PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 40, 2004, Pages 14479-14484

  Chen, Jing ^a   DeAngelo, Daniel J ^b   Kutok, Jeffery L ^c   Williams, Ifor R ^d   Lee, Benjamin H ^a,c   Wadleigh, Martha ^b   Duclos, Nicole ^a   Cohen, Sarah ^a   Adelsperger, Jennifer ^a   Okabe, Rachel ^a   Coburn, Allison ^a   Galinsky, Ilene ^b   Huntly, Brian ^a   Cohen, Pamela S ^e   Meyer, Thomas ^e   Fabbro, Doriano ^e   Roesel, Johannes ^e   Banerji, Lolita ^b   Griffin, James D ^b   Xiao, Sheng ^b   Fletcher, Jonathan A ^b   Stone, Richard M ^b   Gilliland, D Gary ^a   more..

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR RECEPTOR 1; MIDOSTAURIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; STAT5 PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; ZINC FINGER PROTEIN 198;

ACUTE GRANULOCYTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CELL TRANSFORMATION; CLINICAL TRIAL; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFICACY; DRUG SAFETY; ENZYME ACTIVATION; ENZYME ACTIVITY; HEMATOPOIETIC CELL; HISTOPATHOLOGY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHASE 2 CLINICAL TRIAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RANDOMIZED CONTROLLED TRIAL; SURVIVAL RATE;

ANIMALS; CELL LINE; CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 8; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; MICE; MICE, INBRED BALB C; MIDDLE AGED; MYELOPROLIFERATIVE DISORDERS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 1; RECEPTORS, FIBROBLAST GROWTH FACTOR; STAUROSPORINE; TRANSFORMATION, GENETIC; TRANSLOCATION, GENETIC; VARIATION (GENETICS); ZINC FINGERS;

ANIMALIA; MURINAE;

EID: 5144234541     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0404438101     Document Type: Article

References (30)

