UCN-01 (7-hydroxystaurosporine) inhibits DNA repair and increases cytotoxicity in normal lymphocytes and chronic lymphocytic leukemia lymphocytes

Molecular Cancer Therapeutics

Volumn 1, Issue 4, 2002, Pages 287-294

  Yamauchi, Takahiro ^a   Keating, Michael J ^a   Plunkett, William ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; 7-HYDROXYSTAUROSPORINE; ALKALOID; ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; DNA; DRUG DERIVATIVE; LIPOCORTIN 5; STAUROSPORINE;

APOPTOSIS; ARTICLE; BLOOD; CELL CULTURE; CELL CYCLE; CELL DIVISION; CHRONIC LYMPHATIC LEUKEMIA; DNA DAMAGE; DNA REPAIR; DOSE RESPONSE; DRUG COMBINATION; DRUG EFFECT; HUMAN; LYMPHOCYTE; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

ALKALOIDS; ANNEXIN A5; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL CYCLE; CELL DIVISION; CELLS, CULTURED; CYCLOPHOSPHAMIDE; DNA DAMAGE; DNA REPAIR; DNA, NEOPLASM; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; HUMANS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; LYMPHOCYTES; STAUROSPORINE; ULTRAVIOLET RAYS;

EID: 0036463955     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Takahashi, I., Kobayashi, E., Asano, K., Yoshida, M., and Nakano, H. UCN-01, a selective inhibitor of protein kinase C from Streptomyces. J. Antibiot. (Tokyo), 40: 1782-1784, 1987. (Pubitemid 18023359)
2. Akinaga, S., Sugiyama, K., and Akiyama, T. UCN-01 (7- hydroxystaurosporine) and other indolocarbazole compounds: a new generation of anti-cancer agents for the new century? Anti-Cancer Drug Des., 15:43-52, 2000. (Pubitemid 30364898)
3. Senderowicz, A. M., and Sausville, E. A. Preclinical and clinical development of cyclin-dependent kinase modulators. J. Natl. Cancer Inst., 92:376-387, 2000. (Pubitemid 30154819)
4. Seynaeve, C. M., Stetler-Stevenson, M., Sebers, S., Kaur, G., Sausville, E. A., and Worland, P. J. Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells. Cancer Res., 53: 2081-2086, 1993. (Pubitemid 23145730)
5. Wang, Q., Worland, P. J., Wang, P., Clark, J. L., Carlson, B. A., and Sausville, E. A. Apoptosis in 7-hydroxystaurosporine-treated T lymphoblasts correlates with activation of cyclin-dependent kinases 1 and 2. Cell Growth Differ., 6: 927-936, 1995.
6. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. Diverse effects of indolocarbazole compounds on the cell cycle progression of ras-transformed rat fibroblast cells. J. Antibiot. (Tokyo), 46: 1767-1771, 1993. (Pubitemid 23355467)
7. Shao, R. G., Shimizu, T., and Pommier, Y. 7-Hydroxystaurosporine (UCN-01) induces apoptosis in human colon carcinoma and leukemia cells independently of p53. Exp. Cell Res., 234: 388-397, 1997. (Pubitemid 27335182)
8. 1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-hydroxystaurosporine). Cancer Res., 59: 4406-4412, 1999.
9. Akinaga, S., Nomura, K., Gomi, K., and Okabe, M. Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C. Cancer Chemother. Pharmacol., 32:183-189, 1993. (Pubitemid 23146810)
10. Wang, Q., Fan, S., Eastman, A., Worland, P. J., Sausville, E. A., and O'Connor, P. M. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53. J. Natl. Cancer Inst., 88: 956-965, 1996. (Pubitemid 26239383)
11. Bunch, R. T., and Eastman, A. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpointinhibitor. Clin. Cancer Res., 2: 791-797, 1996. (Pubitemid 26168931)
12. Bunch, R. T., and Eastman, A. 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells. Cell Growth Differ., 8: 779-788, 1997. (Pubitemid 27287809)
13. Shao, R. G., Cao, C. X., Shimizu, T., O'Connor, P. M., Kohn, K. W., and Pommier, Y. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function. Cancer Res., 57:4029-4035, 1997. (Pubitemid 27427693)
14. Shi, Z., Azuma, A., Sampath, D., Li, Y-X., Huang, P., and Plunkett, W. S-Phase arrest by nucleoside analogues and abrogation of survival without cell cycle progression by 7-hydroxystaurosporine. Cancer Res., 61:1065-1072, 2001. (Pubitemid 32174426)
15. Graves, P. R., Yu, L., Schwarz, J. K., Gales, J., Sausville, E. A., O'Connor, P. M., and Piwnica-Worms, H. The Chk1 protein kinase and the Cdc25C regulatory pathways are targets of the anticancer agent UCN-01. J. Biol. Chem., 275: 5600-5605, 2000. (Pubitemid 30115197)
16. Sausville, E. A., Arbuck, S. G., Messmann, R., Headlee, D., Bauer, K. S., Lush, R. M., Murgo, A., Smith, A. C., Figg, W. D., Lahusen, T., Jaken, S., Jing, X., Roberge, M., Fuse, E., Kuwabara, T., and Senderowicz, A. M. Phase I trial of 72-hour continuous infusion UCN-01 in patients with refractory neoplasms. J. Clin. Oncol., 19: 2319-2333, 2001. (Pubitemid 32366984)
17. Jiang, H., and Yang, L-Y. Cell cycle checkpoint abrogator UCN-01 inhibits DNA repair: association with attenuation of the interaction of XPA and ERCC1 nucleotide excision repair proteins. Cancer Res., 59: 4529-4534, 1999. (Pubitemid 29428952)
