-
1
-
-
5144226782
-
Novel immunomodulatory therapies in the treatment of multiple myeloma
-
Anderson KC. Novel immunomodulatory therapies in the treatment of multiple myeloma. Oncology (Huntingt) 2004;18:988-90.
-
(2004)
Oncology (Huntingt.)
, vol.18
, pp. 988-990
-
-
Anderson, K.C.1
-
2
-
-
0037303437
-
Moving disease biology from the lab to the clinic
-
Anderson KC. Moving disease biology from the lab to the clinic. Cancer 2003;97:796-801.
-
(2003)
Cancer
, vol.97
, pp. 796-801
-
-
Anderson, K.C.1
-
3
-
-
0023849455
-
Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
-
Kawano M, Hirano T, Matsuda T, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988;332:83-5.
-
(1988)
Nature
, vol.332
, pp. 83-85
-
-
Kawano, M.1
Hirano, T.2
Matsuda, T.3
-
4
-
-
0024503249
-
Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
-
Klein B, Zhang XG, Jourdan M, et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 1989;73:517-26.
-
(1989)
Blood
, vol.73
, pp. 517-526
-
-
Klein, B.1
Zhang, X.G.2
Jourdan, M.3
-
5
-
-
0027133422
-
Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
-
Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 1993;82: 3712-20.
-
(1993)
Blood
, vol.82
, pp. 3712-3720
-
-
Uchiyama, H.1
Barut, B.A.2
Mohrbacher, A.F.3
Chauhan, D.4
Anderson, K.C.5
-
6
-
-
0030041147
-
Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
-
Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB. Blood 1996;87:1104-12.
-
(1996)
Blood
, vol.87
, pp. 1104-1112
-
-
Chauhan, D.1
Uchiyama, H.2
Akbarali, Y.3
-
7
-
-
0029019664
-
Interleukin-6 inhibits apoptosis of malignant plasma cells
-
Lichtenstein A, Tu Y, Fady C, Vescio R, Berenson J. Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol 1995;162:248-55.
-
(1995)
Cell Immunol.
, vol.162
, pp. 248-255
-
-
Lichtenstein, A.1
Tu, Y.2
Fady, C.3
Vescio, R.4
Berenson, J.5
-
8
-
-
0027303072
-
Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226
-
Freund GG, Kulas DT, Mooney RA. Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. J Immunol 1993;151:1811.
-
(1993)
J. Immunol.
, vol.151
, pp. 1811
-
-
Freund, G.G.1
Kulas, D.T.2
Mooney, R.A.3
-
9
-
-
13544255403
-
The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications
-
Epub 2004 Oct 07
-
Podar K, Anderson KC. The pathophysiological role of VEGF in hematological malignancies: therapeutic implications. Blood 2005;105: 1383-95. Epub 2004 Oct 07.
-
(2005)
Blood
, vol.105
, pp. 1383-1395
-
-
Podar, K.1
Anderson, K.C.2
-
11
-
-
4944261541
-
Bortezomib therapy for myeloma
-
Anderson KC. Bortezomib therapy for myeloma. Curr Hematol Rep 2004;3:65.
-
(2004)
Curr. Hematol. Rep.
, vol.3
, pp. 65
-
-
Anderson, K.C.1
-
12
-
-
0035300479
-
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
-
Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61: 3071-6.
-
(2001)
Cancer Res.
, vol.61
, pp. 3071-3076
-
-
Hideshima, T.1
Richardson, P.2
Chauhan, D.3
-
13
-
-
0042167462
-
Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications
-
Chauhan D, Anderson KC. Mechanisms of cell death and survival in multiple myeloma (MM): therapeutic implications. Apoptosis 2003;8: 337-43.
-
(2003)
Apoptosis
, vol.8
, pp. 337-343
-
-
Chauhan, D.1
Anderson, K.C.2
-
14
-
-
0032539909
-
The ubiquitin-proteasome pathway: The complexity and myriad functions of proteins death
-
Ciechanover A, Schwartz AL. The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci U S A 1998;95:2727-30.
-
(1998)
Proc. Natl. Acad. Sci. U. S. A.
, vol.95
, pp. 2727-2730
-
-
Ciechanover, A.1
Schwartz, A.L.2
-
15
-
-
0035736099
-
The proteasome: A new target for novel drug therapies
-
Elliott PJ, Ross JS. The proteasome: a new target for novel drug therapies. Am J Clin Pathol 2001;116:637-46.
