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Volumn 4, Issue 4, 2005, Pages 686-692

Proteasome inhibitor therapy in multiple myeloma

Author keywords

[No Author keywords available]

Indexed keywords

6 CHLORO 8 NICOTINAMIDO BETA CARBOLINE; ALKYLATING AGENT; ANTHRACYCLINE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BORTEZOMIB; CORTICOSTEROID; DEXAMETHASONE; DOXORUBICIN; HEAT SHOCK PROTEIN 27; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INHIBITOR OF APOPTOSIS PROTEIN; IRINOTECAN; MELPHALAN; MG 115; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MITOXANTRONE; PROTEASOME; PROTEASOME INHIBITOR; PROTEIN BCL 2; PROTEIN BCL XL; RELVIMID; STRESS ACTIVATED PROTEIN KINASE; THALIDOMIDE; TRITERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

EID: 18044395798     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-04-0338     Document Type: Short Survey
Times cited : (158)

References (71)
  • 1
    • 5144226782 scopus 로고    scopus 로고
    • Novel immunomodulatory therapies in the treatment of multiple myeloma
    • Anderson KC. Novel immunomodulatory therapies in the treatment of multiple myeloma. Oncology (Huntingt) 2004;18:988-90.
    • (2004) Oncology (Huntingt.) , vol.18 , pp. 988-990
    • Anderson, K.C.1
  • 2
    • 0037303437 scopus 로고    scopus 로고
    • Moving disease biology from the lab to the clinic
    • Anderson KC. Moving disease biology from the lab to the clinic. Cancer 2003;97:796-801.
    • (2003) Cancer , vol.97 , pp. 796-801
    • Anderson, K.C.1
  • 3
    • 0023849455 scopus 로고
    • Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas
    • Kawano M, Hirano T, Matsuda T, et al. Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature 1988;332:83-5.
    • (1988) Nature , vol.332 , pp. 83-85
    • Kawano, M.1    Hirano, T.2    Matsuda, T.3
  • 4
    • 0024503249 scopus 로고
    • Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6
    • Klein B, Zhang XG, Jourdan M, et al. Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6. Blood 1989;73:517-26.
    • (1989) Blood , vol.73 , pp. 517-526
    • Klein, B.1    Zhang, X.G.2    Jourdan, M.3
  • 5
    • 0027133422 scopus 로고
    • Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion
    • Uchiyama H, Barut BA, Mohrbacher AF, Chauhan D, Anderson KC. Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion. Blood 1993;82: 3712-20.
    • (1993) Blood , vol.82 , pp. 3712-3720
    • Uchiyama, H.1    Barut, B.A.2    Mohrbacher, A.F.3    Chauhan, D.4    Anderson, K.C.5
  • 6
    • 0030041147 scopus 로고    scopus 로고
    • Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB
    • Chauhan D, Uchiyama H, Akbarali Y, et al. Multiple myeloma cell adhesion-induced interleukin-6 expression in bone marrow stromal cells involves activation of NF-κB. Blood 1996;87:1104-12.
    • (1996) Blood , vol.87 , pp. 1104-1112
    • Chauhan, D.1    Uchiyama, H.2    Akbarali, Y.3
  • 8
    • 0027303072 scopus 로고
    • Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226
    • Freund GG, Kulas DT, Mooney RA. Insulin and IGF-1 increase mitogenesis and glucose metabolism in the multiple myeloma cell line, RPMI 8226. J Immunol 1993;151:1811.
    • (1993) J. Immunol. , vol.151 , pp. 1811
    • Freund, G.G.1    Kulas, D.T.2    Mooney, R.A.3
  • 9
    • 13544255403 scopus 로고    scopus 로고
    • The pathophysiological role of VEGF in hematological malignancies: Therapeutic implications
    • Epub 2004 Oct 07
    • Podar K, Anderson KC. The pathophysiological role of VEGF in hematological malignancies: therapeutic implications. Blood 2005;105: 1383-95. Epub 2004 Oct 07.
