Transformation of hematopoietic cells by BCR/ABL requires activation of a PI-3k/Akt-dependent pathway

EMBO Journal

Volumn 16, Issue 20, 1997, Pages 6151-6161

  Skorski, Tomasz ^a   Bellacosa, Alfonso ^b   Nieborowska Skorska, Margaret ^a   Majewski, Miroslaw ^a   Martinez, Robert ^a   Choi, John K ^c   Trotta, Rossana ^a   Wlodarski, Pawel ^a   Perrotti, Danilo ^a   Chan, Tung O ^b   Wasik, Mariusz A ^c   Tsichlis, Philip N ^b   Calabretta, Bruno ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

ABL; Activation; Akt; BCR; Leukemogenesis; PI 3k

Indexed keywords

BCR ABL PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN SUBUNIT; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CELL TRANSFORMATION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HEMATOPOIETIC CELL; LEUKEMIA; LEUKEMOGENESIS; MOUSE; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RETROVIRUS INFECTION; TRANSCRIPTION INITIATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BONE MARROW; BONE MARROW CELLS; CELL TRANSFORMATION, NEOPLASTIC; ENZYME ACTIVATION; FUSION PROTEINS, BCR-ABL; GENES, BCL-2; GENES, MYC; LEUKEMIA, EXPERIMENTAL; LIVER; MICE; MICE, INBRED C57BL; MICE, SCID; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SPLEEN;

ANIMALIA; MURINAE; UNIDENTIFIED RETROVIRUS;

EID: 0030710188     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.20.6151     Document Type: Article

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