-
(2001)
Am. J. Clin. Pathol.
, vol.116
, pp. 637-646
-
-
Elliott, P.J.1
Ross, J.S.2
-
16
-
-
0036104603
-
Not just research tools: Proteasome inhibitors offer therapeutic promise
-
Goldberg AL, Rock K. Not just research tools: proteasome inhibitors offer therapeutic promise. Nat Med 2002;8:338-40.
-
(2002)
Nat. Med.
, vol.8
, pp. 338-340
-
-
Goldberg, A.L.1
Rock, K.2
-
17
-
-
0037397606
-
The ubiquitin proteolytic system and pathogenesis of human diseases: A novel platform for mechanism-based drug targeting
-
Ciechanover A. The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting. Biochem Soc Trans 2003;31:474-81.
-
(2003)
Biochem. Soc. Trans.
, vol.31
, pp. 474-481
-
-
Ciechanover, A.1
-
18
-
-
0032844108
-
Proteasome inhibition: A novel mechanism to combat asthma
-
Elliott PJ, Pien CS, McCormack ID, Chapman ID, Adams J. Proteasome inhibition: a novel mechanism to combat asthma. J Allergy Clin Immunol 1999;104:1-7.
-
(1999)
J. Allergy Clin. Immunol.
, vol.104
, pp. 1-7
-
-
Elliott, P.J.1
Pien, C.S.2
McCormack, I.D.3
Chapman, I.D.4
Adams, J.5
-
20
-
-
0024413057
-
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin
-
Eytan E, Ganoth D, Armon T, Hershko A. ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A 1989;86:7751-5.
-
(1989)
Proc. Natl. Acad. Sci. U. S. A.
, vol.86
, pp. 7751-7755
-
-
Eytan, E.1
Ganoth, D.2
Armon, T.3
Hershko, A.4
-
21
-
-
0842303313
-
Back to the future with ubiquitin
-
Pickart CM. Back to the future with ubiquitin. Cell 2004;116: 181-90.
-
(2004)
Cell
, vol.116
, pp. 181-190
-
-
Pickart, C.M.1
-
22
-
-
0038510204
-
Regulation of apoptosis by ubiquitination
-
Lee JC, Peter ME. Regulation of apoptosis by ubiquitination. Immunol Rev 2003;193:39-47.
-
(2003)
Immunol. Rev.
, vol.193
, pp. 39-47
-
-
Lee, J.C.1
Peter, M.E.2
-
23
-
-
0037377060
-
Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
-
Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15: 164-71.
-
(2003)
Curr. Opin. Cell Biol.
, vol.15
, pp. 164-171
-
-
Brooks, C.L.1
Gu, W.2
-
24
-
-
2342613652
-
The proteasome: A suitable antineoplastic target
-
Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004;4:349-60.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 349-360
-
-
Adams, J.1
-
25
-
-
0036240701
-
The proteasome: A novel target for cancer chemotherapy
-
Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433-43.
-
(2002)
Leukemia
, vol.16
, pp. 433-443
-
-
Almond, J.B.1
Cohen, G.M.2
-
26
-
-
0030812809
-
Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle
-
Yew PR, Kirschner MW. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science 1997;277: 1672-6.
-
(1997)
Science
, vol.277
, pp. 1672-1676
-
-
Yew, P.R.1
Kirschner, M.W.2
-
27
-
-
0030929469
-
SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities
-
Verma R, Feldman RM, Deshaies RJ. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol Biol Cell 1997;8:1427-37.
-
(1997)
Mol. Biol. Cell
, vol.8
, pp. 1427-1437
-
-
Verma, R.1
Feldman, R.M.2
Deshaies, R.J.3
-
28
-
-
0023722309
-
The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme
-
Goebl MG, Yochem J, Jentsch S, McGrath JP, Varshavsky A, Byers B. The yeast cell cycle gene CDC34 encodes a ubiquitin-conjugating enzyme. Science 1988;241:1331-5.
-
(1988)
Science
, vol.241
, pp. 1331-1335
-
-
Goebl, M.G.1
Yochem, J.2
Jentsch, S.3
McGrath, J.P.4
Varshavsky, A.5
Byers, B.6
-
29
-
-
0033059459
-
Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin
-
Masdehors P, Omura S, Merle-Beral H, et al. Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br J Haematol 1999;105:752-7.