    • (2005) Blood , vol.105 , pp. 1383-1395
    • Podar, K.1    Anderson, K.C.2
  • 11
    • 4944261541 scopus 로고    scopus 로고
    • Bortezomib therapy for myeloma
    • Anderson KC. Bortezomib therapy for myeloma. Curr Hematol Rep 2004;3:65.
    • (2004) Curr. Hematol. Rep. , vol.3 , pp. 65
    • Anderson, K.C.1
  • 12
    • 0035300479 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells
    • Hideshima T, Richardson P, Chauhan D, et al. The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res 2001;61: 3071-6.
    • (2001) Cancer Res. , vol.61 , pp. 3071-3076
    • Hideshima, T.1    Richardson, P.2    Chauhan, D.3
  • 13
    • 0042167462 scopus 로고    scopus 로고
    • Mechanisms of cell death and survival in multiple myeloma (MM): Therapeutic implications
    • Chauhan D, Anderson KC. Mechanisms of cell death and survival in multiple myeloma (MM): therapeutic implications. Apoptosis 2003;8: 337-43.
    • (2003) Apoptosis , vol.8 , pp. 337-343
    • Chauhan, D.1    Anderson, K.C.2
  • 14
    • 0032539909 scopus 로고    scopus 로고
    • The ubiquitin-proteasome pathway: The complexity and myriad functions of proteins death
    • Ciechanover A, Schwartz AL. The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death. Proc Natl Acad Sci U S A 1998;95:2727-30.
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 2727-2730
    • Ciechanover, A.1    Schwartz, A.L.2
  • 15
    • 0035736099 scopus 로고    scopus 로고
    • The proteasome: A new target for novel drug therapies
    • Elliott PJ, Ross JS. The proteasome: a new target for novel drug therapies. Am J Clin Pathol 2001;116:637-46.
    • (2001) Am. J. Clin. Pathol. , vol.116 , pp. 637-646
    • Elliott, P.J.1    Ross, J.S.2
  • 16
    • 0036104603 scopus 로고    scopus 로고
    • Not just research tools: Proteasome inhibitors offer therapeutic promise
    • Goldberg AL, Rock K. Not just research tools: proteasome inhibitors offer therapeutic promise. Nat Med 2002;8:338-40.
    • (2002) Nat. Med. , vol.8 , pp. 338-340
    • Goldberg, A.L.1    Rock, K.2
  • 17
    • 0037397606 scopus 로고    scopus 로고
    • The ubiquitin proteolytic system and pathogenesis of human diseases: A novel platform for mechanism-based drug targeting
    • Ciechanover A. The ubiquitin proteolytic system and pathogenesis of human diseases: a novel platform for mechanism-based drug targeting. Biochem Soc Trans 2003;31:474-81.
    • (2003) Biochem. Soc. Trans. , vol.31 , pp. 474-481
    • Ciechanover, A.1
  • 19
    • 0027707607 scopus 로고
    • Structural features of 26S and 20S proteasomes
    • Lupas A, Koster AJ, Baumeister W. Structural features of 26S and 20S proteasomes. Enzyme Protein 1993;47:252-73.
    • (1993) Enzyme Protein , vol.47 , pp. 252-273
    • Lupas, A.1    Koster, A.J.2    Baumeister, W.3
  • 20
    • 0024413057 scopus 로고
    • ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin
    • Eytan E, Ganoth D, Armon T, Hershko A. ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A 1989;86:7751-5.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 7751-7755
    • Eytan, E.1    Ganoth, D.2    Armon, T.3    Hershko, A.4
  • 21
    • 0842303313 scopus 로고    scopus 로고
    • Back to the future with ubiquitin
    • Pickart CM. Back to the future with ubiquitin. Cell 2004;116: 181-90.
    • (2004) Cell , vol.116 , pp. 181-190
    • Pickart, C.M.1
  • 22
    • 0038510204 scopus 로고    scopus 로고
    • Regulation of apoptosis by ubiquitination
    • Lee JC, Peter ME. Regulation of apoptosis by ubiquitination. Immunol Rev 2003;193:39-47.
