-
1
-
-
0034894958
-
Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis
-
Alas, S., Emmanouilides, C., Bonavida, B. (2001) Inhibition of interleukin 10 by rituximab results in down-regulation of bcl-2 and sensitization of B-cell non-Hodgkin's lymphoma to apoptosis. Clin. Cancer Res. 7, 709-723.
-
(2001)
Clin. Cancer Res.
, vol.7
, pp. 709-723
-
-
Alas, S.1
Emmanouilides, C.2
Bonavida, B.3
-
2
-
-
0037236924
-
Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis
-
Alas, S., Bonavida, B. (2003) Inhibition of constitutive STAT3 activity sensitizes resistant non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin. Cancer Res. 9, 316-326.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 316-326
-
-
Alas, S.1
Bonavida, B.2
-
3
-
-
21144435503
-
A novel CDK inhibitor, CYC2O2 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival
-
Alvi, A. J., Austen, B., Weston, V. J., Fegan, C., MacCallum, D., Gianella-Borradori, A., Lane, D. P., Hubank, M., Powell, J. E., Wei, W., Taylor, A. M., Moss, P. A., Stankovic, T. (2005) A novel CDK inhibitor, CYC2O2 (R-roscovitine), overcomes the defect in p53-dependent apoptosis in B-CLL by down-regulation of genes involved in transcription regulation and survival. Blood 105, 4484-4491.
-
(2005)
Blood
, vol.105
, pp. 4484-4491
-
-
Alvi, A.J.1
Austen, B.2
Weston, V.J.3
Fegan, C.4
MacCallum, D.5
Gianella-Borradori, A.6
Lane, D.P.7
Hubank, M.8
Powell, J.E.9
Wei, W.10
Taylor, A.M.11
Moss, P.A.12
Stankovic, T.13
-
4
-
-
0030746636
-
A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma
-
Ambrosini, G., Adida, C., Altieri, D. C. (1997) A novel antiapoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 3, 917-921.
-
(1997)
Nat. Med.
, vol.3
, pp. 917-921
-
-
Ambrosini, G.1
Adida, C.2
Altieri, D.C.3
-
5
-
-
0032080335
-
Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting
-
Ambrosini, G., Adida, C., Sirugo, G., Altieri, D. C. (1998) Induction of apoptosis and inhibition of cell proliferation by survivin gene targeting. J. Biol. Chem. 273, 11177-11182.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 11177-11182
-
-
Ambrosini, G.1
Adida, C.2
Sirugo, G.3
Altieri, D.C.4
-
6
-
-
0037441888
-
Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma
-
Aoki, Y., Feldman, G. M., Tosato, G. (2003) Inhibition of STAT3 signaling induces apoptosis and decreases survivin expression in primary effusion lymphoma. Blood 101, 1535-1542.
-
(2003)
Blood
, vol.101
, pp. 1535-1542
-
-
Aoki, Y.1
Feldman, G.M.2
Tosato, G.3
-
7
-
-
0037103624
-
Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
-
Apperley, J. F., Gardembas, M., Melo, J. V., Russell-Jones, R., Bain, B. J., Baxter, J., Chase, A., Chessells, J. M., Colombat, M., Dearden, C. E., Dimitrijevic, S., Mahon, F. X., Marin, D., Nikolova, Z., Olavarria, E., Silberman, S., Schultheis, B., Cross, N. C. P., Goldman, J. M. (2002) Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N. Engl. J. Med. 347, 481-487.
-
(2002)
N. Engl. J. Med.
, vol.347
, pp. 481-487
-
-
Apperley, J.F.1
Gardembas, M.2
Melo, J.V.3
Russell-Jones, R.4
Bain, B.J.5
Baxter, J.6
Chase, A.7
Chessells, J.M.8
Colombat, M.9
Dearden, C.E.10
Dimitrijevic, S.11
Mahon, F.X.12
Marin, D.13
Nikolova, Z.14
Olavarria, E.15
Silberman, S.16
Schultheis, B.17
Cross, N.C.P.18
Goldman, J.M.19
-
8
-
-
0038494686
-
Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLiP protein
-
Aron, J. L., Parthun, M. R., Marcucci, G., Kitada, S., Mone, A. P., Davis, M. E., Shen, T., Murphy, T., Wickham, J., Kanakry, C., Lucas, D. M., Reed, J. C., Grever, M. R., Byrd, J. C. (2003) Depsipeptide (FR901228) induces histone acetylation and inhibition of histone deacetylase in chronic lymphocytic leukemia cells concurrent with activation of caspase 8-mediated apoptosis and down-regulation of c-FLiP protein. Blood 102, 652-658.
-
(2003)
Blood
, vol.102
, pp. 652-658
-
-
Aron, J.L.1
Parthun, M.R.2
Marcucci, G.3
Kitada, S.4
Mone, A.P.5
Davis, M.E.6
Shen, T.7
Murphy, T.8
Wickham, J.9
Kanakry, C.10
Lucas, D.M.11
Reed, J.C.12
Grever, M.R.13
Byrd, J.C.14
-
9
-
-
27544479318
-
Role of tyrosine kinase inhibitors in cancer therapy
-
Arora, A., Scholar, E. M. (2005) Role of tyrosine kinase inhibitors in cancer therapy. J. Pharmacol. Exp. Ther. 315, 971-979.
-
(2005)
J. Pharmacol. Exp. Ther.
, vol.315
, pp. 971-979
-
-
Arora, A.1
Scholar, E.M.2
-
10
-
-
0032713075
-
Safety and antitumor activity of recombinant soluble Apo2 ligand
-
Ashkenazi, A., Pai, R. C., Fong, S., Leung, S., Lawrence, D. A., Marsters, S. A., Blackie, C., Chang, L., McMurtney, A. E., Hebert, A., DeForge, L., Koumenis, I. L., Lewis, D., Harris, L., Bussiere, J., Koeppen, H., Shahrokh, Z., Schwall, R. H. (1999) Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155-162.
-
(1999)
J. Clin. Invest.
, vol.104
, pp. 155-162
-
-
Ashkenazi, A.1
Pai, R.C.2
Fong, S.3
Leung, S.4
Lawrence, D.A.5
Marsters, S.A.6
Blackie, C.7
Chang, L.8
McMurtney, A.E.9
Hebert, A.10
DeForge, L.11
Koumenis, I.L.12
Lewis, D.13
Harris, L.14
Bussiere, J.15
Koeppen, H.16
Shahrokh, Z.17
Schwall, R.H.18
-
11
-
-
23044452536
-
Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients
-
Badros, A. Z., Goloubeva, O., Rapoport, A. P., Ratterree, B., Gahres, N., Meisenberg, B., Takebe, N., Heyman, M., Zwiebel, J., Streicher, H., Gocke, C. D., Tomic, D., Flaws, J. A., Zhang, B., Fenton, R. G. (2005) Phase II study of G3139, a Bcl-2 antisense oligonucleotide, in combination with dexamethasone and thalidomide in relapsed multiple myeloma patients. J. Clin. Oncol. 23, 4089-4099.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 4089-4099
-
-
Badros, A.Z.1
Goloubeva, O.2
Rapoport, A.P.3
Ratterree, B.4
Gahres, N.5
Meisenberg, B.6
Takebe, N.7
Heyman, M.8
Zwiebel, J.9
Streicher, H.10
Gocke, C.D.11
Tomic, D.12
Flaws, J.A.13
Zhang, B.14
Fenton, R.G.15
-
12
-
-
12144289654
-
Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells
-
Ballestrero, A., Nencioni, A., Boy, D., Rocco, I., Garuti, A., Mela, G. S., Van Parijs, L., Brossart, P., Wesselborg, S., Patrone, F. (2004) Tumor necrosis factor-related apoptosis-inducing ligand cooperates with anticancer drugs to overcome chemoresistance in antiapoptotic Bcl-2 family members expressing jurkat cells. Clin. Cancer Res. 10, 1463-1470.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 1463-1470
-
-
Ballestrero, A.1
Nencioni, A.2
Boy, D.3
Rocco, I.4
Garuti, A.5
Mela, G.S.6
Van Parijs, L.7
Brossart, P.8
Wesselborg, S.9
Patrone, F.10
-
13
-
-
0037089403
-
Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells
-
Barragan, M., Bellosillo, B., Campas, C., Colomer, D., Pons, G., Gil, J. (2002) Involvement of protein kinase C and phosphatidylinositol 3-kinase pathways in the survival of B-cell chronic lymphocytic leukemia cells. Blood 99, 2969-2976.
-
(2002)
Blood
, vol.99
, pp. 2969-2976
-
-
Barragan, M.1
Bellosillo, B.2
Campas, C.3
Colomer, D.4
Pons, G.5
Gil, J.6
-
14
-
-
0141889267
-
STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1
-
Battle, T. E., Frank, D. A. (2003) STAT1 mediates differentiation of chronic lymphocytic leukemia cells in response to Bryostatin 1. Blood 102, 3016-3024.
-
(2003)
Blood
, vol.102
, pp. 3016-3024
-
-
Battle, T.E.1
Frank, D.A.2
-
15
-
-
0035912109
-
Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL
-
Belka, C., Schmid, B., Marini, P., Durand, E., Rudner, J., Faltin, H., Bamberg, M., Schulze-Osthoff, K., Budach, W. (2001) Sensitization of resistant lymphoma cells to irradiation-induced apoptosis by the death ligand TRAIL. Oncogene 20, 2190-2196.
-
(2001)
Oncogene
, vol.20
, pp. 2190-2196
-
-
Belka, C.1
Schmid, B.2
Marini, P.3
Durand, E.4
Rudner, J.5
Faltin, H.6
Bamberg, M.7
Schulze-Osthoff, K.8
Budach, W.9
-
16
-
-
0038820386
-
Signal transducer and activator of transcription proteins in leukemias
-
Benekli, M., Baer, M. R., Baumann, H., Wetzler, M. (2003) Signal transducer and activator of transcription proteins in leukemias. Blood 101, 2940-2954.
-
(2003)
Blood
, vol.101
, pp. 2940-2954
-
-
Benekli, M.1
Baer, M.R.2
Baumann, H.3
Wetzler, M.4
-
17
-
-
31144454066
-
Key cancer cell signal transduction pathways as therapeutic targets
-
Bianco, R., Melisi, D., Ciardiello, F., Tortora, G. (2006) Key cancer cell signal transduction pathways as therapeutic targets. Eur. J. Cancer 42, 290-294.
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 290-294
-
-
Bianco, R.1
Melisi, D.2
Ciardiello, F.3
Tortora, G.4
-
18
-
-
85047695528
-
Hsp-90-associated oncoproteins: Multiple targets of geldanamycin and its analogs
-
Blagosklonny, M. V. (2002) Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs. Leukemia 16, 455-462.
-
(2002)
Leukemia
, vol.16
, pp. 455-462
-
-
Blagosklonny, M.V.1
-
19
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen, P., Hunter, T. (2001) Oncogenic kinase signalling. Nature 411, 355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
20
-
-
20344396647
-
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL
-
Bruserud, O. (2005) TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica 90, 579.
-
(2005)
Haematologica
, vol.90
, pp. 579
-
-
Bruserud, O.1
-
21
-
-
29144484694
-
Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia
-
Bug, G., Ritter, M., Wassmann, B., Schoch, C., Heinzel, T., Schwarz, K., Romanski, A., Kramer, O. H., Kampfmann, M., Hoelzer, D., Neubauer, A., Ruthardt, M., Ottmann, O. G. (2005) Clinical trial of valproic acid and all-trans retinoic acid in patients with poor-risk acute myeloid leukemia. Cancer 104, 2717-2725.
-
(2005)
Cancer
, vol.104
, pp. 2717-2725
-
-
Bug, G.1
Ritter, M.2
Wassmann, B.3
Schoch, C.4
Heinzel, T.5
Schwarz, K.6
Romanski, A.7
Kramer, O.H.8
Kampfmann, M.9
Hoelzer, D.10
Neubauer, A.11
Ruthardt, M.12
Ottmann, O.G.13
-
22
-
-
0037437796
-
Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties
-
Buss, J. L., Neuzil, J., Gellert, N., Weber, C., Ponka, P. (2003) Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties. Biochem. Pharmacol. 65, 161-172.
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 161-172
-
-
Buss, J.L.1
Neuzil, J.2
Gellert, N.3
Weber, C.4
Ponka, P.5
-
23
-
-
10644257442
-
Iron chelators in cancer chemotherapy
-
Buss, J. L., Greene, B. T., Turner, J., Torti, F. M., Torti, S. V. (2004) Iron chelators in cancer chemotherapy. Curr. Top. Med. Chem. 4, 1623-1635.
-
(2004)
Curr. Top. Med. Chem.
, vol.4
, pp. 1623-1635
-
-
Buss, J.L.1
Greene, B.T.2
Turner, J.3
Torti, F.M.4
Torti, S.V.5
-
24
-
-
19944432566
-
A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia
-
Byrd, J. C., Marcucci, G., Parthun, M. R., Xiao, J. J., Klisovic, R. B., Moran, M., Lin, T. S., Liu, S., Sklenar, A. R., Davis, M. E., Lucas, D. M., Fischer, B., Shank, R., Tejaswi, S. L., Binkley, P., Wright, J., Chan, K. K., Greven, M. R. (2005) A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia. Blood 105, 959-967.
-
(2005)
Blood
, vol.105
, pp. 959-967
-
-
Byrd, J.C.1
Marcucci, G.2
Parthun, M.R.3
Xiao, J.J.4
Klisovic, R.B.5
Moran, M.6
Lin, T.S.7
Liu, S.8
Sklenar, A.R.9
Davis, M.E.10
Lucas, D.M.11
Fischer, B.12
Shank, R.13
Tejaswi, S.L.14
Binkley, P.15
Wright, J.16
Chan, K.K.17
Greven, M.R.18
-
25
-
-
23944515294
-
Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma
-
Campo, S., Serlupi-Crescenzi, O., Arseni, B., Rossi, S., Saggio, I., Salone, B., Cherubini, G., Carminati, P., De Santis, R. (2005) Comparative activity of Sant7 and anti-IL-6, IL-6R monoclonal antibodies in a murine model of B-cell lymphoma. Cytokine 31, 368-374.
-
(2005)
Cytokine
, vol.31
, pp. 368-374
-
-
Campo, S.1
Serlupi-Crescenzi, O.2
Arseni, B.3
Rossi, S.4
Saggio, I.5
Salone, B.6
Cherubini, G.7
Carminati, P.8
De Santis, R.9
-
26
-
-
20844437755
-
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
-
Carter, B. Z., Gronda, M., Wang, Z., Welsh, K., Pinilla, C., Andreeff, M., Schober, W. D., Nefzi, A., Pond, G. R., Mawji, I. A., Houghten, R. A., Ostresh, J., Brandwein, J., Minden, M. D., Schuh, A. C., Wells, R. A., Messner, H., Chun, K., Reed, J. C., Schimmer, A. D. (2005) Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. Blood 105, 4043-4050.
-
(2005)
Blood
, vol.105
, pp. 4043-4050
-
-
Carter, B.Z.1
Gronda, M.2
Wang, Z.3
Welsh, K.4
Pinilla, C.5
Andreeff, M.6
Schober, W.D.7
Nefzi, A.8
Pond, G.R.9
Mawji, I.A.10
Houghten, R.A.11
Ostresh, J.12
Brandwein, J.13
Minden, M.D.14
Schuh, A.C.15
Wells, R.A.16
Messner, H.17
Chun, K.18
Reed, J.C.19
Schimmer, A.D.20
more..