18. Chaney, S. G., and Sancar, A. DNA repair: enzymatic mechanisms and relevance to drug response. J. Natl. Cancer. Inst., 88: 1346-1360, 1996. (Pubitemid 26329752)
19. Lindahl, T., and Wood, R. D. Quality control by DNA repair. Science (Wash. DC), 286: 1897-1905, 1999. (Pubitemid 129515891)
20. Wood, R. D. DNA repair in eukaryotes. Annu. Rev. Biochem., 65:135-167, 1996. (Pubitemid 26250607)
21. Sandoval, A., Consoli, U., and Plunkett, W. Fludarabine-mediated inhibition of nucleotide excision repair induces apoptosis in quiescent human lymphocytes. Clin. Cancer Res., 2: 1731-1741, 1996. (Pubitemid 26356359)
22. Kawai, Y., and Plunkett, W. DNA repair induced by 4- hydroperoxycyclophosphamide permits fludarabine nucleotide incorporation and is associated with synergistic induction of apoptosis in quiescent human lymphocytes. Blood, 94: 655a, 1999.
23. Yamauchi, T., Nowak, B. J., Keating, M. J., and Plunkett, W. DNA repair initiated in chronic lymphocytic leukemia lymphocytes by 4- hydroperoxycyclophosphamide is inhibited by fludarabine and clofarabine. Clin. Cancer Res., 7: 3580-3589, 2001. (Pubitemid 33069998)
24. Tew, K. D., Colvin, M., and Chabner, B. A. Alkylating agents. In: B. A. Chabner and D. L. Longo (eds.), Cancer Chemotherapy and Biotherapy, pp. 297-317. Philadelphia: Lippincott-Raven Publishers, 1996.
25. Ludeman, S. M. The chemistry of the metabolites of cyclophosphamide. Curr. Pharm. Des., 8: 627-643, 1999. (Pubitemid 29484993)
26. + human bone marrow progenitor cells. Mol. Pharmacol., 50: 610-615, 1996.
27. Thompson, L. H. 18 Nucleotide excision repair. In: J. A. Nickoloff and M. F. Hoekstra (eds.), DNA Damage and Repair, Vol. 2. DNA Repair in Higher Eukaryotes, pp. 335-393. Totowa, NJ: Humana Press, Inc., 1998.
28. Muller, M. R., Buschfort, C., Thomale, J., Lensing, C., Rajewsky, M. F., and Seeber, S. DNA repair and cellular resistance to alkylating agents in chronic lymphocytic leukemia. Clin. Cancer Res., 11: 2055-2061, 1997. (Pubitemid 27505133)
29. Sancar, A. DNA excision repair. Annu. Rev. Biochem., 65: 43-81, 1996. (Pubitemid 26250604)
30. Sladek, N. E. Metabolism of oxazaphosphorines. Pharmacol. Ther., 37: 301-355, 1988.
31. Panasci, L., Paiement, J-P., Christodoulopoulos, G., Belenkov, A., Malapetsa, A., and Aloyz, R. Chlorambucil drug resistance in chronic lymphocytic leukemia: the emerging role of DNA repair. Clin. Cancer Res., 7: 454-461, 2001. (Pubitemid 32707964)
32. Byrd, J. C., Shinn, C., Willis, C. R., Flinn, I. W., Lehman, T., Sausville, E., Lucas, D., and Grever, M. R. UCN-01 induces cytotoxicity toward human CLL cells through a p53-independent mechanism. Exp. Hematol., 29: 701-708, 2001.
33. Kitada, S., Zapata, J. M., Andreeff, M., and Reed, J. C. Protein kinase inhibitors flavopiridol and 7-hydroxystaurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood, 96:393-397, 2000. (Pubitemid 30463354)
34. Rao, V. A., and Plunkett, W. Mechanism of fludarabine-induced apoptosis in human lymphocytes undergoing DNA repair. Proc. Am. Assoc. Cancer Res., 42: 556, 2001.
35. 1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells. Cancer Res., 57: 1495-1501, 1997.
36. Busby, E. C., Leistritz, D. F., Abraham, R. T., Karnitz, L., M., and Sarkaria, J. L. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer Res., 60:2108-2112, 2000. (Pubitemid 30225168)
37. Dutta, A., and Stillman, B. cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J., 11: 2189-2199, 1992.
38. Liu, V. F., and Weaver, D. T. The ionizing radiation-induced replication protein A phosphorylation response differs between ataxia telangiectasia and normal human cells. Mol. Cell. Biol., 13: 7222-7231, 1993. (Pubitemid 23354245)
39. Carty, M. P., Zernik-Kobak, M., McGrath, S., and Dixon, K. UV light-induced DNA synthesis arrest in HeLa cells is associated with changes in phosphorylation of human single-stranded DNA-binding protein. EMBO J., 13: 2114-2123, 1994. (Pubitemid 24139724)
40. Aoufouchi, S., Prigent, C., Ford, C., Thiebaud, P., Philippe, M., and Theze, N. Cyclin B/p34cdc2 triggers phosphorylation of DNA ligase I during Xenopus laevis oocyte maturation. Eur. J. Biochem., 230: 491-497, 1995.
41. 2+/calmodulin-dependent protein kinase II inhibits DNA synthesis. Biochemistry, 36: 5300-5310, 1997.
42. Koundrioukoff, S., Jonsson, Z. O., Hasan, S., de Jong, R. N., van der Vliet, P. C., Hottiger, M. O., and Hubscher, U. A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation. J. Biol. Chem., 275: 22882-22887, 2000. (Pubitemid 30646174)
43. Zhou, B-B. S., and Elledge, S. J. The DNA damage response: putting checkpoints in perspective. Nature (Lond.), 408: 433-439, 2000.