    • (2003) Immunol. Rev. , vol.193 , pp. 39-47
    • Lee, J.C.1    Peter, M.E.2
  • 23
    • 0037377060 scopus 로고    scopus 로고
    • Ubiquitination, phosphorylation and acetylation: The molecular basis for p53 regulation
    • Brooks CL, Gu W. Ubiquitination, phosphorylation and acetylation: the molecular basis for p53 regulation. Curr Opin Cell Biol 2003;15: 164-71.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , pp. 164-171
    • Brooks, C.L.1    Gu, W.2
  • 24
    • 2342613652 scopus 로고    scopus 로고
    • The proteasome: A suitable antineoplastic target
    • Adams J. The proteasome: a suitable antineoplastic target. Nat Rev Cancer 2004;4:349-60.
    • (2004) Nat. Rev. Cancer , vol.4 , pp. 349-360
    • Adams, J.1
  • 25
    • 0036240701 scopus 로고    scopus 로고
    • The proteasome: A novel target for cancer chemotherapy
    • Almond JB, Cohen GM. The proteasome: a novel target for cancer chemotherapy. Leukemia 2002;16:433-43.
    • (2002) Leukemia , vol.16 , pp. 433-443
    • Almond, J.B.1    Cohen, G.M.2
  • 26
    • 0030812809 scopus 로고    scopus 로고
    • Proteolysis and DNA replication: The CDC34 requirement in the Xenopus egg cell cycle
    • Yew PR, Kirschner MW. Proteolysis and DNA replication: the CDC34 requirement in the Xenopus egg cell cycle. Science 1997;277: 1672-6.
    • (1997) Science , vol.277 , pp. 1672-1676
    • Yew, P.R.1    Kirschner, M.W.2
  • 27
    • 0030929469 scopus 로고    scopus 로고
    • SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities
    • Verma R, Feldman RM, Deshaies RJ. SIC1 is ubiquitinated in vitro by a pathway that requires CDC4, CDC34, and cyclin/CDK activities. Mol Biol Cell 1997;8:1427-37.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 1427-1437
    • Verma, R.1    Feldman, R.M.2    Deshaies, R.J.3
  • 29
    • 0033059459 scopus 로고    scopus 로고
    • Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin
    • Masdehors P, Omura S, Merle-Beral H, et al. Increased sensitivity of CLL-derived lymphocytes to apoptotic death activation by the proteasome-specific inhibitor lactacystin. Br J Haematol 1999;105:752-7.
    • (1999) Br. J. Haematol. , vol.105 , pp. 752-757
    • Masdehors, P.1    Omura, S.2    Merle-Beral, H.3
  • 30
    • 0033965742 scopus 로고    scopus 로고
    • Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells
    • Drexler HC, Risau W, Konerding MA. Inhibition of proteasome function induces programmed cell death in proliferating endothelial cells. Faseb J 2000;14:65-77.
    • (2000) Faseb. J. , vol.14 , pp. 65-77
    • Drexler, H.C.1    Risau, W.2    Konerding, M.A.3
  • 31
    • 0033621851 scopus 로고    scopus 로고
    • p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells
    • Kudo Y, Takata T, Ogawa I, et al. p27Kip1 accumulation by inhibition of proteasome function induces apoptosis in oral squamous cell carcinoma cells. Clin Cancer Res 2000;6:916-23.
    • (2000) Clin. Cancer Res. , vol.6 , pp. 916-923
    • Kudo, Y.1    Takata, T.2    Ogawa, I.3
  • 32
    • 0037335386 scopus 로고    scopus 로고
    • Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: Involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways
    • Bogner C, Schneller F, Hipp S, Ringshausen I, Paschal C, Decker T. Cycling B-CLL cells are highly susceptible to inhibition of the proteasome: involvement of p27, early D-type cyclins, Bax, and caspase-dependent and -independent pathways. Exp Hematol 2003;31:218-25.