-
27
-
-
27144551963
-
ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: Inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia
-
Castro, J. E., Prada, C. E., Loria, O., Kamal, A., Chen, L., Burrows, F. J., Kipps, T. J. (2005) ZAP-70 is a novel conditional heat shock protein 90 (Hsp90) client: inhibition of Hsp90 leads to ZAP-70 degradation, apoptosis, and impaired signaling in chronic lymphocytic leukemia. Blood 106, 2506-2512.
-
(2005)
Blood
, vol.106
, pp. 2506-2512
-
-
Castro, J.E.1
Prada, C.E.2
Loria, O.3
Kamal, A.4
Chen, L.5
Burrows, F.J.6
Kipps, T.J.7
-
28
-
-
11144357610
-
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance
-
Chauhan, D., Li, G., Podar, K., Hideshima, T., Shringarpure, R., Catley, L., Mitsiades, C., Munshi, N., Tai, Y. T., Suh, N., Gribble, G. W., Honda, T., Schlossman, R., Richardson, P., Sporn, M. B., Anderson, K. C. (2004) The bortezomib/proteasome inhibitor PS-341 and triterpenoid CDDO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood 103, 3158-3166.
-
(2004)
Blood
, vol.103
, pp. 3158-3166
-
-
Chauhan, D.1
Li, G.2
Podar, K.3
Hideshima, T.4
Shringarpure, R.5
Catley, L.6
Mitsiades, C.7
Munshi, N.8
Tai, Y.T.9
Suh, N.10
Gribble, G.W.11
Honda, T.12
Schlossman, R.13
Richardson, P.14
Sporn, M.B.15
Anderson, K.C.16
-
29
-
-
18044395798
-
Proteasome inhibitor therapy in multiple myeloma
-
Chauhan, D., Hideshima, T., Mitsiades, C., Richardson, P., Anderson, K. C. (2005) Proteasome inhibitor therapy in multiple myeloma. Mol. Cancer Ther. 4, 686-692.
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 686-692
-
-
Chauhan, D.1
Hideshima, T.2
Mitsiades, C.3
Richardson, P.4
Anderson, K.C.5
-
30
-
-
5144234541
-
PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
-
Chen, J., DeAngelo, D. J., Kutok, J. L., Williams, I. R., Lee, B. H., Wadleigh, M., Duclos, N., Cohen, S., Adelsperger, J., Okabe, R., Coburn, A., Galinsky, I., Huntly, B., Cohen, P. S., Meyer, T., Fabbro, D., Roesel, J., Banerji, L., Griffin, J. D., Xiao, S., Fletcher, J. A., Stone, R. M., Gilliland, D. G. (2004) PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder. Proc. Natl. Acad. Sci. USA 101, 14479-14484.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 14479-14484
-
-
Chen, J.1
DeAngelo, D.J.2
Kutok, J.L.3
Williams, I.R.4
Lee, B.H.5
Wadleigh, M.6
Duclos, N.7
Cohen, S.8
Adelsperger, J.9
Okabe, R.10
Coburn, A.11
Galinsky, I.12
Huntly, B.13
Cohen, P.S.14
Meyer, T.15
Fabbro, D.16
Roesel, J.17
Banerji, L.18
Griffin, J.D.19
Xiao, S.20
Fletcher, J.A.21
Stone, R.M.22
Gilliland, D.G.23
more..
-
31
-
-
27144434812
-
Transcription inhibition by flavopiridol: Mechanism of chronic lymphocytic leukemia cell death
-
Chen, R., Keating, M. J., Gandhi, V., Plunkett, W. (2005) Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood 106, 2513-2519.
-
(2005)
Blood
, vol.106
, pp. 2513-2519
-
-
Chen, R.1
Keating, M.J.2
Gandhi, V.3
Plunkett, W.4
-
32
-
-
0032478331
-
Stabilization and activation of p53 are regulated independently by different phosphorylation events
-
Chernov, M. V., Ramana, C. V., Adler, V. V., Stark, G. R. (1998) Stabilization and activation of p53 are regulated independently by different phosphorylation events. Proc. Natl. Acad. Sci. USA 95, 2284-2289.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 2284-2289
-
-
Chernov, M.V.1
Ramana, C.V.2
Adler, V.V.3
Stark, G.R.4
-
33
-
-
21344445244
-
Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids
-
Chowdhury, S. A., Kishino, K., Satoh, R., Hashimoto, K., Kikuchi, H., Nishikawa, H., Shirataki, Y., Sakagami, H. (2005) Tumor-specificity and apoptosis-inducing activity of stilbenes and flavonoids. Anticancer Res. 25, 2055-2063.
-
(2005)
Anticancer Res.
, vol.25
, pp. 2055-2063
-
-
Chowdhury, S.A.1
Kishino, K.2
Satoh, R.3
Hashimoto, K.4
Kikuchi, H.5
Nishikawa, H.6
Shirataki, Y.7
Sakagami, H.8
-
34
-
-
0036493359
-
In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: Evidence for Fas-dependent apoptosis
-
Claessens, Y. E., Bouscary, D., Dupont, J. M., Picard, F., Melle, J., Gisselbrecht, S., Lacombe, C., Dreyfus, F., Mayeux, P., Fontenay-Roupie, M. (2002) In vitro proliferation and differentiation of erythroid progenitors from patients with myelodysplastic syndromes: evidence for Fas-dependent apoptosis. Blood 99, 1594-1601.
-
(2002)
Blood
, vol.99
, pp. 1594-1601
-
-
Claessens, Y.E.1
Bouscary, D.2
Dupont, J.M.3
Picard, F.4
Melle, J.5
Gisselbrecht, S.6
Lacombe, C.7
Dreyfus, F.8
Mayeux, P.9
Fontenay-Roupie, M.10
-
35
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools, J., DeAngelo, D. J., Gotlib, J., Stover, E. H., Legare, R. D., Cortes, J., Kutok, J., Clark, J., Galinsky, I., Griffin, J. D., Cross, N. C. P., Tefferi, A., Malone, J., Alam, R., Schrier, S. L., Schmid, J., Rose, M., Vandenberghe, P., Verhoef, G., Boogaerts, M., Wlodarska, I., Kantarjian, H., Marynen, P., Coutre, S. E., Stone, R., Gilliland, D. G. (2003a) A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N. Engl. J. Med. 348, 1201-1214.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
Stover, E.H.4
Legare, R.D.5
Cortes, J.6
Kutok, J.7
Clark, J.8
Galinsky, I.9
Griffin, J.D.10
Cross, N.C.P.11
Tefferi, A.12
Malone, J.13
Alam, R.14
Schrier, S.L.15
Schmid, J.16
Rose, M.17
Vandenberghe, P.18
Verhoef, G.19
Boogaerts, M.20
Wlodarska, I.21
Kantarjian, H.22
Marynen, P.23
Coutre, S.E.24
Stone, R.25
Gilliland, D.G.26
more..
-
36
-
-
0142119964
-
PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease
-
Cools, J., Stover, E. H., Boulton, C. L., Gotlib, J., Legare, R. D., Amaral, S. M., Curley, D. P., Duclos, N., Rowan, R., Kutok, J. L., Lee, B. H., Williams, I. R., Coutre, S. E., Stone, R. M., DeAngelo, D. J., Marynen, P., Manley, P. W., Meyer, T., Fabbro, D., Neuberg, D., Weisberg, E., Griffin, J. D., Gilliland, D. G. (2003b) PKC412 overcomes resistance to imatinib in a murine model of FIP1L1-PDGFRα-induced myeloproliferative disease. Cancer Cell 3, 459-469.
-
(2003)
Cancer Cell
, vol.3
, pp. 459-469
-
-
Cools, J.1
Stover, E.H.2
Boulton, C.L.3
Gotlib, J.4
Legare, R.D.5
Amaral, S.M.6
Curley, D.P.7
Duclos, N.8
Rowan, R.9
Kutok, J.L.10
Lee, B.H.11
Williams, I.R.12
Coutre, S.E.13
Stone, R.M.14
DeAngelo, D.J.15
Marynen, P.16
Manley, P.W.17
Meyer, T.18
Fabbro, D.19
Neuberg, D.20
Weisberg, E.21
Griffin, J.D.22
Gilliland, D.G.23
more..
-
37
-
-
0037372488
-
Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies
-
Cortes, J., Albitar, M., Thomas, D., Giles, F., Kurzrock, R., Thibault, A., Rackoff, W., Koller, C., O'Brien, S., Garcia-Manero, G., Talpaz, M., Kantarjian, H. (2003) Efficacy of the farnesyl transferase inhibitor R115777 in chronic myeloid leukemia and other hematologic malignancies. Blood 101, 1692-1697.
-
(2003)
Blood
, vol.101
, pp. 1692-1697
-
-
Cortes, J.1
Albitar, M.2
Thomas, D.3
Giles, F.4
Kurzrock, R.5
Thibault, A.6
Rackoff, W.7
Koller, C.8
O'Brien, S.9
Garcia-Manero, G.10
Talpaz, M.11
Kantarjian, H.12
-
38
-
-
16344395659
-
Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: Evidence for interactive effects of flavopiridol, LY 294002, roscovitine, wortmannin and UCN-01
-
Cory, A. H., Somerville, L., Cory, J. G. (2005) Blockage of cyclin cdk's, PKC and phosphoinositol 3-kinase pathways leads to augmentation of apoptosis in drug-resistant leukemia cells: evidence for interactive effects of flavopiridol, LY 294002, roscovitine, wortmannin and UCN-01. Anticancer Res. 25, 101-106.
-
(2005)
Anticancer Res.
, vol.25
, pp. 101-106
-
-
Cory, A.H.1
Somerville, L.2
Cory, J.G.3
-
39
-
-
0028066802
-
Antisense oligonucleotides suppress B-cell lymphoma growth in a Scid-hu mouse model
-
Cotter, F. E., Johnson, P., Hall, P., Pocock, C., Almahdi, N., Cowell, J. K., Morgan, G. (1994) Antisense oligonucleotides suppress B-cell lymphoma growth in a Scid-hu mouse model. Oncogene 9, 3049-3055.
-
(1994)
Oncogene
, vol.9
, pp. 3049-3055
-
-
Cotter, F.E.1
Johnson, P.2
Hall, P.3
Pocock, C.4
Almahdi, N.5
Cowell, J.K.6
Morgan, G.7
-
40
-
-
0035393498
-
Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells
-
Dai, Y., Yu, C., Singh, V., Tang, L., Wang, Z., McInistry, R., Dent, P., Grant, S. (2001) Pharmacological inhibitors of the mitogen-activated protein kinase (MAPK) kinase/MAPK cascade interact synergistically with UCN-01 to induce mitochondrial dysfunction and apoptosis in human leukemia cells. Cancer Res. 61, 5106-5115.
-
(2001)
Cancer Res.
, vol.61
, pp. 5106-5115
-
-
Dai, Y.1
Yu, C.2
Singh, V.3
Tang, L.4
Wang, Z.5
McInistry, R.6
Dent, P.7
Grant, S.8
-
41
-
-
13544274109
-
Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK
-
Dai, Y., Rahmani, M., Pei, X. Y., Khanna, P., Han, S. I., Mitchell, C., Dent, P., Grant, S. (2005) Farnesyltransferase inhibitors interact synergistically with the Chk1 inhibitor UCN-01 to induce apoptosis in human leukemia cells through interruption of both Akt and MEK/ERK pathways and activation of SEK1/JNK. Blood 105, 1706-1716.
-
(2005)
Blood
, vol.105
, pp. 1706-1716
-
-
Dai, Y.1
Rahmani, M.2
Pei, X.Y.3
Khanna, P.4
Han, S.I.5
Mitchell, C.6
Dent, P.7
Grant, S.8
-
42
-
-
8844244753
-
Inhibitor of apoptosis proteins: New therapeutic targets in hematological cancer?
-
De Graaf, A. O., de Witte, T., Jansen, J. H. (2004) Inhibitor of apoptosis proteins: new therapeutic targets in hematological cancer? Leukemia 18, 1751-1759.
-
(2004)
Leukemia
, vol.18
, pp. 1751-1759
-
-
De Graaf, A.O.1
de Witte, T.2
Jansen, J.H.3
-
43
-
-
31444455008
-
Chronic myeloproliferative disorders: A tyrosine kinase tale
-
De Keersmaecker, K., Cools, J. (2006) Chronic myeloproliferative disorders: a tyrosine kinase tale. Leukemia 20, 200-205.
-
(2006)
Leukemia
, vol.20
, pp. 200-205
-
-
De Keersmaecker, K.1
Cools, J.2
-
44
-
-
0034670036
-
The molecular biology of chronic myeloid leukemia
-
Deininger, M. W. N., Goldman, J. M., Melo, J. V. (2000) The molecular biology of chronic myeloid leukemia. Blood 96, 3343-3356.
-
(2000)
Blood
, vol.96
, pp. 3343-3356
-
-
Deininger, M.W.N.1
Goldman, J.M.2
Melo, J.V.3
-
45
-
-
0033636118
-
An overview on the use of TNF-alpha: Our experience with regional administration and developments towards new opportunities for systemic application
-
Der Veen, A. H., ten Hagen, T. L., de Wilt, J. H., van Ijken, M. G., Eggermont, A. M. (2000) An overview on the use of TNF-alpha: our experience with regional administration and developments towards new opportunities for systemic application. Anticancer Res. 20, 3467-3474.
-
(2000)
Anticancer Res.
, vol.20
, pp. 3467-3474
-
-
Der Veen, A.H.1
ten Hagen, T.L.2
de Wilt, J.H.3
van Ijken, M.G.4
Eggermont, A.M.5
-
46
-
-
0036659905
-
Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells
-
Derenne, S., Monia, B., Dean, N. M., Taylor, J. K., Rapp, M. J., Harousseau, J. L., Bataille, R., Amiot, M. (2002) Antisense strategy shows that Mcl-1 rather than Bcl-2 or Bcl-x(L) is an essential survival protein of human myeloma cells. Blood 100, 194-199.
-
(2002)
Blood
, vol.100
, pp. 194-199
-
-
Derenne, S.1
Monia, B.2
Dean, N.M.3
Taylor, J.K.4
Rapp, M.J.5
Harousseau, J.L.6
Bataille, R.7
Amiot, M.8
-
47
-
-
33645393211
-
Flavopiridol in patients with relapsed or refractory multiple myeloma: A phase 2 trial with clinical and pharmacodynamic endpoints
-
Dispenzieri, A., Gertz, M. A., Lacy, M. Q., Geyer, S. M., Fitch, T. R., Fenton, R. G., Fonseca, R., Isham, C. R., Ziesmer, S. C., Erlichman, C., Bible, K. C. (2006) Flavopiridol in patients with relapsed or refractory multiple myeloma: a phase 2 trial with clinical and pharmacodynamic endpoints. Haematologica 91, 390-393.
-
(2006)
Haematologica
, vol.91
, pp. 390-393
-
-
Dispenzieri, A.1
Gertz, M.A.2
Lacy, M.Q.3
Geyer, S.M.4
Fitch, T.R.5
Fenton, R.G.6
Fonseca, R.7
Isham, C.R.8
Ziesmer, S.C.9
Erlichman, C.10
Bible, K.C.11
-
48
-
-
12744275046
-
BMS-354825: A novel drug with potential for the treatment of imatinib-resistant chronic myeloid leukaemia
-
Doggrell, S. A. (2005) BMS-354825: a novel drug with potential for the treatment of imatinib-resistant chronic myeloid leukaemia. Expert. Opin. Investig. Drugs 14, 89-91.
-
(2005)
Expert. Opin. Investig. Drugs
, vol.14
, pp. 89-91
-
-
Doggrell, S.A.1
-
49
-
-
0024445695
-
Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells
-
Drexler, H. G., Gignac, S. M., Jones, R. A., Scott, C. S., Pettit, G. R., Hoffbrand, A. V. (1989) Bryostatin 1 induces differentiation of B-chronic lymphocytic leukemia cells. Blood 74, 1747-1757.
