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Volumn 277, Issue 19, 2002, Pages 16448-16455
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The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) potently enhances apoptosis induced by tumor necrosis factor in human leukemia cells
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Author keywords
[No Author keywords available]
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Indexed keywords
CYTOLOGY;
PROTEINS;
RNA;
TUMOR NECROSIS FACTOR (TNF);
BIOCHEMISTRY;
2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID;
CASPASE 3;
CASPASE 8;
CASPASE INHIBITOR;
CYTOCHROME C;
IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;
PHORBOL ESTER DERIVATIVE;
PROTEIN BAX;
PROTEIN BCL X;
PROTEIN BID;
STRESS ACTIVATED PROTEIN KINASE;
TRITERPENOID;
TUMOR NECROSIS FACTOR;
UNCLASSIFIED DRUG;
APOPTOSIS;
ARTICLE;
CELL NUCLEUS;
CONTROLLED STUDY;
DRUG TARGETING;
ENZYME ACTIVATION;
GENE EXPRESSION;
HUMAN;
HUMAN CELL;
LEUKEMIA CELL;
MITOCHONDRION;
PRIORITY JOURNAL;
PROTEIN SYNTHESIS;
PROTEIN TRANSPORT;
RNA SYNTHESIS;
SIGNAL TRANSDUCTION;
APOPTOSIS;
BCL-2-ASSOCIATED X PROTEIN;
BCL-X PROTEIN;
CARCINOGENS;
CASPASE 3;
CASPASE 8;
CASPASE 9;
CASPASES;
CELL NUCLEUS;
CHROMATIN;
CYTOCHROME C GROUP;
CYTOSOL;
DNA-BINDING PROTEINS;
DOSE-RESPONSE RELATIONSHIP, DRUG;
ENZYME ACTIVATION;
GENE EXPRESSION REGULATION;
HUMANS;
I-KAPPA B PROTEINS;
IMMUNOBLOTTING;
JNK MITOGEN-ACTIVATED PROTEIN KINASES;
LEUKEMIA;
MAP KINASE KINASE 4;
MITOCHONDRIA;
MITOGEN-ACTIVATED PROTEIN KINASE KINASES;
NF-KAPPA B;
NITRIC OXIDE;
OLEANOLIC ACID;
PROTEIN TRANSPORT;
PROTO-ONCOGENE PROTEINS;
PROTO-ONCOGENE PROTEINS C-BCL-2;
SIGNAL TRANSDUCTION;
TETRADECANOYLPHORBOL ACETATE;
TIME FACTORS;
TUMOR CELLS, CULTURED;
TUMOR NECROSIS FACTOR-ALPHA;
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EID: 0037053358
PISSN: 00219258
EISSN: None
Source Type: Journal
DOI: 10.1074/jbc.M108974200 Document Type: Article |
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Times cited : (91)
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References (40)
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