    • (2003) Exp. Hematol. , vol.31 , pp. 218-225
    • Bogner, C.1    Schneller, F.2    Hipp, S.3    Ringshausen, I.4    Paschal, C.5    Decker, T.6
  • 33
    • 0036348365 scopus 로고    scopus 로고
    • Proteasome inhibitors in the treatment of B-cell malignancies
    • Schenkein D. Proteasome inhibitors in the treatment of B-cell malignancies. Clin Lymphoma 2002;3:49-55.
    • (2002) Clin. Lymphoma , vol.3 , pp. 49-55
    • Schenkein, D.1
  • 34
    • 0030613758 scopus 로고    scopus 로고
    • NF-κB activation: The IκB kinase revealed?
    • Stancovski I, Baltimore D. NF-κB activation: the IκB kinase revealed? Cell 1997;91:299-302.
    • (1997) Cell , vol.91 , pp. 299-302
    • Stancovski, I.1    Baltimore, D.2
  • 35
    • 0037096221 scopus 로고    scopus 로고
    • NF-κB: Arresting a major culprit in cancer
    • Haefner B. NF-κB: arresting a major culprit in cancer. Drug Discov Today 2002;7:653-63.
    • (2002) Drug Discov. Today , vol.7 , pp. 653-663
    • Haefner, B.1
  • 36
    • 0031810458 scopus 로고    scopus 로고
    • Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells
    • Jeremias I, Kupatt C, Baumann B, Herr I, Wirth T, Debatin KM. Inhibition of nuclear factor κB activation attenuates apoptosis resistance in lymphoid cells. Blood 1998;91:4624-31.
    • (1998) Blood , vol.91 , pp. 4624-4631
    • Jeremias, I.1    Kupatt, C.2    Baumann, B.3    Herr, I.4    Wirth, T.5    Debatin, K.M.6
  • 37
    • 0028985191 scopus 로고
    • In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB
    • Alkalay I, Yaron A, Hatzubai A, et al. In vivo stimulation of IκB phosphorylation is not sufficient to activate NF-κB. Mol Cell Biol 1995; 15:1294-301.
    • (1995) Mol. Cell Biol. , vol.15 , pp. 1294-1301
    • Alkalay, I.1    Yaron, A.2    Hatzubai, A.3
  • 38
    • 0346505340 scopus 로고    scopus 로고
    • The IKK NF-κB system: A treasure trove for drug development
    • Karin M, Yamamoto Y, Wang GM. The IKK NF-κB system: a treasure trove for drug development. Nat Rev Drug Discov 2004;3:17-26.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 17-26
    • Karin, M.1    Yamamoto, Y.2    Wang, G.M.3
  • 39
    • 0033121314 scopus 로고    scopus 로고
    • Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoids-induced apoptosis by Bcl-2
    • Feinman R, Koury J, Thames M, Barlogie B, Epstein J. Role of NF-κB in the rescue of multiple myeloma cells from glucocorticoids-induced apoptosis by Bcl-2. Blood 1999;93:3044-52.
    • (1999) Blood , vol.93 , pp. 3044-3052
    • Feinman, R.1    Koury, J.2    Thames, M.3    Barlogie, B.4    Epstein, J.5
  • 40
    • 0033887015 scopus 로고    scopus 로고
    • Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line
    • Ogawa M, Nishiura T, Oritani K, et al. Cytokines prevent dexamethasone-induced apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase pathways in a new multiple myeloma cell line. Cancer Res 2000;60:4262-9.
    • (2000) Cancer Res. , vol.60 , pp. 4262-4269
    • Ogawa, M.1    Nishiura, T.2    Oritani, K.3
  • 41
    • 0037342894 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents
    • Ma MH, Yang HH, Parker K, et al. The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res 2003;9:1136-44.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 1136-1144
    • Ma, M.H.1    Yang, H.H.2    Parker, K.3
  • 42
  • 43
    • 0036624741 scopus 로고    scopus 로고
    • Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Biologic sequelae of nuclear factor-κB blockade in multiple myeloma: therapeutic applications. Blood 2002;99:4079-86.