-
(1989)
Blood
, vol.74
, pp. 1747-1757
-
-
Drexler, H.G.1
Gignac, S.M.2
Jones, R.A.3
Scott, C.S.4
Pettit, G.R.5
Hoffbrand, A.V.6
-
50
-
-
2342588619
-
Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death
-
Dutton, A., O'Neil, J. D., Milner, A. E., Reynolds, G. M., Starczynski, J., Crocker, J., Young, L. S., Murray, P. G. (2004) Expression of the cellular FLICE-inhibitory protein (c-FLIP) protects Hodgkin's lymphoma cells from autonomous Fas-mediated death. Proc. Natl. Acad. Sci. USA 101, 6611-6616.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 6611-6616
-
-
Dutton, A.1
O'Neil, J.D.2
Milner, A.E.3
Reynolds, G.M.4
Starczynski, J.5
Crocker, J.6
Young, L.S.7
Murray, P.G.8
-
51
-
-
7344233085
-
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL
-
Emery, J. G., McDonnell, P., Burke, M. B., Deen, K. C., Lyn, S., Silverman, C., Dul, E., Appelbaum, E. R., Eichman, C., DiPrinzio, R., Dodds, R. A., James, I. E., Rosenberg, M., Lee, J. C., Young, P. R. (1998) Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J. Biol. Chem. 273, 14363-14367.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 14363-14367
-
-
Emery, J.G.1
McDonnell, P.2
Burke, M.B.3
Deen, K.C.4
Lyn, S.5
Silverman, C.6
Dul, E.7
Appelbaum, E.R.8
Eichman, C.9
DiPrinzio, R.10
Dodds, R.A.11
James, I.E.12
Rosenberg, M.13
Lee, J.C.14
Young, P.R.15
-
52
-
-
0033230955
-
Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Steinberg cells
-
Emmerich, F., Meiser, M., Hummel, M., Demel, G., Foss, H. D., Jundt, F., Mathas, S., Krappmann, D., Scheidereit, C., Stein, H., Dorken, B. (1999) Overexpression of I kappa B alpha without inhibition of NF-kappaB activity and mutations in the I kappa B alpha gene in Reed-Steinberg cells. Blood 94, 3129-3134.
-
(1999)
Blood
, vol.94
, pp. 3129-3134
-
-
Emmerich, F.1
Meiser, M.2
Hummel, M.3
Demel, G.4
Foss, H.D.5
Jundt, F.6
Mathas, S.7
Krappmann, D.8
Scheidereit, C.9
Stein, H.10
Dorken, B.11
-
53
-
-
0035136846
-
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression
-
Epling-Burnette, P. K., Liu, J. H., Catlett-Falcone, R., Turkson, J., Oshiro, M., Kothapalli, R., Li, Y., Wang, J. M., Yang-Yen, H. F., Karras, J., Jove, R., Loughran, T. P., Jr. (2001) Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression. J. Clin. Invest. 107, 351-362.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 351-362
-
-
Epling-Burnette, P.K.1
Liu, J.H.2
Catlett-Falcone, R.3
Turkson, J.4
Oshiro, M.5
Kothapalli, R.6
Li, Y.7
Wang, J.M.8
Yang-Yen, H.F.9
Karras, J.10
Jove, R.11
Loughran Jr., T.P.12
-
54
-
-
20244368521
-
AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: Interference with the Akt /NF-kappaB survival pathway
-
Escobar-Diaz, E., Lopez-Martin, E. M., Hernandez, d. C., Puig-Kroger, A., Soto-Cerrato, V., Montaner, B., Giralt, E., Garcia-Marco, J. A., Perez-Tomas, R., Garcia-Pardo, A. (2005) AT514, a cyclic depsipeptide from Serratia marcescens, induces apoptosis of B-chronic lymphocytic leukemia cells: interference with the Akt/NF-kappaB survival pathway. Leukemia 19, 572-579.
-
(2005)
Leukemia
, vol.19
, pp. 572-579
-
-
Escobar-Diaz, E.1
Lopez-Martin, E.M.2
Hernandez, D.C.3
Puig-Kroger, A.4
Soto-Cerrato, V.5
Montaner, B.6
Giralt, E.7
Garcia-Marco, J.A.8
Perez-Tomas, R.9
Garcia-Pardo, A.10
-
55
-
-
0033031279
-
The clinical significance of Fas expression in leukemia: Questions and controversies
-
Findley, H. W., Zhou, M. (1999) The clinical significance of Fas expression in leukemia: questions and controversies. Leukemia 13, 147-149.
-
(1999)
Leukemia
, vol.13
, pp. 147-149
-
-
Findley, H.W.1
Zhou, M.2
-
56
-
-
0034757838
-
Antisense therapeutics: Lessons from early clinical trials
-
Flaherty, K. T., Stevenson, J. P., O'Dwyer, P. J. (2001) Antisense therapeutics: lessons from early clinical trials. Curr. Opin. Oncol. 13, 499-505.
-
(2001)
Curr. Opin. Oncol.
, vol.13
, pp. 499-505
-
-
Flaherty, K.T.1
Stevenson, J.P.2
O'Dwyer, P.J.3
-
57
-
-
0041328359
-
The phosphoinositide (PI) 3-kinase family
-
Foster, F. M., Traer, C. J., Abraham, S. M., Fry, M. J. (2003) The phosphoinositide (PI) 3-kinase family. J. Cell. Sci. 116, 3037-3040.
-
(2003)
J. Cell. Sci.
, vol.116
, pp. 3037-3040
-
-
Foster, F.M.1
Traer, C.J.2
Abraham, S.M.3
Fry, M.J.4
-
58
-
-
0141761420
-
The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate
-
Gatto, S., Scappini, B., Pham, L., Onida, F., Milella, M., Ball, G., Ricci, C., Divoky, V., Verstovsek, S., Kantarjian, H. M., Keating, M. J., Cortes-Franco, J. E., Beran, M. (2003) The proteasome inhibitor PS-341 inhibits growth and induces apoptosis in Bcr/Abl-positive cell lines sensitive and resistant to imatinib mesylate. Haematologica 88, 853-863.
-
(2003)
Haematologica
, vol.88
, pp. 853-863
-
-
Gatto, S.1
Scappini, B.2
Pham, L.3
Onida, F.4
Milella, M.5
Ball, G.6
Ricci, C.7
Divoky, V.8
Verstovsek, S.9
Kantarjian, H.M.10
Keating, M.J.11
Cortes-Franco, J.E.12
Beran, M.13
-
59
-
-
0035925537
-
Activity of a novel bcl-2/bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins
-
Gautschi, O., Tschopp, S., Olie, R. A., Leech, S. H., Simoes-Wust, A. P., Ziegler, A., Baumann, B., Odermatt, B., Hall, J., Stahel, R. A., Zangemeister-Wittke, U. (2001) Activity of a novel bcl-2/ bcl-xL-bispecific antisense oligonucleotide against tumors of diverse histologic origins. J. Natl. Cancer Inst. 93, 463-471.
-
(2001)
J. Natl. Cancer Inst.
, vol.93
, pp. 463-471
-
-
Gautschi, O.1
Tschopp, S.2
Olie, R.A.3
Leech, S.H.4
Simoes-Wust, A.P.5
Ziegler, A.6
Baumann, B.7
Odermatt, B.8
Hall, J.9
Stahel, R.A.10
Zangemeister-Wittke, U.11
-
60
-
-
0141643347
-
δBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF
-
Gavin, A. L., Ait-Azzouzene, D., Ware, C. F., Nemazee, D. (2003) δBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF. J. Biol. Chem. 278, 38220-38228.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 38220-38228
-
-
Gavin, A.L.1
Ait-Azzouzene, D.2
Ware, C.F.3
Nemazee, D.4
-
61
-
-
29244459713
-
Mammalian target of rapamycin as a therapeutic target in leukemia
-
Giles, F. J., Albitar, M. (2005) Mammalian target of rapamycin as a therapeutic target in leukemia. Curr. Mol. Med. 5, 653-661.
-
(2005)
Curr. Mol. Med.
, vol.5
, pp. 653-661
-
-
Giles, F.J.1
Albitar, M.2
-
62
-
-
0036850211
-
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
-
Gojo, I., Zhang, B., Fenton, R. G. (2002) The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin. Cancer Res. 8, 3527-3538.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3527-3538
-
-
Gojo, I.1
Zhang, B.2
Fenton, R.G.3
-
63
-
-
0141528828
-
Chronic myeloid leukemia - Advances in biology and new approaches to treatment
-
Goldman, J. M., Melo, J. V. (2003) Chronic myeloid leukemia - advances in biology and new approaches to treatment. N. Engl. J. Med. 349, 1451-1464.
-
(2003)
N. Engl. J. Med.
, vol.349
, pp. 1451-1464
-
-
Goldman, J.M.1
Melo, J.V.2
-
64
-
-
0037108448
-
BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90
-
Gorre, M. E., Ellwood-Yen, K., Chiosis, G., Rosen, N., Sawyers, C. L. (2002) BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90. Blood 100, 3041-3044.
-
(2002)
Blood
, vol.100
, pp. 3041-3044
-
-
Gorre, M.E.1
Ellwood-Yen, K.2
Chiosis, G.3
Rosen, N.4
Sawyers, C.L.5
-
65
-
-
0142124775
-
Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: Pathways, targets, and therapeutic tools
-
Greil, R., Anether, G., Johrer, K., Tinhofer, I. (2003) Tracking death dealing by Fas and TRAIL in lymphatic neoplastic disorders: pathways, targets, and therapeutic tools. J. Leukoc. Biol. 74, 311-330.
-
(2003)
J. Leukoc. Biol.
, vol.74
, pp. 311-330
-
-
Greil, R.1
Anether, G.2
Johrer, K.3
Tinhofer, I.4
-
66
-
-
0042334512
-
Fas ligand is not constitutively expressed in low-grade B-cell lymphoma and B-lymphoblastoid cells
-
Grullich, C., Richter, M., Exner, S., Finke, J. (2003) Fas ligand is not constitutively expressed in low-grade B-cell lymphoma and B-lymphoblastoid cells. Eur. J. Haematol. 71, 184-188.
-
(2003)
Eur. J. Haematol.
, vol.71
, pp. 184-188
-
-
Grullich, C.1
Richter, M.2
Exner, S.3
Finke, J.4
-
67
-
-
19944433616
-
Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells
-
Guo, F., Sigua, C., Bali, P., George, P., Fiskus, W., Scuto, A., Annavarapu, S., Mouttaki, A., Sondarva, G., Wei, S., Wu, J., Djeu, J., Bhalla, K. (2005) Mechanistic role of heat shock protein 70 in Bcr-Abl-mediated resistance to apoptosis in human acute leukemia cells. Blood 105, 1246-1255.
-
(2005)
Blood
, vol.105
, pp. 1246-1255
-
-
Guo, F.1
Sigua, C.2
Bali, P.3
George, P.4
Fiskus, W.5
Scuto, A.6
Annavarapu, S.7
Mouttaki, A.8
Sondarva, G.9
Wei, S.10
Wu, J.11
Djeu, J.12
Bhalla, K.13
-
68
-
-
15944394073
-
Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways
-
Hahn, M., Li, W., Yu, C., Rahmani, M., Dent, P., Grant, S. (2005) Rapamycin and UCN-01 synergistically induce apoptosis in human leukemia cells through a process that is regulated by the Raf-1/MEK/ERK, Akt, and JNK signal transduction pathways. Mol. Cancer Ther. 4, 457-470.
-
(2005)
Mol. Cancer Ther.
, vol.4
, pp. 457-470
-
-
Hahn, M.1
Li, W.2
Yu, C.3
Rahmani, M.4
Dent, P.5
Grant, S.6
-
69
-
-
9244237679
-
TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice
-
Hao, C., Song, J. H., Hsi, B., Lewis, J., Song, D. K., Petruk, K. C., Tyrrell, D. L., Kneteman, N. M. (2004) TRAIL inhibits tumor growth but is nontoxic to human hepatocytes in chimeric mice. Cancer Res. 64, 8502-8506.
-
(2004)
Cancer Res.
, vol.64
, pp. 8502-8506
-
-
Hao, C.1
Song, J.H.2
Hsi, B.3
Lewis, J.4
Song, D.K.5
Petruk, K.C.6
Tyrrell, D.L.7
Kneteman, N.M.8
-
70
-
-
18044376203
-
Clinical importance of circulating and cellular expression levels of Fas and Fas ligand in pediatric patients with lymphoproliferative malignancies
-
Hazar, V., Berber, Z., Pestereli, E., Coskun, M., Yesilipek, A., Karpuzoglu, G., Yegin, O. (2005) Clinical importance of circulating and cellular expression levels of Fas and Fas ligand in pediatric patients with lymphoproliferative malignancies. Pediatr. Hematol. Oncol. 22, 247-256.
-
(2005)
Pediatr. Hematol. Oncol.
, vol.22
, pp. 247-256
-
-
Hazar, V.1
Berber, Z.2
Pestereli, E.3
Coskun, M.4
Yesilipek, A.5
Karpuzoglu, G.6
Yegin, O.7
-
71
-
-
1342282154
-
Lymphoma B cells evade apoptosis through the TNF family members BAFF /BLyS and APRIL
-
He, B., Chadburn, A., Jou, E., Schattner, E. J., Knowles, D. M., Cerutti, A. (2004) Lymphoma B cells evade apoptosis through the TNF family members BAFF/BLyS and APRIL. J. Immunol. 172, 3268-3279.
-
(2004)
J. Immunol.
, vol.172
, pp. 3268-3279
-
-
He, B.1
Chadburn, A.2
Jou, E.3
Schattner, E.J.4
Knowles, D.M.5
Cerutti, A.6
-
72
-
-
0027260656
-
Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death
-
Henderson, S., Huen, D., Rowe, M., Dawson, C., Johnson, G., Rickinson, A. (1993) Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death. Proc. Natl. Acad. Sci. USA 90, 8479-8483.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8479-8483
-
-
Henderson, S.1
Huen, D.2
Rowe, M.3
Dawson, C.4
Johnson, G.5
Rickinson, A.6
-
73
-
-
0025204548
-
Bcl-2 is an inner mitochondrial-membrane protein that blocks programmed cell death
-
sHockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D., Korsmeyer, S. J. (1990) Bcl-2 is an inner mitochondrial-membrane protein that blocks programmed cell death. Nature 348, 334-336.
-
(1990)
Nature
, vol.348
, pp. 334-336
-
-
sHockenbery, D.1
Nunez, G.2
Milliman, C.3
Schreiber, R.D.4
Korsmeyer, S.J.5
-
74
-
-
0034905394
-
XIAP: Apoptotic brake and promising therapeutic target
-
Holcik, M., Gibson, H., Korneluk, R. G. (2001) XIAP: apoptotic brake and promising therapeutic target. Apoptosis 6, 253-261.
-
(2001)
Apoptosis
, vol.6
, pp. 253-261
-
-
Holcik, M.1
Gibson, H.2
Korneluk, R.G.3
-
75
-
-
1642512653
-
Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers?
-
Huang, Y., Lu, M., Wu, H. (2004) Antagonizing XIAP-mediated caspase-3 inhibition: Achilles' heel of cancers? Cancer Cell 5, 1-2.
-
(2004)
Cancer Cell
, vol.5
, pp. 1-2
-
-
Huang, Y.1
Lu, M.2
Wu, H.3
-
76
-
-
4444281592
-
Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid
-
Ikeda, T., Nakata, Y., Kimura, F., Sato, K., Anderson, K., Motoyoshi, K., Sporn, M., Kufe, D. (2004) Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid. Mol. Cancer Ther. 3, 39-45.