1. Macdonald, D., Aguiar, R. C., Mason, P. J., Goldman, J. M. & Cross, N. C. (1995) Leukemia 9, 1628-1630.
2. Inhorn, R. C., Aster, J. C., Roach, S. A., Slapak, C. A., Soiffer, R., Tantravahi, R. & Stone, R. M. (1995) Blood 85, 1881-1887.
3. Xiao, S., Nalabolu, S. R., Aster, J. C., Ma, J., Abruzzo, L., Jaffe, E. S., Stone, R., Weissman, S. M., Hudson, T. J. & Fletcher, J. A. (1998) Nat. Genet. 18, 84-87.
4. Guasch, G., Mack, G. J., Popovici, C., Dastugue, N., Birnbaum, D., Rattner, J. B. & Pebusque, M. J. (2000) Blood 95, 1788-1796.
5. Popovici, C., Zhang, B., Gregoire, M. J., Jonveaux, P., Lafage-Pochitaloff, M., Birnbaum, D. & Pebusque, M. J. (1999) Blood 93, 1381-1389.
6. Demiroglu, A., Steer, E. J., Heath, C., Taylor, K., Bentley, M., Allen, S. L., Koduru, P., Brody, J. P., Hawson, G., Rodwell, R., et al. (2001) Blood 98, 3778-3783.
7. Guasch, G., Popovici, C., Mugneret, F., Chaffanet, M., Pontarotti, P., Birnbaum, D. & Pebusque, M. J. (2003) Blood 101, 286-288.
8. Ollendorff, V., Guasch, G., Isnardon, D., Galindo, R., Birnbaum, D. & Pebusque, M. J. (1999) J. Biol. Chem. 274, 26922-26930.
9. Xiao, S., McCarthy, J. G., Aster, J. C. & Fletcher, J. A. (2000) Blood 96, 699-704.
10. Smedley, D., Demiroglu, A., Abdul-Rauf, M., Heath, C., Cooper, C., Shipley, J. & Cross, N. C. (1999) Neoplasia 1, 349-355.
11. Guasch, G., Ollendorff, V., Borg, J. P., Birnbaum, D. & Pebusque, M. J. (2001) Mol. Cell. Biol. 21, 8129-8142.
12. Fabbro, D., Ruetz, S., Bodis, S., Pruschy, M., Csermak, K., Man, A., Campochiaro, P., Wood, J., O'Reilly, T. & Meyer, T. (2000) Anticancer Drug Des. 15, 17-28.
13. Andrejauskas-Buchdunger, E. & Regenass, U. (1992) Cancer Res. 52, 5353-5358.
14. Weisberg, E., Boulton, C., Kelly, L. M., Manley, P., Fabbro, D., Meyer, T., Gilliland, D. G. & Griffin, J. D. (2002) Cancer Cell 1, 433-443.
15. Schwaller, J., Frantsve, J., Aster, J., Williams, I. R., Tomasson, M. H., Ross, T. S., Peeters, P., Van Rompaey, L., Van Etten, R. A., Ilaria, R., Jr., et al. (1998) EMBO J. 17, 5321-5333.
16. Liu, Q., Schwaller, J., Kutok, J., Cain, D., Aster, J. C., Williams, I. R. & Gilliland, D. G. (2000) EMBO J. 19, 1827-1838.
17. Chen, J., Williams, I. R., Kutok, J. L., Duclos, N., Anastasiadou, E., Masters, S. C., Fu, H. & Gilliland, D. G. (2004) Blood, Epub 2004 Mar 30.
18. Cools, J., Stover, E. H., Boulton, C. L., Gotlib, J., Legare, R. D., Amaral, S. M., Curley, D. P., Duclos, N., Rowan, R., Kutok, J. L., et al. (2003) Cancer Cell 3, 459-469.
19. Kelly, L. M., Yu, J. C., Boulton, C. L., Apatira, M., Li, J., Sullivan, C. M., Williams, I., Amaral, S. M., Curley, D. P., Duclos, N., et al. (2002) Cancer Cell 1, 421-432.
20. Hart, K. C., Robertson, S. C., Kanemitsu, M. Y., Meyer, A. N., Tynan, J. A. & Donoghue, D. J. (2000) Oncogene 19, 3309-3320.
21. Ryan, P. J. & Gillespie, L. L. (1994) Dev. Biol. 166, 101-111.
22. Druker, B. J. (2003) Semin. Hematol. 40, 50-58.
23. Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., Heinrich, M. C., Tuveson, D. A., Singer, S., Janicek, M., et al. (2002) N. Engl. J. Med. 347, 472-480.
24. Apperley, J. F., Gardembas, M., Melo, J. V., Russell-Jones, R., Bain, B. J., Baxter, E. J., Chase, A., Chessells, J. M., Colombat, M., Dearden, C. E., et al. (2002) N. Engl. J. Med. 347, 481-487.
25. Roumiantsev, S., Krause, D. S., Neumann, C. A., Dimitri, C. A., Asiedu, F., Cross, N. C. & Van Etten, R. A. (2004) Cancer Cell 5, 287-298.
26. Guasch, G., Delaval, B., Arnoulet, C., Xie, M. J., Xerri, L., Sainty, D., Birnbaum, D. & Pebusque, M. J. (2004) Blood 103, 309-312.
27. Muenke, M., Schell, U., Hehr, A., Robin, N. H., Losken, H. W., Schinzel, A., Pulleyn, L. J., Rutland, P., Reardon, W., Malcolm, S., et al. (1994) Nat. Genet. 8, 269-274.
28. Luqmani, Y. A., Graham, M. & Coombes, R. C. (1992) Br. J. Cancer 66, 273-280.
29. Kobrin, M. S., Yamanaka, Y., Friess, H., Lopez, M. E. & Korc, M. (1993) Cancer Res. 53, 4741-4744.
30. Morrison, R. S., Yamaguchi, F., Bruner, J. M., Tang, M., McKeehan, W. & Berger, M. S. (1994) Cancer Res. 54, 2794-2799.