    • (2002) Blood , vol.99 , pp. 4079-4086
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 44
    • 0242496212 scopus 로고    scopus 로고
    • Molecular sequelae of proteasome inhibition in human multiple myeloma cells
    • Mitsiades N, Mitsiades CS, Poulaki V, et al. Molecular sequelae of proteasome inhibition in human multiple myeloma cells. Proc Natl Acad Sci U S A 2002;99:14374-9.
    • (2002) Proc. Natl. Acad. Sci. U. S. A. , vol.99 , pp. 14374-14379
    • Mitsiades, N.1    Mitsiades, C.S.2    Poulaki, V.3
  • 45
    • 0141953292 scopus 로고    scopus 로고
    • Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells
    • Chauhan D, Li G, Shringarpure R, et al. Blockade of Hsp27 overcomes bortezomib/proteasome inhibitor PS-341 resistance in lymphoma cells. Cancer Res 2003;63:6174-7.
    • (2003) Cancer Res. , vol.63 , pp. 6174-6177
    • Chauhan, D.1    Li, G.2    Shringarpure, R.3
  • 46
    • 0038719671 scopus 로고    scopus 로고
    • JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells
    • Chauhan D, Li G, Hideshima T, et al. JNK-dependent release of mitochondrial protein, Smac, during apoptosis in multiple myeloma (MM) cells. J Biol Chem 2003;278:17593-6.
    • (2003) J. Biol. Chem. , vol.278 , pp. 17593-17596
    • Chauhan, D.1    Li, G.2    Hideshima, T.3
  • 47
    • 0142025122 scopus 로고    scopus 로고
    • Superoxide-dependent and independent mitochondrial signaling during apoptosis in multiple myeloma (MM) cells
    • In Press
    • Chauhan D, Guilan L, Sattler M, et al. Superoxide-dependent and independent mitochondrial signaling during apoptosis in multiple myeloma (MM) cells. Oncogene. In Press 2003.
    • (2003) Oncogene
    • Chauhan, D.1    Guilan, L.2    Sattler, M.3
  • 48
    • 7644242953 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells
    • Fribley A, Zeng Q, Wang CY. Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells. Mol Cell Siol 2004;24:9695-704.
    • (2004) Mol. Cell Siol. , vol.24 , pp. 9695-9704
    • Fribley, A.1    Zeng, Q.2    Wang, C.Y.3
  • 49
    • 0141706672 scopus 로고    scopus 로고
    • Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells
    • Ling YH, Liebes L, Zou Y, Perez-Soler R. Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cells. J Biol Chem 2003;278:33714-23.
    • (2003) J. Biol. Chem. , vol.278 , pp. 33714-33723
    • Ling, Y.H.1    Liebes, L.2    Zou, Y.3    Perez-Soler, R.4
  • 50
    • 0037443551 scopus 로고    scopus 로고
    • The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: Therapeutic applications
    • Mitsiades N, Mitsiades CS, Richardson PG, et al. The proteasome inhibitor PS-341 potentiates sensitivity of multiple myeloma cells to conventional chemotherapeutic agents: therapeutic applications. Blood 2003;101:2377-80.
    • (2003) Blood , vol.101 , pp. 2377-2380
    • Mitsiades, N.1    Mitsiades, C.S.2    Richardson, P.G.3
  • 51
    • 0036884062 scopus 로고    scopus 로고
    • Molecular mechanisms of novel therapeutic approaches for multiple myeloma
    • Hideshima T, Anderson KC. Molecular mechanisms of novel therapeutic approaches for multiple myeloma. Nat Rev Cancer 2002;2: 927-37.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 927-937
    • Hideshima, T.1    Anderson, K.C.2
  • 52
    • 0037441760 scopus 로고    scopus 로고
    • Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341
    • Hideshima T, Mitsiades C, Akiyama M, et al. Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341. Blood 2003;101:1530-4.