-
(2004)
Mol. Cancer Ther.
, vol.3
, pp. 39-45
-
-
Ikeda, T.1
Nakata, Y.2
Kimura, F.3
Sato, K.4
Anderson, K.5
Motoyoshi, K.6
Sporn, M.7
Kufe, D.8
-
77
-
-
12744261484
-
Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies
-
Inoue, S., MacFarlane, M., Harper, N., Wheat, L. M., Dyer, M. J., Cohen, G. M. (2004a) Histone deacetylase inhibitors potentiate TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in lymphoid malignancies. Cell Death. Differ. 11, S193-S206.
-
(2004)
Cell Death. Differ.
, vol.11
-
-
Inoue, S.1
MacFarlane, M.2
Harper, N.3
Wheat, L.M.4
Dyer, M.J.5
Cohen, G.M.6
-
78
-
-
2342465492
-
CDDO induces apoptosis via the intrinsic pathway in lymphoid cells
-
Inoue, S., Snowden, R. T., Dyer, M. J., Cohen, G. M. (2004b) CDDO induces apoptosis via the intrinsic pathway in lymphoid cells. Leukemia 18, 948-952.
-
(2004)
Leukemia
, vol.18
, pp. 948-952
-
-
Inoue, S.1
Snowden, R.T.2
Dyer, M.J.3
Cohen, G.M.4
-
79
-
-
0034077629
-
The novel triterpenoid 2-cyano-3, 12-dioxoolean- 1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism
-
Ito, Y., Pandey, P., Place, A., Sporn, M. B., Gribble, G. W., Honda, T., Kharbanda, S., Kufe, D. (2000) The novel triterpenoid 2-cyano-3, 12-dioxoolean- 1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism. Cell Growth Differ. 11, 261-267.
-
(2000)
Cell Growth Differ.
, vol.11
, pp. 261-267
-
-
Ito, Y.1
Pandey, P.2
Place, A.3
Sporn, M.B.4
Gribble, G.W.5
Honda, T.6
Kharbanda, S.7
Kufe, D.8
-
80
-
-
17844383458
-
A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera
-
James, C., Ugo, V., Le Couedic, J. P., Staerk, J., Delhommeau, F., Lacout, C., Garcon, L., Raslova, H., Berger, R., Bennaceur-Griscelli, A., Villeval, J. L., Constantinescu, S. N., Casadevall, N., Vainchenker, W. (2005) A unique clonal JAK2 mutation leading to constitutive signalling causes polycythaemia vera. Nature 434, 1144-1148.
-
(2005)
Nature
, vol.434
, pp. 1144-1148
-
-
James, C.1
Ugo, V.2
Le Couedic, J.P.3
Staerk, J.4
Delhommeau, F.5
Lacout, C.6
Garcon, L.7
Raslova, H.8
Berger, R.9
Bennaceur-Griscelli, A.10
Villeval, J.L.11
Constantinescu, S.N.12
Casadevall, N.13
Vainchenker, W.14
-
81
-
-
27644447574
-
The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumorigenesis and targeted antitumour therapy
-
Janus, A., Robak, T., Smolewski, P. (2005) The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumorigenesis and targeted antitumour therapy. Cell Mol. Biol. Lett. 10, 479-498.
-
(2005)
Cell Mol. Biol. Lett.
, vol.10
, pp. 479-498
-
-
Janus, A.1
Robak, T.2
Smolewski, P.3
-
82
-
-
0042441979
-
Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways
-
Jia, W., Yu, C., Rahmani, M., Krystal, G., Sausville, E. A., Dent, P., Grant, S. (2003) Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways. Blood 102, 1824-1832.
-
(2003)
Blood
, vol.102
, pp. 1824-1832
-
-
Jia, W.1
Yu, C.2
Rahmani, M.3
Krystal, G.4
Sausville, E.A.5
Dent, P.6
Grant, S.7
-
83
-
-
0034022160
-
Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand
-
Jo, M., Kim, T. H., Seol, D. W., Esplen, J. E., Dorko, K., Billiar, T. R., Strom, S. C. (2000) Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand. Nat. Med. 6, 564-567.
-
(2000)
Nat. Med.
, vol.6
, pp. 564-567
-
-
Jo, M.1
Kim, T.H.2
Seol, D.W.3
Esplen, J.E.4
Dorko, K.5
Billiar, T.R.6
Strom, S.C.7
-
84
-
-
29844457587
-
The evolution of iron chelators for the treatment of iron overload disease and cancer
-
Kalinowski, D. S., Richardson, D. R. (2005) The evolution of iron chelators for the treatment of iron overload disease and cancer. Pharmacol. Rev. 57, 547-583.
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 547-583
-
-
Kalinowski, D.S.1
Richardson, D.R.2
-
85
-
-
28544443503
-
Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias
-
Karp, J. E., Passaniti, A., Gojo, I., Kaufmann, S., Bible, K., Garimella, T. S., Greer, J., Briel, J., Smith, B. D., Gore, S. D., Tidwell, M. L., Ross, D. D., Wright, J. J., Colevas, A. D., Bauer, K. S. (2005) Phase I and pharmacokinetic study of flavopiridol followed by 1-beta-D-arabinofuranosylcytosine and mitoxantrone in relapsed and refractory adult acute leukemias. Clin. Cancer Res. 11, 8403-8412.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8403-8412
-
-
Karp, J.E.1
Passaniti, A.2
Gojo, I.3
Kaufmann, S.4
Bible, K.5
Garimella, T.S.6
Greer, J.7
Briel, J.8
Smith, B.D.9
Gore, S.D.10
Tidwell, M.L.11
Ross, D.D.12
Wright, J.J.13
Colevas, A.D.14
Bauer, K.S.15
-
86
-
-
12444321545
-
Phase I clinical trial of histone deacetylase inhibitor: Suberoylanilide hydroxamic acid administered intravenously
-
Kelly, W. K., Richon, V. M., O'Connor, O., Curley, T., MacGregor-Curtelli, B., Tong, W., Klang, M., Schwartz, L., Richardson, S., Rosa, E., Drobnjak, M., Cordon-Cordo, C., Chiao, J. H., Rifkind, R., Marks, P. A., Scher, H. (2003) Phase I clinical trial of histone deacetylase inhibitor: suberoylanilide hydroxamic acid administered intravenously. Clin. Cancer Res. 9, 3578-3588.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 3578-3588
-
-
Kelly, W.K.1
Richon, V.M.2
O'Connor, O.3
Curley, T.4
MacGregor-Curtelli, B.5
Tong, W.6
Klang, M.7
Schwartz, L.8
Richardson, S.9
Rosa, E.10
Drobnjak, M.11
Cordon-Cordo, C.12
Chiao, J.H.13
Rifkind, R.14
Marks, P.A.15
Scher, H.16
-
87
-
-
21244464349
-
Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer
-
Kelly, W. K., O'Connor, O. A., Krug, L. M., Chiao, J. H., Heaney, M., Curley, T., MacGregore-Cortelli, B., Tong, W., Secrist, J. P., Schwartz, L., Richardson, S., Chu, E., Olgac, S., Marks, P. A., Scher, H., Richon, V. M. (2005) Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. J. Clin. Oncol. 23, 3923-3931.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 3923-3931
-
-
Kelly, W.K.1
O'Connor, O.A.2
Krug, L.M.3
Chiao, J.H.4
Heaney, M.5
Curley, T.6
MacGregore-Cortelli, B.7
Tong, W.8
Secrist, J.P.9
Schwartz, L.10
Richardson, S.11
Chu, E.12
Olgac, S.13
Marks, P.A.14
Scher, H.15
Richon, V.M.16
-
88
-
-
0032808154
-
Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
-
Kennedy, S. G., Kandel, E. S., Cross, T. K., Hay, N. (1999) Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19, 5800-5810.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 5800-5810
-
-
Kennedy, S.G.1
Kandel, E.S.2
Cross, T.K.3
Hay, N.4
-
89
-
-
9144220762
-
Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway
-
Kern, C., Cornuel, J. F., Billard, C., Tang, R., Rouillard, D., Stenou, V., Defrance, T., Ajchenbaum-Cymbalista, F., Simonin, P. Y., Feldblum, S., Kolb, J. P. (2004) Involvement of BAFF and APRIL in the resistance to apoptosis of B-CLL through an autocrine pathway. Blood 103, 679-688.
-
(2004)
Blood
, vol.103
, pp. 679-688
-
-
Kern, C.1
Cornuel, J.F.2
Billard, C.3
Tang, R.4
Rouillard, D.5
Stenou, V.6
Defrance, T.7
Ajchenbaum-Cymbalista, F.8
Simonin, P.Y.9
Feldblum, S.10
Kolb, J.P.11
-
90
-
-
33645999706
-
NF-κB and IKK as therapeutic targets in cancer
-
Kim, H. J., Hawke, N., Baldwin, A. S. (2006) NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ 13, 738-747.
-
(2006)
Cell Death Differ
, vol.13
, pp. 738-747
-
-
Kim, H.J.1
Hawke, N.2
Baldwin, A.S.3
-
91
-
-
0037151079
-
An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
-
Kim, Y., Suh, N., Sporn, M., Reed, J. C. (2002) An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J. Biol. Chem. 277, 22320-22329.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 22320-22329
-
-
Kim, Y.1
Suh, N.2
Sporn, M.3
Reed, J.C.4
-
92
-
-
33746817865
-
Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: Overview of apoptotic pathways
-
Klener, P. Jr., Anděra, L., Klener, P., Nečas, E., Živný, J. (2006) Cell death signalling pathways in the pathogenesis and therapy of haematologic malignancies: overview of apoptotic pathways. Folia Biol. (Praha) 52, 34-44.
-
(2006)
Folia Biol. (Praha)
, vol.52
, pp. 34-44
-
-
Klener Jr., P.1
Anděra, L.2
Klener, P.3
Nečas, E.4
Živný, J.5
-
93
-
-
0037328501
-
Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells
-
Klisovic, M. I., Maghraby, E. A., Parthun, M. R., Guimond, M., Sklenar, A. R., Whitman, S. P., Chan, K. K., Murphy, T., Anon, J., Archer, K. J., Rush, L. J., Plass, C., Grever, M. R., Byrd, J. C., Marcucci, G. (2003) Depsipeptide (FR 901228) promotes histone acetylation, gene transcription, apoptosis and its activity is enhanced by DNA methyltransferase inhibitors in AML1/ETO-positive leukemic cells. Leukemia 17, 350-358.
-
(2003)
Leukemia
, vol.17
, pp. 350-358
-
-
Klisovic, M.I.1
Maghraby, E.A.2
Parthun, M.R.3
Guimond, M.4
Sklenar, A.R.5
Whitman, S.P.6
Chan, K.K.7
Murphy, T.8
Anon, J.9
Archer, K.J.10
Rush, L.J.11
Plass, C.12
Grever, M.R.13
Byrd, J.C.14
Marcucci, G.15
-
94
-
-
33645845151
-
Protein kinase C (PKC) family in cancer progression
-
Koivunen, J., Aaltonen, V., Peltonen, J. (2006) Protein kinase C (PKC) family in cancer progression. Cancer Lett. 235, 1-10.
-
(2006)
Cancer Lett.
, vol.235
, pp. 1-10
-
-
Koivunen, J.1
Aaltonen, V.2
Peltonen, J.3
-
95
-
-
0036095959
-
Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia
-
Konopleva, M., Tsao, T., Ruvolo, P., Stiouf, I., Estrov, Z., Leysath, C. E., Zhao, S., Harris, D., Chang, S., Jackson, C. E., Munsell, M., Suh, N., Gribble, G., Honda, T., May, W. S., Sporn, M. B., Andreeff M. (2002) Novel triterpenoid CDDO-Me is a potent inducer of apoptosis and differentiation in acute myelogenous leukemia. Blood 99, 326-335.
-
(2002)
Blood
, vol.99
, pp. 326-335
-
-
Konopleva, M.1
Tsao, T.2
Ruvolo, P.3
Stiouf, I.4
Estrov, Z.5
Leysath, C.E.6
Zhao, S.7
Harris, D.8
Chang, S.9
Jackson, C.E.10
Munsell, M.11
Suh, N.12
Gribble, G.13
Honda, T.14
May, W.S.15
Sporn, M.B.16
Andreeff, M.17
-
96
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
Kralovics, R., Passamonti, F., Buser, A. S., Teo, S., Tiedt, R., Passweg, J. R., Tichelli, A., Cazzola, M., Skoda, R. C. (2005) A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352, 1779-1790.
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
97
-
-
4444309863
-
Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid
-
Kuendgen, A., Strupp, C., Aivado, M., Bernhardt, A., Hildebrandt, B., Haas, R., Germing, U., Gattermann, N. (2004) Treatment of myelodysplastic syndromes with valproic acid alone or in combination with all-trans retinoic acid. Blood 104, 1266-1269.
-
(2004)
Blood
, vol.104
, pp. 1266-1269
-
-
Kuendgen, A.1
Strupp, C.2
Aivado, M.3
Bernhardt, A.4
Hildebrandt, B.5
Haas, R.6
Germing, U.7
Gattermann, N.8
-
98
-
-
29744454120
-
The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia
-
Kuendgen, A., Schmid, M., Schlenk, R., Knipp, S., Hildebrandt, B., Steidl, C., Germing, U., Haas, R., Dohner, H., Gattermann, N. (2006) The histone deacetylase (HDAC) inhibitor valproic acid as monotherapy or in combination with all-trans retinoic acid in patients with acute myeloid leukemia. Cancer 106, 112-119.
-
(2006)
Cancer
, vol.106
, pp. 112-119
-
-
Kuendgen, A.1
Schmid, M.2
Schlenk, R.3
Knipp, S.4
Hildebrandt, B.5
Steidl, C.6
Germing, U.7
Haas, R.8
Dohner, H.9
Gattermann, N.10
-
99
-
-
2142712474
-
Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome
-
Kurzrock, R., Albitar, M., Cortes, J. E., Estey, E. H., Faderl, S. H., Garcia-Manero, G., Thomas, D. A., Giles, F. J., Ryback, M. E., Thibault, A., De Porre, P., Kantarjian, H. M. (2004) Phase II study of R115777, a farnesyl transferase inhibitor, in myelodysplastic syndrome. J. Clin. Oncol. 22, 1287-1292.
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 1287-1292
-
-
Kurzrock, R.1
Albitar, M.2
Cortes, J.E.3
Estey, E.H.4
Faderl, S.H.5
Garcia-Manero, G.6
Thomas, D.A.7
Giles, F.J.8
Ryback, M.E.9
Thibault, A.10
De Porre, P.11
Kantarjian, H.M.12
-
100
-
-
0037672877
-
Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics
-
Kurzrock, R., Kantarjian, H. M., Druker, B. J., Talpaz, M. (2003) Philadelphia chromosome-positive leukemias: From basic mechanisms to molecular therapeutics. Ann. Intern. Med. 138, 819-830.
-
(2003)
Ann. Intern. Med.
, vol.138
, pp. 819-830
-
-
Kurzrock, R.1
Kantarjian, H.M.2
Druker, B.J.3
Talpaz, M.4
-
101
-
-
25444502962
-
In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas
-
Lacrima, K., Valentini, A., Lambertini, C., Taborelli, M., Rinaldi, A., Zucca, E., Catapano, C., Cavalli, F., Gianella-Borradori, A., MacCallum, D. E., Bertoni, F. (2005) In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas. Ann. Oncol. 16, 1169-1176.
-
(2005)
Ann. Oncol.