-
(1999)
Br. J. Haematol.
, vol.105
, pp. 752-757
-
-
Masdehors, P.1
Omura, S.2
Merle-Beral, H.3
-
30
-
-
0033965742
-
Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells
-
Drexler HC, Risau W, Konerding MA. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. Faseb J 2000;14:65-77.
-
(2000)
Faseb. J.
, vol.14
, pp. 65-77
-
-
Drexler, H.C.1
Risau, W.2
Konerding, M.A.3
-
31
-
-
0033621851
-
p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells
-
Kudo Y, Takata T, Ogawa I, et al. p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin Cancer Res 2000;6:916-23.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 916-923
-
-
Kudo, Y.1
Takata, T.2
Ogawa, I.3
-
32
-
-
0037335386
-
Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: Involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways
-
Bogner C, Schneller F, Hipp S, Ringshausen I, Paschal C, Decker T. Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways. Exp Hematol 2003;31:218-25.
-
(2003)
Exp. Hematol.
, vol.31
, pp. 218-225
-
-
Bogner, C.1
Schneller, F.2
Hipp, S.3
Ringshausen, I.4
Paschal, C.5
Decker, T.6
-
33
-
-
0036348365
-
Proteasome inhibitors in the treatment of B-cell malignancies
-
Schenkein D. Proteasome inhibitors in the treatment of B-cell malignancies. Clin Lymphoma 2002;3:49-55.
-
(2002)
Clin. Lymphoma
, vol.3
, pp. 49-55
-
-
Schenkein, D.1
-
34
-
-
0030613758
-
NF-κB activation: The IκB kinase revealed?
-
Stancovski I, Baltimore D. NF-κB activation: the IκB kinase revealed? Cell 1997;91:299-302.
-
(1997)
Cell
, vol.91
, pp. 299-302
-
-
Stancovski, I.1
Baltimore, D.2
-
35
-
-
0037096221
-
NF-κB: Arresting a major culprit in cancer
-
Haefner B. NF-κB: arresting a major culprit in cancer. Drug Discov Today 2002;7:653-63.
-
(2002)
Drug Discov. Today
, vol.7
, pp. 653-663
-
-
Haefner, B.1
-
36
-
-
0031810458
-
Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells
-
Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM. Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells. Blood 1998;91:4624-31.
-
(1998)
Blood
, vol.91
, pp. 4624-4631
-
-
Jeremias, I.1
Kupatt, C.2
Baumann, B.3
Herr, I.4
Wirth, T.5
Debatin, K.M.6
-
37
-
-
0028985191
-
In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB
-
Alkalay I, Yaron A, Hatzubai A, et al. In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB. Mol Cell Biol 1995; 15:1294-301.
-
(1995)
Mol. Cell Biol.
, vol.15
, pp. 1294-1301
-
-
Alkalay, I.1
Yaron, A.2
Hatzubai, A.3
-
38
-
-
0346505340
-
The IKK NF-κB system: A treasure trove for drug development
-
Karin M, Yamamoto Y, Wang GM. The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 2004;3:17-26.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 17-26
-
-
Karin, M.1
Yamamoto, Y.2
Wang, G.M.3
-
39
-
-
0033121314
-
Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoids-induced apoptosis by Bcl-2
-
Feinman R, Koury J, Thames M, Barlogie B, Epstein J. Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoids-induced apoptosis by Bcl-2. Blood 1999;93:3044-52.
-
(1999)
Blood
, vol.93
, pp. 3044-3052
-
-
Feinman, R.1
Koury, J.2
Thames, M.3
Barlogie, B.4
Epstein, J.5
-
40
-
-
0033887015
-
Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line
-
Ogawa M, Nishiura T, Oritani K, et al. Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line. Cancer Res 2000;60:4262-9.
-
(2000)
Cancer Res.
, vol.60
, pp. 4262-4269
-
-
Ogawa, M.1
Nishiura, T.2
Oritani, K.3
-
41
-
-
0037342894
-
The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
-
Ma MH, Yang HH, Parker K, et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003;9:1136-44.
-
(2003)
Clin. Cancer Res.