    • (2003) Blood , vol.101 , pp. 1530-1534
    • Hideshima, T.1    Mitsiades, C.2    Akiyama, M.3
  • 53
    • 1642486367 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-jun/AP-1 signaling
    • Yang Y, Ikezoe T, Saito T, Kobayashi M, Koeffler HP, Taguchi H. Proteasome inhibitor PS-341 induces growth arrest and apoptosis of non-small cell lung cancer cells via the JNK/c-jun/AP-1 signaling. Cancer Sci 2004;95:176-80.
    • (2004) Cancer Sci. , vol.95 , pp. 176-180
    • Yang, Y.1    Ikezoe, T.2    Saito, T.3    Kobayashi, M.4    Koeffler, H.P.5    Taguchi, H.6
  • 54
    • 0026801062 scopus 로고
    • Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    • Livingstone LR, White A, Sprouse J, Livanos E, Jacks T, Tlsty TD. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53. Cell 1992;70:923-35.
    • (1992) Cell , vol.70 , pp. 923-935
    • Livingstone, L.R.1    White, A.2    Sprouse, J.3    Livanos, E.4    Jacks, T.5    Tlsty, T.D.6
  • 55
    • 0035328584 scopus 로고    scopus 로고
    • Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: Implications for systemic nuclear factor-κB inhibition
    • Cusack JC Jr, Liu R, Houston M, et al. Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-κB inhibition. Cancer Res 2001; 61:3535-40.
    • (2001) Cancer Res. , vol.61 , pp. 3535-3540
    • Cusack Jr., J.C.1    Liu, R.2    Houston, M.3
  • 56
    • 13244262655 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM)
    • Yin D, Zhou H, Kumagai T, et al. Proteasome inhibitor PS-341 causes cell growth arrest and apoptosis in human glioblastoma multiforme (GBM). Oncogene 2005;24:344-54.
    • (2005) Oncogene , vol.24 , pp. 344-354
    • Yin, D.1    Zhou, H.2    Kumagai, T.3
  • 57
    • 0033920566 scopus 로고    scopus 로고
    • Protease inhibitor-induced apoptosis: Accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
    • An WG, Hwang SG, Trepel JB, Blagosklonny MV. Protease inhibitor-induced apoptosis: accumulation of wt p53, p21WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000;14:1276-83.
    • (2000) Leukemia , vol.14 , pp. 1276-1283
    • An, W.G.1    Hwang, S.G.2    Trepel, J.B.3    Blagosklonny, M.V.4
  • 58
    • 0242610835 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells
    • Williams SA, McConkey DJ. The proteasome inhibitor bortezomib stabilizes a novel active form of p53 in human LNCaP-Pro5 prostate cancer cells. Cancer Res 2003;63:7338-44.
    • (2003) Cancer Res. , vol.63 , pp. 7338-7344
    • Williams, S.A.1    McConkey, D.J.2
  • 59
    • 0036735298 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model
    • LeBlanc R, Catley LP, Hideshima T, et al. Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model. Cancer Res 2002;62:4996-5000.
    • (2002) Cancer Res. , vol.62 , pp. 4996-5000
    • LeBlanc, R.1    Catley, L.P.2    Hideshima, T.3
  • 60
    • 0037111832 scopus 로고    scopus 로고
    • Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies
    • Orlowski RZ, Stinchcombe TE, Mitchell BS, et al. Phase I trial of the proteasome inhibitor PS-341 in patients with refractory hematologic malignancies. J Clin Oncol 2002;20:4420-7.
    • (2002) J. Clin. Oncol. , vol.20 , pp. 4420-4427
    • Orlowski, R.Z.1    Stinchcombe, T.E.2    Mitchell, B.S.3
  • 61
    • 0036023407 scopus 로고    scopus 로고
    • A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies
    • Aghajanian C, Soignet S, Dizon DS, et al. A phase I trial of the novel proteasome inhibitor PS341 in advanced solid tumor malignancies. Clin Cancer Res 2002;8:2505-11.