, vol.16
, pp. 1169-1176
-
-
Lacrima, K.1
Valentini, A.2
Lambertini, C.3
Taborelli, M.4
Rinaldi, A.5
Zucca, E.6
Catapano, C.7
Cavalli, F.8
Gianella-Borradori, A.9
MacCallum, D.E.10
Bertoni, F.11
-
102
-
-
0345689346
-
Farnesyltransferase inhibitors in hematologic malignancies: New horizons in therapy
-
Lancet, J. E., Karp, J. E. (2003) Farnesyltransferase inhibitors in hematologic malignancies: new horizons in therapy. Blood 102, 3880-3889.
-
(2003)
Blood
, vol.102
, pp. 3880-3889
-
-
Lancet, J.E.1
Karp, J.E.2
-
103
-
-
0037009846
-
The role of iron in cell cycle progression and the proliferation of neoplastic cells
-
Le, N. T., Richardson, D. R. (2002) The role of iron in cell cycle progression and the proliferation of neoplastic cells. Biochim. Biophys. Acta 1603, 31-46.
-
(2002)
Biochim. Biophys. Acta
, vol.1603
, pp. 31-46
-
-
Le, N.T.1
Richardson, D.R.2
-
104
-
-
0034782573
-
Increased angiogenesis and Fas-ligand expression are independent processes in acute myeloid leukemia
-
Lee, J. J., Chung, I. J., Park, M. R., Ryang, D. W., Park, C. S., Kim, H. J. (2001) Increased angiogenesis and Fas-ligand expression are independent processes in acute myeloid leukemia. Leuk. Res. 25, 1067-1073.
-
(2001)
Leuk. Res.
, vol.25
, pp. 1067-1073
-
-
Lee, J.J.1
Chung, I.J.2
Park, M.R.3
Ryang, D.W.4
Park, C.S.5
Kim, H.J.6
-
105
-
-
27944503331
-
MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38 alpha protein
-
Lee, M. R., Dominguez, C. (2005) MAP kinase p38 inhibitors: Clinical results and an intimate look at their interactions with p38 alpha protein. Curr. Med. Chem. 12, 2979-2994.
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 2979-2994
-
-
Lee, M.R.1
Dominguez, C.2
-
106
-
-
33644857142
-
Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy
-
Lee, Y. K., Isham, C. R., Kaufman, S. H., Bible, K. C. (2006) Flavopiridol disrupts STAT3/DNA interactions, attenuates STAT3-directed transcription, and combines with the Jak kinase inhibitor AG490 to achieve cytotoxic synergy. Mol. Cancer Ther. 5, 138-148.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 138-148
-
-
Lee, Y.K.1
Isham, C.R.2
Kaufman, S.H.3
Bible, K.C.4
-
107
-
-
0031845360
-
Fas/APO-1 (CD95) expression in myelodysplastic syndromes
-
Lepelley, P., Grardel, N., Erny, O., Iaru, T., Obein, V., Cosson, A., Fenaux, P. (1998) Fas/APO-1 (CD95) expression in myelodysplastic syndromes. Leuk. Lymphoma 30, 307-312.
-
(1998)
Leuk. Lymphoma
, vol.30
, pp. 307-312
-
-
Lepelley, P.1
Grardel, N.2
Erny, O.3
Iaru, T.4
Obein, V.5
Cosson, A.6
Fenaux, P.7
-
108
-
-
4544340539
-
Antiapoptotic BCL-2 is required for maintenance of a model leukemia
-
Letai, A., Sorcinelli, M. D., Beard, C., Korsmeyer, S. J. (2004) Antiapoptotic BCL-2 is required for maintenance of a model leukemia. Cancer Cell 6, 241-249.
-
(2004)
Cancer Cell
, vol.6
, pp. 241-249
-
-
Letai, A.1
Sorcinelli, M.D.2
Beard, C.3
Korsmeyer, S.J.4
-
109
-
-
26444558130
-
Pharmacological manipulation of Bcl-2 family members to control cell death
-
Letai, A. (2005) Pharmacological manipulation of Bcl-2 family members to control cell death. J. Clin. Invest. 115, 2648-2655.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2648-2655
-
-
Letai, A.1
-
110
-
-
0036624916
-
A FLT3 -targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
-
Levis, M., Allebach, J., Tse, K. F., Zheng, R., Baldwin, B. R., Smith, B. D., Jones-Bolin, S., Ruggeri, B., Dionne, C., Small, D. (2002) A FLT3 -targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood 99, 3885-3891.
-
(2002)
Blood
, vol.99
, pp. 3885-3891
-
-
Levis, M.1
Allebach, J.2
Tse, K.F.3
Zheng, R.4
Baldwin, B.R.5
Smith, B.D.6
Jones-Bolin, S.7
Ruggeri, B.8
Dionne, C.9
Small, D.10
-
111
-
-
0035893740
-
Evaluation of farnesyl: Protein transferase and geranylgeranyl: Protein transferase inhibitor combinations in preclinical models
-
Lobell, R. B., Omer, C. A., Abrams, M. T., Bhimnathwala, H. G., Brucker, M. J., Buser, C. A., Davide, J. P., deSolms, S. J., Dinsmore, C. J., Ellis-Hutchings, M. S., Kral, A. M., Liu, D., Lumma, W. C., Machotka, S. V., Rands, E., Williams, T. M., Graham, S. L., Hartman, G. D., Oliff, A. I., Heimbrook, D. C., Kohl, N. E. (2001) Evaluation of farnesyl: protein transferase and geranylgeranyl: protein transferase inhibitor combinations in preclinical models. Cancer Res. 61, 8758-8768.
-
(2001)
Cancer Res.
, vol.61
, pp. 8758-8768
-
-
Lobell, R.B.1
Omer, C.A.2
Abrams, M.T.3
Bhimnathwala, H.G.4
Brucker, M.J.5
Buser, C.A.6
Davide, J.P.7
deSolms, S.J.8
Dinsmore, C.J.9
Ellis-Hutchings, M.S.10
Kral, A.M.11
Liu, D.12
Lumma, W.C.13
Machotka, S.V.14
Rands, E.15
Williams, T.M.16
Graham, S.L.17
Hartman, G.D.18
Oliff, A.I.19
Heimbrook, D.C.20
Kohl, N.E.21
more..
-
112
-
-
0035936797
-
The TNF and TNF receptor superfamilies: Integrating mammalian biology
-
Locksley, R. M., Killeen, N., Lenardo, M. J. (2001) The TNF and TNF receptor superfamilies: integrating mammalian biology. Cell 104, 487-501.
-
(2001)
Cell
, vol.104
, pp. 487-501
-
-
Locksley, R.M.1
Killeen, N.2
Lenardo, M.J.3
-
113
-
-
0037986658
-
Iron chelators as anti-neoplastic agents: Current developments and promise of the PIH class of chelators
-
Lovejoy, D. B., Richardson, P. R. (2003) Iron chelators as anti-neoplastic agents: Current developments and promise of the PIH class of chelators. Curr. Med. Chem. 10, 1035-1049.
-
(2003)
Curr. Med. Chem.
, vol.10
, pp. 1035-1049
-
-
Lovejoy, D.B.1
Richardson, P.R.2
-
114
-
-
13944249521
-
Cytokine overexpression and constitutive NF kappa B in cancer
-
Lu, T., Stark, G. R. (2004) Cytokine overexpression and constitutive NF kappa B in cancer. Cell Cycle 3, 1114-1117.
-
(2004)
Cell Cycle
, vol.3
, pp. 1114-1117
-
-
Lu, T.1
Stark, G.R.2
-
115
-
-
33644857988
-
Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin
-
Ma, Y., Lakshmikanthan, V., Lewis, R. W., Kumar, M. V. (2006) Sensitization of TRAIL-resistant cells by inhibition of heat shock protein 90 with low-dose geldanamycin. Mol. Cancer Ther. 5, 170-178.
-
(2006)
Mol. Cancer Ther.
, vol.5
, pp. 170-178
-
-
Ma, Y.1
Lakshmikanthan, V.2
Lewis, R.W.3
Kumar, M.V.4
-
116
-
-
20444477948
-
Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1
-
MacCallum, D. E., Melville, J., Frame, S., Watt, K., Anderson, S., Gianella-Borradori, A., Lane, D. P., Green, S. R. (2005) Seliciclib (CYC202, R-Roscovitine) induces cell death in multiple myeloma cells by inhibition of RNA polymerase II-dependent transcription and down-regulation of Mcl-1. Cancer Res. 65, 5399-5407.
-
(2005)
Cancer Res.
, vol.65
, pp. 5399-5407
-
-
MacCallum, D.E.1
Melville, J.2
Frame, S.3
Watt, K.4
Anderson, S.5
Gianella-Borradori, A.6
Lane, D.P.7
Green, S.R.8
-
117
-
-
0038692705
-
BAFF and APRIL: A tutorial on B cell survival
-
Mackay, F., Schneider, P., Rennert, P., Browning, J. (2003) BAFF and APRIL: a tutorial on B cell survival. Annu. Rev. Immunol. 21, 231-264.
-
(2003)
Annu. Rev. Immunol.
, vol.21
, pp. 231-264
-
-
Mackay, F.1
Schneider, P.2
Rennert, P.3
Browning, J.4
-
118
-
-
0037438586
-
Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia
-
Marcucci, G., Byrd, J. C., Dai, G., Klisovic, M. I., Kourlas, P. J., Young, D. C., Cataland, S. R., Fisher, D. B., Lucas, D., Chan, K. K., Porcu, P., Lin, Z. P., Farag, S. F., Frankel, S. R., Zwiebel, J. A., Kraut, E. H., Balcerzak, S. P., Bloomfield, C. D., Grever, M. R., Caligiuri, M. A. (2003) Phase 1 and pharmacodynamic studies of G3139, a Bcl-2 antisense oligonucleotide, in combination with chemotherapy in refractory or relapsed acute leukemia. Blood 101, 425-432.
-
(2003)
Blood
, vol.101
, pp. 425-432
-
-
Marcucci, G.1
Byrd, J.C.2
Dai, G.3
Klisovic, M.I.4
Kourlas, P.J.5
Young, D.C.6
Cataland, S.R.7
Fisher, D.B.8
Lucas, D.9
Chan, K.K.10
Porcu, P.11
Lin, Z.P.12
Farag, S.F.13
Frankel, S.R.14
Zwiebel, J.A.15
Kraut, E.H.16
Balcerzak, S.P.17
Bloomfield, C.D.18
Grever, M.R.19
Caligiuri, M.A.20
more..
-
119
-
-
20644469046
-
Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: Pharmacokinetics, pharmacodynamics, and clinical activity
-
Marcucci, G., Stock, W., Dai, G., Klisovic, R. B., Liu, S., Klisovic, M. I., Blum, W., Kefauver, C., Sher, D. A., Green, M., Moran, M., Maharry, K., Novick, S., Bloomfield, C. D., Zwiebel, J. A., Larson, R. A., Grever, M. R., Chan, K. K., Byrd, J. C. (2005) Phase I study of oblimersen sodium, an antisense to Bcl-2, in untreated older patients with acute myeloid leukemia: pharmacokinetics, pharmacodynamics, and clinical activity. J. Clin. Oncol. 23, 3404-3411.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 3404-3411
-
-
Marcucci, G.1
Stock, W.2
Dai, G.3
Klisovic, R.B.4
Liu, S.5
Klisovic, M.I.6
Blum, W.7
Kefauver, C.8
Sher, D.A.9
Green, M.10
Moran, M.11
Maharry, K.12
Novick, S.13
Bloomfield, C.D.14
Zwiebel, J.A.15
Larson, R.A.16
Grever, M.R.17
Chan, K.K.18
Byrd, J.C.19
-
120
-
-
0035755974
-
Histone deacetylases and cancer: Causes and therapies
-
Marks, P., Rifkind, R. A., Richon, V. M., Breslow, R., Miller, T., Kelly, W. K. (2001) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer 1, 194-202.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
Rifkind, R.A.2
Richon, V.M.3
Breslow, R.4
Miller, T.5
Kelly, W.K.6
-
121
-
-
2442545178
-
c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis
-
Mathas, S., Lietz, A., Anagnostopoulos, I., Hummel, F., Wiesner, B., Janz, M., Jundt, F., Hirsch, B., Jobrens-Leder, K., Vornlocher, H. P., Bommert, K., Stein, H., Dorken, B. (2004) c-FLIP mediates resistance of Hodgkin/Reed-Sternberg cells to death receptor-induced apoptosis. J. Exp. Med. 199, 1041-1052.
-
(2004)
J. Exp. Med.
, vol.199
, pp. 1041-1052
-
-
Mathas, S.1
Lietz, A.2
Anagnostopoulos, I.3
Hummel, F.4
Wiesner, B.5
Janz, M.6
Jundt, F.7
Hirsch, B.8
Jobrens-Leder, K.9
Vornlocher, H.P.10
Bommert, K.11
Stein, H.12
Dorken, B.13
-
122
-
-
0037514395
-
In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia
-
Mesa, R. A., Tefferi, A., Gray, L. A., Reeder, T., Schroeder, G., Kaufmann, S. H. (2003) In vitro antiproliferative activity of the farnesyltransferase inhibitor R115777 in hematopoietic progenitors from patients with myelofibrosis with myeloid metaplasia. Leukemia 17, 849-855.
-
(2003)
Leukemia
, vol.17
, pp. 849-855
-
-
Mesa, R.A.1
Tefferi, A.2
Gray, L.A.3
Reeder, T.4
Schroeder, G.5
Kaufmann, S.H.6
-
123
-
-
22944432512
-
Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects
-
Milella, M., Precupanu, C. M., Gregorj, C., Riceiardi, M. R., Petrucci, M. T., Kornblau, S. M., Tafuri, A., Andreeff, M. (2005) Beyond single pathway inhibition: MEK inhibitors as a platform for the development of pharmacological combinations with synergistic anti-leukemic effects. Curr. Pharm. Des. 11, 2779-2795.
-
(2005)
Curr. Pharm. Des.
, vol.11
, pp. 2779-2795
-
-
Milella, M.1
Precupanu, C.M.2
Gregorj, C.3
Riceiardi, M.R.4
Petrucci, M.T.5
Kornblau, S.M.6
Tafuri, A.7
Andreeff, M.8
-
124
-
-
31544436323
-
Antimyeloma activity of heat shock protein-90 inhibition
-
Mitsiades, C. S., Mitsiades, N. S., McMullan, C. J., Poulaki, V., Kung, A. L., Davies, F. E., Morgan, G., Akiyama, M., Shringarpure, R., Munshi, N. C., Richardson, P. G., Hideshima, T., Chauhan, D., Gu, X., Bailey, C., Joseph, M., Libermann, T. A., Rosen, N. S., Anderson, K. C. (2006) Antimyeloma activity of heat shock protein-90 inhibition. Blood 107, 1092-1100.
-
(2006)
Blood
, vol.107
, pp. 1092-1100
-
-
Mitsiades, C.S.1
Mitsiades, N.S.2
McMullan, C.J.3
Poulaki, V.4
Kung, A.L.5
Davies, F.E.6
Morgan, G.7
Akiyama, M.8
Shringarpure, R.9
Munshi, N.C.10
Richardson, P.G.11
Hideshima, T.12
Chauhan, D.13
Gu, X.14
Bailey, C.15
Joseph, M.16
Libermann, T.A.17
Rosen, N.S.18
Anderson, K.C.19
-
125
-
-
11144355586
-
BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone
-
Moreaux, J., Legouffe, E., Jourdan, E., Quittet, P., Reme, T., Lugagne, C., Moine, P., Rossi, J. F., Klein, B., Tarte, K. (2004) BAFF and APRIL protect myeloma cells from apoptosis induced by interleukin 6 deprivation and dexamethasone. Blood 103, 3148-3157.
