BCR-ABL point mutants isolated from patients with imatinib mesylate-resistant chronic myeloid leukemia remain sensitive to inhibitors of the BCR-ABL chaperone heat shock protein 90

Blood

Volumn 100, Issue 8, 2002, Pages 3041-3044

  Gorre, Mercedes E ^a,b   Ellwood Yen, Katharine ^a,b   Chiosis, Gabriela ^a,b   Rosen, Neal ^a,b   Sawyers, Charles L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

17 ALLYLAMINOGELDANAMYCIN; BCR ABL PROTEIN; CHAPERONE; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; IMATINIB; UNCLASSIFIED DRUG;

ARTICLE; CELL GROWTH; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG POTENCY; GENE AMPLIFICATION; GENE ISOLATION; GENE TARGETING; GENETIC RESISTANCE; GROWTH INHIBITION; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; INHIBITION KINETICS; MOLECULAR GENETICS; PHILADELPHIA 1 CHROMOSOME; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; SENSITIVITY ANALYSIS; WILD TYPE;

EID: 0037108448     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-05-1361     Document Type: Article

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