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats J Biol Chem 271 1996 15091 15098
4. D Keppler IM. Arias Transport across the hepatocyte canalicular membrane FASEB J 11 1997 15 18
5. ZC Gatmaitan IM. Arias ATP-dependent transport systems in the canalicular membrane of the hepatocyte Physiol Rev 75 1995 261 275
6. K Taniguchi M Wada K Kohno T Nakamura T Kawabe M Kawakami K Kagotani K Okumura S Akiyama M. Kuwano A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation Cancer Res 56 1996 4124 4129
7. CC Paulusma PJ Bosma GJR Zaman CTM Bakker M Otter GL Scheffer RJ Scheper P Borst RPJ. Oude-Elferink Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene Science 271 1996 1126 1128
8. RPJ Oude-Elferink DKF Meijer F Kuipers PLM Jansen AK Groen GMM. Groothuis Hepatobiliary secretion of organic compounds: molecular mechanisms of membrane transport Biochim Biophys Acta 1241 1995 215 268
9. J Kartenbeck U Leuschner R Mayer D. Keppler Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome Hepatology 23 1996 1061 1066
10. PLM Jansen RPJ. Oude-Elferink Defective hepatic anion secretion in mutant TR- rats 1st ed N Tavoloni PD Berk Hepatic transport and bile secretion: physiology and pathophysiology. 1993 Raven New York 721 730
11. NA Bradbury RJ. Bridges Role of membrane trafficking in plasma membrane solute transport Am J Physiol 267 1994 C1 C24
12. KM Madsen CC. Tisher Response of intercalated cells of rat outer medullary collecting duct to chronic metabolic acidosis Lab Invest 51 1984 268 276
13. R Kubitz D D'Urso D Keppler D. Häussinger Osmodependent dynamic localization of the multidrug resistance protein 2 in the rat hepatocyte canalicular membrane Gastroenterology 113 1997 1438 1442
14. H Roelofsen CJ Soroka D Keppler JL. Boyer Cyclic AMP stimulates sorting of the canalicular organic anion transporter (Mrp2/cMOAT) to the apical domain in hepatocyte couplets J Cell Sci 111 1998 1137 1145
15. − exchanger in rat hepatocytes Proc Natl Acad Sci USA 91 1994 792 796
16. JL Boyer CJ. Soroka Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets Gastroenterology 109 1995 1600 1611
17. D Häussinger C Hallbrucker N Saha F Lang W. Gerok Cell volume and bile acid secretion Biochem J 288 1992 681 689
18. D Häussinger N Saha C Hallbrucker F Lang W. Gerok Involvement of microtubules in the swelling-induced stimulation of transcellular taurocholate transport in perfused rat liver Biochem J 291 1993 355 360
19. R Bruck P Haddad J Graf JL. Boyer Regulatory volume decrease stimulates bile flow, bile acid excretion and exocytosis in isolated perfused rat liver Am J Physiol 262 1992 G806 G812
20. B Noe F Schliess M Wettstein S Heinrich D. Häussinger Regulation of taurocholate excretion by a hyposmolarity-activated signal transduction pathway in rat liver Gastroenterology 110 1996 858 865
21. F Schliess AK Kurz S vom Dahl D. Häussinger Activation of mitogen-activated protein kinases Erk-1 and Erk-2 mediates the stimulation of bile acid excretion by tauroursodesoxycholate Gastroenterology 113 1997 1306 1314
22. W Hagmann C Denzlinger D. Keppler Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action Circ Shock 14 1984 223 235
23. H Roelofsen B Schoemaker C Bakker R Ottenhoff PLM Jansen RPJ. Oude-Elferink Impaired hepatocanalicular organic anion transport in endotoxinemic rats Am J Physiol 269 1995 G427 G434
24. U Bolder HT Ton-Nu C Schteingart E Frick AF. Hofmann Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion Gastroenterology 112 1997 214 225
25. 3− excretion and blocks the choleretic effect of nitric oxide in rat liver Hepatology 25 1997 1184 1191
26. JF Whiting RM Green AB Rosenbluth JL. Gollan Tumor necrosis factor α decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis Hepatology 22 1995 1273 1278
27. M Trauner M Arrese CJ Soroka A Meenakshisundaram TA Koeppel S Schlosser FJ Suchy D Keppler JL. Boyer The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis Gastroenterology 113 1997 255 264
28. BR Stevenson JD Siliciano MS Mooseker DA. Goodenough Identification of ZO-1: a high molecular weight polypeptide associated with the tight junction (zonula occludens) in a variety of epithelia J Cell Biol 103 1986 755 766
29. A Becker R Neumeier C Heidrich N Loch S Hartel W. Reutter Cell surface glycoproteins of hepatocytes and hepatoma cells identified by monoclonal antibodies Biol Chem Hoppe-Seyler 357 1986 681 688
30. PL Jansen GM Groothuis WH Peters DF. Meijer Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia Hepatology 7 1987 71 76
31. P Chomczynski N. Sacchi Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction Anal Biochem 162 1987 156 159
32. U Warskulat F Zhang D. Häussinger Taurine is an osmolyte in rat liver macrophages J Hepatol 26 1997 1340 1347
33. M Wettstein B Noe D. Häussinger Metabolism of cysteinyl leukotrienes in the perfused rat liver: the influence of endotoxin pretreatment and the cellular hydration state Hepatology 22 1995 235 240
34. D Qian JT. Brosnan Administration of Escherichia coli endotoxin to rat increases liver mass and hepatocyte volume in vivo Biochem J 313 1996 479 486
35. SL Weinstein JS Sanghera K Lemke AL De Franco SL. Pelech Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages J Biol Chem 267 1992 14955 14962
36. JC Lee PR. Young Role of CSBP/p38/RK stress response kinase in LPS and cytokine signalling mechanisms J Leukoc Biol 59 1996 152 157
37. F Schliess R Schreiber D. Häussinger Activation of extracellular signal-regulated kinases Erk-1 and Erk-2 by cell swelling in H4IIE hepatoma cells Biochem J 309 1995 13 17
38. F Schliess S Heinrich R Kubitz S vom Dahl AK Kurz S Rosnowsky D. Häussinger Osmosignalling in liver D Häussinger PC Heinrich Signalling in the liver. 1998 Kluwer Dordrecht, Netherlands 128 150
39. F Lang GL Busch M Ritter H Völkl S Waldegger E Gulbins D. Häussinger Functional significance of cell volume regulatory mechanisms Physiol Rev 78 1998 247 306
40. JG Bode T Peters-Regehr F Schliess D. Häussinger Activation of mitogen-activated protein kinases and IL-6 release in response to lipopolysaccharides in Kupffer cells is modulated by anisoosmolarity J Hepatol 28 1998 795 802
41. HM Kauffmann D. Schrenk Sequence analysis and functional characterization of the 5'-flanking region of the rat multidrug resistance protein 2 (MRP2) gene Biochem Biophys Res Commun 245 1998 325 331