-
(2004)
Blood
, vol.103
, pp. 3148-3157
-
-
Moreaux, J.1
Legouffe, E.2
Jourdan, E.3
Quittet, P.4
Reme, T.5
Lugagne, C.6
Moine, P.7
Rossi, J.F.8
Klein, B.9
Tarte, K.10
-
126
-
-
0344393408
-
Regulation of map kinase signaling modules by scaffold proteins in mammals
-
Morrison, D. K., Davis, R. J. (2003) Regulation of map kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell. Dev. Biol. 19, 91-118.
-
(2003)
Annu. Rev. Cell. Dev. Biol.
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
127
-
-
0032730429
-
Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer
-
Nemunaitis, J., Holmlund, J. T., Kraynak, M., Richards, D., Bruce, J., Ognoskie, N., Kwoh, T. J., Geary, R., Dorr, A., Von Hoff, D., Eckhardt, S. G. (1999) Phase I evaluation of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C-alpha, in patients with advanced cancer. J. Clin. Oncol. 17, 3586-3595.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3586-3595
-
-
Nemunaitis, J.1
Holmlund, J.T.2
Kraynak, M.3
Richards, D.4
Bruce, J.5
Ognoskie, N.6
Kwoh, T.J.7
Geary, R.8
Dorr, A.9
Von Hoff, D.10
Eckhardt, S.G.11
-
128
-
-
0030091222
-
Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease
-
Nguyen, P. L., Harris, N. L., Ritz, J., Robertson, M. J. (1996) Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease. Am. J. Pathol. 148, 847-853.
-
(1996)
Am. J. Pathol.
, vol.148
, pp. 847-853
-
-
Nguyen, P.L.1
Harris, N.L.2
Ritz, J.3
Robertson, M.J.4
-
129
-
-
0038107396
-
High-level expression of BCL3 differentiates t(2; 5)(p23; q35)-positive anaplastic large cell lymphoma from Hodgkin disease
-
Nishikori, M., Maesako, Y., Ueda, C., Kurata, M., Uchiyama, T., Ohno, H. (2003) High-level expression of BCL3 differentiates t(2; 5)(p23; q35)-positive anaplastic large cell lymphoma from Hodgkin disease. Blood 101, 2789-2796.
-
(2003)
Blood
, vol.101
, pp. 2789-2796
-
-
Nishikori, M.1
Maesako, Y.2
Ueda, C.3
Kurata, M.4
Uchiyama, T.5
Ohno, H.6
-
130
-
-
23044514711
-
Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α
-
Nishio, M., Endo, T., Tsukada, N., Ohata, J., Kitada, S., Reed, J. C., Zvaifler, N. J., Kipps, T. J. (2005) Nurselike cells express BAFF and APRIL, which can promote survival of chronic lymphocytic leukemia cells via a paracrine pathway distinct from that of SDF-1α. Blood 106, 1012-1020.
-
(2005)
Blood
, vol.106
, pp. 1012-1020
-
-
Nishio, M.1
Endo, T.2
Tsukada, N.3
Ohata, J.4
Kitada, S.5
Reed, J.C.6
Zvaifler, N.J.7
Kipps, T.J.8
-
131
-
-
32944475363
-
Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense
-
O'Brien, S. M., Cunningham, C. C., Golenkov, A. K., Turkina, A. G., Novick, S. C., Rai, K. R. (2005) Phase I to II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in patients with advanced chronic lymphocytic leukemia. J. Clin. Oncol. 23, 7697-7702.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 7697-7702
-
-
O'Brien, S.M.1
Cunningham, C.C.2
Golenkov, A.K.3
Turkina, A.G.4
Novick, S.C.5
Rai, K.R.6
-
132
-
-
0027291205
-
Lethal effect of the anti-Fas antibody in mice
-
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., Nagata, S. (1993) Lethal effect of the anti-Fas antibody in mice. Nature 364, 806-809.
-
(1993)
Nature
, vol.364
, pp. 806-809
-
-
Ogasawara, J.1
Watanabe-Fukunaga, R.2
Adachi, M.3
Matsuzawa, A.4
Kasugai, T.5
Kitamura, Y.6
Itoh, N.7
Suda, T.8
Nagata, S.9
-
133
-
-
0034634750
-
Amplification and expression of a decoy receptor for fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas
-
Ohshima, K., Haraoka, S., Sugihara, M., Suzumiya, J., Kawasaki, C., Kanda, M., Kikuchi, M. (2000) Amplification and expression of a decoy receptor for fas ligand (DcR3) in virus (EBV or HTLV-I) associated lymphomas. Cancer Lett. 160, 89-97.
-
(2000)
Cancer Lett.
, vol.160
, pp. 89-97
-
-
Ohshima, K.1
Haraoka, S.2
Sugihara, M.3
Suzumiya, J.4
Kawasaki, C.5
Kanda, M.6
Kikuchi, M.7
-
134
-
-
0029135134
-
BHRF1, the Epstein-Barr virus (EBV) homologue of the BCL-2 protooncogene, is transcribed in EBV-associated B-cell lymphomas and in reactive lymphocytes
-
van, d., V.
-
Oudejans, J. J., van den Brule, A. J., Jiwa, N. M., de Bruin, P. C., Ossenkoppele, G. J., van, d., V., Walboomers, J. M., Meijer, C. J. (1995) BHRF1, the Epstein-Barr virus (EBV) homologue of the BCL-2 protooncogene, is transcribed in EBV-associated B-cell lymphomas and in reactive lymphocytes. Blood 86, 1893-1902.
-
(1995)
Blood
, vol.86
, pp. 1893-1902
-
-
Oudejans, J.J.1
van den Brule, A.J.2
Jiwa, N.M.3
de Bruin, P.C.4
Ossenkoppele, G.J.5
Walboomers, J.M.6
Meijer, C.J.7
-
135
-
-
4644276702
-
Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders
-
Pardanani, A., Tefferi, A. (2004) Imatinib targets other than bcr/abl and their clinical relevance in myeloid disorders. Blood 104, 1931-1939.
-
(2004)
Blood
, vol.104
, pp. 1931-1939
-
-
Pardanani, A.1
Tefferi, A.2
-
136
-
-
0042090495
-
Novel mechanisms of apoptosis induced by histone deacetylase inhibitors
-
Peart, M. J., Tainton, K. M., Ruefli, A. A., Dear, A. E., Sedelies, K. A., O'Reilly, L. A., Waterhouse, N. J., Trapani, J. A., Johnstone, R. W. (2003) Novel mechanisms of apoptosis induced by histone deacetylase inhibitors. Cancer Res. 63, 4460-4471.
-
(2003)
Cancer Res.
, vol.63
, pp. 4460-4471
-
-
Peart, M.J.1
Tainton, K.M.2
Ruefli, A.A.3
Dear, A.E.4
Sedelies, K.A.5
O'Reilly, L.A.6
Waterhouse, N.J.7
Trapani, J.A.8
Johnstone, R.W.9
-
137
-
-
2542523228
-
Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors
-
Pei, X. Y., Dai, Y., Grant, S. (2004) Synergistic induction of oxidative injury and apoptosis in human multiple myeloma cells by the proteasome inhibitor bortezomib and histone deacetylase inhibitors. Clin. Cancer Res. 10, 3839-3852.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 3839-3852
-
-
Pei, X.Y.1
Dai, Y.2
Grant, S.3
-
138
-
-
0037179847
-
Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma
-
Pene, F., Claessens, Y. E., Muller, O., Viguie, F., Mayeux, P., Dreyfus, F., Lacombe, C., Bouscary, D. (2002) Role of the phosphatidylinositol 3-kinase/Akt and mTOR/P70S6-kinase pathways in the proliferation and apoptosis in multiple myeloma. Oncogene 21, 6587-6597.
-
(2002)
Oncogene
, vol.21
, pp. 6587-6597
-
-
Pene, F.1
Claessens, Y.E.2
Muller, O.3
Viguie, F.4
Mayeux, P.5
Dreyfus, F.6
Lacombe, C.7
Bouscary, D.8
-
139
-
-
0038206722
-
Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis
-
Pham, L. V., Tamayo, A. T., Yoshimura, L. C., Lo, P., Ford, R. J. (2003) Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosis. J. Immunol. 171, 88-95.
-
(2003)
J. Immunol.
, vol.171
, pp. 88-95
-
-
Pham, L.V.1
Tamayo, A.T.2
Yoshimura, L.C.3
Lo, P.4
Ford, R.J.5
-
140
-
-
85009895235
-
TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors
-
Plasilova, M., Zivny, J., Jelinek, J., Neuwirtova, R., Cermak, J., Necas, E., Andera, L., Stopka, T. (2002) TRAIL (Apo2L) suppresses growth of primary human leukemia and myelodysplasia progenitors. Leukemia 16, 67-73.
-
(2002)
Leukemia
, vol.16
, pp. 67-73
-
-
Plasilova, M.1
Zivny, J.2
Jelinek, J.3
Neuwirtova, R.4
Cermak, J.5
Necas, E.6
Andera, L.7
Stopka, T.8
-
141
-
-
0038792224
-
Map kinase signaling pathways and hematologic malignancies
-
Platanias, L. C. (2003) Map kinase signaling pathways and hematologic malignancies. Blood 101, 4667-4679.
-
(2003)
Blood
, vol.101
, pp. 4667-4679
-
-
Platanias, L.C.1
-
142
-
-
0035281737
-
Twelves, C. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
-
Propper, D. J., McDonald, A. C., Man, A., Thavasu, P., Balkwill, F., Braybrooke, J. P., Caponigro, F., Graf, P., Dutreix, C., Blackie, R., Kaye, S. B., Ganesan, T. S., Talbot, D. C., Harris, A. L., Twelves, C. (2001) Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J. Clin. Oncol. 19, 1485-1492.
-
(2001)
J. Clin. Oncol.
, vol.19
, pp. 1485-1492
-
-
Propper, D.J.1
McDonald, A.C.2
Man, A.3
Thavasu, P.4
Balkwill, F.5
Braybrooke, J.P.6
Caponigro, F.7
Graf, P.8
Dutreix, C.9
Blackie, R.10
Kaye, S.B.11
Ganesan, T.S.12
Talbot, D.C.13
Harris, A.L.14
-
143
-
-
22544466164
-
Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia
-
Raffoux, E., Chaibi, P., Dombret, H., Degos, L. (2005) Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia. Haematologica 90, 986-988.
-
(2005)
Haematologica
, vol.90
, pp. 986-988
-
-
Raffoux, E.1
Chaibi, P.2
Dombret, H.3
Degos, L.4
-
144
-
-
0036635846
-
UCN-01 (7-hydroxystaurosporine) blocks PMA-induced maturation and reciprocally promotes apoptosis in human myelomonocytic leukemia cells (U937)
-
Rahmani, M., Grant, S. (2002) UCN-01 (7-hydroxystaurosporine) blocks PMA-induced maturation and reciprocally promotes apoptosis in human myelomonocytic leukemia cells (U937). Cell Cycle 1, 273-281.
-
(2002)
Cell Cycle
, vol.1
, pp. 273-281
-
-
Rahmani, M.1
Grant, S.2
-
145
-
-
23044439051
-
Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma
-
Raje, N., Kumar, S., Hideshima, T., Roccaro, A., Ishitsuka, K., Yasui, H., Shiraishi, N., Chauhan, D., Munshi, N. C., Green, S. R., Anderson, K. C. (2005) Seliciclib (CYC202 or R-roscovitine), a small-molecule cyclin-dependent kinase inhibitor, mediates activity via down-regulation of Mcl-1 in multiple myeloma. Blood 106, 1042-1047.
-
(2005)
Blood
, vol.106
, pp. 1042-1047
-
-
Raje, N.1
Kumar, S.2
Hideshima, T.3
Roccaro, A.4
Ishitsuka, K.5
Yasui, H.6
Shiraishi, N.7
Chauhan, D.8
Munshi, N.C.9
Green, S.R.10
Anderson, K.C.11
-
146
-
-
18744421982
-
Chromosomal and gene amplification in diffuse large B-cell lymphoma
-
Rao, P. H., Houldsworth, J., Dyomina, K., Parsa, N. Z., Cigudosa, J. C., Louie, D. C., Popplewell, L., Offit, K., Jhanwar, S. C., Chaganti, R. S. (1998) Chromosomal and gene amplification in diffuse large B-cell lymphoma. Blood 92, 234-240.
-
(1998)
Blood
, vol.92
, pp. 234-240
-
-
Rao, P.H.1
Houldsworth, J.2
Dyomina, K.3
Parsa, N.Z.4
Cigudosa, J.C.5
Louie, D.C.6
Popplewell, L.7
Offit, K.8
Jhanwar, S.C.9
Chaganti, R.S.10
-
147
-
-
4644305430
-
Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma
-
Rao, S., Watkins, D., Cunningham, D., Dunlop, D., Johnson, P., Selby, P., Hancock, B. W., Fegan, C., Culligan, D., Schey, S., Morris, T. C., Lissitchkov, T., Oliver, J. W., Holmlund, J. T. (2004) Phase II study of ISIS 3521, an antisense oligodeoxynucleotide to protein kinase C alpha, in patients with previously treated low-grade non-Hodgkin's lymphoma. Ann. Oncol. 15, 1413-1418.
-
(2004)
Ann. Oncol.
, vol.15
, pp. 1413-1418
-
-
Rao, S.1
Watkins, D.2
Cunningham, D.3
Dunlop, D.4
Johnson, P.5
Selby, P.6
Hancock, B.W.7
Fegan, C.8
Culligan, D.9
Schey, S.10
Morris, T.C.11
Lissitchkov, T.12
Oliver, J.W.13
Holmlund, J.T.14
-
148
-
-
4143151967
-
Genomic mechanisms of p210BCR-ABL signaling: Induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis
-
Ray, S., Lu, Y., Kaufmann, S. H., Gustafson, W. C., Karp, J. E., Boldogh, I., Fields, A. P., Brasier, A. R. (2004) Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis. J. Biol. Chem. 279, 35604-35615.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 35604-35615
-
-
Ray, S.1
Lu, Y.2
Kaufmann, S.H.3
Gustafson, W.C.4
Karp, J.E.5
Boldogh, I.6
Fields, A.P.7
Brasier, A.R.8
-
149
-
-
20144363954
-
Antileukemic activity of rapamycin in acute myeloid leukemia
-
Recher, C., Beyne-Rauzy, O., Demur, C., Chicanne, G., Dos, S. C., Mas, V. M., Benzaquen, D., Laurent, G., Huguet, F., Payrastre, B. (2005a) Antileukemic activity of rapamycin in acute myeloid leukemia. Blood 105, 2527-2534.
-
(2005)
Blood
, vol.105
, pp. 2527-2534
-
-
Recher, C.1
Beyne-Rauzy, O.2
Demur, C.3
Chicanne, G.4
Dos, S.C.5
Mas, V.M.6
Benzaquen, D.7
Laurent, G.8
Huguet, F.9
Payrastre, B.10
-
150
-
-
27744507024
-
mTOR, a new therapeutic target in acute myeloid leukemia
-
Recher, C., Dos, S. C., Demur, C., Payrastre, B. (2005b) mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 4, 1540-1549.
-
(2005)
Cell Cycle
, vol.4
, pp. 1540-1549
-
-
Recher, C.1
Dos, S.C.2
Demur, C.3
Payrastre, B.4
-
151
-
-
22144460556
-
Apoptosis-based therapies for hematologic malignancies
-
Reed, J. C., Pellecchia, M. (2005) Apoptosis-based therapies for hematologic malignancies. Blood 106, 408-418.
