Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties

Biochemical Pharmacology

Volumn 65, Issue 2, 2003, Pages 161-172

  Buss, Joan L ^a   Neuzil, Jiri ^b,c,e   Gellert, Nina ^c   Weber, Christian ^c,d   Ponka, Prem ^a  

^a MCGILL UNIVERSITY   (Canada)

^b LINKÖPING UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^e GRIFFITH UNIVERSITY   (Australia)

Author keywords

Apoptosis; Iron chelators; Jurkat; K562; Pyridoxal isonicotinoyl hydrazone

Indexed keywords

2 HYDROXY 1 NAPHTHYLALDEHYDE ISONICOTINOYLHYDRAZONE; BENZYLOXYCARBONYLVALYLALANYLASPARTYL FLUOROMETHYL KETONE; CASPASE; CASPASE 8; CASPASE INHIBITOR; CHELATING AGENT; HYDRAZONE DERIVATIVE; IRON 59; IRON COMPLEX; ISONIAZID DERIVATIVE; PHENIPRAZINE; PHOSPHATIDYLSERINE; PROTEIN BCL 2; PYRIDOXAL ISONICOTINOYLHYDRAZONE; SALICYLALDEHYDE ISONICOTINOYLHYDRAZONE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER; CELL STRAIN K 562; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; EXPERIMENT; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; INCUBATION TIME; IRON CHELATION; IRON OVERLOAD; LEUKEMIA CELL LINE; LYSOSOME; MITOCHONDRION; MORPHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETICULOCYTE; T LYMPHOCYTE;

APOPTOSIS; FERRIC COMPOUNDS; HEMATOPOIETIC STEM CELLS; HUMANS; IRON; IRON CHELATING AGENTS; ISONIAZID; JURKAT CELLS; K562 CELLS; MITOCHONDRIA; PYRIDOXAL; RETICULOCYTES;

EID: 0037437796     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(02)01512-5     Document Type: Article

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