    • (2002) Clin. Cancer Res. , vol.8 , pp. 2505-2511
    • Aghajanian, C.1    Soignet, S.2    Dizon, D.S.3
  • 62
    • 0037973279 scopus 로고    scopus 로고
    • A phase 2 study of bortezomib in relapsed, refractory myeloma
    • Richardson PG, Barlogie B, Berenson J, et al. A phase 2 study of bortezomib in relapsed, refractory myeloma. N Engl J Med 2003;348: 2609-17.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 2609-2617
    • Richardson, P.G.1    Barlogie, B.2    Berenson, J.3
  • 63
    • 5644250621 scopus 로고    scopus 로고
    • A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma
    • Jagannath S, Barlogie B, Berenson J, et al. A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol 2004;127:165-72.
    • (2004) Br. J. Haematol. , vol.127 , pp. 165-172
    • Jagannath, S.1    Barlogie, B.2    Berenson, J.3
  • 64
    • 18044364448 scopus 로고    scopus 로고
    • Bortezomib demonstrates superior efficacy to high-dose dexamethasone in relapsed multiple myeloma: Final report of the APEX Study
    • San Deigo (CA): American Society of Hematology; Abstract
    • Richardson PG, Sonneveld MS, Irwin D, et al. Bortezomib demonstrates superior efficacy to high-dose dexamethasone in relapsed multiple myeloma: final report of the APEX Study. San Deigo (CA): American Society of Hematology; 2004. Abstract.
    • (2004)
    • Richardson, P.G.1    Sonneveld, M.S.2    Irwin, D.3
  • 65
    • 18044369886 scopus 로고    scopus 로고
    • Bortezomib (VELCADE®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: Preliminary results of an IFM Phase II Study
    • San Deigo (CA): American Society of Hematology; Abstract
    • Harousseau JL, Leleu X, Gressin R, Hulin C, Fuzibet JG, Troncy. Bortezomib (VELCADE®) plus dexamethasone as induction treatment prior to autologous stem cell transplantation in patients with newly diagnosed multiple myeloma: preliminary results of an IFM Phase II Study. San Deigo (CA): American Society of Hematology; 2004. Abstract.
    • (2004)
    • Harousseau, J.L.1    Leleu, X.2    Gressin, R.3    Hulin, C.4    Fuzibet, J.G.5    Troncy6
  • 66
    • 11144357610 scopus 로고    scopus 로고
    • The bortezomib/proteasome inhibitor PS-341 and triterpenoid CODO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance
    • Chauhan D, Li G, Podar K, et al. The bortezomib/proteasome inhibitor PS-341 and triterpenoid CODO-Im induce synergistic anti-multiple myeloma (MM) activity and overcome bortezomib resistance. Blood 2004; 103:3158-66.
    • (2004) Blood , vol.103 , pp. 3158-3166
    • Chauhan, D.1    Li, G.2    Podar, K.3
  • 68
    • 1942467844 scopus 로고    scopus 로고
    • Update on the proteasome inhibitor bortezomib in hematologic malignancies
    • Goy A, Gilles F. Update on the proteasome inhibitor bortezomib in hematologic malignancies. Clin Lymphoma 2004;4:230-7.
    • (2004) Clin. Lymphoma , vol.4 , pp. 230-237
    • Goy, A.1    Gilles, F.2
  • 69
    • 9944242716 scopus 로고    scopus 로고
    • p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells
    • Hideshima T, Podar K, Chauhan D, et al. p38 MAPK inhibition enhances PS-341 (bortezomib)-induced cytotoxicity against multiple myeloma cells. Oncogene 2004;23:8766-76.
    • (2004) Oncogene , vol.23 , pp. 8766-8776
    • Hideshima, T.1    Podar, K.2    Chauhan, D.3
  • 70
    • 0036181371 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor PS-341
    • Adams J. Development of the proteasome inhibitor PS-341. Oncologist 2002;7:9-16.
    • (2002) Oncologist , vol.7 , pp. 9-16
    • Adams, J.1
  • 71
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: Regulators of the cellular life-or-death switch
    • Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer 2002;2:647-56.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.