-
(2005)
Blood
, vol.106
, pp. 408-418
-
-
Reed, J.C.1
Pellecchia, M.2
-
152
-
-
20344396647
-
TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL
-
Riccioni, R., Pasquini, L., Mariani, G., Saulle, E., Rossini, A., Diverio, D., Pelosi, E., Vitale, A., Chierichini, A., Cedrone, M., Foa, R., Lo, C. F., Peschle, C., Testa, U. (2005) TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL. Haematologica 90, 612-624.
-
(2005)
Haematologica
, vol.90
, pp. 612-624
-
-
Riccioni, R.1
Pasquini, L.2
Mariani, G.3
Saulle, E.4
Rossini, A.5
Diverio, D.6
Pelosi, E.7
Vitale, A.8
Chierichini, A.9
Cedrone, M.10
Foa, R.11
Lo, C.F.12
Peschle, C.13
Testa, U.14
-
153
-
-
27744528421
-
Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer
-
Richardson, D. R. (2005) Molecular mechanisms of iron uptake by cells and the use of iron chelators for the treatment of cancer. Curr. Med. Chem. 12, 2711-2729.
-
(2005)
Curr. Med. Chem.
, vol.12
, pp. 2711-2729
-
-
Richardson, D.R.1
-
154
-
-
0037111661
-
Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: Association with protein kinase Cδ
-
Ringshausen, I., Schneller, F., Bogner, C., Hipp, S., Duyster, J., Peschel, C., Decker, T. (2002) Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ. Blood 100, 3741-3748.
-
(2002)
Blood
, vol.100
, pp. 3741-3748
-
-
Ringshausen, I.1
Schneller, F.2
Bogner, C.3
Hipp, S.4
Duyster, J.5
Peschel, C.6
Decker, T.7
-
155
-
-
8844228917
-
Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation
-
Rosato, R. R., Dai, Y., Almenara, J. A., Maggio, S. C., Grant, S. (2004) Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation. Leukemia 18, 1780-1788.
-
(2004)
Leukemia
, vol.18
, pp. 1780-1788
-
-
Rosato, R.R.1
Dai, Y.2
Almenara, J.A.3
Maggio, S.C.4
Grant, S.5
-
156
-
-
4344643781
-
Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro
-
Satou, Y., Nosaka, K., Koya, Y., Yasunaga, J. I., Toyokuni, S., Matsuoka, M. (2004) Proteasome inhibitor, bortezomib, potently inhibits the growth of adult T-cell leukemia cells both in vivo and in vitro. Leukemia 18, 1357-1363.
-
(2004)
Leukemia
, vol.18
, pp. 1357-1363
-
-
Satou, Y.1
Nosaka, K.2
Koya, Y.3
Yasunaga, J.I.4
Toyokuni, S.5
Matsuoka, M.6
-
157
-
-
19444376495
-
HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun
-
Schepers, H., Geugien, M., van der, T. M., Bryantsev, A. L., Kampinga, H. H., Eggen, B. J., Vellenga, E. (2005) HSP27 protects AML cells against VP-16-induced apoptosis through modulation of p38 and c-Jun. Exp. Hematol. 33, 660-670.
-
(2005)
Exp. Hematol.
, vol.33
, pp. 660-670
-
-
Schepers, H.1
Geugien, M.2
van der, T.M.3
Bryantsev, A.L.4
Kampinga, H.H.5
Eggen, B.J.6
Vellenga, E.7
-
158
-
-
5644259587
-
Inhibitor of apoptosis proteins: Translating basic knowledge into clinical practice
-
Schimmer, A. D. (2004) Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice. Cancer Res. 64, 7183-7190.
-
(2004)
Cancer Res.
, vol.64
, pp. 7183-7190
-
-
Schimmer, A.D.1
-
159
-
-
9144234685
-
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
-
Schimmer, A. D., Welsh, K., Pinilla, C., Wang, Z., Krajewska, M., Bonneau, M. J., Pedersen, I. M., Kitada, S., Scott, F. L., Bailly-Maitre, B., Glinsky, G., Scudiero, D., Sausville, E., Salvesen, G., Nefzi, A., Ostresh, J. M., Houghten, R. A., Reed, J. C. (2004) Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 5, 25-35.
-
(2004)
Cancer Cell
, vol.5
, pp. 25-35
-
-
Schimmer, A.D.1
Welsh, K.2
Pinilla, C.3
Wang, Z.4
Krajewska, M.5
Bonneau, M.J.6
Pedersen, I.M.7
Kitada, S.8
Scott, F.L.9
Bailly-Maitre, B.10
Glinsky, G.11
Scudiero, D.12
Sausville, E.13
Salvesen, G.14
Nefzi, A.15
Ostresh, J.M.16
Houghten, R.A.17
Reed, J.C.18
-
160
-
-
31544459272
-
Dasatinib (BMS354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
-
Schittenhelm, M. M., Shiraga, S., Schroeder, A., Corbin, A. S., Griffith, D., Lee, F. Y., Bokemeyer, C., Deininger, M. W., Druker, B. J., Heinrich, M. C. (2006) Dasatinib (BMS354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies. Cancer Res. 66, 473-481.
-
(2006)
Cancer Res.
, vol.66
, pp. 473-481
-
-
Schittenhelm, M.M.1
Shiraga, S.2
Schroeder, A.3
Corbin, A.S.4
Griffith, D.5
Lee, F.Y.6
Bokemeyer, C.7
Deininger, M.W.8
Druker, B.J.9
Heinrich, M.C.10
-
161
-
-
0037824626
-
BAFF and the regulation of B cell survival
-
Schneider, P., Tschopp, J. (2003) BAFF and the regulation of B cell survival. Immunol. Lett. 88, 57-62.
-
(2003)
Immunol. Lett.
, vol.88
, pp. 57-62
-
-
Schneider, P.1
Tschopp, J.2
-
162
-
-
0036499140
-
Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines
-
Shain, K. H., Landowski, T. H., Dalton, W. S. (2002) Adhesion-mediated intracellular redistribution of c-Fas-associated death domain-like IL-1-converting enzyme-like inhibitory protein-long confers resistance to CD95-induced apoptosis in hematopoietic cancer cell lines. J. Immunol. 168, 2544-2553.
-
(2002)
J. Immunol.
, vol.168
, pp. 2544-2553
-
-
Shain, K.H.1
Landowski, T.H.2
Dalton, W.S.3
-
163
-
-
11144221007
-
Apoptotic and autophagic cell death induced by histone deacetylase inhibitors
-
Shao, Y., Gao, Z., Marks, P. A., Jiang, X. (2004) Apoptotic and autophagic cell death induced by histone deacetylase inhibitors. Proc. Natl. Acad. Sci. USA 101, 18030-18035.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 18030-18035
-
-
Shao, Y.1
Gao, Z.2
Marks, P.A.3
Jiang, X.4
-
164
-
-
3042536038
-
Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol
-
Shapiro, G. I. (2004) Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. Clin. Cancer Res. 10, 4270s-4275s.
-
(2004)
Clin. Cancer Res.
, vol.10
-
-
Shapiro, G.I.1
-
165
-
-
3343011970
-
Caspase activation, inhibition, and reactivation: A mechanistic view
-
Shi, Y. (2004) Caspase activation, inhibition, and reactivation: a mechanistic view. Protein Sci. 13, 1979-1987.
-
(2004)
Protein Sci.
, vol.13
, pp. 1979-1987
-
-
Shi, Y.1
-
166
-
-
0037374460
-
Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
-
Shipman, C. M., Croucher, P. I. (2003) Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res. 63, 912-916.
-
(2003)
Cancer Res.
, vol.63
, pp. 912-916
-
-
Shipman, C.M.1
Croucher, P.I.2
-
167
-
-
0021802841
-
Fused transcript of Abl and Bcr genes in chronic myelogenous leukemia
-
Shtivelman, E., Lifshitz, B., Gale, R. P., Canaani, E. (1985) Fused transcript of Abl and Bcr genes in chronic myelogenous leukemia. Nature 315, 550-554.
-
(1985)
Nature
, vol.315
, pp. 550-554
-
-
Shtivelman, E.1
Lifshitz, B.2
Gale, R.P.3
Canaani, E.4
-
168
-
-
0028170816
-
Structure, regulation and function of NF-κB
-
Siebenlist, U., Franzoso, G., Brown, K. (1994) Structure, regulation and function of NF-κB. Annu. Rev. Cell Biol. 10 405-455.
-
(1994)
Annu. Rev. Cell Biol.
, vol.10
, pp. 405-455
-
-
Siebenlist, U.1
Franzoso, G.2
Brown, K.3
-
169
-
-
0344321886
-
Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis
-
Siegmund, D., Hadwiger, P., Pfizenmaier, K., Vornlocher, H. P., Wajant, H. (2002) Selective inhibition of FLICE-like inhibitory protein expression with small interfering RNA oligonucleotides is sufficient to sensitize tumor cells for TRAIL-induced apoptosis. Mol. Med. 8, 725-732.
-
(2002)
Mol. Med.
, vol.8
, pp. 725-732
-
-
Siegmund, D.1
Hadwiger, P.2
Pfizenmaier, K.3
Vornlocher, H.P.4
Wajant, H.5
-
170
-
-
0037079728
-
Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Steinberg cells of Hodgkin lymphoma
-
Skinnider, B. F., Elia, A. J., Gascoyne, R. D., Patterson, B., Trumper, L., Kapp, U., Mak, T. W. (2002) Signal transducer and activator of transcription 6 is frequently activated in Hodgkin and Reed-Steinberg cells of Hodgkin lymphoma. Blood 99, 618-626.
-
(2002)
Blood
, vol.99
, pp. 618-626
-
-
Skinnider, B.F.1
Elia, A.J.2
Gascoyne, R.D.3
Patterson, B.4
Trumper, L.5
Kapp, U.6
Mak, T.W.7
-
171
-
-
0030710188
-
Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway
-
Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., Wasik, M. A., Tsichlis, P. N., Calabretta, B. (1997) Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway. EMBO J. 16, 6151-6161.
-
(1997)
EMBO J.
, vol.16
, pp. 6151-6161
-
-
Skorski, T.1
Bellacosa, A.2
Nieborowska-Skorska, M.3
Majewski, M.4
Martinez, R.5
Choi, J.K.6
Trotta, R.7
Wlodarski, P.8
Perrotti, D.9
Chan, T.O.10
Wasik, M.A.11
Tsichlis, P.N.12
Calabretta, B.13
-
172
-
-
0141446032
-
Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes
-
Soh, J. W., Weinstein, I. B. (2003) Roles of specific isoforms of protein kinase C in the transcriptional control of cyclin D1 and related genes. J. Biol. Chem. 278, 34709-34716.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 34709-34716
-
-
Soh, J.W.1
Weinstein, I.B.2
-
173
-
-
17144395975
-
The activation of Akt/PKB signaling pathway and cell survival
-
Song, G., Ouyang, G., Bao, S. (2005) The activation of Akt/PKB signaling pathway and cell survival. J. Cell Mol. Med. 9, 59-71.
-
(2005)
J. Cell Mol. Med.
, vol.9
, pp. 59-71
-
-
Song, G.1
Ouyang, G.2
Bao, S.3
-
174
-
-
0034781481
-
Constitutive activation of STAT transcription factors in acute myelogenous leukemia
-
Spiekermann, K., Biethahn, S., Wilde, S., Hiddemann, W., Alves, F. (2001) Constitutive activation of STAT transcription factors in acute myelogenous leukemia. Eur. J. Haematol. 67, 63-71.
-
(2001)
Eur. J. Haematol.
, vol.67
, pp. 63-71
-
-
Spiekermann, K.1
Biethahn, S.2
Wilde, S.3
Hiddemann, W.4
Alves, F.5
-
175
-
-
0037053358
-
The novel triterpenoid 2-cyano-3, 12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells
-
Stadheim, T. A., Suh, N., Ganju, N., Sporn, M. B., Eastman, A. (2002) The novel triterpenoid 2-cyano-3, 12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells. J. Biol. Chem. 277, 16448-16455.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 16448-16455
-
-
Stadheim, T.A.1
Suh, N.2
Ganju, N.3
Sporn, M.B.4
Eastman, A.5
-
176
-
-
10944238407
-
Distinctive activation mechanisms and functions for protein kinase Cδ
-
Steinberg, S. F. (2004) Distinctive activation mechanisms and functions for protein kinase Cδ. Biochem. J. 384, 449-459.
-
(2004)
Biochem. J.
, vol.384
, pp. 449-459
-
-
Steinberg, S.F.1
-
177
-
-
19944427559
-
Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412
-
Stone, R. M., DeAngelo, D. J., Klimek, V., Galinsky, I., Estey, E., Nimer, S. D., Grandin, W., Lebwohl, D., Wang, Y., Cohen, P., Fox, E. A., Neuberg, D., Clark, J., Gilliland, D. G., Griffin, J. D. (2005) Patients with acute myeloid leukemia and an activating mutation in FLT3 respond to a small-molecule FLT3 tyrosine kinase inhibitor, PKC412. Blood 105, 54-60.
-
(2005)
Blood
, vol.105
, pp. 54-60
-
-
Stone, R.M.1
DeAngelo, D.J.2
Klimek, V.3
Galinsky, I.4
Estey, E.5
Nimer, S.D.6
Grandin, W.7
Lebwohl, D.8
Wang, Y.9
Cohen, P.10
Fox, E.A.11
Neuberg, D.12
Clark, J.13
Gilliland, D.G.14
Griffin, J.D.15
-
178
-
-
0031452949
-
Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing
-
Suda, T., Hashimoto, H., Tanaka, M., Ochi, T., Nagata, S. (1997) Membrane Fas ligand kills human peripheral blood T lymphocytes, and soluble Fas ligand blocks the killing. J. Exp. Med. 186, 2045-2050.
-
(1997)
J. Exp. Med.
, vol.186
, pp. 2045-2050
-
-
Suda, T.1
Hashimoto, H.2
Tanaka, M.3
Ochi, T.4
Nagata, S.5
-
179
-
-
0036134975
-
Suppression of Akt signaling induces Fas ligand expression: Involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation
-
Suhara, T., Kim, H. S., Kirshenbaum, L. A., Walsh, K. (2002) Suppression of Akt signaling induces Fas ligand expression: involvement of caspase and Jun kinase activation in Akt-mediated Fas ligand regulation. Mol. Cell Biol. 22, 680-691.
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 680-691
-
-
Suhara, T.1
Kim, H.S.2
Kirshenbaum, L.A.3
Walsh, K.4
-
180
-
-
31144449861
-
Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib
-
Sutheesophon, K., Kobayashi, Y., Takatoku, M. A., Ozawa, K., Kano, Y., Ishii, H., Furukawa, Y. (2006) Histone deacetylase inhibitor depsipeptide (FK228) induces apoptosis in leukemic cells by facilitating mitochondrial translocation of Bax, which is enhanced by the proteasome inhibitor bortezomib. Acta Haematol. 115, 78-90.
-
(2006)
Acta Haematol.
, vol.115
, pp. 78-90
-
-
Sutheesophon, K.1
Kobayashi, Y.2
Takatoku, M.A.3
Ozawa, K.4
Kano, Y.5
Ishii, H.6
Furukawa, Y.7
-
181
-
-
0037148518
-
Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development
-
Takeda, K., Smyth, M. J., Cretney, E., Hayakawa, Y., Kayagaki, N., Yagita, H., Okumura, K. (2002) Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J. Exp. Med. 195, 161-169.
