Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells

Blood

Volumn 105, Issue 10, 2005, Pages 4043-4050

  Carter, Bing Z ^b   Gronda, Marcela ^b   Wang, Zhiliang ^b   Welsh, Kate ^b   Pinilla, Clemencia ^b   Andreeff, Michael ^b   Schober, Wendy D ^b   Nefzi, Adel ^b   Pond, Gregory R ^b   Mawji, Imtiaz A ^b   Houghten, Richard A ^b   Ostresh, John ^b   Brandwein, Joseph ^b   Minden, Mark D ^b   Schuh, Andre C ^b   Wells, Richard A ^b   Messner, Hans ^b   Chun, Kathy ^b   Reed, John C ^b   Schimmer, Aaron D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; N [6 [(ANILINOCARBONYL)AMINO] 5 [[ANILINOCARBONYL [1 (4 CYCLOHEXYLBUTYL)PYRROLIDIN 2 YL]METHYL]AMINO]HEXYL] N METHYL N' PHENYLUREA; POLYPHENYLUREA; PROTEIN BCL 2; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS; X LINKED INHIBITOR OF APOPTOSIS ANTAGONIST;

ACUTE GRANULOCYTIC LEUKEMIA; ADULT; AGED; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWNSTREAM PROCESSING; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; FEMALE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; LD 50; LETHALITY; MALE; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

EID: 20844437755     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-08-3168     Document Type: Article

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