, vol.9
, pp. 1136-1144
-
-
Ma, M.H.1
Yang, H.H.2
Parker, K.3
-
43
-
-
0036624741
-
Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: Therapeutic applications
-
Mitsiades N, Mitsiades CS, Poulaki V, et al. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 2002;99:4079-86.
-
(2002)
Blood
, vol.99
, pp. 4079-4086
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Poulaki, V.3
-
45
-
-
0141953292
-
Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
-
Chauhan D, Li G, Shringarpure R, et al. Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 2003;63:6174-7.
-
(2003)
Cancer Res.
, vol.63
, pp. 6174-6177
-
-
Chauhan, D.1
Li, G.2
Shringarpure, R.3
-
46
-
-
0038719671
-
JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells
-
Chauhan D, Li G, Hideshima T, et al. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem 2003;278:17593-6.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 17593-17596
-
-
Chauhan, D.1
Li, G.2
Hideshima, T.3
-
47
-
-
0142025122
-
Superoxide-dependent and independent mitochondrial signaling during apoptosis in multiple myeloma (MM) cells
-
In Press
-
Chauhan D, Guilan L, Sattler M, et al. Superoxide-dependent and independent mitochondrial signaling during apoptosis in multiple myeloma (MM) cells. Oncogene. In Press 2003.
-
(2003)
Oncogene
-
-
Chauhan, D.1
Guilan, L.2
Sattler, M.3
-
48
-
-
7644242953
-
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells
-
Fribley A, Zeng Q, Wang CY. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Siol 2004;24:9695-704.
-
(2004)
Mol. Cell Siol.
, vol.24
, pp. 9695-9704
-
-
Fribley, A.1
Zeng, Q.2
Wang, C.Y.3
-
49
-
-
0141706672
-
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
-
Ling YH, Liebes L, Zou Y, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003;278:33714-23.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33714-33723
-
-
Ling, Y.H.1
Liebes, L.2
Zou, Y.3
Perez-Soler, R.4
-
50
-
-
0037443551
-
The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
-
Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003;101:2377-80.
-
(2003)
Blood
, vol.101
, pp. 2377-2380
-
-
Mitsiades, N.1
Mitsiades, C.S.2
Richardson, P.G.3
-
51
-
-
0036884062
-
Molecular mechanisms of novel therapeutic approaches for multiple myeloma
-
Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2002;2: 927-37.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 927-937
-
-
Hideshima, T.1
Anderson, K.C.2
-
52
-
-
0037441760
-
Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
-
Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 2003;101:1530-4.
-
(2003)
Blood
, vol.101
, pp. 1530-1534
-
-
Hideshima, T.1
Mitsiades, C.2
Akiyama, M.3
-
53
-
-
1642486367
-
Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-jun/AP-1 signaling
-
Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP, Taguchi H. Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-jun/AP-1 signaling. Cancer Sci 2004;95:176-80.
-
(2004)
Cancer Sci.
, vol.95
, pp. 176-180
-
-
Yang, Y.1
Ikezoe, T.2
Saito, T.3
Kobayashi, M.4
Koeffler, H.P.5
Taguchi, H.6
-
54
-
-
0026801062
-
Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
-
Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992;70:923-35.
-
(1992)
Cell
, vol.70
, pp. 923-935
-
-
Livingstone, L.R.1
White, A.2
Sprouse, J.3
Livanos, E.4
Jacks, T.5
Tlsty, T.D.6
-
55
-
-
0035328584
-
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
-
Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res 2001; 61:3535-40.
-
(2001)
Cancer Res.
, vol.61
, pp. 3535-3540
-
-
Cusack Jr., J.C.1
Liu, R.2
Houston, M.3
-
56
-
-
13244262655
-
Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
-
Yin D, Zhou H, Kumagai T, et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene 2005;24:344-54.
-
(2005)
Oncogene
, vol.24
, pp. 344-354
-
-
Yin, D.1
Zhou, H.2
Kumagai, T.3
-
57
-
-
0033920566
-
Protease inhibitor-induced apoptosis: Accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
-
An WG, Hwang SG, Trepel JB, Blagosklonny MV. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000;14:1276-83.
-
(2000)
Leukemia
, vol.14
, pp. 1276-1283
-
-
An, W.G.1
Hwang, S.G.2
Trepel, J.B.3
Blagosklonny, M.V.4
-
58
-
-
0242610835
-
The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells
-
Williams SA, McConkey DJ. The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells. Cancer Res 2003;63:7338-44.