-
(2002)
J. Exp. Med.
, vol.195
, pp. 161-169
-
-
Takeda, K.1
Smyth, M.J.2
Cretney, E.3
Hayakawa, Y.4
Kayagaki, N.5
Yagita, H.6
Okumura, K.7
-
182
-
-
20344385768
-
Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu in vivo model of human multiple myeloma
-
Tassone, P., Neri, P., Burger, R., Savino, R., Shammas, M., Catley, L., Podar, K., Chauhan, D., Masciari, S., Gozzini, A., Tagliaferri, P., Venuta, S., Munshi, N. C., Anderson, K. C. (2005) Combination therapy with interleukin-6 receptor superantagonist Sant7 and dexamethasone induces antitumor effects in a novel SCID-hu in vivo model of human multiple myeloma. Clin. Cancer Res. 11, 4251-4258.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 4251-4258
-
-
Tassone, P.1
Neri, P.2
Burger, R.3
Savino, R.4
Shammas, M.5
Catley, L.6
Podar, K.7
Chauhan, D.8
Masciari, S.9
Gozzini, A.10
Tagliaferri, P.11
Venuta, S.12
Munshi, N.C.13
Anderson, K.C.14
-
183
-
-
31544443832
-
The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL
-
Teachey, D. T., Obzut, D. A., Cooperman, J., Fang, J., Carroll, M., Choi, J. K., Houghton, P. J., Brown, V. I., Grupp, S. A. (2006) The mTOR inhibitor CCI-779 induces apoptosis and inhibits growth in preclinical models of primary adult human ALL. Blood 107, 1149-1155.
-
(2006)
Blood
, vol.107
, pp. 1149-1155
-
-
Teachey, D.T.1
Obzut, D.A.2
Cooperman, J.3
Fang, J.4
Carroll, M.5
Choi, J.K.6
Houghton, P.J.7
Brown, V.I.8
Grupp, S.A.9
-
184
-
-
0036105506
-
Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells
-
Thomas, R. K., Kallenborn, A., Wickenhauser, C., Schultze, J. L., Draube, A., Vockerodt, M., Re, D., Diehl, V., Wolf, J. (2002) Constitutive expression of c-FLIP in Hodgkin and Reed-Sternberg cells. Am. J. Pathol. 160, 1521-1528.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 1521-1528
-
-
Thomas, R.K.1
Kallenborn, A.2
Wickenhauser, C.3
Schultze, J.L.4
Draube, A.5
Vockerodt, M.6
Re, D.7
Diehl, V.8
Wolf, J.9
-
185
-
-
25144462634
-
Heat shock proteins and acute leukemias
-
Thomas, X., Campos, L., Le, Q. H., Guyotat, D. (2005) Heat shock proteins and acute leukemias. Hematology 10, 225-235.
-
(2005)
Hematology
, vol.10
, pp. 225-235
-
-
Thomas, X.1
Campos, L.2
Le, Q.H.3
Guyotat, D.4
-
186
-
-
0037312522
-
Combined targeted inhibition of bcl-2, bcl-XL, epidermal growth factor receptor, and protein kinase A type I causes potent antitumor, apoptotic, and antiangiogenic activity
-
Tortora, G., Caputo, R., Damiano, V., Caputo, R., Troiani, T., Veneziani, B. M., De Placido, S., Bianco, A. R., Zangemeister-Wittke, U., Ciardiello, F. (2003) Combined targeted inhibition of bcl-2, bcl-XL, epidermal growth factor receptor, and protein kinase A type I causes potent antitumor, apoptotic, and antiangiogenic activity. Clin. Cancer Res. 9, 866-871.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 866-871
-
-
Tortora, G.1
Caputo, R.2
Damiano, V.3
Caputo, R.4
Troiani, T.5
Veneziani, B.M.6
De Placido, S.7
Bianco, A.R.8
Zangemeister-Wittke, U.9
Ciardiello, F.10
-
187
-
-
3242880626
-
Cancer. Gleevec, chapter two: New leukemia drug aims to overcome resistance
-
Travis, J. (2004) Cancer. Gleevec, chapter two: new leukemia drug aims to overcome resistance. Science 305, 319-321.
-
(2004)
Science
, vol.305
, pp. 319-321
-
-
Travis, J.1
-
188
-
-
4444236952
-
Switching leukemia cell phenotype between life and death
-
Tucker, S. J., Rae, C., Littlejohn, A. F., Paul, A., MacEwan, D. J. (2004) Switching leukemia cell phenotype between life and death. Proc. Natl. Acad. Sci. USA 101, 12940-12945.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 12940-12945
-
-
Tucker, S.J.1
Rae, C.2
Littlejohn, A.F.3
Paul, A.4
MacEwan, D.J.5
-
189
-
-
0029789967
-
Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf
-
Ueda, Y., Hirai, S., Osada, S., Suzuki, A., Mizuno, K., Ohno, S. (1996) Protein kinase C activates the MEK-ERK pathway in a manner independent of Ras and dependent on Raf. J. Biol. Chem. 271, 23512-23519.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 23512-23519
-
-
Ueda, Y.1
Hirai, S.2
Osada, S.3
Suzuki, A.4
Mizuno, K.5
Ohno, S.6
-
190
-
-
8644229153
-
TRAIL induction by radiation in lymphoma patients
-
Unnithan, J., Macklis, R. M. (2004) TRAIL induction by radiation in lymphoma patients. Cancer Invest. 22, 522-525.
-
(2004)
Cancer Invest.
, vol.22
, pp. 522-525
-
-
Unnithan, J.1
Macklis, R.M.2
-
191
-
-
32144453842
-
JAW/STAT signal transduction: Regulators and implication in hematological malignancies
-
Valentino, L., Pierre, J. (2006) JAW/STAT signal transduction: Regulators and implication in hematological malignancies. Biochem. Pharmacol. 71, 713-721.
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 713-721
-
-
Valentino, L.1
Pierre, J.2
-
192
-
-
2942666279
-
G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma
-
van de Donk, N. W., de Weerdt, O., Veth, G., Eurelings, M., van Stralen, E., Frankel, S. R., Hagenbeek, A., Bloem, A. C., Lokhorst, H. M. (2004) G3139, a Bcl-2 antisense oligodeoxynucleotide, induces clinical responses in VAD refractory myeloma. Leukemia 18, 1078-1084.
-
(2004)
Leukemia
, vol.18
, pp. 1078-1084
-
-
van de Donk, N.W.1
de Weerdt, O.2
Veth, G.3
Eurelings, M.4
van Stralen, E.5
Frankel, S.R.6
Hagenbeek, A.7
Bloem, A.C.8
Lokhorst, H.M.9
-
193
-
-
33645782015
-
TNF-α in cancer treatment: Molecular insights, antitumor effects, and clinical utility
-
van Horssen, R., ten Hagen, T. L. M., Eggermont, A. M. M. (2006) TNF-α in cancer treatment: molecular insights, antitumor effects, and clinical utility. Oncologist 11, 397-408.
-
(2006)
Oncologist
, vol.11
, pp. 397-408
-
-
van Horssen, R.1
ten Hagen, T.L.M.2
Eggermont, A.M.M.3
-
194
-
-
0037218430
-
Bryostatin 1 and UCN-01 potentiate 1-β-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms
-
Wang, S., Wang, Z., Grant, S. (2003a) Bryostatin 1 and UCN-01 potentiate 1-β-D-arabinofuranosylcytosine-induced apoptosis in human myeloid leukemia cells through disparate mechanisms. Mol. Pharmacol. 63, 232-242.
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 232-242
-
-
Wang, S.1
Wang, Z.2
Grant, S.3
-
195
-
-
0242721548
-
Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists
-
Wang, S., Yang, D., Lippman, M. E. (2003b) Targeting Bcl-2 and Bcl-XL with nonpeptidic small-molecule antagonists. Semin. Oncol. 30, 133-142.
-
(2003)
Semin. Oncol.
, vol.30
, pp. 133-142
-
-
Wang, S.1
Yang, D.2
Lippman, M.E.3
-
196
-
-
9144265592
-
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors
-
Wang, Z., Cuddy, M., Samuel, T., Welsh, K., Schimmer, A., Hanaii, F., Houghten, R., Pinilla, C., Reed, J. C. (2004) Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J. Biol. Chem. 279, 48168-48176.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 48168-48176
-
-
Wang, Z.1
Cuddy, M.2
Samuel, T.3
Welsh, K.4
Schimmer, A.5
Hanaii, F.6
Houghten, R.7
Pinilla, C.8
Reed, J.C.9
-
197
-
-
0034015672
-
Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma
-
Waters, J. S., Webb, A., Cunningham, D., Clarke, P. A., Raynaud, F., di Stefano, F., Cotter, F. E. (2000) Phase I clinical and pharmacokinetic study of bcl-2 antisense oligonucleotide therapy in patients with non-Hodgkin's lymphoma. J. Clin. Oncol. 18, 1812-1823.
-
(2000)
J. Clin. Oncol.
, vol.18
, pp. 1812-1823
-
-
Waters, J.S.1
Webb, A.2
Cunningham, D.3
Clarke, P.A.4
Raynaud, F.5
di Stefano, F.6
Cotter, F.E.7
-
198
-
-
0345103741
-
Mitochondria play a central role in apoptosis induced by α-tocopheryl succinate, an agent with antineoplastic activity: Comparison with receptor-mediated pro-apoptotic signaling
-
Weber, T., Dalen, H., Andera, L., Negre-Salvayre, A., Auge, N., Sticha, M., Lloret, A., Terman, A., Witting, P. K., Higuchi, M., Plasilova, M., Zivny, J., Gellert, N., Weber, C., Neuzil, J. (2003) Mitochondria play a central role in apoptosis induced by α-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. Biochemistry 42, 4277-4291.
-
(2003)
Biochemistry
, vol.42
, pp. 4277-4291
-
-
Weber, T.1
Dalen, H.2
Andera, L.3
Negre-Salvayre, A.4
Auge, N.5
Sticha, M.6
Lloret, A.7
Terman, A.8
Witting, P.K.9
Higuchi, M.10
Plasilova, M.11
Zivny, J.12
Gellert, N.13
Weber, C.14
Neuzil, J.15
-
199
-
-
0036595143
-
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC4 12
-
Weisberg, E., Boulton, C., Kelly, L. M., Manley, P., Fabbro, D., Meyer, T., Gilliland, D. G., Griffin, J. D. (2002) Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC4 12. Cancer Cell 1, 433-443.
-
(2002)
Cancer Cell
, vol.1
, pp. 433-443
-
-
Weisberg, E.1
Boulton, C.2
Kelly, L.M.3
Manley, P.4
Fabbro, D.5
Meyer, T.6
Gilliland, D.G.7
Griffin, J.D.8
-
200
-
-
1642494839
-
The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway
-
Whittaker, S. R., Walton, M. I., Garrett, M. D., Workman, P. (2004) The Cyclin-dependent kinase inhibitor CYC202 (R-roscovitine) inhibits retinoblastoma protein phosphorylation, causes loss of Cyclin D1, and activates the mitogen-activated protein kinase pathway. Cancer Res. 64, 262-272.
-
(2004)
Cancer Res.
, vol.64
, pp. 262-272
-
-
Whittaker, S.R.1
Walton, M.I.2
Garrett, M.D.3
Workman, P.4
-
201
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig, T. E., Geyer, S. M., Ghobrial, I., Inwards, D. J., Fonseca, R., Kurtin, P., Ansell, S. M., Luyun, R., Flynn, P. J., Morton, R. F., Dakhil, S. R., Gross, H., Kaufmann, S. H. (2005) Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J. Clin. Oncol. 23, 5347-5356.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
Ansell, S.M.7
Luyun, R.8
Flynn, P.J.9
Morton, R.F.10
Dakhil, S.R.11
Gross, H.12
Kaufmann, S.H.13
-
202
-
-
23044447053
-
Molecular pharmacology of the interaction of anthracyclines with iron
-
Xu, X., Persson, H. L., Richardson, D. R. (2005) Molecular pharmacology of the interaction of anthracyclines with iron. Mol. Pharmacol. 68, 261-271.
-
(2005)
Mol. Pharmacol.
, vol.68
, pp. 261-271
-
-
Xu, X.1
Persson, H.L.2
Richardson, D.R.3
-
203
-
-
0036463955
-
UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes
-
Yamauchi, T., Keating, M. J., Plunkett, W. (2002) UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes. Mol. Cancer Ther. 1, 287-294.
-
(2002)
Mol. Cancer Ther.
, vol.1
, pp. 287-294
-
-
Yamauchi, T.1
Keating, M.J.2
Plunkett, W.3
-
204
-
-
31544482800
-
Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia
-
Yanamandra, N., Colaco, N. M., Parquet, N. A., Buzzeo, R. W., Boulware, D., Wright, G., Perez, L. E., Dalton, W. S., Beaupre, D. M. (2006) Tipifarnib and bortezomib are synergistic and overcome cell adhesion-mediated drug resistance in multiple myeloma and acute myeloid leukemia. Clin. Cancer Res. 12, 591-599.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 591-599
-
-
Yanamandra, N.1
Colaco, N.M.2
Parquet, N.A.3
Buzzeo, R.W.4
Boulware, D.5
Wright, G.6
Perez, L.E.7
Dalton, W.S.8
Beaupre, D.M.9
-
205
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz, O. H., Valdez, R., Theisen, B. K., Guo, W., Ferguson, D. O., Wu, H., Morrison, S. J. (2006) Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482.
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
206
-
-
0242493856
-
The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to ST1571
-
Yu, C., Rahmani, M., Conrad, D., Subler, M., Dent, P., Grant, S. (2003) The proteasome inhibitor bortezomib interacts synergistically with histone deacetylase inhibitors to induce apoptosis in Bcr/Abl+ cells sensitive and resistant to ST1571. Blood 102, 3765-3774.
-
(2003)
Blood
, vol.102
, pp. 3765-3774
-
-
Yu, C.1
Rahmani, M.2
Conrad, D.3
Subler, M.4
Dent, P.5
Grant, S.6
-
207
-
-
0034096268
-
A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells
-
Zangemeister-Wittke, U., Leech, S. H., Olie, R. A., Simoes-Wust, A. P., Gautschi, O., Luedke, G. H., Natt, F., Haner, R., Martin, P., Hall, J., Nalin, C. M., Stahel, R. A. (2000) A novel bispecific antisense oligonucleotide inhibiting both bcl-2 and bcl-xL expression efficiently induces apoptosis in tumor cells. Clin. Cancer Res. 6, 2547-2555.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2547-2555
-
-
Zangemeister-Wittke, U.1
Leech, S.H.2
Olie, R.A.3
Simoes-Wust, A.P.4
Gautschi, O.5
Luedke, G.H.6
Natt, F.7
Haner, R.8
Martin, P.9
Hall, J.10
Nalin, C.M.11
Stahel, R.A.12
-
208
-
-
0034653499
-
Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs
-
Zeytun, A., Nagarkatti, M., Nagarkatti, P. S. (2000) Growth of FasL-bearing tumor cells in syngeneic murine host induces apoptosis and toxicity in Fas(+) organs. Blood 95, 2111-2117.
-
(2000)
Blood
, vol.95
, pp. 2111-2117
-
-
Zeytun, A.1
Nagarkatti, M.2
Nagarkatti, P.S.3
-
209
-
-
1942534018
-
Regulation of apoptosis proteins in cancer cells by ubiquitin
-
Zhang, H. G., Wang, J., Yang, X., Hsu, H. C., Mountz, J. D. (2004) Regulation of apoptosis proteins in cancer cells by ubiquitin. Oncogene 23, 2009-2015.
-
(2004)
Oncogene
, vol.23
, pp. 2009-2015
-
-
Zhang, H.G.1
Wang, J.2
Yang, X.3
Hsu, H.C.4
Mountz, J.D.5
|