Induction of redox imbalance and apoptosis in multiple myeloma cells by the novel triterpenoid 2-cyano-3, 12-dioxoolean-1,9-dien-28-oic acid

Molecular Cancer Therapeutics

Volumn 3, Issue 1, 2004, Pages 39-45

  Ikeda, Takashi ^a   Nakata, Yukiko ^b   Kimura, Fumihiko ^b   Sato, Ken ^b   Anderson, Kenneth ^a   Motoyoshi, Kazuo ^b   Sporn, Michael ^c   Kufe, Donald W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL DEFENSE MEDICAL COLLEGE   (Japan)

^c DARTMOUTH COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 CYANO 3,12 DIOXOOLEAN 1,9 DIEN 28 OIC ACID IMIDAZOLIDE ESTER; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; ACETYLCYSTEINE; ANTINEOPLASTIC AGENT; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; CASPASE 8; CATALASE; DITHIOTHREITOL; FAS ASSOCIATED DEATH DOMAIN PROTEIN; FLICE INHIBITORY PROTEIN; GLUTATHIONE; GLUTATHIONE SYNTHASE; REACTIVE OXYGEN METABOLITE; TRITERPENOID; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MULTIPLE MYELOMA; OXIDATION REDUCTION STATE; PRIORITY JOURNAL;

ANTIOXIDANTS; APOPTOSIS; BONE MARROW CELLS; CARRIER PROTEINS; CASP8 AND FADD-LIKE APOPTOSIS REGULATING PROTEIN; CASPASE 8; CASPASES; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTATHIONE; HUMANS; IMIDAZOLES; INTRACELLULAR MEMBRANES; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE POTENTIALS; MITOCHONDRIA; MULTIPLE MYELOMA; OLEANOLIC ACID; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES;

EID: 4444281592     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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