-
(2003)
Cancer Res.
, vol.63
, pp. 7338-7344
-
-
Williams, S.A.1
McConkey, D.J.2
-
59
-
-
0036735298
-
Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
-
LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002;62:4996-5000.
-
(2002)
Cancer Res.
, vol.62
, pp. 4996-5000
-
-
LeBlanc, R.1
Catley, L.P.2
Hideshima, T.3
-
60
-
-
0037111832
-
Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
-
Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20:4420-7.
-
(2002)
J. Clin. Oncol.
, vol.20
, pp. 4420-4427
-
-
Orlowski, R.Z.1
Stinchcombe, T.E.2
Mitchell, B.S.3
-
61
-
-
0036023407
-
A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
-
Aghajanian C, Soignet S, Dizon DS, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002;8:2505-11.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 2505-2511
-
-
Aghajanian, C.1
Soignet, S.2
Dizon, D.S.3
-
62
-
-
0037973279
-
A phase 2 study of bortezomib in relapsed, refractory myeloma
-
Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348: 2609-17.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 2609-2617
-
-
Richardson, P.G.1
Barlogie, B.2
Berenson, J.3
-
63
-
-
5644250621
-
A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
-
Jagannath S, Barlogie B, Berenson J, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004;127:165-72.
-
(2004)
Br. J. Haematol.
, vol.127
, pp. 165-172
-
-
Jagannath, S.1
Barlogie, B.2
Berenson, J.3
-
64
-
-
18044364448
-
Bortezomib demonstrates superior efficacy to high-dose dexamethasone in relapsed multiple myeloma: Final report of the APEX Study
-
San Deigo (CA): American Society of Hematology; Abstract
-
Richardson PG, Sonneveld MS, Irwin D, et al. Bortezomib demonstrates superior efficacy to high-dose dexamethasone in relapsed multiple myeloma: final report of the APEX Study. San Deigo (CA): American Society of Hematology; 2004. Abstract.
-
(2004)
-
-
Richardson, P.G.1
Sonneveld, M.S.2
Irwin, D.3
-
65
-
-
18044369886
-
Bortezomib (VELCADE®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: Preliminary results of an IFM Phase II Study
-
San Deigo (CA): American Society of Hematology; Abstract
-
Harousseau JL, Leleu X, Gressin R, Hulin C, Fuzibet JG, Troncy. Bortezomib (VELCADE®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: preliminary results of an IFM Phase II Study. San Deigo (CA): American Society of Hematology; 2004. Abstract.
-
(2004)
-
-
Harousseau, J.L.1
Leleu, X.2
Gressin, R.3
Hulin, C.4
Fuzibet, J.G.5
Troncy6
-
66
-
-
11144357610
-
The bortezomib/proteasome inhibitor PS-341 and triterpenoid CODO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance
-
Chauhan D, Li G, Podar K, et al. The bortezomib/proteasome inhibitor PS-341 and triterpenoid CODO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood 2004; 103:3158-66.
-
(2004)
Blood
, vol.103
, pp. 3158-3166
-
-
Chauhan, D.1
Li, G.2
Podar, K.3
-
68
-
-
1942467844
-
Update on the proteasome inhibitor bortezomib in hematologic malignancies
-
Goy A, Gilles F. Update on the proteasome inhibitor bortezomib in hematologic malignancies. Clin Lymphoma 2004;4:230-7.
-
(2004)
Clin. Lymphoma
, vol.4
, pp. 230-237
-
-
Goy, A.1
Gilles, F.2
-
69
-
-
9944242716
-
p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
-
Hideshima T, Podar K, Chauhan D, et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 2004;23:8766-76.
-
(2004)
Oncogene
, vol.23
, pp. 8766-8776
-
-
Hideshima, T.1
Podar, K.2
Chauhan, D.3
-
70
-
-
0036181371
-
Development of the proteasome inhibitor PS-341
-
Adams J. Development of the proteasome inhibitor PS-341. Oncologist 2002;7:9-16.
-
(2002)
Oncologist
, vol.7
, pp. 9-16
-
-
Adams, J.1
-
71
-
-
0036716281
-
The Bcl2 family: Regulators of the cellular life-or-death switch
-
Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56.
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 647-656
-
-
Cory, S.1
Adams, J.M.2
|